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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of ERBB signaling pathway
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Accession:GO:1901184 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of ERBB signaling pathway.
Synonyms:exact_synonym: regulation of EGF receptor family signaling pathway;   regulation of ERBB signalling pathway;   regulation of ErbB signaling
 related_synonym: regulation of EGFR family signaling pathway

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regulation of ERBB signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sh3tc2 SH3 domain and tetratricopeptide repeats 2 acts_upstream_of_or_within ISO (PMID:23553667) MGI PMID:23553667 NCBI chrNW_004955415:5,286,475...5,354,880
Ensembl chrNW_004955415:5,303,311...5,355,672 		JBrowse link
epidermal growth factor catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rab7a RAB7A, member RAS oncogene family involved_in ISO (PMID:18272684)
(PMID:16282324)		 BHF-UCL
UniProt		 PMID:16282324 PMID:18272684 NCBI chrNW_004955429:15,103,792...15,167,498 JBrowse link
G Snx5 sorting nexin 5 ISO RGD PMID:16487940 RGD:13508623 NCBI chrNW_004955415:26,786,836...26,805,762
Ensembl chrNW_004955415:26,785,326...26,796,566 		JBrowse link
negative regulation of epidermal growth factor receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbl Cbl proto-oncogene involved_in ISO (PMID:23457600)
(PMID:25178484)
(PMID:11823423)
(PMID:12754251)		 MGI
UniProt		 PMID:11823423 PMID:12754251 PMID:23457600 PMID:25178484 NCBI chrNW_004955412:20,307,011...20,388,539
Ensembl chrNW_004955412:20,307,011...20,388,539 		JBrowse link
G Cblc Cbl proto-oncogene C involved_in ISO (PMID:10362357) BHF-UCL PMID:10362357 NCBI chrNW_004955555:1,921,896...1,941,247
Ensembl chrNW_004955555:1,921,912...1,935,096 		JBrowse link
G Dab2ip DAB2 interacting protein involved_in ISO PMID:11812785 BHF-UCL PMID:11812785 RGD:632628 NCBI chrNW_004955419:6,229,437...6,416,619
Ensembl chrNW_004955419:6,228,591...6,416,402 		JBrowse link
G Dusp3 dual specificity phosphatase 3 involved_in ISO (PMID:28759036) BHF-UCL PMID:28759036 NCBI chrNW_004955451:17,064,739...17,069,964 JBrowse link
G Egfr epidermal growth factor receptor involved_in ISO (PMID:23457600)
(PMID:11823423)		 MGI PMID:11823423 PMID:23457600 NCBI chrNW_004955456:321,222...456,431 JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 involved_in ISO (PMID:19710174) RGD
UniProt		 PMID:19204184 PMID:19710174 RGD:9685562 NCBI chrNW_004955486:4,941,143...4,955,693
Ensembl chrNW_004955486:4,941,143...4,955,693 		JBrowse link
G Itga1 integrin subunit alpha 1 involved_in ISO (PMID:15592458) UniProt PMID:15592458 NCBI chrNW_004955446:14,439,571...14,582,236
Ensembl chrNW_004955446:14,446,300...14,577,605 		JBrowse link
G Mvp major vault protein involved_in ISO (PMID:16441665) UniProt PMID:16441665 NCBI chrNW_004955493:7,113,194...7,141,944
Ensembl chrNW_004955493:7,113,319...7,143,582 		JBrowse link
G Nppa natriuretic peptide A involved_in ISO (PMID:20353436) UniProt PMID:20353436 NCBI chrNW_004955486:2,061,196...2,062,805
Ensembl chrNW_004955486:2,060,735...2,063,003 		JBrowse link
G Nup62 nucleoporin 62 involved_in ISO (PMID:11489947) UniProt PMID:11489947 NCBI chrNW_004955559:1,012,919...1,033,465
Ensembl chrNW_004955559:1,030,894...1,032,462 		JBrowse link
G Ptpn2 protein tyrosine phosphatase non-receptor type 2 involved_in ISO (PMID:15592458) UniProt PMID:15592458 NCBI chrNW_004955402:771,410...846,671 JBrowse link
G Ptprf protein tyrosine phosphatase receptor type F ISO RGD PMID:8557682 RGD:1642757 NCBI chrNW_004955537:3,096,601...3,185,682
Ensembl chrNW_004955537:3,096,603...3,185,682 		JBrowse link
G Ptprj protein tyrosine phosphatase receptor type J involved_in ISO (PMID:19836242) UniProt PMID:19836242 NCBI chrNW_004955422:396,266...438,792
Ensembl chrNW_004955422:399,357...443,054 		JBrowse link
G Rnf115 ring finger protein 115 involved_in ISO (PMID:23418353) UniProt PMID:23418353 NCBI chrNW_004955568:263,302...349,192
Ensembl chrNW_004955568:263,302...349,192 		JBrowse link
G Rnf126 ring finger protein 126 involved_in ISO (PMID:23418353) UniProt PMID:23418353 NCBI chrNW_004955495:7,083,952...7,098,442
Ensembl chrNW_004955495:7,095,336...7,102,757 		JBrowse link
G Sh3gl2 SH3 domain containing GRB2 like 2, endophilin A1 involved_in ISO (PMID:24854121) ARUK-UCL PMID:24854121 NCBI chrNW_004955434:20,332,727...20,381,320
Ensembl chrNW_004955434:20,331,779...20,381,376 		JBrowse link
G Tfap2a transcription factor AP-2 alpha acts_upstream_of_or_within ISO (PMID:16449191) MGI PMID:16449191 NCBI chrNW_004955465:3,877,896...3,900,259
Ensembl chrNW_004955465:3,882,549...3,898,929 		JBrowse link
G Tsg101 tumor susceptibility 101 involved_in ISO (PMID:16554368) ParkinsonsUK-UCL PMID:16554368 NCBI chrNW_004955414:33,154,812...33,193,769
Ensembl chrNW_004955414:33,154,812...33,193,769 		JBrowse link
G Zfyve28 zinc finger FYVE-type containing 28 involved_in ISO (PMID:19460345) UniProt PMID:19460345 NCBI chrNW_004955514:1,366,186...1,450,982
Ensembl chrNW_004955514:1,367,067...1,450,909 		JBrowse link
negative regulation of epidermal growth factor-activated receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chmp6 charged multivesicular body protein 6 involved_in ISO (PMID:16973552) UniProt PMID:16973552 NCBI chrNW_004955506:1,987,710...1,994,731
Ensembl chrNW_004955506:1,987,195...1,994,666 		JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 involved_in ISO (PMID:16648858)
(PMID:18046415)
PMID:17599051		 UniProt PMID:16648858 PMID:17599051 PMID:18046415 RGD:8553726 NCBI chrNW_004955486:4,941,143...4,955,693
Ensembl chrNW_004955486:4,941,143...4,955,693 		JBrowse link
G Gprc5a G protein-coupled receptor class C group 5 member A involved_in ISO (PMID:25744720) UniProt PMID:25744720 NCBI chrNW_004955413:9,765,564...9,784,847
Ensembl chrNW_004955413:9,765,564...9,785,856 		JBrowse link
G Psen1 presenilin 1 involved_in ISO (PMID:20208556) BHF-UCL PMID:20208556 NCBI chrNW_004955523:2,128,529...2,210,737
Ensembl chrNW_004955523:2,128,529...2,210,737 		JBrowse link
G Psen2 presenilin 2 involved_in ISO (PMID:20208556) BHF-UCL PMID:20208556 NCBI chrNW_004955406:5,727,367...5,748,798
Ensembl chrNW_004955406:5,727,367...5,752,234 		JBrowse link
G Socs4 suppressor of cytokine signaling 4 involved_in ISO (PMID:15590694) UniProt PMID:15590694 NCBI chrNW_004955409:8,522,540...8,539,551
Ensembl chrNW_004955409:8,527,291...8,528,616 		JBrowse link
G Socs5 suppressor of cytokine signaling 5 involved_in ISO (PMID:15590694) UniProt PMID:15590694 NCBI chrNW_004955441:13,593,342...13,657,389
Ensembl chrNW_004955441:13,593,342...13,657,389 		JBrowse link
G Tsg101 tumor susceptibility 101 involved_in ISO (PMID:16973552) UniProt PMID:16973552 NCBI chrNW_004955414:33,154,812...33,193,769
Ensembl chrNW_004955414:33,154,812...33,193,769 		JBrowse link
G Vps25 vacuolar protein sorting 25 homolog involved_in ISO (PMID:16973552) UniProt PMID:16973552 NCBI chrNW_004955451:16,589,509...16,593,730
Ensembl chrNW_004955451:16,589,509...16,594,497 		JBrowse link
G Zfyve28 zinc finger FYVE-type containing 28 involved_in ISO (PMID:19460345) UniProt PMID:19460345 NCBI chrNW_004955514:1,366,186...1,450,982
Ensembl chrNW_004955514:1,367,067...1,450,909 		JBrowse link
G Zgpat zinc finger CCCH-type and G-patch domain containing involved_in ISO (PMID:19644445) UniProt PMID:19644445 NCBI chrNW_004955528:493,051...519,780
Ensembl chrNW_004955528:493,051...519,780 		JBrowse link
negative regulation of ERBB signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lgmn legumain involved_in ISO (PMID:21292981) UniProt PMID:21292981 NCBI chrNW_004955438:14,905,856...14,938,722
Ensembl chrNW_004955438:14,905,856...14,939,256 		JBrowse link
negative regulation of ERBB4 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp4 acid phosphatase 4 involved_in ISO (PMID:15219672) UniProt PMID:15219672 NCBI chrNW_004955559:481,953...488,464
Ensembl chrNW_004955559:483,071...486,592 		JBrowse link
G Cadm1 cell adhesion molecule 1 ISO RGD PMID:23769722 RGD:152975632 NCBI chrNW_004955412:16,673,401...17,005,082
Ensembl chrNW_004955412:16,669,099...17,005,014 		JBrowse link
positive regulation of epidermal growth factor receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam17 ADAM metallopeptidase domain 17 involved_in
acts_upstream_of		 ISO (PMID:17655843)
(PMID:18625725)		 BHF-UCL PMID:17655843 PMID:18625725 NCBI chrNW_004955487:5,180,241...5,218,298
Ensembl chrNW_004955487:5,180,252...5,218,216 		JBrowse link
G Adra2a adrenoceptor alpha 2A involved_in ISO (PMID:17655843) BHF-UCL PMID:17655843 NCBI chrNW_004955485:384,405...387,332
Ensembl chrNW_004955485:385,800...387,240 		JBrowse link
G Afap1l2 actin filament associated protein 1 like 2 involved_in ISO (PMID:17412687) HGNC-UCL PMID:17412687 NCBI chrNW_004955431:19,275,257...19,378,507
Ensembl chrNW_004955431:19,276,412...19,315,446 		JBrowse link
G Agr2 anterior gradient 2, protein disulphide isomerase family member involved_in ISO (PMID:25666625) UniProt PMID:25666625 NCBI chrNW_004955410:19,984,768...19,995,446
Ensembl chrNW_004955410:19,984,768...19,995,733 		JBrowse link
G Agt angiotensinogen involved_in ISO (PMID:15652490) BHF-UCL PMID:15652490 NCBI chrNW_004955492:7,863,662...7,874,863
Ensembl chrNW_004955492:7,866,833...7,873,357 		JBrowse link
G Arhgef2 Rho/Rac guanine nucleotide exchange factor 2 involved_in ISO (PMID:23389627) AgBase PMID:23389627 NCBI chrNW_004955545:2,149,107...2,192,986
Ensembl chrNW_004955545:2,149,107...2,197,153 		JBrowse link
G Ccdc88a coiled-coil domain containing 88A involved_in ISO (PMID:20462955) UniProt PMID:20462955 NCBI chrNW_004955424:27,617,833...27,771,385
Ensembl chrNW_004955424:27,617,833...27,771,385 		JBrowse link
G Cnot9 CCR4-NOT transcription complex subunit 9 involved_in ISO (PMID:20878056) UniProt PMID:20878056 NCBI chrNW_004955453:14,819,007...14,845,879
Ensembl chrNW_004955453:14,816,910...14,845,912 		JBrowse link
G Dgkd diacylglycerol kinase delta involved_in ISO (PMID:17021016) UniProt PMID:17021016 NCBI chrNW_004955453:2,740,922...2,802,669
Ensembl chrNW_004955453:2,742,842...2,835,811 		JBrowse link
G Esr1 estrogen receptor 1 ISO RGD PMID:17928626 RGD:5128669 NCBI chrNW_004955439:9,588,631...9,953,606
Ensembl chrNW_004955439:9,588,201...9,963,353 		JBrowse link
G Esr2 estrogen receptor 2 ISO RGD PMID:17928626 RGD:5128669 NCBI chrNW_004955466:5,587,003...5,644,765
Ensembl chrNW_004955466:5,575,088...5,638,946 		JBrowse link
G Fam83b family with sequence similarity 83 member B involved_in ISO (PMID:22886302), (PMID:23912460)
(PMID:23676467)		 UniProt PMID:22886302 PMID:23676467 PMID:23912460 NCBI chrNW_004955411:1,248,945...1,306,848
Ensembl chrNW_004955411:1,247,005...1,301,953 		JBrowse link
G Faslg Fas ligand ISO RGD PMID:18471522 RGD:2315731 NCBI chrNW_004955406:13,098,479...13,107,045
Ensembl chrNW_004955406:13,098,662...13,107,389 		JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 involved_in ISO (PMID:15705806)
(PMID:21673097)		 UniProt
RGD		 PMID:15705806 PMID:20445128 PMID:21673097 RGD:4892084 NCBI chrNW_004955460:8,790,798...8,794,902
Ensembl chrNW_004955460:8,790,798...8,794,902 		JBrowse link
G Hip1 huntingtin interacting protein 1 involved_in ISO (PMID:14732715) ParkinsonsUK-UCL PMID:14732715 NCBI chrNW_004955456:14,389,282...14,529,317
Ensembl chrNW_004955456:14,392,921...14,529,213 		JBrowse link
G Hip1r huntingtin interacting protein 1 related involved_in ISO (PMID:14732715) ParkinsonsUK-UCL PMID:14732715 NCBI chrNW_004955482:5,885,807...5,896,386
Ensembl chrNW_004955482:5,884,839...5,896,389 		JBrowse link
G Mmp9 matrix metallopeptidase 9 involved_in ISO (PMID:22984561) CACAO PMID:22984561 NCBI chrNW_004955445:11,295,500...11,303,322
Ensembl chrNW_004955445:11,295,448...11,303,288 		JBrowse link
G Neu3 neuraminidase 3 involved_in ISO (PMID:17334392) UniProt PMID:17334392 NCBI chrNW_004955414:16,783,996...16,798,368
Ensembl chrNW_004955414:16,788,171...16,798,535 		JBrowse link
G Pde6g phosphodiesterase 6G acts_upstream_of_or_within ISO (PMID:11502744) MGI PMID:11502744 NCBI chrNW_004955506:1,437,645...1,441,758
Ensembl chrNW_004955506:1,437,645...1,441,750 		JBrowse link
G Pde6h phosphodiesterase 6H acts_upstream_of_or_within ISO (PMID:11502744) MGI PMID:11502744 NCBI chrNW_004955413:11,654,252...11,711,799
Ensembl chrNW_004955413:11,703,378...11,712,075 		JBrowse link
G Plaur plasminogen activator, urokinase receptor involved_in ISO (PMID:22984561) CACAO PMID:22984561 NCBI chrNW_004955555:1,378,505...1,393,395
Ensembl chrNW_004955555:1,378,793...1,393,324 		JBrowse link
G Rala RAS like proto-oncogene A involved_in ISO (PMID:34096503) FlyBase PMID:34096503 NCBI chrNW_004955460:3,789,136...3,853,315
Ensembl chrNW_004955460:3,789,136...3,808,676 		JBrowse link
G Ralb RAS like proto-oncogene B involved_in ISO (PMID:34096503) FlyBase PMID:34096503 NCBI chrNW_004955459:9,533,081...9,574,464
Ensembl chrNW_004955459:9,531,538...9,574,766 		JBrowse link
G Shkbp1 SH3KBP1 binding protein 1 involved_in ISO (PMID:21830225) UniProt PMID:21830225 NCBI chrNW_004955578:716,818...730,593
Ensembl chrNW_004955578:716,632...730,593 		JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 ISO RGD PMID:8577724 RGD:1581110 NCBI chrNW_004955441:6,649,895...6,724,271
Ensembl chrNW_004955441:6,646,385...6,713,028 		JBrowse link
G Spry2 sprouty RTK signaling antagonist 2 involved_in ISO (PMID:15962011) MGI PMID:15962011 NCBI chrNW_004955404:27,349,286...27,353,706
Ensembl chrNW_004955404:27,349,519...27,353,706 		JBrowse link
G Tgfb1 transforming growth factor beta 1 acts_upstream_of ISO (PMID:18625725) BHF-UCL PMID:18625725 NCBI chrNW_004955555:274,405...288,441
Ensembl chrNW_004955555:270,652...288,441 		JBrowse link
positive regulation of ERBB signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rbpj recombination signal binding protein for immunoglobulin kappa J region involved_in ISO (PMID:17336907) BHF-UCL PMID:17336907 NCBI chrNW_004955443:18,783,061...19,029,441
Ensembl chrNW_004955443:18,783,061...18,910,228 		JBrowse link
positive regulation of ERBB3 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rtn4 reticulon 4 involved_in ISO (PMID:27353365) CAFA PMID:27353365 NCBI chrNW_004955424:28,061,346...28,125,838 JBrowse link
regulation of epidermal growth factor receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdh13 cadherin 13 involved_in ISO (PMID:17573778) BHF-UCL PMID:17573778 NCBI chrNW_004955564:407,120...1,549,880
Ensembl chrNW_004955564:408,730...1,426,841 		JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 involved_in ISO PMID:15467833
(PMID:15467833)		 UniProt PMID:15467833 RGD:11059592 NCBI chrNW_004955555:426,894...446,235 JBrowse link
G Fer FER tyrosine kinase involved_in ISO (PMID:21518868) UniProt PMID:21518868 NCBI chrNW_004955418:5,612,919...5,981,549
Ensembl chrNW_004955418:5,614,950...5,981,636 		JBrowse link
G Mvb12a multivesicular body subunit 12A involved_in ISO (PMID:20654576) UniProt PMID:20654576 NCBI chrNW_004955524:839,328...842,160
Ensembl chrNW_004955524:839,328...840,664 		JBrowse link
G Mvb12b multivesicular body subunit 12B involved_in ISO (PMID:20654576) UniProt PMID:20654576 NCBI chrNW_004955419:1,949,211...2,116,525
Ensembl chrNW_004955419:1,949,156...2,104,098 		JBrowse link
G Ptpn12 protein tyrosine phosphatase non-receptor type 12 involved_in ISO (PMID:27134172) UniProt PMID:27134172 NCBI chrNW_004955410:7,556,283...7,599,170
Ensembl chrNW_004955410:7,557,103...7,599,139 		JBrowse link
G Rhbdf1 rhomboid 5 homolog 1 involved_in ISO (PMID:18832597) UniProt PMID:18832597 NCBI chrNW_004955442:17,090,962...17,098,068
Ensembl chrNW_004955442:17,078,864...17,098,999 		JBrowse link
G Wdr54 WD repeat domain 54 involved_in ISO (PMID:30458214) UniProt PMID:30458214 NCBI chrNW_004955424:11,358,694...11,362,138
Ensembl chrNW_004955424:11,358,694...11,362,053 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12562
    regulation of biological process 8772
      regulation of response to stimulus 3508
        regulation of signal transduction 2729
          regulation of ERBB signaling pathway 70
            negative regulation of ERBB signaling pathway + 32
            positive regulation of ERBB signaling pathway + 29
            regulation of ERBB3 signaling pathway + 1
            regulation of epidermal growth factor receptor signaling pathway + 64
Path 2
Term Annotations click to browse term
  biological_process 12562
    biological regulation 9077
      regulation of biological process 8772
        signaling 4528
          signal transduction 4038
            cell surface receptor signaling pathway 2194
              enzyme-linked receptor protein signaling pathway 859
                cell surface receptor protein tyrosine kinase signaling pathway 545
                  ERBB signaling pathway 125
                    regulation of ERBB signaling pathway 70
                      negative regulation of ERBB signaling pathway + 32
                      positive regulation of ERBB signaling pathway + 29
                      regulation of ERBB3 signaling pathway + 1
                      regulation of epidermal growth factor receptor signaling pathway + 64
paths to the root