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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of epidermal growth factor receptor signaling pathway
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Accession:GO:0042058 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.
Synonyms:exact_synonym: regulation of EGF receptor signaling pathway;   regulation of EGF receptor signalling pathway;   regulation of EGFR signaling pathway


show annotations for term's descendants           Sort by:
regulation of epidermal growth factor receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdh13 cadherin 13 involved_in ISO (PMID:17573778) RGD PMID:17573778 NCBI chr19:46,349,562...47,387,462
Ensembl chr19:46,349,430...47,387,459 		JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 involved_in IMP
ISO
ISS		 PMID:15467833
(MGI:3057041|PMID:15467833)
GO_REF:0000024		 RGD
UniProt		 PMID:15467833 PMID:15467833 GO_REF:0000024 MGI:3057041, RGD:11059592 NCBI chr 1:81,043,595...81,060,050
Ensembl chr 1:81,043,595...81,059,992 		JBrowse link
G Fer FER tyrosine kinase involved_in ISS
ISO		 GO_REF:0000024
(PMID:21518868)		 UniProt
RGD		 PMID:21518868 GO_REF:0000024 NCBI chr 9:103,520,452...103,827,364
Ensembl chr 9:103,520,493...103,821,451 		JBrowse link
G Mir21 microRNA 21 involved_in ISO (PMID:24012640) RGD PMID:24012640 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348 		JBrowse link
G Mvb12a multivesicular body subunit 12A involved_in ISO
IBA		 (PMID:20654576)
PMID:21873635		 RGD PMID:20654576 PMID:21873635 RGD:13792537 NCBI chr16:18,252,227...18,257,111
Ensembl chr16:18,252,222...18,257,539 		JBrowse link
G Mvb12b multivesicular body subunit 12B involved_in ISO
IBA		 (PMID:20654576)
PMID:21873635		 RGD PMID:20654576 PMID:21873635 RGD:13792537 NCBI chr 3:17,034,002...17,192,658
Ensembl chr 3:17,034,003...17,193,202 		JBrowse link
G Ptpn12 protein tyrosine phosphatase, non-receptor type 12 involved_in ISO
IBA		 (PMID:27134172)
PMID:21873635		 RGD PMID:27134172 PMID:21873635 RGD:13792537 NCBI chr 4:14,020,997...14,092,931
Ensembl chr 4:14,021,052...14,092,927 		JBrowse link
G Rhbdf1 rhomboid 5 homolog 1 involved_in IBA
ISO
ISS		 PMID:21873635
(PMID:18832597)
GO_REF:0000024		 RGD
UniProt		 PMID:18832597 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr10:15,406,832...15,419,765
Ensembl chr10:15,406,859...15,419,763 		JBrowse link
G Rhbdf2 rhomboid 5 homolog 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:101,833,157...101,860,283
Ensembl chr10:101,833,157...101,860,283 		JBrowse link
G Wdr54 WD repeat domain 54 involved_in ISO (PMID:30458214) RGD PMID:30458214 NCBI chr 4:115,654,968...115,677,979
Ensembl chr 4:115,654,968...115,661,562 		JBrowse link
epidermal growth factor catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rab7a RAB7A, member RAS oncogene family involved_in ISO (PMID:18272684)
(PMID:16282324)		 RGD PMID:16282324 PMID:18272684 NCBI chr 4:120,461,966...120,510,756
Ensembl chr 4:120,461,963...120,506,889 		JBrowse link
G Snx5 sorting nexin 5 IDA RGD PMID:16487940 RGD:13508623 NCBI chr 3:131,621,709...131,641,205
Ensembl chr 3:131,621,880...131,641,192 		JBrowse link
negative regulation of epidermal growth factor receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbl Cbl proto-oncogene involved_in ISO (PMID:25178484)
MGI:2180578|MGI:95294 (MGI:5502501|PMID:23457600), (MGI:7471045|PMID:12754251), (MGI:7471047|PMID:11823423)		 RGD PMID:11823423 PMID:12754251 PMID:23457600 PMID:25178484 MGI:5502501 MGI:7471045 MGI:7471047 NCBI chr 8:44,487,824...44,571,620
Ensembl chr 8:44,489,410...44,571,176 		JBrowse link
G Cblc Cbl proto-oncogene C involved_in ISO (PMID:10362357) RGD PMID:10362357 NCBI chr 1:79,439,975...79,456,755
Ensembl chr 1:79,439,977...79,456,755 		JBrowse link
G Dab2ip DAB2 interacting protein involved_in IDA PMID:11812785 BHF-UCL PMID:11812785 RGD:632628 NCBI chr 3:18,915,290...19,086,282
Ensembl chr 3:18,915,290...19,086,280 		JBrowse link
G Dusp3 dual specificity phosphatase 3 involved_in ISO (MGI:6101044|PMID:28759036) RGD PMID:28759036 MGI:6101044 NCBI chr10:86,920,014...86,933,739
Ensembl chr10:86,920,014...86,933,962 		JBrowse link
G Egfr epidermal growth factor receptor involved_in ISO (MGI:5502501|PMID:23457600), (MGI:7471047|PMID:11823423) RGD PMID:11823423 PMID:23457600 MGI:5502501 MGI:7471047 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 involved_in IMP
ISO
IBA		 (MGI:4366137|PMID:19710174)
PMID:21873635		 RGD PMID:19710174 PMID:19204184 PMID:21873635 MGI:4366137, RGD:9685562, RGD:13792537 NCBI chr 5:161,323,981...161,337,289
Ensembl chr 5:161,323,998...161,337,282 		JBrowse link
G Itga1 integrin subunit alpha 1 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5488887|PMID:15592458)		 UniProt
RGD		 PMID:15592458 GO_REF:0000024 MGI:5488887 NCBI chr 2:46,646,125...46,812,237
Ensembl chr 2:46,653,193...46,812,238 		JBrowse link
G Mvp major vault protein involved_in ISO
IEA		 (PMID:16441665)
GO_REF:0000107		 RGD
Ensembl		 PMID:16441665 GO_REF:0000107 NCBI chr 1:181,594,734...181,622,336
Ensembl chr 1:181,594,734...181,622,380 		JBrowse link
G Nppa natriuretic peptide A involved_in ISO (PMID:20353436) RGD PMID:20353436 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Nup62 nucleoporin 62 involved_in ISO (MGI:3526674|PMID:11489947) RGD PMID:11489947 MGI:3526674 NCBI chr 1:95,298,995...95,314,902
Ensembl chr 1:95,295,526...95,315,174 		JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 involved_in ISS
ISO		 GO_REF:0000024
(PMID:15592458)		 UniProt
RGD		 PMID:15592458 GO_REF:0000024 NCBI chr18:61,229,012...61,294,662
Ensembl chr18:61,229,014...61,294,627 		JBrowse link
G Ptprf protein tyrosine phosphatase, receptor type, F IMP RGD PMID:8557682 RGD:1642757 NCBI chr 5:131,741,959...131,824,000
Ensembl chr 5:131,742,754...131,810,023 		JBrowse link
G Ptprj protein tyrosine phosphatase, receptor type, J involved_in ISO (PMID:19836242) RGD PMID:19836242 NCBI chr 3:76,405,917...76,561,842
Ensembl chr 3:76,405,927...76,562,260 		JBrowse link
G Rnf115 ring finger protein 115 involved_in ISO (PMID:23418353) RGD PMID:23418353 NCBI chr 2:184,262,087...184,329,841
Ensembl chr 2:184,262,371...184,329,823 		JBrowse link
G Rnf126 ring finger protein 126 involved_in ISO (PMID:23418353) RGD PMID:23418353 NCBI chr 7:9,939,359...9,946,963
Ensembl chr 7:9,938,229...9,946,738 		JBrowse link
G Tfap2a transcription factor AP-2 alpha acts_upstream_of_or_within ISO MGI:3038304 (MGI:3616382|PMID:16449191) RGD PMID:16449191 MGI:3616382 NCBI chr17:24,028,716...24,047,507
Ensembl chr17:24,024,432...24,047,507 		JBrowse link
G Tsg101 tumor susceptibility 101 involved_in ISO (PMID:16554368) RGD PMID:16554368 NCBI chr 1:97,412,689...97,442,589
Ensembl chr 1:97,410,848...97,442,554 		JBrowse link
G Zfyve28 zinc finger FYVE-type containing 28 involved_in ISO (PMID:19460345) RGD PMID:19460345 NCBI chr14:76,468,424...76,554,039
Ensembl chr14:76,468,424...76,554,039 		JBrowse link
negative regulation of epidermal growth factor receptor signaling pathway involved in heart process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mir133a1 microRNA 133a-1 involved_in ISO (PMID:23069713) RGD PMID:23069713 NCBI chr18:1,885,082...1,885,168 JBrowse link
G Mir3582 microRNA 3582 involved_in ISO (PMID:23069713) RGD PMID:23069713 NCBI chr18:1,885,063...1,885,180
Ensembl chr18:1,885,063...1,885,180 		JBrowse link
negative regulation of epidermal growth factor-activated receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbl Cbl proto-oncogene involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:44,487,824...44,571,620
Ensembl chr 8:44,489,410...44,571,176 		JBrowse link
G Cblb Cbl proto-oncogene B involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr11:48,589,878...48,756,940
Ensembl chr11:48,592,703...48,756,839 		JBrowse link
G Cblc Cbl proto-oncogene C involved_in ISO
IBA		 (PMID:10362357)
PMID:21873635		 RGD PMID:10362357 PMID:21873635 RGD:13792537 NCBI chr 1:79,439,975...79,456,755
Ensembl chr 1:79,439,977...79,456,755 		JBrowse link
G Chmp6 charged multivesicular body protein 6 involved_in ISO (PMID:16973552) RGD PMID:16973552 NCBI chr10:105,191,972...105,197,642
Ensembl chr10:105,191,950...105,197,640 		JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 involved_in ISS
ISO
IDA		 GO_REF:0000024
(MGI:3629275|PMID:16648858)
PMID:17599051
(PMID:18046415)		 UniProt
RGD		 PMID:16648858 PMID:18046415 PMID:17599051 GO_REF:0000024 MGI:3629275, RGD:8553726 NCBI chr 5:161,323,981...161,337,289
Ensembl chr 5:161,323,998...161,337,282 		JBrowse link
G Gprc5a G protein-coupled receptor, class C, group 5, member A involved_in ISO (MGI:5635952|PMID:25744720) RGD PMID:25744720 MGI:5635952 NCBI chr 4:167,903,542...167,922,276
Ensembl chr 4:167,903,542...167,922,260 		JBrowse link
G Psen1 presenilin 1 involved_in ISO (MGI:4887523|PMID:20208556) RGD PMID:20208556 MGI:4887523 NCBI chr 6:103,323,014...103,375,088
Ensembl chr 6:103,323,120...103,371,650 		JBrowse link
G Psen2 presenilin 2 involved_in ISO (MGI:4887523|PMID:20208556) RGD PMID:20208556 MGI:4887523 NCBI chr13:91,967,506...91,993,240
Ensembl chr13:91,967,983...91,993,174 		JBrowse link
G Socs4 suppressor of cytokine signaling 4 involved_in ISO (PMID:15590694) RGD PMID:15590694 NCBI chr15:20,523,406...20,537,889
Ensembl chr15:20,523,183...20,542,494 		JBrowse link
G Socs5 suppressor of cytokine signaling 5 involved_in ISO (PMID:15590694) RGD PMID:15590694 NCBI chr 6:7,481,039...7,512,644
Ensembl chr 6:7,481,095...7,514,834 		JBrowse link
G Tsg101 tumor susceptibility 101 involved_in ISO (PMID:16973552) RGD PMID:16973552 NCBI chr 1:97,412,689...97,442,589
Ensembl chr 1:97,410,848...97,442,554 		JBrowse link
G Vps25 vacuolar protein sorting 25 homolog involved_in ISO (PMID:16973552) RGD PMID:16973552 NCBI chr10:86,196,062...86,201,606
Ensembl chr10:86,188,812...86,231,829 		JBrowse link
G Zfyve28 zinc finger FYVE-type containing 28 involved_in ISO
IBA		 (PMID:19460345)
PMID:21873635		 RGD PMID:19460345 PMID:21873635 RGD:13792537 NCBI chr14:76,468,424...76,554,039
Ensembl chr14:76,468,424...76,554,039 		JBrowse link
G Zgpat zinc finger CCCH-type and G-patch domain containing involved_in ISO
ISS		 (PMID:19644445)
GO_REF:0000024		 RGD
UniProt		 PMID:19644445 GO_REF:0000024 NCBI chr 3:168,473,836...168,490,380
Ensembl chr 3:168,473,981...168,490,380 		JBrowse link
positive regulation of epidermal growth factor receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Afap1l2 actin filament associated protein 1-like 2 involved_in IBA
ISO		 PMID:21873635
(PMID:17412687)		 RGD PMID:17412687 PMID:21873635 RGD:13792537 NCBI chr 1:255,964,238...256,060,828
Ensembl chr 1:255,964,238...256,060,820 		JBrowse link
G Agr2 anterior gradient 2, protein disulphide isomerase family member involved_in ISO (PMID:25666625) RGD PMID:25666625 NCBI chr 6:52,708,602...52,729,378
Ensembl chr 6:52,708,602...52,729,371 		JBrowse link
G Agt angiotensinogen involved_in ISO (PMID:15652490) RGD PMID:15652490 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Arhgef2 Rho/Rac guanine nucleotide exchange factor 2 involved_in ISO (PMID:23389627) RGD PMID:23389627 NCBI chr 2:174,061,126...174,118,355
Ensembl chr 2:174,062,976...174,118,355 		JBrowse link
G Bcar3 BCAR3 adaptor protein, NSP family member involved_in ISO (PMID:18722344) RGD PMID:18722344 NCBI chr 2:210,525,260...210,638,674
Ensembl chr 2:210,525,260...210,638,798 		JBrowse link
G Ccdc88a coiled coil domain containing 88A involved_in ISO (PMID:20462955) RGD PMID:20462955 NCBI chr14:103,104,091...103,256,112
Ensembl chr14:103,103,513...103,252,368 		JBrowse link
G Cnot9 CCR4-NOT transcription complex subunit 9 involved_in ISO (PMID:20878056) RGD PMID:20878056 NCBI chr 9:76,084,269...76,109,111
Ensembl chr 9:76,084,334...76,109,100 		JBrowse link
G Dgkd diacylglycerol kinase, delta involved_in ISO (MGI:3691361|PMID:17021016) RGD PMID:17021016 MGI:3691361 NCBI chr 9:88,516,686...88,607,349
Ensembl chr 9:88,516,715...88,607,345 		JBrowse link
G Esr1 estrogen receptor 1 IMP RGD PMID:17928626 RGD:5128669 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 IMP RGD PMID:17928626 RGD:5128669 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Fam83b family with sequence similarity 83, member B involved_in ISO
IEA		 (PMID:22886302), (PMID:23676467), (PMID:23912460)
GO_REF:0000107		 RGD
Ensembl		 PMID:22886302 PMID:23676467 PMID:23912460 GO_REF:0000107 NCBI chr 8:77,287,351...77,363,795
Ensembl chr 8:77,287,351...77,363,795 		JBrowse link
G Faslg Fas ligand IMP RGD PMID:18471522 RGD:2315731 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 involved_in IMP
IEA
ISO		 GO_REF:0000107
(MGI:5141337|PMID:21673097)
(PMID:15705806)		 Ensembl
RGD		 PMID:15705806 PMID:21673097 PMID:20445128 GO_REF:0000107 MGI:5141337, RGD:4892084 NCBI chr12:15,217,217...15,222,679
Ensembl chr12:15,217,442...15,221,889 		JBrowse link
G Hap1 huntingtin-associated protein 1 involved_in IMP PMID:12890790 UniProt PMID:12890790 RGD:10047165 NCBI chr10:85,277,890...85,286,126
Ensembl chr10:85,277,890...85,286,126 		JBrowse link
G Hip1 huntingtin interacting protein 1 involved_in ISO (PMID:14732715) RGD PMID:14732715 NCBI chr12:21,133,319...21,267,796
Ensembl chr12:21,133,406...21,267,725 		JBrowse link
G Hip1r huntingtin interacting protein 1 related involved_in ISO (PMID:14732715) RGD PMID:14732715 NCBI chr12:32,590,164...32,618,841
Ensembl chr12:32,590,165...32,618,734 		JBrowse link
G Mir29a microRNA 29a involved_in ISO (PMID:25058496) RGD PMID:25058496 NCBI chr 4:59,650,608...59,650,695 JBrowse link
G Mmp9 matrix metallopeptidase 9 involved_in ISO
IEA		 (PMID:22984561)
GO_REF:0000107		 RGD
Ensembl		 PMID:22984561 GO_REF:0000107 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Neu3 neuraminidase 3 involved_in ISO (PMID:17334392) RGD PMID:17334392 NCBI chr 1:154,137,732...154,148,879
Ensembl chr 1:154,050,855...154,148,813 		JBrowse link
G Pde6g phosphodiesterase 6G involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
(MGI:2156093|PMID:11502744)		 RGD PMID:11502744 PMID:21873635 MGI:2156093, RGD:13792537 NCBI chr10:105,721,502...105,727,204
Ensembl chr10:105,721,682...105,726,719 		JBrowse link
G Pde6h phosphodiesterase 6H involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
(MGI:2156093|PMID:11502744)		 RGD PMID:11502744 PMID:21873635 MGI:2156093, RGD:13792537 NCBI chr 4:169,857,793...169,872,969
Ensembl chr 4:169,857,812...169,872,969 		JBrowse link
G Plaur plasminogen activator, urokinase receptor involved_in ISO (PMID:22984561) RGD PMID:22984561 NCBI chr 1:80,053,441...80,068,384
Ensembl chr 1:80,050,324...80,068,595 		JBrowse link
G Rala RAS like proto-oncogene A involved_in ISO UniProtKB:P11234 (PMID:34096503) RGD PMID:34096503 NCBI chr17:47,092,139...47,145,192
Ensembl chr17:47,092,207...47,144,063 		JBrowse link
G Ralb RAS like proto-oncogene B involved_in ISO
IEA		 UniProtKB:P11233 (PMID:34096503)
GO_REF:0000107		 RGD
Ensembl		 PMID:34096503 GO_REF:0000107 NCBI chr13:30,588,036...30,624,199
Ensembl chr13:30,588,033...30,624,202 		JBrowse link
G Shkbp1 Sh3kbp1 binding protein 1 involved_in ISS
IBA
ISO		 GO_REF:0000024
PMID:21873635
(MGI:5700492|PMID:21830225)		 UniProt
RGD		 PMID:21830225 PMID:21873635 GO_REF:0000024 MGI:5700492, RGD:13792537 NCBI chr 1:82,636,797...82,650,330
Ensembl chr 1:82,636,797...82,650,375 		JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 IEP RGD PMID:8577724 RGD:1581110 NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107 		JBrowse link
G Spry2 sprouty RTK signaling antagonist 2 involved_in ISO (MGI:3583038|PMID:15962011) RGD PMID:15962011 MGI:3583038 NCBI chr15:82,692,312...82,697,408
Ensembl chr15:82,692,143...82,698,009 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19738
    regulation of biological process 13021
      regulation of response to stimulus 4109
        regulation of signal transduction 3136
          regulation of ERBB signaling pathway 74
            regulation of epidermal growth factor receptor signaling pathway 68
              negative regulation of epidermal growth factor receptor signaling pathway + 31
              positive regulation of epidermal growth factor receptor signaling pathway + 27
              regulation of epidermal growth factor receptor signaling pathway involved in heart process + 2
Path 2
Term Annotations click to browse term
  biological_process 19738
    biological regulation 13436
      regulation of biological process 13021
        regulation of cellular process 11037
          signal transduction 7035
            cell surface receptor signaling pathway 2786
              enzyme-linked receptor protein signaling pathway 1024
                transmembrane receptor protein tyrosine kinase signaling pathway 643
                  ERBB signaling pathway 125
                    regulation of ERBB signaling pathway 74
                      regulation of epidermal growth factor receptor signaling pathway 68
                        negative regulation of epidermal growth factor receptor signaling pathway + 31
                        positive regulation of epidermal growth factor receptor signaling pathway + 27
                        regulation of epidermal growth factor receptor signaling pathway involved in heart process + 2
paths to the root