Tsg101 (tumor susceptibility 101) - Rat Genome Database

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Gene: Tsg101 (tumor susceptibility 101) Chinchilla lanigera
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Symbol: Tsg101
Name: tumor susceptibility 101
RGD ID: 9005788
Description: ENCODES a protein that exhibits calcium-dependent protein binding (ortholog); protein homodimerization activity (ortholog); protein-containing complex binding (ortholog); INVOLVED IN cell differentiation (ortholog); endosome to lysosome transport (ortholog); exosomal secretion (ortholog); PARTICIPATES IN autophagy pathway; ASSOCIATED WITH breast cancer (ortholog); breast carcinoma (ortholog); cervix carcinoma (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); early endosome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: tumor susceptibility gene 101
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541433,154,812 - 33,193,769 (-)EnsemblChiLan1.0 Ensembl
ChiLan1.0NW_00495541433,154,812 - 33,193,769 (-)NCBIChiLan1.0ChiLan1.0
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Tsg101
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541433,154,812 - 33,193,769 (-)EnsemblChiLan1.0 Ensembl
ChiLan1.0NW_00495541433,154,812 - 33,193,769 (-)NCBIChiLan1.0ChiLan1.0
TSG101
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381118,480,311 - 18,526,942 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1118,468,336 - 18,526,965 (-)EnsemblGRCh38.p14 Ensemblhg38GRCh38
GRCh371118,501,858 - 18,548,489 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361118,458,434 - 18,505,065 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341118,458,435 - 18,505,065NCBI
Celera1118,637,463 - 18,684,120 (-)NCBICelera
Cytogenetic Map11p15.1NCBI
HuRef1118,187,557 - 18,234,372 (-)NCBIHuRef
CHM1_11118,501,223 - 18,547,842 (-)NCBICHM1_1
T2T-CHM13v2.01118,578,331 - 18,624,993 (-)NCBIT2T-CHM13v2.0
Tsg101
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39746,538,693 - 46,569,716 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl746,528,034 - 46,569,863 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38746,888,949 - 46,926,320 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl746,888,949 - 46,919,969 (-)EnsemblGRCm38.p6 Ensemblmm10GRCm38
MGSCv37754,144,397 - 54,175,300 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36746,757,396 - 46,787,915 (-)NCBIMGSCv36mm8
Celera742,369,255 - 42,400,171 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map730.62NCBI
Tsg101
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81106,549,035 - 106,578,859 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1106,535,021 - 106,578,775 (-)EnsemblGRCr8
mRatBN7.2197,412,689 - 97,442,589 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl197,410,848 - 97,442,554 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1102,805,766 - 102,835,099 (-)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01111,277,750 - 111,307,082 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01104,561,098 - 104,590,847 (-)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1105,188,587 - 105,218,349 (-)NCBI
Lyon_Normotensive1110,298,646 - 110,328,406 (-)NCBI
Lyon_Hypertensive1106,831,929 - 106,861,679 (-)NCBI
F344_StmMcwi1105,288,981 - 105,318,745 (-)NCBI
Rnor_6.01102,941,151 - 102,971,017 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1102,941,231 - 102,970,950 (-)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.01104,015,969 - 104,044,641 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4197,445,040 - 97,475,141 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera191,659,356 - 91,689,173 (-)NCBICelera
RGSC_v3.1197,523,152 - 97,553,252 (-)NCBI
Cytogenetic Map1q22NCBI
TSG101
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2920,797,111 - 20,843,855 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11120,757,432 - 20,804,234 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01118,518,110 - 18,564,814 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11118,201,381 - 18,248,149 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1118,189,868 - 18,248,149 (-)EnsemblPanPan1.1 EnsemblpanPan2panpan1.1
TSG101
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12140,910,870 - 40,952,922 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2140,910,874 - 40,952,808 (-)EnsemblCanFam3.1 EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2140,390,143 - 40,432,212 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02142,032,656 - 42,074,737 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2142,032,614 - 42,074,722 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12141,026,209 - 41,068,217 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02141,213,135 - 41,255,211 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02141,590,866 - 41,632,952 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC120889616
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mIctTri1.hap1444,440,161 - 44,560,393 (+)NCBImIctTri1.hap1
HiC_Itri_2NW_02440494744,836,536 - 44,841,475 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936528752,694 - 808,888 (+)NCBISpeTri2.0 Ensembl
SpeTri2.0 EnsemblNW_004936528752,694 - 808,888 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936528752,572 - 809,127 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TSG101
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1240,673,187 - 40,720,681 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2243,759,512 - 43,783,691 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TSG101
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mChlSab1.0.hap1146,258,896 - 46,316,768 (+)NCBImChlSab1.0.hap1
Vero_WHO_p1.0NW_023666038143,746,335 - 143,804,463 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ChlSab1.1146,401,889 - 46,451,122 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl146,402,024 - 46,450,916 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Tsg101
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247669,932,190 - 9,977,725 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
HetGla_female_1.0 EnsemblNW_0046247669,934,228 - 9,977,697 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
Naked mole-rat maternal Ensembl5106,354,671 - 106,431,081 (+)Ensembl
Tsg101
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12152,457,588 - 152,486,918 (+)NCBIRrattus_CSIRO_v1Rrattus_CSIRO_v1


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000025254   ⟹   ENSCLAP00000025010
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495541433,154,812 - 33,193,769 (-)Ensembl
Ensembl Acc Id: ENSCLAT00000025255   ⟹   ENSCLAP00000025011
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495541433,154,812 - 33,193,768 (-)Ensembl
Ensembl Acc Id: ENSCLAT00000025256   ⟹   ENSCLAP00000025012
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495541433,155,061 - 33,187,458 (-)Ensembl
RefSeq Acc Id: XM_005380422   ⟹   XP_005380479
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541433,154,812 - 33,193,768 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005380423   ⟹   XP_005380480
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541433,154,812 - 33,193,769 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005380479 (Get FASTA)   NCBI Sequence Viewer  
  XP_005380480 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000025010
  ENSCLAP00000025010.1
  ENSCLAP00000025011
  ENSCLAP00000025011.1
  ENSCLAP00000025012.1
RefSeq Acc Id: XP_005380480   ⟸   XM_005380423
- Peptide Label: isoform X2
- UniProtKB: A0A8C2W730 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005380479   ⟸   XM_005380422
- Peptide Label: isoform X1
- UniProtKB: A0A8C2W921 (UniProtKB/TrEMBL),   A0A8C2W4F7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000025012   ⟸   ENSCLAT00000025256
Ensembl Acc Id: ENSCLAP00000025011   ⟸   ENSCLAT00000025255
Ensembl Acc Id: ENSCLAP00000025010   ⟸   ENSCLAT00000025254
Protein Domains
SB   UEV


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000017169 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000025254 ENTREZGENE
  ENSCLAT00000025254.1 UniProtKB/TrEMBL
  ENSCLAT00000025255 ENTREZGENE
  ENSCLAT00000025255.1 UniProtKB/TrEMBL
  ENSCLAT00000025256.1 UniProtKB/TrEMBL
Gene3D-CATH 3.10.110.10 UniProtKB/TrEMBL
  6.10.140.820 UniProtKB/TrEMBL
  6.10.250.370 UniProtKB/TrEMBL
InterPro ESCRT-I_UEV_domain UniProtKB/TrEMBL
  ESCRT_assembly_dom UniProtKB/TrEMBL
  SB_dom UniProtKB/TrEMBL
  UBQ-conjugating_enzyme/RWD UniProtKB/TrEMBL
  UEV_N UniProtKB/TrEMBL
NCBI Gene Tsg101 ENTREZGENE
PANTHER TUMOR SUSCEPTIBILITY GENE 101 PROTEIN UniProtKB/TrEMBL
  TUMOR SUSCEPTIBILITY GENE 101 PROTEIN-RELATED UniProtKB/TrEMBL
Pfam UEV UniProtKB/TrEMBL
  Vps23_core UniProtKB/TrEMBL
PROSITE PS51312 UniProtKB/TrEMBL
  UEV UniProtKB/TrEMBL
SMART UBCc UniProtKB/TrEMBL
Superfamily-SCOP SSF140111 UniProtKB/TrEMBL
  SSF54495 UniProtKB/TrEMBL
UniProt A0A8C2W4F7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2W730 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2W921 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-08-25 Tsg101  tumor susceptibility 101    tumor susceptibility gene 101  Symbol and/or name change 5135510 APPROVED