TSG101 (tumor susceptibility 101) - Rat Genome Database

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Gene: TSG101 (tumor susceptibility 101) Homo sapiens
Analyze
Symbol: TSG101
Name: tumor susceptibility 101
RGD ID: 1349732
HGNC Page HGNC
Description: Enables several functions, including protein homodimerization activity; ubiquitin protein ligase binding activity; and virion binding activity. Involved in several processes, including positive regulation of exosomal secretion; positive regulation of viral life cycle; and regulation of protein kinase activity. Located in several cellular components, including endosome; extracellular exosome; and nucleolus. Part of ESCRT I complex. Implicated in breast cancer; breast carcinoma; cervix carcinoma; endometrial adenocarcinoma; and prostate cancer. Biomarker of breast cancer and ovarian cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ESCRT-I complex subunit TSG101; TSG10; tumor susceptibility gene 10; tumor susceptibility gene 101; tumor susceptibility protein; VPS23
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1118,468,336 - 18,526,951 (-)EnsemblGRCh38hg38GRCh38
GRCh381118,480,311 - 18,526,942 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371118,501,858 - 18,548,489 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361118,458,434 - 18,505,065 (-)NCBINCBI36hg18NCBI36
Build 341118,458,435 - 18,505,065NCBI
Celera1118,637,463 - 18,684,120 (-)NCBI
Cytogenetic Map11p15.1NCBI
HuRef1118,187,557 - 18,234,372 (-)NCBIHuRef
CHM1_11118,501,223 - 18,547,842 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

Additional References at PubMed
PMID:9241264   PMID:9241265   PMID:9242438   PMID:9366528   PMID:9465061   PMID:9840940   PMID:10440698   PMID:10508170   PMID:10888872   PMID:11031247   PMID:11134028   PMID:11172000  
PMID:11427703   PMID:11595185   PMID:11726971   PMID:11805336   PMID:11838966   PMID:11916981   PMID:11943869   PMID:12006492   PMID:12029088   PMID:12101421   PMID:12205095   PMID:12379843  
PMID:12388682   PMID:12477932   PMID:12505256   PMID:12559917   PMID:12598123   PMID:12663786   PMID:12725919   PMID:12743307   PMID:12767222   PMID:12802020   PMID:12900394   PMID:12900395  
PMID:12915533   PMID:12927808   PMID:13679614   PMID:14505569   PMID:14505570   PMID:14519844   PMID:14526201   PMID:14556380   PMID:14581525   PMID:14581576   PMID:14722278   PMID:14761944  
PMID:14991575   PMID:15033475   PMID:15039775   PMID:15053872   PMID:15126635   PMID:15143060   PMID:15163754   PMID:15168195   PMID:15218037   PMID:15240819   PMID:15256501   PMID:15326289  
PMID:15342556   PMID:15452250   PMID:15489334   PMID:15509564   PMID:15604093   PMID:15611048   PMID:15657031   PMID:15795524   PMID:15858022   PMID:15908698   PMID:16004603   PMID:16118794  
PMID:16138902   PMID:16189514   PMID:16234236   PMID:16256744   PMID:16344560   PMID:16407257   PMID:16434471   PMID:16470130   PMID:16501490   PMID:16552148   PMID:16554368   PMID:16571793  
PMID:16571837   PMID:16707569   PMID:16778200   PMID:16808324   PMID:16940516   PMID:16973552   PMID:17014699   PMID:17060450   PMID:17083721   PMID:17110434   PMID:17174262   PMID:17182674  
PMID:17182691   PMID:17229889   PMID:17320394   PMID:17321722   PMID:17350572   PMID:17428861   PMID:17538020   PMID:17556548   PMID:17714434   PMID:17853893   PMID:17940959   PMID:17942528  
PMID:17982468   PMID:18005716   PMID:18029348   PMID:18077552   PMID:18256029   PMID:18267010   PMID:18321968   PMID:18367816   PMID:18439901   PMID:18600204   PMID:18641129   PMID:18643869  
PMID:18676680   PMID:18789977   PMID:18948538   PMID:18976975   PMID:19020832   PMID:19053244   PMID:19056867   PMID:19060904   PMID:19064259   PMID:19099395   PMID:19143627   PMID:19143632  
PMID:19158374   PMID:19170196   PMID:19244744   PMID:19282983   PMID:19362095   PMID:19380743   PMID:19401538   PMID:19520058   PMID:19542561   PMID:19549727   PMID:19625176   PMID:19692168  
PMID:19692479   PMID:19703557   PMID:19787439   PMID:19802344   PMID:19808888   PMID:19914066   PMID:20012524   PMID:20018238   PMID:20088757   PMID:20176808   PMID:20331378   PMID:20360068  
PMID:20372822   PMID:20399684   PMID:20426868   PMID:20427536   PMID:20504928   PMID:20588296   PMID:20654576   PMID:20691033   PMID:20712566   PMID:20720181   PMID:20929444   PMID:21070952  
PMID:21110817   PMID:21113135   PMID:21117030   PMID:21118109   PMID:21152581   PMID:21159863   PMID:21191027   PMID:21304933   PMID:21455631   PMID:21505419   PMID:21528537   PMID:21643473  
PMID:21666754   PMID:21706016   PMID:21757351   PMID:21762796   PMID:21762798   PMID:21841072   PMID:21875593   PMID:21880841   PMID:21988832   PMID:22004035   PMID:22232651   PMID:22291694  
PMID:22315426   PMID:22348143   PMID:22405001   PMID:22421880   PMID:22658674   PMID:22660413   PMID:22675076   PMID:22754649   PMID:22761998   PMID:22768867   PMID:22939629   PMID:23027949  
PMID:23092844   PMID:23146908   PMID:23217182   PMID:23222715   PMID:23266279   PMID:23305486   PMID:23317503   PMID:23330719   PMID:23376485   PMID:23383273   PMID:23408603   PMID:23533145  
PMID:23895345   PMID:23933150   PMID:24105262   PMID:24107264   PMID:24237697   PMID:24244542   PMID:24284069   PMID:24436186   PMID:24522922   PMID:24561123   PMID:25010273   PMID:25099357  
PMID:25330247   PMID:25416956   PMID:25488808   PMID:25510868   PMID:25633977   PMID:25640309   PMID:25659891   PMID:25666610   PMID:25681748   PMID:25710462   PMID:25749978   PMID:25754235  
PMID:25919665   PMID:25921289   PMID:25963657   PMID:25973004   PMID:26066081   PMID:26109641   PMID:26186194   PMID:26268989   PMID:26317613   PMID:26343856   PMID:26344197   PMID:26400331  
PMID:26456826   PMID:26457367   PMID:26496610   PMID:26537625   PMID:26549023   PMID:26608825   PMID:26673895   PMID:26729199   PMID:26811492   PMID:26871637   PMID:26972000   PMID:27107012  
PMID:27173435   PMID:27280284   PMID:27377049   PMID:27609421   PMID:27648839   PMID:27716508   PMID:27764233   PMID:28065597   PMID:28190767   PMID:28335037   PMID:28483816   PMID:28514442  
PMID:28581508   PMID:29123089   PMID:29199609   PMID:29395067   PMID:29509190   PMID:29540532   PMID:29760280   PMID:29859188   PMID:30126636   PMID:30217970   PMID:30343281   PMID:30450735  
PMID:30471916   PMID:30619736   PMID:30675171   PMID:30759747   PMID:30873590   PMID:30948266   PMID:31048545   PMID:31091453   PMID:31203368   PMID:31492760   PMID:31515488   PMID:31519728  
PMID:31519756   PMID:31753913   PMID:31980649   PMID:31995728   PMID:32235678   PMID:32296183   PMID:32326417   PMID:32917811   PMID:32994219   PMID:32994395   PMID:33144569   PMID:33277362  
PMID:33419951   PMID:33616717   PMID:33623047  


Genomics

Comparative Map Data
TSG101
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1118,468,336 - 18,526,951 (-)EnsemblGRCh38hg38GRCh38
GRCh381118,480,311 - 18,526,942 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371118,501,858 - 18,548,489 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361118,458,434 - 18,505,065 (-)NCBINCBI36hg18NCBI36
Build 341118,458,435 - 18,505,065NCBI
Celera1118,637,463 - 18,684,120 (-)NCBI
Cytogenetic Map11p15.1NCBI
HuRef1118,187,557 - 18,234,372 (-)NCBIHuRef
CHM1_11118,501,223 - 18,547,842 (-)NCBICHM1_1
Tsg101
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39746,538,697 - 46,569,717 (-)NCBIGRCm39mm39
GRCm39 Ensembl746,538,697 - 46,569,717 (-)Ensembl
GRCm38746,888,949 - 46,926,320 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl746,888,949 - 46,919,969 (-)EnsemblGRCm38mm10GRCm38
MGSCv37754,144,397 - 54,175,300 (-)NCBIGRCm37mm9NCBIm37
MGSCv36746,757,396 - 46,787,915 (-)NCBImm8
Celera742,369,255 - 42,400,171 (-)NCBICelera
Cytogenetic Map7B3NCBI
Tsg101
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2197,412,689 - 97,442,589 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl197,410,848 - 97,442,554 (-)Ensembl
Rnor_6.01102,941,151 - 102,971,017 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1102,941,231 - 102,970,950 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01104,015,969 - 104,044,641 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4197,445,040 - 97,475,141 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1197,523,152 - 97,553,252 (-)NCBI
Celera191,659,356 - 91,689,173 (-)NCBICelera
Cytogenetic Map1q22NCBI
Tsg101
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541433,154,812 - 33,193,769 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541433,154,812 - 33,193,769 (-)NCBIChiLan1.0ChiLan1.0
TSG101
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11118,201,381 - 18,248,149 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1118,189,868 - 18,248,149 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01118,518,110 - 18,564,814 (-)NCBIMhudiblu_PPA_v0panPan3
TSG101
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12140,910,870 - 40,952,922 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2140,910,874 - 40,952,808 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2140,390,143 - 40,432,212 (-)NCBI
ROS_Cfam_1.02142,032,656 - 42,074,737 (-)NCBI
UMICH_Zoey_3.12141,026,209 - 41,068,217 (-)NCBI
UNSW_CanFamBas_1.02141,213,135 - 41,255,211 (-)NCBI
UU_Cfam_GSD_1.02141,590,866 - 41,632,952 (-)NCBI
Tsg101
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530374,871,547 - 74,872,227 (+)NCBI
SpeTri2.0NW_00493659061,352 - 62,037 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TSG101
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1240,673,187 - 40,720,681 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2243,759,512 - 43,783,691 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TSG101
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1146,401,889 - 46,451,122 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl146,402,024 - 46,450,916 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666038143,746,335 - 143,804,463 (+)NCBIVero_WHO_p1.0
Tsg101
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247669,932,190 - 9,977,725 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
D11S4280  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371118,501,876 - 18,502,043UniSTSGRCh37
Build 361118,458,452 - 18,458,619RGDNCBI36
Celera1118,637,481 - 18,637,648RGD
Cytogenetic Map11p15UniSTS
HuRef1118,187,575 - 18,187,742UniSTS
Whitehead-YAC Contig Map11 UniSTS
D11S2247E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371118,503,193 - 18,503,310UniSTSGRCh37
Build 361118,459,769 - 18,459,886RGDNCBI36
Celera1118,638,798 - 18,638,915RGD
Cytogenetic Map11p15UniSTS
HuRef1118,188,892 - 18,189,009UniSTS
GeneMap99-GB4 RH Map1171.49UniSTS
RH104402  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371118,542,650 - 18,542,732UniSTSGRCh37
Build 361118,499,226 - 18,499,308RGDNCBI36
Celera1118,678,281 - 18,678,363RGD
Cytogenetic Map11p15UniSTS
HuRef1118,228,519 - 18,228,601UniSTS
GeneMap99-GB4 RH Map1164.32UniSTS
D20S528E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372043,536,905 - 43,537,009UniSTSGRCh37
Build 362042,970,319 - 42,970,423RGDNCBI36
Celera2040,245,543 - 40,245,647RGD
Cytogenetic Map11p15UniSTS
Cytogenetic Map20q13.1UniSTS
HuRef2040,278,737 - 40,278,841UniSTS
HuRef1118,195,297 - 18,195,403UniSTS
YWHAB__1218  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372043,535,422 - 43,536,139UniSTSGRCh37
GRCh371118,510,753 - 18,511,456UniSTSGRCh37
Build 361118,467,329 - 18,468,032RGDNCBI36
Celera2040,244,060 - 40,244,777UniSTS
Celera1118,646,358 - 18,647,061RGD
HuRef2040,277,254 - 40,277,971UniSTS
HuRef1118,196,452 - 18,197,155UniSTS
SHGC-37252  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372043,535,257 - 43,535,387UniSTSGRCh37
GRCh371118,511,491 - 18,511,620UniSTSGRCh37
Build 361118,468,067 - 18,468,196RGDNCBI36
Celera2040,243,895 - 40,244,025UniSTS
Celera1118,647,096 - 18,647,225RGD
Cytogenetic Map11p15UniSTS
Cytogenetic Map20q13.1UniSTS
HuRef2040,277,089 - 40,277,219UniSTS
HuRef1118,197,190 - 18,197,319UniSTS
GeneMap99-G3 RH Map202293.0UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1781
Count of miRNA genes:916
Interacting mature miRNAs:1059
Transcripts:ENST00000251968, ENST00000357193, ENST00000438874, ENST00000535077, ENST00000536719, ENST00000540555, ENST00000542488, ENST00000543054, ENST00000543087, ENST00000544804, ENST00000545247, ENST00000580814, ENST00000584526
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2431 2747 1656 557 1821 399 4355 2096 3429 412 1446 1607 171 1204 2788 4
Low 5 243 69 67 130 66 1 101 295 7 14 6 3 1 2 2
Below cutoff 1 1 1 10 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000251968   ⟹   ENSP00000251968
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1118,480,311 - 18,526,942 (-)Ensembl
RefSeq Acc Id: ENST00000438874
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1118,502,543 - 18,526,899 (-)Ensembl
RefSeq Acc Id: ENST00000535077
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1118,506,866 - 18,526,920 (-)Ensembl
RefSeq Acc Id: ENST00000536719   ⟹   ENSP00000438471
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1118,468,336 - 18,526,951 (-)Ensembl
RefSeq Acc Id: ENST00000540555
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1118,481,491 - 18,484,061 (-)Ensembl
RefSeq Acc Id: ENST00000542488
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1118,506,857 - 18,526,821 (-)Ensembl
RefSeq Acc Id: ENST00000543054
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1118,483,936 - 18,514,850 (-)Ensembl
RefSeq Acc Id: ENST00000543087
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1118,490,830 - 18,514,843 (-)Ensembl
RefSeq Acc Id: ENST00000544804
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1118,502,485 - 18,526,881 (-)Ensembl
RefSeq Acc Id: ENST00000545247
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1118,483,836 - 18,526,913 (-)Ensembl
RefSeq Acc Id: ENST00000580814   ⟹   ENSP00000464386
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1118,469,031 - 18,481,731 (-)Ensembl
RefSeq Acc Id: ENST00000584526   ⟹   ENSP00000463213
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1118,475,219 - 18,481,771 (-)Ensembl
RefSeq Acc Id: NM_006292   ⟹   NP_006283
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381118,480,311 - 18,526,942 (-)NCBI
GRCh371118,501,858 - 18,548,503 (-)ENTREZGENE
Build 361118,458,434 - 18,505,065 (-)NCBI Archive
HuRef1118,187,557 - 18,234,372 (-)ENTREZGENE
CHM1_11118,501,223 - 18,547,842 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005253108   ⟹   XP_005253165
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381118,480,311 - 18,526,940 (-)NCBI
GRCh371118,501,858 - 18,548,503 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_006283   ⟸   NM_006292
- UniProtKB: Q99816 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_005253165   ⟸   XM_005253108
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSP00000464386   ⟸   ENST00000580814
RefSeq Acc Id: ENSP00000463213   ⟸   ENST00000584526
RefSeq Acc Id: ENSP00000438471   ⟸   ENST00000536719
RefSeq Acc Id: ENSP00000251968   ⟸   ENST00000251968
Protein Domains
SB   UEV

Promoters
RGD ID:6789483
Promoter ID:HG_KWN:12457
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000357193,   NM_006292,   UC001MOS.1,   UC009YHS.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361118,504,736 - 18,506,032 (-)MPROMDB
RGD ID:6852272
Promoter ID:EP73942
Type:multiple initiation site
Name:HS_TSG101
Description:Tumor susceptibility gene 101.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Mammalian gene collection (MGC) full-length cDNA cloning
Position:
Human AssemblyChrPosition (strand)Source
Build 361118,504,983 - 18,505,043EPD
RGD ID:7219801
Promoter ID:EPDNEW_H15646
Type:initiation region
Name:TSG101_1
Description:tumor susceptibility 101
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H15647  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381118,526,923 - 18,526,983EPDNEW
RGD ID:7219803
Promoter ID:EPDNEW_H15647
Type:initiation region
Name:TSG101_2
Description:tumor susceptibility 101
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H15646  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381118,527,649 - 18,527,709EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
TSG101, VAL-ALA, 1162T-C single nucleotide variant Familial cancer of breast [RCV000008661] Chr11:11p15.2-p15.1 pathogenic|uncertain significance
GRCh38/hg38 11p15.1(chr11:17905089-19674505)x1 copy number loss See cases [RCV000052646] Chr11:17905089..19674505 [GRCh38]
Chr11:17926636..19696051 [GRCh37]
Chr11:17883212..19652627 [NCBI36]
Chr11:11p15.1
pathogenic
GRCh38/hg38 11p15.5-13(chr11:202758-31726224)x3 copy number gain See cases [RCV000053613] Chr11:202758..31726224 [GRCh38]
Chr11:202758..31747772 [GRCh37]
Chr11:192758..31704348 [NCBI36]
Chr11:11p15.5-13
pathogenic
Single allele deletion Intellectual disability [RCV001293382] Chr11:118359328..118372573 [GRCh37]
Chr11:11p15.3-q23.3
pathogenic
GRCh38/hg38 11p15.5-15.1(chr11:446754-18904742)x3 copy number gain See cases [RCV000133997] Chr11:446754..18904742 [GRCh38]
Chr11:446754..18926289 [GRCh37]
Chr11:436754..18882865 [NCBI36]
Chr11:11p15.5-15.1
pathogenic
GRCh38/hg38 11p15.1(chr11:18526222-20748125)x3 copy number gain See cases [RCV000134932] Chr11:18526222..20748125 [GRCh38]
Chr11:18547769..20769671 [GRCh37]
Chr11:18504345..20726247 [NCBI36]
Chr11:11p15.1
uncertain significance
GRCh37/hg19 11p15.1-13(chr11:18536224-31923308)x1 copy number loss Aniridia 1 [RCV000420782] Chr11:18536224..31923308 [GRCh37]
Chr11:11p15.1-13
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470) copy number gain See cases [RCV000511729] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-12(chr11:230615-37698540)x3 copy number gain See cases [RCV000511561] Chr11:230615..37698540 [GRCh37]
Chr11:11p15.5-12
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3 copy number gain See cases [RCV000510881] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-14.3(chr11:230615-25584362)x3 copy number gain See cases [RCV000512225] Chr11:230615..25584362 [GRCh37]
Chr11:11p15.5-14.3
pathogenic
GRCh37/hg19 11p15.5-13(chr11:230615-31995219)x3 copy number gain See cases [RCV000512477] Chr11:230615..31995219 [GRCh37]
Chr11:11p15.5-13
pathogenic
GRCh37/hg19 11p15.1(chr11:17527585-18606820)x1 copy number loss not provided [RCV000683355] Chr11:17527585..18606820 [GRCh37]
Chr11:11p15.1
uncertain significance
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3 copy number gain not provided [RCV000737348] Chr11:198510..134934063 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3 copy number gain not provided [RCV000749874] Chr11:70864..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
NM_006292.4(TSG101):c.954C>T (p.Ile318=) single nucleotide variant not provided [RCV000954633] Chr11:18481759 [GRCh38]
Chr11:18503306 [GRCh37]
Chr11:11p15.1
benign
GRCh37/hg19 11p15.5-13(chr11:235934-33826995)x3 copy number gain not provided [RCV001006372] Chr11:235934..33826995 [GRCh37]
Chr11:11p15.5-13
pathogenic
GRCh37/hg19 11p15.2-14.1(chr11:13970757-27565888)x3 copy number gain not provided [RCV001006388] Chr11:13970757..27565888 [GRCh37]
Chr11:11p15.2-14.1
pathogenic
GRCh37/hg19 11p15.3-13(chr11:11053978-34732891)x3 copy number gain not provided [RCV001006387] Chr11:11053978..34732891 [GRCh37]
Chr11:11p15.3-13
pathogenic
GRCh37/hg19 11p15.1(chr11:18441339-18526284)x1 copy number loss not provided [RCV001259578] Chr11:18441339..18526284 [GRCh37]
Chr11:11p15.1
uncertain significance
NC_000011.9:g.(?_17552691)_(19213995_?)dup duplication Epilepsy, progressive myoclonic 7 [RCV001295201] Chr11:17552691..19213995 [GRCh37]
Chr11:11p15.1
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:15971 AgrOrtholog
COSMIC TSG101 COSMIC
Ensembl Genes ENSG00000074319 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000251968 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000438471 UniProtKB/TrEMBL
  ENSP00000463213 UniProtKB/TrEMBL
  ENSP00000464386 UniProtKB/TrEMBL
Ensembl Transcript ENST00000251968 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000536719 UniProtKB/TrEMBL
  ENST00000580814 UniProtKB/TrEMBL
  ENST00000584526 UniProtKB/TrEMBL
Gene3D-CATH 3.10.110.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000074319 GTEx
HGNC ID HGNC:15971 ENTREZGENE
Human Proteome Map TSG101 Human Proteome Map
InterPro ESCRT_assembly_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SB_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBQ-conjugating_enzyme/RWD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UEV_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:7251 UniProtKB/Swiss-Prot
NCBI Gene 7251 ENTREZGENE
OMIM 601387 OMIM
Pfam UEV UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Vps23_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA38068 PharmGKB
PROSITE PS51312 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UEV UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF140111 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54495 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D3DQY6_HUMAN UniProtKB/TrEMBL
  F5H442_HUMAN UniProtKB/TrEMBL
  J3QKS4_HUMAN UniProtKB/TrEMBL
  J3QRU6_HUMAN UniProtKB/TrEMBL
  L0L6B6_HUMAN UniProtKB/TrEMBL
  Q86SI0_HUMAN UniProtKB/TrEMBL
  Q99816 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q9BUM5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-09-03 TSG101  tumor susceptibility 101    tumor susceptibility gene 101  Symbol and/or name change 5135510 APPROVED
2011-08-16 TSG101  tumor susceptibility gene 101  TSG101  tumor susceptibility gene 101  Symbol and/or name change 5135510 APPROVED