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Gene: TSG101 (tumor susceptibility 101) Homo sapiens
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Symbol: TSG101
Name: tumor susceptibility 101
Description: Exhibits several functions, including protein homodimerization activity; ubiquitin protein ligase binding activity; and virion binding activity. Involved in several processes, including positive regulation of exosomal secretion; positive regulation of viral life cycle; and regulation of protein kinase activity. Localizes to several cellular components, including endosome; extracellular exosome; and nucleolus. Implicated in breast cancer; breast carcinoma; cervix carcinoma; endometrial adenocarcinoma; and prostate cancer. Biomarker of breast cancer and ovarian cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ESCRT-I complex subunit TSG101; TSG10; tumor susceptibility gene 10; tumor susceptibility gene 101; tumor susceptibility protein; VPS23
Orthologs:
Mus musculus (house mouse) : Tsg101 (tumor susceptibility gene 101)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tsg101 (tumor susceptibility 101)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tsg101 (tumor susceptibility 101)
Pan paniscus (bonobo/pygmy chimpanzee) : TSG101 (tumor susceptibility 101)
Canis lupus familiaris (dog) : TSG101 (tumor susceptibility 101)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tsg101 (tumor susceptibility 101)
Sus scrofa (pig) : TSG101 (tumor susceptibility 101)
Chlorocebus sabaeus (African green monkey) : TSG101 (tumor susceptibility 101)
Heterocephalus glaber (naked mole-rat) : Tsg101 (tumor susceptibility 101)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1118,468,336 - 18,526,951 (-)EnsemblGRCh38hg38GRCh38
GRCh381118,480,311 - 18,526,942 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371118,501,858 - 18,548,503 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361118,458,434 - 18,505,065 (-)NCBINCBI36hg18NCBI36
Build 341118,458,435 - 18,505,065NCBI
Celera1118,637,463 - 18,684,120 (-)NCBI
Cytogenetic Map11p15.1NCBI
HuRef1118,187,557 - 18,234,372 (-)NCBIHuRef
CHM1_11118,501,223 - 18,547,842 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on TSG101
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1349732
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-07-28
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.