Gene: TSG101 (tumor susceptibility 101) Chlorocebus sabaeus

Analyze

Symbol:

TSG101

Name:

tumor susceptibility 101

RGD ID:

18517907

Description:

ENCODES a protein that exhibits calcium-dependent protein binding (inferred); protein homodimerization activity (inferred); protein-containing complex binding (inferred); INVOLVED IN cell differentiation (ortholog); endosome to lysosome transport (ortholog); keratinocyte differentiation (ortholog); PARTICIPATES IN autophagy pathway; ASSOCIATED WITH breast cancer (ortholog); breast carcinoma (ortholog); cervix carcinoma (ortholog); FOUND IN cytoplasm (ortholog); early endosome membrane (ortholog); endosome (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

tumor susceptibility gene 101 protein

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mChlSab1.0.hap1	1	46,258,896 - 46,316,768 (+)	NCBI		mChlSab1.0.hap1
Vero_WHO_p1.0	NW_023666038	143,746,335 - 143,804,463 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0
ChlSab1.1	1	46,401,889 - 46,451,122 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	46,402,024 - 46,450,916 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

breast cancer (ISO)

breast carcinoma (ISO)

cervix carcinoma (ISO)

endometrial adenocarcinoma (ISO)

lung cancer (ISO)

ovarian cancer (ISO)

ovarian serous cystadenocarcinoma (ISO)

pancreatic adenocarcinoma (ISO)

prostate cancer (ISO)

sarcoma (ISO)

Thyroid Carcinoma, Nonmedullary 1 (ISO)

uterine corpus endometrial carcinoma (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell differentiation (ISO)

endosome to lysosome transport (IEA,ISO)

exosomal secretion (IEA)

extracellular transport (IEA)

keratinocyte differentiation (ISO)

macroautophagy (IEA)

multivesicular body assembly (IEA)

negative regulation of cell population proliferation (ISO)

negative regulation of DNA-templated transcription (IEA)

negative regulation of epidermal growth factor receptor signaling pathway (IEA)

negative regulation of epidermal growth factor-activated receptor activity (ISO)

negative regulation of transcription by RNA polymerase II (ISO)

positive regulation of DNA-templated transcription (ISO)

positive regulation of exosomal secretion (IEA)

positive regulation of protein monoubiquitination (ISO)

positive regulation of ubiquitin-dependent endocytosis (IEA)

positive regulation of viral budding via host ESCRT complex (IEA)

protein transport (IEA)

regulation of cell cycle (ISO)

regulation of cell growth (ISO)

regulation of DNA-templated transcription (IEA)

regulation of extracellular exosome assembly (IEA)

regulation of MAP kinase activity (ISO)

ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (IEA)

viral budding (IEA)

viral budding via host ESCRT complex (IEA)

viral release from host cell (IEA)

Cellular Component

cytoplasm (IEA,ISO)

cytosol (IEA)

early endosome (IEA)

early endosome membrane (ISO)

endosome (IEA,ISO)

endosome membrane (ISO)

ESCRT I complex (IEA)

extracellular exosome (IEA)

late endosome (IEA)

late endosome membrane (IEA)

nucleus (ISO)

plasma membrane (IEA)

Molecular Function

calcium-dependent protein binding (IEA)

protein homodimerization activity (IEA)

protein-containing complex binding (IEA)

transcription corepressor activity (IEA)

ubiquitin binding (IEA)

ubiquitin protein ligase binding (IEA)

virion binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

autophagy pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

TSG101
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mChlSab1.0.hap1	1	46,258,896 - 46,316,768 (+)	NCBI		mChlSab1.0.hap1
Vero_WHO_p1.0	NW_023666038	143,746,335 - 143,804,463 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0
ChlSab1.1	1	46,401,889 - 46,451,122 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	46,402,024 - 46,450,916 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM

TSG101
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	18,480,311 - 18,526,942 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	18,468,336 - 18,526,965 (-)	Ensembl		GRCh38.p14 Ensembl	hg38	GRCh38
GRCh37	11	18,501,858 - 18,548,489 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	18,458,434 - 18,505,065 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	11	18,458,435 - 18,505,065	NCBI
Celera	11	18,637,463 - 18,684,120 (-)	NCBI		Celera
Cytogenetic Map	11	p15.1	NCBI
HuRef	11	18,187,557 - 18,234,372 (-)	NCBI		HuRef
CHM1_1	11	18,501,223 - 18,547,842 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	11	18,578,331 - 18,624,993 (-)	NCBI		T2T-CHM13v2.0

Tsg101
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	46,538,693 - 46,569,716 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	46,528,034 - 46,569,863 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	7	46,888,949 - 46,926,320 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	46,888,949 - 46,919,969 (-)	Ensembl		GRCm38.p6 Ensembl	mm10	GRCm38
MGSCv37	7	54,144,397 - 54,175,300 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	7	46,757,396 - 46,787,915 (-)	NCBI		MGSCv36	mm8
Celera	7	42,369,255 - 42,400,171 (-)	NCBI		Celera
Cytogenetic Map	7	B3	NCBI
cM Map	7	30.62	NCBI

Tsg101
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	106,549,035 - 106,578,859 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	106,535,021 - 106,578,775 (-)	Ensembl				GRCr8
mRatBN7.2	1	97,412,689 - 97,442,589 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	97,410,848 - 97,442,554 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	102,805,766 - 102,835,099 (-)	NCBI	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	111,277,750 - 111,307,082 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	104,561,098 - 104,590,847 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	1	105,188,587 - 105,218,349 (-)	NCBI
Lyon_Normotensive	1	110,298,646 - 110,328,406 (-)	NCBI
Lyon_Hypertensive	1	106,831,929 - 106,861,679 (-)	NCBI
F344_StmMcwi	1	105,288,981 - 105,318,745 (-)	NCBI
Rnor_6.0	1	102,941,151 - 102,971,017 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	102,941,231 - 102,970,950 (-)	Ensembl		Rnor_6.0 Ensembl	rn6	Rnor6.0
Rnor_5.0	1	104,015,969 - 104,044,641 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	97,445,040 - 97,475,141 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	91,659,356 - 91,689,173 (-)	NCBI		Celera
RGSC_v3.1	1	97,523,152 - 97,553,252 (-)	NCBI
Cytogenetic Map	1	q22	NCBI

Tsg101
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955414	33,154,812 - 33,193,769 (-)	Ensembl		ChiLan1.0 Ensembl
ChiLan1.0	NW_004955414	33,154,812 - 33,193,769 (-)	NCBI	ChiLan1.0	ChiLan1.0

TSG101
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	20,797,111 - 20,843,855 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	20,757,432 - 20,804,234 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	18,518,110 - 18,564,814 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	18,201,381 - 18,248,149 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	18,189,868 - 18,248,149 (-)	Ensembl		PanPan1.1 Ensembl	panPan2	panpan1.1

TSG101
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	21	40,910,870 - 40,952,922 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	21	40,910,874 - 40,952,808 (-)	Ensembl		CanFam3.1 Ensembl	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	21	40,390,143 - 40,432,212 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	21	42,032,656 - 42,074,737 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	21	42,032,614 - 42,074,722 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	21	41,026,209 - 41,068,217 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	21	41,213,135 - 41,255,211 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	21	41,590,866 - 41,632,952 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

LOC120889616
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mIctTri1.hap1	4	44,440,161 - 44,560,393 (+)	NCBI		mIctTri1.hap1
HiC_Itri_2	NW_024404947	44,836,536 - 44,841,475 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936528	752,694 - 808,888 (+)	NCBI		SpeTri2.0 Ensembl
SpeTri2.0 Ensembl	NW_004936528	752,694 - 808,888 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936528	752,572 - 809,127 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TSG101
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	2	40,673,187 - 40,720,681 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	43,759,512 - 43,783,691 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Tsg101
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624766	9,932,190 - 9,977,725 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2
HetGla_female_1.0 Ensembl	NW_004624766	9,934,228 - 9,977,697 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
Naked mole-rat maternal Ensembl	5	106,354,671 - 106,431,081 (+)	Ensembl

Tsg101
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	2	152,457,588 - 152,486,918 (+)	NCBI	Rrattus_CSIRO_v1	Rrattus_CSIRO_v1

Variants

Variants in TSG101
1201 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
76	36	20	36	36	60	20

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008004714	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JBLKOC010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000003084 ⟹ ENSCSAP00000001374

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	1	46,402,024 - 46,450,916 (+)	Ensembl

RefSeq Acc Id:

XM_008004714 ⟹ XP_008002905

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
mChlSab1.0.hap1	1	46,258,896 - 46,316,768 (+)	NCBI
Vero_WHO_p1.0	NW_023666038	143,746,335 - 143,804,463 (+)	NCBI
ChlSab1.1	1	46,401,889 - 46,451,122 (+)	NCBI

Sequence:

show sequence

GGAAGTGGTGCTTTGGTTCCGACTTCCTGTTGTTTGAGGCCGGGTCGGGGGTGTGCGATTGTGT
GGGACGGCCTGGGGCAGCCCAGCAGCGGCTGACTTTCTGCCTGCGGGAAAGGGAGTCGCAAGTG
GGCCGTCATGGCGGTGTCGGAGAGCCAGCTCAAGAAAATGGTGTCCAAGTACAAATACAGAGAC
CTAACTGTACGTGAAACTGTCAATGTCATTACTCTATACAAAGATCTCAAACCCGTTTTGGATT
CATATGTTTTTAATGATGGCAGTTCCAGGGAACTAATGAACCTCACTGGAACAATTCCTGTGCC
TTATAGAGGTAATACATATAATATTCCAATATGCCTATGGCTACTGGACACATACCCATATAAT
CCCCCTATCTGTTTTGTTAAGCCTACTAGTTCAATGACTATTAAAACGGGAAAGCATGTTGATG
CAAATGGGAAGATATATCTTCCTTATCTACATGAATGGAAACACCCACAGTCAGACTTGTTGGG
GCTTATTCAGGTCATGATTGTGGTATTTGGAGATGAACCTCCAGTCTTCTCTCGTCCTATTTCG
GCATCCTATCCACCATACCAGGCAACGGGGCCACCGAATACTTCCTACATGCCAGGCATGCCAG
GTGGAATCTCTCCATACCCATCCGGATACCCTCCCAATCCCAGTGGTTACCCAGGCTGTCCTTA
CCCACCTGGTGGTCCATATCCTGCCACAACAAGTTCTCAGTACCCTTCCCAGCCTCCTGTGACC
ACTGTTGGTCCCAGTAGGGATGGCACAATCAGCGAGGACACCATCCGAGCCTCTCTCATCTCAG
CGGTCAGTGACAAACTGAGATGGCGGATGAAGGAGGAAATGGATCGTGCCCAGGCAGAGCTCAA
TGCCTTGAAACGAACAGAAGAAGACCTGAAAAAGGGTCACCAAAAACTGGAAGAGATGGTTACC
CGTTTAGATCAAGAAGTAGCCGAGGTTGATAAAAACATAGAACTTTTGAAAAAGAAGGATGAAG
AACTCAGTTCTGCTCTGGAGAAAATGGAAAATCAGTCTGAAAATAATGATATCGATGAAGTTAT
CATTCCCACAGCTCCCTTATACAAACAGATCCTGAATCTGTATGCAGAAGAAAACGCTATTGAA
GACACTATCTTTTACTTGGGAGAAGCCTTGAGAAGGGGAGTGATAGACCTGGATGTCTTCCTGA
AGCATGTACGTCTTCTGTCCCGTAAACAGTTCCAGCTGAGGGCACTAATGCAAAAAGCAAGAAA
GACTGCCGGTCTCAGTGACCTCTACTGACTTCTCTGATACCAGCTGGAAGTTGAGCTCTTCTTA
AAGTATTCTTTTCTTCTCTTCCTTTCTCTTATCAGTAGGTGCCCAGAATAAGTTATTGCAGTTT
ATCATTCAAGTGTAAAATATTTTGAATCAATAATATATTTTCTGTTTTCTTTTGGTAAAGACTG
GCTTTTATTAATGCACTTTCTATCCTCTGTAAACTTTTTGTGCTGAATGTTGGGACTGCTAAAT
AAAATTTGTTGCATAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_008002905	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000001374
	ENSCSAP00000001374.1

RefSeq Acc Id:	XP_008002905 ⟸ XM_008004714
- UniProtKB:	A0A0D9QYD5 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCSAP00000001374 ⟸ ENSCSAT00000003084

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000005050	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000003084.1	UniProtKB/TrEMBL
Gene3D-CATH	3.10.110.10	UniProtKB/TrEMBL
	6.10.140.820	UniProtKB/TrEMBL
	6.10.250.370	UniProtKB/TrEMBL
InterPro	ESCRT-I_UEV_domain	UniProtKB/TrEMBL
	ESCRT_assembly_dom	UniProtKB/TrEMBL
	SB_dom	UniProtKB/TrEMBL
	UBQ-conjugating_enzyme/RWD	UniProtKB/TrEMBL
	UEV_N	UniProtKB/TrEMBL
KEGG Report	csab:103239119	UniProtKB/TrEMBL
NCBI Gene	TSG101	ENTREZGENE
PANTHER	TUMOR SUSCEPTIBILITY GENE 101 PROTEIN	UniProtKB/TrEMBL
	TUMOR SUSCEPTIBILITY GENE 101 PROTEIN-RELATED	UniProtKB/TrEMBL
Pfam	UEV	UniProtKB/TrEMBL
	Vps23_core	UniProtKB/TrEMBL
PROSITE	PS51312	UniProtKB/TrEMBL
	UEV	UniProtKB/TrEMBL
SMART	UBCc	UniProtKB/TrEMBL
Superfamily-SCOP	SSF140111	UniProtKB/TrEMBL
	SSF54495	UniProtKB/TrEMBL
UniProt	A0A0D9QYD5	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

RGD Manual Annotations

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Imported Disease Annotations - ClinVar

RGD Manual Annotations