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ONTOLOGY REPORT - ANNOTATIONS

Term:pyroptotic inflammatory response
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Accession:GO:0070269 term browser browse the term
Definition:A gasdermin-dependent inflammatory response that is associated with the generation of pyrogenic mediators such as IL-1beta and IL-18. Gasdermins are activated by caspase-1 or caspase-4/11, or by certain granzymes. In some, but not all cells, it can lead to pyroptotic programmed cell death.
Synonyms:broad_synonym: pyroptosis
 xref: Reactome:R-HSA-5620971 "Pyroptosis"


show annotations for term's descendants           Sort by:
pyroptotic inflammatory response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aim2 absent in melanoma 2 involved_in ISO (PMID:19158675), (PMID:19158676)
(PMID:19158676), (PMID:27846608), (PMID:29033131), (PMID:32350463), (PMID:34006824)		 RGD PMID:19158675 PMID:19158676 PMID:27846608 PMID:29033131 PMID:32350463 More... NCBI chr13:88,397,516...88,439,325
Ensembl chr13:85,866,284...85,906,975 		JBrowse link
G Apip APAF1 interacting protein involved_in ISO (PMID:24367089) RGD PMID:24367089 NCBI chr 3:109,886,919...109,913,295
Ensembl chr 3:89,432,037...89,458,340 		JBrowse link
G Casp1 caspase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO
ISS		 GO_REF:0000107
(PMID:32109412), (PMID:32553275)
GO_REF:0000024
MGI:2158744 (PMID:22002608)
(PMID:21147462)		 Ensembl
RGD
UniProt		 PMID:21147462 PMID:22002608 PMID:32109412 PMID:32553275 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp3 caspase 3 involved_in ISO (PMID:36426955) RGD PMID:36426955 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp4 caspase 4 involved_in
acts_upstream_of_or_within		 ISO (PMID:31268602), (PMID:32109412), (PMID:34671164)
(PMID:23348507), (PMID:30135078), (PMID:30589883), (PMID:32109412), (PMID:34671164)
MGI:5468949 (PMID:22002608)		 RGD PMID:22002608 PMID:23348507 PMID:30135078 PMID:30589883 PMID:31268602 More... NCBI chr 8:10,883,817...10,919,978
Ensembl chr 8:2,598,876...2,635,092 		JBrowse link
G Casp6 caspase 6 involved_in ISO
IEA
ISS		 (PMID:32298652)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:32298652 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:221,140,287...221,152,727
Ensembl chr 2:218,466,076...218,478,502 		JBrowse link
G Casp8 caspase 8 involved_in ISS
ISO		 GO_REF:0000024
(PMID:30361383), (PMID:31748744)		 UniProt
RGD		 PMID:30361383 PMID:31748744 GO_REF:0000024 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Dhx9 DExH-box helicase 9 involved_in ISO (PMID:28636595) RGD PMID:28636595 NCBI chr13:68,152,813...68,189,580
Ensembl chr13:65,602,323...65,639,069 		JBrowse link
G Dpp9 dipeptidyl peptidase 9 acts_upstream_of_negative_effect ISO (PMID:33731929), (PMID:34019797) RGD PMID:33731929 PMID:34019797 NCBI chr 9:1,098,505...1,133,500
Ensembl chr 9:1,011,351...1,046,541 		JBrowse link
G Gsdma gasdermin A involved_in ISO
IBA		 (PMID:35110732), (PMID:35545676)
GO_REF:0000033		 RGD
GO_Central		 PMID:35110732 PMID:35545676 GO_REF:0000033 NCBI chr10:84,110,590...84,135,804
Ensembl chr10:83,627,051...83,639,543 		JBrowse link
G Gsdmc gasdermin C involved_in ISO
IBA		 (PMID:32929201), (PMID:34012073)
GO_REF:0000033		 RGD
GO_Central		 PMID:32929201 PMID:34012073 GO_REF:0000033 NCBI chr 7:97,482,713...97,509,985
Ensembl chr 7:95,594,015...95,611,344 		JBrowse link
G Gsdmd gasdermin D involved_in ISO
IBA		 (PMID:36227980)
GO_REF:0000033
(PMID:27339137), (PMID:29576317), (PMID:32109412), (PMID:32553275)
(PMID:26611636), (PMID:27383986), (PMID:35705808), (PMID:37988464)
(PMID:32109412), (PMID:33883744)
(PMID:28392147), (PMID:30361383)		 RGD
GO_Central		 PMID:26611636 PMID:27339137 PMID:27383986 PMID:28392147 PMID:29576317 More... GO_REF:0000033 NCBI chr 7:109,423,209...109,427,771
Ensembl chr 7:107,542,083...107,547,055 		JBrowse link
G Gsdmdl1 gasdermin D like 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:97,509,288...97,519,788
Ensembl chr 7:95,620,061...95,630,532 		JBrowse link
G Gsdme gasdermin E involved_in ISO (PMID:28459430)
(PMID:28045099)
(PMID:33852854), (PMID:35594856)
(PMID:31953257), (PMID:32188940)		 RGD PMID:28045099 PMID:28459430 PMID:31953257 PMID:32188940 PMID:33852854 More... NCBI chr 4:80,590,344...80,651,943
Ensembl chr 4:79,257,804...79,320,806 		JBrowse link
G Gzma granzyme A involved_in ISO (PMID:32299851) RGD PMID:32299851 NCBI chr 2:46,473,763...46,485,696
Ensembl chr 2:44,740,569...44,752,493 		JBrowse link
G Gzmb granzyme B involved_in ISS
ISO		 GO_REF:0000024
(PMID:32188940)		 UniProt
RGD		 PMID:32188940 GO_REF:0000024 NCBI chr15:34,459,007...34,462,469
Ensembl chr15:30,173,603...30,346,814 		JBrowse link
G Ifi27 interferon, alpha-inducible protein 27 involved_in ISO (PMID:36426955) RGD PMID:36426955 NCBI chr 6:128,355,312...128,361,783
Ensembl chr 6:122,590,472...122,779,294 		JBrowse link
G Map3k20 mitogen-activated protein kinase kinase kinase 20 acts_upstream_of_positive_effect ISS
ISO		 GO_REF:0000024
(PMID:35857590)		 UniProt
RGD		 PMID:35857590 GO_REF:0000024 NCBI chr 3:77,538,146...77,697,540
Ensembl chr 3:57,130,551...57,289,626 		JBrowse link
G Naip5 NLR family, apoptosis inhibitory protein 5 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:33,289,785...33,342,807
Ensembl chr 2:31,557,817...31,608,634 		JBrowse link
G Naip6 NLR family, apoptosis inhibitory protein 6 involved_in IBA
ISO		 GO_REF:0000033
(PMID:21874021)		 GO_Central
RGD		 PMID:21874021 GO_REF:0000033 NCBI chr 2:33,241,520...33,293,184
Ensembl chr 2:31,507,424...31,570,542 		JBrowse link
G Nlrc4 NLR family, CARD domain containing 4 involved_in ISS
ISO		 GO_REF:0000024
(PMID:16648852), (PMID:16648853), (PMID:21874021), (PMID:22484733), (PMID:22885697)		 UniProt
RGD		 PMID:16648852 PMID:16648853 PMID:21874021 PMID:22484733 PMID:22885697 GO_REF:0000024 NCBI chr 6:26,743,658...26,771,783
Ensembl chr 6:20,995,266...21,018,248 		JBrowse link
G Nlrp1a NLR family, pyrin domain containing 1A involved_in ISO (PMID:33093214)
(PMID:33731929)		 RGD PMID:33093214 PMID:33731929 NCBI chr10:56,277,134...56,332,229
Ensembl chr10:55,778,560...55,825,180 		JBrowse link
G Nlrp6 NLR family, pyrin domain containing 6 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:34678144)
(PMID:30248149)		 Ensembl
RGD		 PMID:30248149 PMID:34678144 GO_REF:0000107 NCBI chr 1:205,434,484...205,441,245
Ensembl chr 1:196,004,953...196,011,113 		JBrowse link
G Nlrp9 NLR family, pyrin domain containing 9 involved_in ISO (PMID:28636595) RGD PMID:28636595 NCBI chr 1:77,320,034...77,370,366
Ensembl chr 1:68,291,180...68,341,512 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 acts_upstream_of_or_within_negative_effect ISO (PMID:29887864) RGD PMID:29887864 NCBI chr 9:20,145,215...20,151,797
Ensembl chr 9:12,647,259...12,654,170 		JBrowse link
G Trim21 tripartite motif-containing 21 involved_in ISO (PMID:36426955) RGD PMID:36426955 NCBI chr 1:166,376,829...166,399,441
Ensembl chr 1:156,964,913...156,987,440 		JBrowse link
G Zbp1 Z-DNA binding protein 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:27917412), (PMID:32350114), (PMID:33109609)		 UniProt
RGD		 PMID:27917412 PMID:32350114 PMID:33109609 GO_REF:0000024 NCBI chr 3:182,411,665...182,427,604
Ensembl chr 3:161,993,351...162,003,870 		JBrowse link
G Zeb2 zinc finger E-box binding homeobox 2 IDA RGD PMID:34852714 RGD:155882542 NCBI chr 3:49,624,028...49,754,323
Ensembl chr 3:29,218,301...29,345,157 		JBrowse link
cytotoxic T cell pyroptotic cell death term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gzma granzyme A involved_in ISO (PMID:32299851) RGD PMID:32299851 NCBI chr 2:46,473,763...46,485,696
Ensembl chr 2:44,740,569...44,752,493 		JBrowse link
negative regulation of pyroptotic inflammatory response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mir223 microRNA 223 involved_in ISO (PMID:34637033) RGD PMID:34637033 NCBI chr  X:65,151,383...65,151,492
Ensembl chr  X:61,141,887...61,141,996 		JBrowse link
positive regulation of pyroptotic inflammatory response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 involved_in ISO (PMID:28459430), (PMID:33852854), (PMID:35594856) RGD PMID:28459430 PMID:33852854 PMID:35594856 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Gbp1 guanylate binding protein 1 involved_in ISO (PMID:31268602)
(PMID:24715728)		 RGD PMID:24715728 PMID:31268602 NCBI chr 2:234,071,366...234,106,012
Ensembl chr 2:231,398,163...231,432,131
Ensembl chr 2:231,398,163...231,432,131 		JBrowse link
G Gbp2 guanylate binding protein 2 involved_in IEA
ISO
ISS		 GO_REF:0000107
(PMID:24715728), (PMID:25774715), (PMID:25774716), (PMID:30062052)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:24715728 PMID:25774715 PMID:25774716 PMID:30062052 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:234,005,727...234,021,812
Ensembl chr 2:231,332,284...231,348,571 		JBrowse link
G Gbp4 guanylate binding protein 4 involved_in ISO (PMID:24715728) RGD PMID:24715728 NCBI chr 2:233,978,163...233,992,124
Ensembl chr 2:231,305,244...231,318,879 		JBrowse link
G Gbp5 guanylate binding protein 5 involved_in ISO (PMID:24715728), (PMID:25774715), (PMID:25774716), (PMID:30589883) RGD PMID:24715728 PMID:25774715 PMID:25774716 PMID:30589883 NCBI chr 2:233,910,999...233,930,320
Ensembl chr 2:231,237,748...231,257,061 		JBrowse link
G Nlrp1a NLR family, pyrin domain containing 1A involved_in IMP
IEA		 GO_REF:0000117 UniProt
RGD		 PMID:24626226 GO_REF:0000117, RGD:38549348 NCBI chr10:56,277,134...56,332,229
Ensembl chr10:55,778,560...55,825,180 		JBrowse link
G Nlrp1b NLR family, pyrin domain containing 1B involved_in IEA GO_REF:0000117 UniProt GO_REF:0000117 NCBI chr10:56,336,957...56,412,796
Ensembl chr10:55,843,001...55,912,774 		JBrowse link
G Nod1 nucleotide-binding oligomerization domain containing 1 involved_in IEA GO_REF:0000117 UniProt GO_REF:0000117 NCBI chr 4:85,391,142...85,442,281
Ensembl chr 4:84,060,880...84,111,404 		JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 involved_in IEA GO_REF:0000117 UniProt GO_REF:0000117 NCBI chr19:34,555,832...34,596,281
Ensembl chr19:18,382,439...18,417,177 		JBrowse link
G Zdhhc5 zinc finger DHHC-type palmitoyltransferase 5 involved_in ISO
ISS		 (PMID:38530158)
(PMID:38530158), (PMID:38599239)
GO_REF:0000024		 RGD
UniProt		 PMID:38530158 PMID:38599239 GO_REF:0000024 NCBI chr 3:90,178,734...90,206,889
Ensembl chr 3:69,771,890...69,799,921 		JBrowse link
G Zdhhc9 zinc finger DHHC-type palmitoyltransferase 9 involved_in ISO (PMID:38530158)
(PMID:38530158), (PMID:38599239)		 RGD PMID:38530158 PMID:38599239 NCBI chr  X:132,230,243...132,266,139
Ensembl chr  X:127,352,345...127,388,245 		JBrowse link
pyroptotic cell death term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp4 caspase 4 involved_in ISO (PMID:38632402) RGD PMID:38632402 NCBI chr 8:10,883,817...10,919,978
Ensembl chr 8:2,598,876...2,635,092 		JBrowse link
G Gsdmd gasdermin D involved_in ISO (PMID:32820063), (PMID:38530158), (PMID:38599239)
(PMID:38632402)
(PMID:27339137), (PMID:27383986)
(PMID:32820063), (PMID:38538834)
(PMID:32109412), (PMID:33883744), (PMID:38632402)
(PMID:36227980)		 RGD PMID:27339137 PMID:27383986 PMID:32109412 PMID:32820063 PMID:33883744 More... NCBI chr 7:109,423,209...109,427,771
Ensembl chr 7:107,542,083...107,547,055 		JBrowse link
G Gsdme gasdermin E involved_in ISO (PMID:32188940), (PMID:33852854), (PMID:35594856) RGD PMID:32188940 PMID:33852854 PMID:35594856 NCBI chr 4:80,590,344...80,651,943
Ensembl chr 4:79,257,804...79,320,806 		JBrowse link
G Ninj1 ninjurin 1 involved_in ISO (PMID:36468682), (PMID:37196676), (PMID:37198476), (PMID:38614101) RGD PMID:36468682 PMID:37196676 PMID:37198476 PMID:38614101 NCBI chr17:15,659,208...15,668,115
Ensembl chr17:15,452,813...15,461,704 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20553
    response to stimulus 11038
      response to stress 4321
        defense response 1943
          inflammatory response 894
            pyroptotic inflammatory response 39
              negative regulation of pyroptotic inflammatory response 1
              positive regulation of pyroptotic inflammatory response 11
              pyroptotic cell death + 5
paths to the root