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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of alpha-beta T cell differentiation
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Accession:GO:0046639 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of alpha-beta T cell differentiation.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: down regulation of alpha-beta T cell differentiation;   downregulation of alpha-beta T cell differentiation;   negative regulation of alpha-beta T lymphocyte differentiation
 narrow_synonym: inhibition of alpha-beta T cell differentiation
 related_synonym: negative regulation of alpha-beta T cell development


show annotations for term's descendants           Sort by:
negative regulation of alpha-beta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gli3 GLI family zinc finger 3 involved_in ISO (PMID:19667090) RGD PMID:19667090 NCBI chr17:49,438,567...49,709,712
Ensembl chr17:49,438,567...49,709,712 		JBrowse link
G Ihh Indian hedgehog signaling molecule involved_in ISO (PMID:19109233) RGD PMID:19109233 NCBI chr 9:76,504,315...76,510,532
Ensembl chr 9:76,504,315...76,510,532 		JBrowse link
G Shh sonic hedgehog signaling molecule involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:10981962)		 Ensembl
RGD		 PMID:10981962 GO_REF:0000107 NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170 		JBrowse link
negative regulation of CD4-positive, alpha-beta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbfb core-binding factor subunit beta involved_in ISO (PMID:18258917) RGD PMID:18258917 NCBI chr19:33,049,162...33,092,752
Ensembl chr19:33,049,172...33,092,751 		JBrowse link
G Hmgb1 high mobility group box 1 involved_in ISO (PMID:22473704) RGD PMID:22473704 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Runx1 RUNX family transcription factor 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:18258917)		 UniProt
RGD		 PMID:18258917 GO_REF:0000024 NCBI chr11:31,839,880...32,074,427
Ensembl chr11:31,843,764...32,074,542 		JBrowse link
G Runx3 RUNX family transcription factor 3 involved_in ISO (PMID:18258917) RGD PMID:18258917 NCBI chr 5:147,360,587...147,419,161
Ensembl chr 5:147,360,994...147,419,156 		JBrowse link
negative regulation of CD8-positive, alpha-beta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc4a2 solute carrier family 4 member 2 involved_in ISS
ISO		 GO_REF:0000024
(PMID:24515893)		 UniProt
RGD		 PMID:24515893 GO_REF:0000024 NCBI chr 4:10,736,419...10,754,407
Ensembl chr 4:10,736,425...10,752,965 		JBrowse link
G Socs1 suppressor of cytokine signaling 1 involved_in IEA
ISO
ISS		 GO_REF:0000107
(PMID:24880459)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:24880459 GO_REF:0000024 GO_REF:0000107 NCBI chr10:4,882,651...4,884,342
Ensembl chr10:4,882,560...4,884,383 		JBrowse link
G Zbtb7b zinc finger and BTB domain containing 7B involved_in ISO (PMID:22730529), (PMID:24880459) RGD PMID:22730529 PMID:24880459 NCBI chr 2:174,795,831...174,811,980
Ensembl chr 2:174,797,453...174,814,236 		JBrowse link
negative regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ascl2 achaete-scute family bHLH transcription factor 2 involved_in ISO (PMID:24463518) RGD PMID:24463518 NCBI chr 1:198,148,999...198,151,406
Ensembl chr 1:198,148,999...198,151,406 		JBrowse link
G Il4r interleukin 4 receptor acts_upstream_of_or_within ISO MGI:96109 (PMID:16424184) RGD PMID:16424184 NCBI chr 1:180,115,061...180,139,981
Ensembl chr 1:180,115,120...180,139,980 		JBrowse link
G Jak3 Janus kinase 3 involved_in ISS
ISO		 GO_REF:0000024
(PMID:16020505)		 BHF-UCL
RGD		 PMID:16020505 GO_REF:0000024 NCBI chr16:18,386,330...18,398,542
Ensembl chr16:18,386,405...18,398,536 		JBrowse link
G Tnfsf4 TNF superfamily member 4 involved_in ISO (PMID:9670042) RGD PMID:9670042 NCBI chr13:73,723,329...73,746,809
Ensembl chr13:73,723,329...73,746,788 		JBrowse link
negative regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ascl2 achaete-scute family bHLH transcription factor 2 involved_in ISO (PMID:24463518) RGD PMID:24463518 NCBI chr 1:198,148,999...198,151,406
Ensembl chr 1:198,148,999...198,151,406 		JBrowse link
G Foxp3 forkhead box P3 involved_in ISO (PMID:23169781) RGD PMID:23169781 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838 		JBrowse link
G Il2 interleukin 2 involved_in ISO RNAcentral:URS000039ED8D_10090 (PMID:25642768) RGD PMID:25642768 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il4 interleukin 4 acts_upstream_of_or_within ISO (PMID:18792410) RGD PMID:18792410 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Pf4 platelet factor 4 IDA RGD PMID:24986443 RGD:329901907 NCBI chr14:17,298,304...17,299,220
Ensembl chr14:17,298,308...17,299,365 		JBrowse link
G Rc3h1 ring finger and CCCH-type domains 1 involved_in ISO (PMID:25282160) RGD PMID:25282160 NCBI chr13:73,174,075...73,245,762
Ensembl chr13:73,173,946...73,238,839 		JBrowse link
G Rc3h2 ring finger and CCCH-type domains 2 involved_in ISO (PMID:25282160) RGD PMID:25282160 NCBI chr 3:21,121,531...21,186,711
Ensembl chr 3:21,110,679...21,179,933 		JBrowse link
G Smad7 SMAD family member 7 involved_in IEA
ISO		 GO_REF:0000107
(PMID:25642768)		 Ensembl
RGD		 PMID:25642768 GO_REF:0000107 NCBI chr18:68,988,429...69,016,774
Ensembl chr18:68,988,429...69,016,765 		JBrowse link
G Tbx21 T-box transcription factor 21 involved_in ISO (PMID:21151104) RGD PMID:21151104 NCBI chr10:82,082,322...82,098,831
Ensembl chr10:82,082,322...82,098,831 		JBrowse link
G Zbtb7b zinc finger and BTB domain containing 7B acts_upstream_of_or_within ISO MGI:3530739 (PMID:23034280) RGD PMID:23034280 NCBI chr 2:174,795,831...174,811,980
Ensembl chr 2:174,797,453...174,814,236 		JBrowse link
G Zc3h12a zinc finger CCCH type containing 12A involved_in ISS
ISO		 GO_REF:0000024
(PMID:25282160)		 UniProt
RGD		 PMID:25282160 GO_REF:0000024 NCBI chr 5:137,376,562...137,385,351
Ensembl chr 5:137,376,564...137,385,351 		JBrowse link
negative regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd69 Cd69 molecule involved_in ISO (PMID:24752896) RGD PMID:24752896 NCBI chr 4:162,725,446...162,733,364
Ensembl chr 4:162,725,446...162,733,542 		JBrowse link
G Jak3 Janus kinase 3 involved_in ISO
IEA		 (PMID:20696842)
GO_REF:0000107		 RGD
Ensembl		 PMID:20696842 GO_REF:0000107 NCBI chr16:18,386,330...18,398,542
Ensembl chr16:18,386,405...18,398,536 		JBrowse link
G Lgals1 galectin 1 involved_in ISO
IEA		 (PMID:24752896)
GO_REF:0000107		 RGD
Ensembl		 PMID:24752896 GO_REF:0000107 NCBI chr 7:110,485,239...110,488,345
Ensembl chr 7:110,481,392...110,488,345 		JBrowse link
G Loxl3 lysyl oxidase-like 3 involved_in ISO (PMID:28065600) RGD PMID:28065600 NCBI chr 4:115,540,640...115,556,958
Ensembl chr 4:115,540,685...115,557,466 		JBrowse link
G Stat5a signal transducer and activator of transcription 5A involved_in ISO
IEA		 (PMID:20696842)
GO_REF:0000107		 RGD
Ensembl		 PMID:20696842 GO_REF:0000107 NCBI chr10:85,785,537...85,809,869
Ensembl chr10:85,785,537...85,809,866 		JBrowse link
G Tbx21 T-box transcription factor 21 involved_in ISO (PMID:21151104) RGD PMID:21151104 NCBI chr10:82,082,322...82,098,831
Ensembl chr10:82,082,322...82,098,831 		JBrowse link
G Tnfsf18 TNF superfamily member 18 involved_in ISO (PMID:24107315) RGD PMID:24107315 NCBI chr13:73,833,478...73,907,249
Ensembl chr13:73,831,252...73,843,169 		JBrowse link
negative regulation of T-helper 2 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa1 annexin A1 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:17008549)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:17008549 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343 		JBrowse link
G Ascl2 achaete-scute family bHLH transcription factor 2 involved_in ISO (PMID:24463518) RGD PMID:24463518 NCBI chr 1:198,148,999...198,151,406
Ensembl chr 1:198,148,999...198,151,406 		JBrowse link
G Bcl6 BCL6, transcription repressor acts_upstream_of_or_within ISO MGI:96559 (PMID:12594267) RGD PMID:12594267 NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389 		JBrowse link
G Hlx H2.0-like homeobox acts_upstream_of_or_within ISO MGI:105367|MGI:2182089 (PMID:16424184) RGD PMID:16424184 NCBI chr13:96,280,335...96,285,750
Ensembl chr13:96,280,339...96,285,750 		JBrowse link
G Socs5 suppressor of cytokine signaling 5 involved_in ISO (PMID:12242343) RGD PMID:12242343 NCBI chr 6:7,481,039...7,512,644
Ensembl chr 6:7,481,095...7,514,834 		JBrowse link
G Zfp35 zinc finger protein 35 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr18:15,268,852...15,284,334
Ensembl chr18:15,268,814...15,285,088 		JBrowse link
negative regulation of T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rc3h1 ring finger and CCCH-type domains 1 acts_upstream_of_or_within ISO MGI:3581675 (PMID:15917799) RGD PMID:15917799 NCBI chr13:73,174,075...73,245,762
Ensembl chr13:73,173,946...73,238,839 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20069
    immune system process 3008
      leukocyte activation 1056
        lymphocyte activation 856
          lymphocyte differentiation 444
            T cell differentiation 330
              negative regulation of T cell differentiation 60
                negative regulation of alpha-beta T cell differentiation 33
                  negative regulation of CD4-positive, alpha-beta T cell differentiation + 28
                  negative regulation of CD8-positive, alpha-beta T cell differentiation 3
                  negative regulation of NK T cell differentiation 0
Path 2
Term Annotations click to browse term
  biological_process 20069
    cellular process 19150
      cellular developmental process 4781
        cell differentiation 4780
          cell development 3325
            hemopoiesis 1075
              leukocyte differentiation 681
                mononuclear cell differentiation 546
                  lymphocyte differentiation 444
                    T cell differentiation 330
                      regulation of T cell differentiation 181
                        negative regulation of T cell differentiation 60
                          negative regulation of alpha-beta T cell differentiation 33
                            negative regulation of CD4-positive, alpha-beta T cell differentiation + 28
                            negative regulation of CD8-positive, alpha-beta T cell differentiation 3
                            negative regulation of NK T cell differentiation 0
paths to the root