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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of T cell differentiation
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Accession:GO:0045581 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of T cell differentiation.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: down regulation of T cell differentiation;   downregulation of T cell differentiation;   negative regulation of T lymphocyte differentiation
 narrow_synonym: inhibition of T cell differentiation
 related_synonym: negative regulation of T cell development



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negative regulation of T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd74 CD74 molecule acts_upstream_of_or_within ISO MGI:1927205 (MGI:52620|PMID:7679955) RGD PMID:7679955 MGI:52620 NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003
JBrowse link
G Cyld CYLD lysine 63 deubiquitinase acts_upstream_of_or_within ISO (MGI:5449492|PMID:23066153) RGD PMID:23066153 MGI:5449492 NCBI chr19:18,310,632...18,373,696
Ensembl chr19:18,314,019...18,373,658
JBrowse link
G Dtx1 deltex E3 ubiquitin ligase 1 acts_upstream_of_or_within ISO (MGI:2663321|PMID:12794108) RGD PMID:12794108 MGI:2663321 NCBI chr12:35,849,647...35,880,835
Ensembl chr12:35,849,617...35,880,838
JBrowse link
G Ifnb1 interferon beta 1 involved_in ISO (PMID:20554961) RGD PMID:20554961 NCBI chr 5:103,020,969...103,021,523
Ensembl chr 5:103,020,969...103,021,523
JBrowse link
G Ifnl1 interferon, lambda 1 involved_in ISO (PMID:19346497) RGD PMID:19346497 NCBI chr 1:83,798,651...83,800,297
Ensembl chr 1:83,798,703...83,800,235
JBrowse link
G Nrarp Notch-regulated ankyrin repeat protein acts_upstream_of_or_within ISO (MGI:2663321|PMID:12794108) RGD PMID:12794108 MGI:2663321 NCBI chr 3:7,992,582...7,995,136
Ensembl chr 3:7,992,552...7,995,133
JBrowse link
G Prdx2 peroxiredoxin 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2668456 (MGI:3796974|PMID:16290204)
Ensembl
RGD
PMID:16290204 GO_REF:0000107 MGI:3796974 NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194
JBrowse link
negative regulation of alpha-beta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gli3 GLI family zinc finger 3 involved_in ISO (MGI:4355451|PMID:19667090) RGD PMID:19667090 MGI:4355451 NCBI chr17:49,438,567...49,709,712
Ensembl chr17:49,438,567...49,709,712
JBrowse link
G Ihh Indian hedgehog signaling molecule involved_in ISO (MGI:3836494|PMID:19109233) RGD PMID:19109233 MGI:3836494 NCBI chr 9:76,504,315...76,510,532
Ensembl chr 9:76,504,315...76,510,532
JBrowse link
G Shh sonic hedgehog signaling molecule involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:1888832|PMID:10981962)
Ensembl
RGD
PMID:10981962 GO_REF:0000107 MGI:1888832 NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170
JBrowse link
negative regulation of CD4-positive, alpha-beta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbfb core-binding factor subunit beta involved_in ISO (MGI:3772948|PMID:18258917) RGD PMID:18258917 MGI:3772948 NCBI chr19:33,049,162...33,092,752
Ensembl chr19:33,049,172...33,092,751
JBrowse link
G Hmgb1 high mobility group box 1 involved_in ISO (PMID:22473704) RGD PMID:22473704 NCBI chr12:5,973,062...5,978,565
Ensembl chr12:5,901,586...5,978,565
JBrowse link
G Runx1 RUNX family transcription factor 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:3772948|PMID:18258917)
UniProt
RGD
PMID:18258917 GO_REF:0000024 MGI:3772948 NCBI chr11:31,839,880...32,074,427
Ensembl chr11:31,843,764...32,074,542
JBrowse link
G Runx3 RUNX family transcription factor 3 involved_in ISO (MGI:3772948|PMID:18258917) RGD PMID:18258917 MGI:3772948 NCBI chr 5:147,393,926...147,419,161
Ensembl chr 5:147,360,994...147,419,156
JBrowse link
negative regulation of CD8-positive, alpha-beta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Socs1 suppressor of cytokine signaling 1 involved_in IEA
ISO
ISS
GO_REF:0000107
(MGI:6140589|PMID:24880459)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:24880459 GO_REF:0000024 GO_REF:0000107 MGI:6140589 NCBI chr10:4,882,651...4,884,342
Ensembl chr10:4,882,560...4,884,383
JBrowse link
G Zbtb7b zinc finger and BTB domain containing 7B involved_in ISO (MGI:5446998|PMID:22730529), (MGI:6140589|PMID:24880459) RGD PMID:22730529 PMID:24880459 MGI:5446998 MGI:6140589 NCBI chr 2:174,795,831...174,811,980
Ensembl chr 2:174,797,453...174,814,236
JBrowse link
negative regulation of cytotoxic T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lilrb4 leukocyte immunoglobulin like receptor B4 involved_in ISO (PMID:16493035) RGD PMID:16493035 NCBI chr 1:69,805,020...69,810,628
Ensembl chr 1:69,805,250...69,810,660
JBrowse link
negative regulation of immature T cell proliferation in thymus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 involved_in IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:12421925)
Ensembl
UniProt
RGD
PMID:12421925 GO_REF:0000024 GO_REF:0000107 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A involved_in ISO (MGI:3615850|PMID:15964995) RGD PMID:15964995 MGI:3615850 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
JBrowse link
G Clec4g C-type lectin domain family 4, member G acts_upstream_of_or_within ISO MGI:5510586 (MGI:5475030|PMID:23487419) RGD PMID:23487419 MGI:5475030 NCBI chr12:1,780,370...1,785,027
Ensembl chr12:1,780,371...1,784,985
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 acts_upstream_of_or_within ISO (MGI:3695084|PMID:16230479) RGD PMID:16230479 MGI:3695084 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
JBrowse link
G Ihh Indian hedgehog signaling molecule involved_in ISO (MGI:3836494|PMID:19109233) RGD PMID:19109233 MGI:3836494 NCBI chr 9:76,504,315...76,510,532
Ensembl chr 9:76,504,315...76,510,532
JBrowse link
G Tmem131l transmembrane 131 like involved_in ISO (PMID:23690469) RGD PMID:23690469 NCBI chr 2:169,257,659...169,391,773
Ensembl chr 2:169,258,289...169,391,711
JBrowse link
negative regulation of memory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgl2 fibrinogen-like 2 acts_upstream_of_or_within ISO MGI:3582343 (MGI:6188369|PMID:29341118) RGD PMID:29341118 MGI:6188369 NCBI chr 4:13,710,566...13,716,207
Ensembl chr 4:13,710,575...13,716,207
JBrowse link
G Ifnl1 interferon, lambda 1 involved_in ISO (PMID:19346497) RGD PMID:19346497 NCBI chr 1:83,798,651...83,800,297
Ensembl chr 1:83,798,703...83,800,235
JBrowse link
negative regulation of positive thymic T cell selection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 involved_in ISS
ISO
GO_REF:0000024
(MGI:5320871|PMID:22080863)
UniProt
RGD
PMID:22080863 GO_REF:0000024 MGI:5320871 NCBI chr18:61,229,012...61,294,662
Ensembl chr18:61,229,014...61,294,627
JBrowse link
negative regulation of regulatory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd44 CD44 molecule (Indian blood group) involved_in ISO (MGI:5688819|PMID:25065622) RGD PMID:25065622 MGI:5688819 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 involved_in IBA
ISO
PMID:21873635
(PMID:18641304)
RGD PMID:18641304 PMID:21873635 RGD:13792537 NCBI chr 9:62,318,874...62,325,978
Ensembl chr 9:62,319,312...62,324,963
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 IMP RGD PMID:30287503 RGD:38549580 NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743
JBrowse link
G Irf1 interferon regulatory factor 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:3803082|PMID:18641303)
UniProt
RGD
PMID:18641303 GO_REF:0000024 MGI:3803082 NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166
JBrowse link
G Lag3 lymphocyte activating 3 involved_in ISS
ISO
GO_REF:0000024
(MGI:3510279|PMID:15485628)
UniProt
RGD
PMID:15485628 GO_REF:0000024 MGI:3510279 NCBI chr 4:157,712,665...157,722,229
Ensembl chr 4:157,712,667...157,720,404
JBrowse link
G Mdk midkine involved_in ISO
ISS
(PMID:22323540)
GO_REF:0000024
RGD
UniProt
PMID:22323540 GO_REF:0000024 NCBI chr 3:77,901,156...77,903,997
Ensembl chr 3:77,901,158...77,903,130
JBrowse link
G Mir21 microRNA 21 involved_in ISO RNAcentral:URS0000338542_9606 (PMID:22387553) RGD PMID:22387553 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348
JBrowse link
G Mir30b microRNA 30b involved_in ISO RNAcentral:URS000039ED8D_9606 (PMID:22387553) RGD PMID:22387553 NCBI chr 7:100,132,589...100,132,675
Ensembl chr 7:100,132,589...100,132,675
JBrowse link
G Tnfsf4 TNF superfamily member 4 involved_in ISO (MGI:3806904|PMID:18713990) RGD PMID:18713990 MGI:3806904 NCBI chr13:73,723,329...73,746,809
Ensembl chr13:73,723,329...73,746,788
JBrowse link
G Tug1 taurine up-regulated 1 IMP RGD PMID:30287503 RGD:38549580 NCBI chr14:78,519,894...78,526,927
Ensembl chr14:78,522,506...78,526,927
JBrowse link
negative regulation of T cell differentiation in thymus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 involved_in ISO (PMID:12421925) RGD PMID:12421925 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306
JBrowse link
G Foxj1 forkhead box J1 involved_in ISO (MGI:3713603|PMID:16339515) RGD PMID:16339515 MGI:3713603 NCBI chr10:101,566,299...101,570,249
Ensembl chr10:101,566,304...101,570,237
JBrowse link
G Ihh Indian hedgehog signaling molecule involved_in ISO (MGI:3836494|PMID:19109233) RGD PMID:19109233 MGI:3836494 NCBI chr 9:76,504,315...76,510,532
Ensembl chr 9:76,504,315...76,510,532
JBrowse link
G Nfkbid NFKB inhibitor delta acts_upstream_of_or_within ISO (MGI:2177878|PMID:11931770) RGD PMID:11931770 MGI:2177878 NCBI chr 1:85,679,353...85,690,415
Ensembl chr 1:85,680,861...85,690,447
JBrowse link
G Rag2 recombination activating 2 IMP RGD PMID:30206106 RGD:38508903 NCBI chr 3:87,902,373...87,910,227
Ensembl chr 3:87,902,238...87,911,066
JBrowse link
G Shh sonic hedgehog signaling molecule acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:1888832|PMID:10981962)
GO_REF:0000107
RGD
Ensembl
PMID:10981962 GO_REF:0000107 MGI:1888832 NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170
JBrowse link
G Zc3h8 zinc finger CCCH type containing 8 involved_in ISO (PMID:12153508) RGD PMID:12153508 NCBI chr 3:116,176,779...116,193,752
Ensembl chr 3:116,176,798...116,193,787
JBrowse link
negative regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il4r interleukin 4 receptor acts_upstream_of_or_within ISO MGI:96109 (MGI:3761239|PMID:16424184) RGD PMID:16424184 MGI:3761239 NCBI chr 1:180,115,061...180,139,981
Ensembl chr 1:180,115,120...180,139,980
JBrowse link
G Jak3 Janus kinase 3 involved_in ISS
ISO
GO_REF:0000024
(MGI:3719947|PMID:16020505)
BHF-UCL
RGD
PMID:16020505 GO_REF:0000024 MGI:3719947 NCBI chr16:18,386,330...18,398,542
Ensembl chr16:18,386,405...18,398,536
JBrowse link
G Tnfsf4 TNF superfamily member 4 involved_in ISO (MGI:4942267|PMID:9670042) RGD PMID:9670042 MGI:4942267 NCBI chr13:73,723,329...73,746,809
Ensembl chr13:73,723,329...73,746,788
JBrowse link
negative regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxp3 forkhead box P3 involved_in ISO (PMID:23169781) RGD PMID:23169781 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838
JBrowse link
G Il2 interleukin 2 involved_in ISO RNAcentral:URS000039ED8D_10090 (MGI:5634593|PMID:25642768) RGD PMID:25642768 MGI:5634593 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il4 interleukin 4 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(MGI:3817792|PMID:18792410)
RGD PMID:18792410 PMID:21873635 MGI:3817792, RGD:13792537 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Rc3h1 ring finger and CCCH-type domains 1 involved_in ISO (MGI:6142401|PMID:25282160) RGD PMID:25282160 MGI:6142401 NCBI chr13:73,174,075...73,245,762
Ensembl chr13:73,173,946...73,238,839
JBrowse link
G Rc3h2 ring finger and CCCH-type domains 2 involved_in ISO (MGI:6142401|PMID:25282160) RGD PMID:25282160 MGI:6142401 NCBI chr 3:21,121,531...21,186,711
Ensembl chr 3:21,110,679...21,179,933
JBrowse link
G Smad7 SMAD family member 7 involved_in IEA
ISO
GO_REF:0000107
(MGI:5634593|PMID:25642768)
Ensembl
RGD
PMID:25642768 GO_REF:0000107 MGI:5634593 NCBI chr18:68,988,429...69,016,774
Ensembl chr18:68,988,429...69,016,765
JBrowse link
G Tbx21 T-box transcription factor 21 involved_in ISO (MGI:4868293|PMID:21151104) RGD PMID:21151104 MGI:4868293 NCBI chr10:82,082,322...82,098,831
Ensembl chr10:82,082,322...82,098,831
JBrowse link
G Zbtb7b zinc finger and BTB domain containing 7B acts_upstream_of_or_within ISO MGI:3530739 (MGI:5450776|PMID:23034280) RGD PMID:23034280 MGI:5450776 NCBI chr 2:174,795,831...174,811,980
Ensembl chr 2:174,797,453...174,814,236
JBrowse link
G Zc3h12a zinc finger CCCH type containing 12A involved_in ISS
ISO
GO_REF:0000024
(MGI:6142401|PMID:25282160)
UniProt
RGD
PMID:25282160 GO_REF:0000024 MGI:6142401 NCBI chr 5:137,376,562...137,385,351
Ensembl chr 5:137,376,564...137,385,351
JBrowse link
negative regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Loxl3 lysyl oxidase-like 3 involved_in ISO (MGI:5825383|PMID:28065600) RGD PMID:28065600 MGI:5825383 NCBI chr 4:115,540,640...115,556,958
Ensembl chr 4:115,540,685...115,557,466
JBrowse link
G Tbx21 T-box transcription factor 21 involved_in ISO (MGI:4868293|PMID:21151104) RGD PMID:21151104 MGI:4868293 NCBI chr10:82,082,322...82,098,831
Ensembl chr10:82,082,322...82,098,831
JBrowse link
G Tnfsf18 TNF superfamily member 18 involved_in ISO (MGI:5551556|PMID:24107315) RGD PMID:24107315 MGI:5551556 NCBI chr13:73,833,478...73,907,249
Ensembl chr13:73,831,252...73,843,169
JBrowse link
negative regulation of T-helper 2 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa1 annexin A1 involved_in ISS
IBA
ISO
GO_REF:0000024
PMID:21873635
(PMID:17008549)
UniProt
RGD
PMID:17008549 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
JBrowse link
G Bcl6 BCL6, transcription repressor acts_upstream_of_or_within ISO MGI:96559 (MGI:2450484|PMID:12594267) RGD PMID:12594267 MGI:2450484 NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389
JBrowse link
G Hlx H2.0-like homeobox acts_upstream_of_or_within ISO MGI:105367|MGI:2182089 (MGI:3761239|PMID:16424184) RGD PMID:16424184 MGI:3761239 NCBI chr13:96,280,335...96,285,750
Ensembl chr13:96,280,339...96,285,750
JBrowse link
G Socs5 suppressor of cytokine signaling 5 involved_in ISO (MGI:3687909|PMID:12242343) RGD PMID:12242343 MGI:3687909 NCBI chr 6:7,481,039...7,512,644
Ensembl chr 6:7,481,095...7,514,834
JBrowse link
G Zfp35 zinc finger protein 35 acts_upstream_of_or_within ISO MGI:4398896 (MGI:4366385|PMID:19783676) RGD PMID:19783676 MGI:4366385 NCBI chr18:15,268,852...15,284,334
Ensembl chr18:15,268,814...15,285,088
JBrowse link
negative regulation of T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rc3h1 ring finger and CCCH-type domains 1 acts_upstream_of_or_within ISO MGI:3581675 (MGI:3580753|PMID:15917799) RGD PMID:15917799 MGI:3580753 NCBI chr13:73,174,075...73,245,762
Ensembl chr13:73,173,946...73,238,839
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20091
    immune system process 2570
      leukocyte activation 1038
        lymphocyte activation 849
          lymphocyte differentiation 438
            T cell differentiation 312
              negative regulation of T cell differentiation 55
                negative regulation of T cell differentiation in thymus + 12
                negative regulation of alpha-beta T cell differentiation + 27
                negative regulation of cytotoxic T cell differentiation 1
                negative regulation of extrathymic T cell differentiation 0
                negative regulation of gamma-delta T cell differentiation 0
                negative regulation of memory T cell differentiation 2
                negative regulation of pro-T cell differentiation 0
                negative regulation of regulatory T cell differentiation + 10
Path 2
Term Annotations click to browse term
  biological_process 20091
    cellular process 18676
      cellular developmental process 4656
        cell differentiation 4633
          cell development 3232
            hemopoiesis 1033
              leukocyte differentiation 650
                mononuclear cell differentiation 497
                  lymphocyte differentiation 438
                    T cell differentiation 312
                      regulation of T cell differentiation 179
                        negative regulation of T cell differentiation 55
                          negative regulation of T cell differentiation in thymus + 12
                          negative regulation of alpha-beta T cell differentiation + 27
                          negative regulation of cytotoxic T cell differentiation 1
                          negative regulation of extrathymic T cell differentiation 0
                          negative regulation of gamma-delta T cell differentiation 0
                          negative regulation of memory T cell differentiation 2
                          negative regulation of pro-T cell differentiation 0
                          negative regulation of regulatory T cell differentiation + 10
paths to the root