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ONTOLOGY REPORT - ANNOTATIONS

Term:positive regulation of receptor signaling pathway via JAK-STAT
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Accession:GO:0046427 term browser browse the term
Definition:Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity.
Synonyms:exact_synonym: up regulation of JAK-STAT cascade;   upregulation of JAK-STAT cascade
 narrow_synonym: activation of JAK-STAT cascade;   positive regulation of STAT protein import into nucleus;   positive regulation of STAT protein nuclear translocation;   stimulation of JAK-STAT cascade
 alt_id: GO:2000366
 xref: Reactome:R-HSA-8849474 "PTK6 Activates STAT3"


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positive regulation of receptor signaling pathway via JAK-STAT term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20075866) Ensembl
MGI		 PMID:20075866 GO_REF:0000107 NCBI chr 5:23,015,777...23,035,943
Ensembl chr 5:23,017,176...23,033,517 		JBrowse link
G AKR1B1 aldo-keto reductase family 1 member B ISO RGD PMID:15746188 RGD:1626095 NCBI chr18:14,593,516...14,752,316
Ensembl chr18:14,684,036...14,752,310 		JBrowse link
G AMCF-II alveolar macrophage-derived chemotactic factor-II ISO RGD PMID:21114767 RGD:5135266 NCBI chr 8:70,008,225...70,010,360
Ensembl chr 8:70,008,162...70,010,358 		JBrowse link
G CALM1 calmodulin 1 involved_in ISO (PMID:11972023), (PMID:35568036) UniProt PMID:11972023 PMID:35568036 NCBI chr 7:112,160,823...112,171,754
Ensembl chr 7:112,160,806...112,171,744 		JBrowse link
G CALM2 calmodulin 2 involved_in ISO (PMID:11972023), (PMID:35568036) UniProt PMID:11972023 PMID:35568036 NCBI chr 3:93,371,765...93,386,378
Ensembl chr 3:93,372,045...93,386,218 		JBrowse link
G CALM3 calmodulin 3 involved_in ISO (PMID:11972023), (PMID:35568036) UniProt PMID:11972023 PMID:35568036 NCBI chr 6:52,506,979...52,516,704
Ensembl chr 6:52,506,674...52,516,703 		JBrowse link
G CAMK2A calcium/calmodulin dependent protein kinase II alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:151,248,356...151,353,907
Ensembl chr 2:151,248,358...151,308,706 		JBrowse link
G CENPJ centromere protein J acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:12198240) MGI
Ensembl		 PMID:12198240 GO_REF:0000107 NCBI chr11:289,660...357,920
Ensembl chr11:289,653...355,581 		JBrowse link
G CNTF ciliary neurotrophic factor ISO RGD PMID:15574731 RGD:1626128 NCBI chr 2:12,492,777...12,495,401
Ensembl chr 2:12,493,169...12,496,159 		JBrowse link
G CRLF3 cytokine receptor like factor 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:42,933,417...42,991,395
Ensembl chr12:42,933,445...42,976,348 		JBrowse link
G CSF2RA colony stimulating factor 2 receptor subunit alpha involved_in IBA GO_Central GO_REF:0000033
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:102,195,743...102,205,687
Ensembl chr 3:102,195,741...102,205,683 		JBrowse link
G EP300 E1A binding protein p300 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:7,311,165...7,394,515
Ensembl chr 5:7,311,171...7,393,760 		JBrowse link
G ERBB4 erb-b2 receptor tyrosine kinase 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:113,966,573...115,096,984
Ensembl chr15:113,974,437...115,096,565 		JBrowse link
G GH1 growth hormone 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr12:15,064,965...15,066,698
Ensembl chr12:15,064,909...15,066,696 		JBrowse link
G GHR growth hormone receptor involved_in ISO
IBA		 RGD
GO_Central		 PMID:10976913 PMID:11064147 GO_REF:0000033 RGD:1624963 RGD:1624964 NCBI chr16:27,126,300...27,422,618
Ensembl chr16:27,126,734...27,421,449 		JBrowse link
G HES1 hes family bHLH transcription factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:131,135,970...131,137,865
Ensembl chr13:131,135,725...131,138,237 		JBrowse link
G HES5 hes family bHLH transcription factor 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:64,409,110...64,410,541
Ensembl chr 6:64,408,956...64,410,881 		JBrowse link
G IFNE interferon epsilon involved_in ISO (PMID:23964570) CACAO PMID:23964570 NCBI chr 1:201,219,848...201,228,361
Ensembl chr 1:201,221,665...201,227,047 		JBrowse link
G IL10 interleukin 10 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 9:67,400,727...67,405,941
Ensembl chr 9:67,400,728...67,405,378 		JBrowse link
G IL10RA interleukin 10 receptor subunit alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:45,310,527...45,324,557
Ensembl chr 9:45,310,534...45,325,168 		JBrowse link
G IL10RB interleukin 10 receptor subunit beta involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:196,853,606...196,884,237
Ensembl chr13:196,853,467...196,884,928 		JBrowse link
G IL26 interleukin 26 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 5:32,568,189...32,583,278
Ensembl chr 5:32,568,023...32,583,239 		JBrowse link
G IL29 interleukin 29 (interferon, lambda 1) involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:51,484,658...51,485,233
Ensembl chr17:51,484,658...51,485,233 		JBrowse link
G IL4 interleukin 4 involved_in IMP (PMID:24280217) AgBase PMID:24280217 NCBI chr 2:134,986,817...134,994,365
Ensembl chr 2:134,986,817...134,994,365 		JBrowse link
G IL5 interleukin 5 ISO RGD PMID:10867506 RGD:2303751 NCBI chr 2:134,832,143...134,846,141
Ensembl chr 2:134,832,147...134,835,212 		JBrowse link
G IL6 interleukin 6 involved_in ISO
IEA
IBA		 STAT3 phosphorylation RGD
Ensembl
GO_Central		 PMID:15659221 PMID:16413512 PMID:19061939 GO_REF:0000033 GO_REF:0000107 RGD:1580483 RGD:1641883 RGD:2306937 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263 		JBrowse link
G IL7R interleukin 7 receptor involved_in IBA GO_Central GO_REF:0000033 NCBI chr16:21,300,141...21,330,156
Ensembl chr16:21,300,111...21,329,585 		JBrowse link
G JAK2 Janus kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:216,849,744...217,002,310
Ensembl chr 1:216,848,689...217,002,148 		JBrowse link
G KIT KIT proto-oncogene, receptor tyrosine kinase involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 8:41,402,334...41,492,306
Ensembl chr 8:41,402,043...41,493,734 		JBrowse link
G LEP leptin involved_in ISO
ISS
IEA		 RGD
UniProt
Ensembl		 PMID:21250909 GO_REF:0000024 GO_REF:0000107 RGD:5128518 NCBI chr18:20,106,867...20,124,071
Ensembl chr18:20,106,868...20,123,323 		JBrowse link
G LOC110257903 granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like involved_in IBA GO_Central GO_REF:0000033 NCBI chr  Y:5,019,990...5,035,462 JBrowse link
G MIR221 microRNA mir-221 involved_in ISO (PMID:25019494) BHF-UCL PMID:25019494 NCBI chr  X:40,571,068...40,571,137
Ensembl chr  X:40,571,068...40,571,137 		JBrowse link
G NOTCH1 notch receptor 1 involved_in IEA Ensembl GO_REF:0000107
G PRL prolactin involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 (PMID:12388746) Ensembl
MGI
GO_Central		 PMID:12388746 GO_REF:0000033 GO_REF:0000107 NCBI chr 7:17,451,367...17,463,771
Ensembl chr 7:17,451,367...17,463,710 		JBrowse link
G STRA6 signaling receptor and transporter of retinol STRA6 acts_upstream_of_or_within ISO (PMID:23839944) MGI PMID:23839944 NCBI chr 7:59,317,930...59,347,274
Ensembl chr 7:59,318,011...59,347,266 		JBrowse link
G TYK2 tyrosine kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:69,157,774...69,183,555
Ensembl chr 2:69,157,811...69,183,456 		JBrowse link
G USP1 ubiquitin specific peptidase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:149,971,471...149,985,946
Ensembl chr 6:149,970,915...149,985,509 		JBrowse link
G WDR48 WD repeat domain 48 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:23,735,566...23,786,312
Ensembl chr13:23,735,567...23,786,308 		JBrowse link
activation of Janus kinase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGTR1 angiotensin II receptor type 1 ISO RGD PMID:9314843 RGD:6478796 NCBI chr13:88,934,873...88,980,317
Ensembl chr13:88,934,868...88,983,105 		JBrowse link
G GHR growth hormone receptor ISO RGD PMID:11244571 RGD:1624962 NCBI chr16:27,126,300...27,422,618
Ensembl chr16:27,126,734...27,421,449 		JBrowse link
G JAK2 Janus kinase 2 involved_in ISS UniProt GO_REF:0000024 NCBI chr 1:216,849,744...217,002,310
Ensembl chr 1:216,848,689...217,002,148 		JBrowse link
G PIBF1 progesterone immunomodulatory binding factor 1 involved_in ISO (PMID:16393965) UniProt PMID:16393965 NCBI chr11:45,076,046...45,362,708
Ensembl chr11:45,076,062...45,362,887 		JBrowse link
G PRLR prolactin receptor involved_in ISO (PMID:10585417) UniProt PMID:10585417 NCBI chr16:20,637,568...20,655,881
Ensembl chr16:20,618,875...20,810,140 		JBrowse link
G PTK2B protein tyrosine kinase 2 beta involved_in ISO (PMID:8670418) RGD
UniProt		 PMID:8670418 PMID:11818507 RGD:633057 NCBI chr14:11,063,662...11,194,196
Ensembl chr14:11,064,492...11,194,192 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18933
    response to stimulus 10090
      positive regulation of response to stimulus 2424
        positive regulation of signal transduction 1710
          positive regulation of receptor signaling pathway via STAT 52
            positive regulation of receptor signaling pathway via JAK-STAT 43
              activation of Janus kinase activity 6
Path 2
Term Annotations click to browse term
  biological_process 18933
    biological regulation 13010
      regulation of biological process 12629
        signaling 7532
          signal transduction 6990
            cell surface receptor signaling pathway 2785
              cell surface receptor signaling pathway via STAT 167
                regulation of receptor signaling pathway via STAT 104
                  regulation of receptor signaling pathway via JAK-STAT 87
                    positive regulation of receptor signaling pathway via JAK-STAT 43
                      activation of Janus kinase activity 6
paths to the root