CALM2 (calmodulin 2) - Rat Genome Database

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Gene: CALM2 (calmodulin 2) Sus scrofa
Analyze
Symbol: CALM2
Name: calmodulin 2
RGD ID: 13994438
Description: ENCODES a protein that exhibits adenylate cyclase activator activity (ortholog); adenylate cyclase binding (ortholog); calcium channel inhibitor activity (ortholog); INVOLVED IN activation of adenylate cyclase activity (ortholog); autophagosome membrane docking (ortholog); calcium-mediated signaling (ortholog); PARTICIPATES IN adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; calcium/calcium-mediated signaling pathway; calcium/calmodulin dependent kinase 2 signaling pathway; ASSOCIATED WITH cannabis abuse (ortholog); Cocaine-Related Disorders (ortholog); COVID-19 (ortholog); FOUND IN calcium channel complex (ortholog); catalytic complex (ortholog); centrosome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: calmodulin
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl393,372,045 - 93,438,068 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1393,371,765 - 93,386,378 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2399,567,552 - 99,582,160 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of adenylate cyclase activity  (ISO)
autophagosome membrane docking  (ISO)
C-5 methylation of cytosine  (IEA)
calcium-mediated signaling  (ISO)
detection of calcium ion  (ISO)
DNA demethylation of male pronucleus  (IEA)
establishment of protein localization to membrane  (ISO)
establishment of protein localization to mitochondrial membrane  (ISO)
G2/M transition of mitotic cell cycle  (ISO)
mitochondrion-endoplasmic reticulum membrane tethering  (ISO)
negative regulation of calcium ion export across plasma membrane  (ISO)
negative regulation of calcium ion transmembrane transporter activity  (ISO)
negative regulation of high voltage-gated calcium channel activity  (ISO)
negative regulation of ryanodine-sensitive calcium-release channel activity  (ISO)
organelle localization by membrane tethering  (ISO)
positive regulation of cyclic-nucleotide phosphodiesterase activity  (ISO)
positive regulation of DNA demethylation  (IEA)
positive regulation of nitric-oxide synthase activity  (ISO)
positive regulation of phosphoprotein phosphatase activity  (ISO)
positive regulation of protein dephosphorylation  (ISO)
positive regulation of ryanodine-sensitive calcium-release channel activity  (ISO)
regulation of calcium-mediated signaling  (ISO)
regulation of cardiac muscle cell action potential  (ISO)
regulation of cardiac muscle contraction  (ISO)
regulation of cytokinesis  (ISO)
regulation of heart rate  (ISO)
regulation of high voltage-gated calcium channel activity  (ISO)
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  (ISO)
regulation of ryanodine-sensitive calcium-release channel activity  (ISO)
regulation of synaptic vesicle endocytosis  (ISO)
regulation of synaptic vesicle exocytosis  (ISO)
response to amphetamine  (ISO)
response to calcium ion  (ISO)
response to corticosterone  (ISO)
substantia nigra development  (ISO)

References
Additional References at PubMed
PMID:14681463   PMID:15679890   PMID:17145712  


Genomics

Comparative Map Data
CALM2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl393,372,045 - 93,438,068 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1393,371,765 - 93,386,378 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2399,567,552 - 99,582,160 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CALM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl247,160,083 - 47,176,921 (-)EnsemblGRCh38hg38GRCh38
GRCh38247,160,082 - 47,176,936 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37247,387,221 - 47,404,075 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36247,240,809 - 47,257,154 (-)NCBINCBI36hg18NCBI36
Build 34247,298,955 - 47,315,301NCBI
Celera247,226,054 - 47,242,551 (-)NCBI
Cytogenetic Map2p21NCBI
HuRef247,124,359 - 47,140,853 (-)NCBIHuRef
CHM1_1247,317,465 - 47,333,922 (-)NCBICHM1_1
Calm2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391787,740,829 - 87,754,363 (-)NCBIGRCm39mm39
GRCm39 Ensembl1787,740,840 - 87,754,363 (-)Ensembl
GRCm381787,433,401 - 87,446,935 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12100,199,435 - 100,209,814 (+)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl1787,433,412 - 87,446,935 (-)EnsemblGRCm38mm10GRCm38
MGSCv371787,832,741 - 87,846,275 (-)NCBIGRCm37mm9NCBIm37
MGSCv361787,341,743 - 87,355,168 (-)NCBImm8
Celera1791,831,455 - 91,844,939 (-)NCBICelera
Cytogenetic Map17E4NCBI
Calm2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.267,091,624 - 7,104,284 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl67,091,567 - 7,104,287 (+)Ensembl
Rnor_6.0611,067,675 - 11,080,078 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1565,506,874 - 65,507,968 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0621,052,945 - 21,068,133 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4664,161,641 - 64,162,751 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11564,177,420 - 64,178,531 (-)NCBI
Celera66,842,934 - 6,855,590 (+)NCBICelera
Cytogenetic Map6q12NCBI
Calm2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495544113,973,147 - 13,988,665 (-)NCBIChiLan1.0ChiLan1.0
CALM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A48,204,518 - 48,220,697 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A48,204,518 - 48,220,697 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A47,274,722 - 47,290,861 (-)NCBIMhudiblu_PPA_v0panPan3
CALM2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11049,299,698 - 49,314,533 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1049,299,897 - 49,314,457 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1049,152,937 - 49,167,816 (-)NCBI
ROS_Cfam_1.01050,169,941 - 50,184,842 (-)NCBI
UMICH_Zoey_3.11049,877,637 - 49,892,535 (-)NCBI
UNSW_CanFamBas_1.01050,167,136 - 50,182,012 (-)NCBI
UU_Cfam_GSD_1.01050,351,274 - 50,366,152 (-)NCBI
Calm2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629233,779,344 - 33,795,171 (+)NCBI
SpeTri2.0NW_0049365085,207,909 - 5,223,780 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CALM2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11460,027,884 - 60,042,041 (+)NCBI
ChlSab1.1 Ensembl1460,027,801 - 60,044,951 (+)Ensembl
ChlSab1.1 Ensembl639,957,320 - 39,966,581 (+)Ensembl
ChlSab1.1 Ensembl2468,133,428 - 68,145,180 (+)Ensembl
Vero_WHO_p1.0NW_02366604551,803,526 - 51,818,114 (-)NCBI
Calm2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473828,525,290 - 28,541,562 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_003125163   ⟹   XP_003125211
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1393,371,765 - 93,386,378 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003125211 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_003125211   ⟸   XM_003125163
- UniProtKB: F2Z5G3 (UniProtKB/TrEMBL)
- Sequence:
Protein Domains
EF-hand


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000008433 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00000022545 UniProtKB/TrEMBL
  ENSSSCG00000025768 UniProtKB/TrEMBL
  ENSSSCG00070000755 UniProtKB/TrEMBL
  ENSSSCG00070003824 UniProtKB/TrEMBL
  ENSSSCG00070028203 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000009000 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000022607 UniProtKB/TrEMBL
  ENSSSCP00000028062 UniProtKB/TrEMBL
  ENSSSCP00000052711 UniProtKB/TrEMBL
  ENSSSCP00000053816 UniProtKB/TrEMBL
  ENSSSCP00000060120 UniProtKB/TrEMBL
  ENSSSCP00000063070 UniProtKB/TrEMBL
  ENSSSCP00000072892 UniProtKB/TrEMBL
  ENSSSCP00070001223 UniProtKB/TrEMBL
  ENSSSCP00070001225 UniProtKB/TrEMBL
  ENSSSCP00070001235 UniProtKB/TrEMBL
  ENSSSCP00070001238 UniProtKB/TrEMBL
  ENSSSCP00070001243 UniProtKB/TrEMBL
  ENSSSCP00070005878 UniProtKB/TrEMBL
  ENSSSCP00070048067 UniProtKB/TrEMBL
  ENSSSCP00070048068 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000009234 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000031940 UniProtKB/TrEMBL
  ENSSSCT00000032084 UniProtKB/TrEMBL
  ENSSSCT00000043548 UniProtKB/TrEMBL
  ENSSSCT00000062446 UniProtKB/TrEMBL
  ENSSSCT00000068935 UniProtKB/TrEMBL
  ENSSSCT00000080297 UniProtKB/TrEMBL
  ENSSSCT00000087158 UniProtKB/TrEMBL
  ENSSSCT00070001414 UniProtKB/TrEMBL
  ENSSSCT00070001417 UniProtKB/TrEMBL
  ENSSSCT00070001428 UniProtKB/TrEMBL
  ENSSSCT00070001432 UniProtKB/TrEMBL
  ENSSSCT00070001438 UniProtKB/TrEMBL
  ENSSSCT00070007183 UniProtKB/TrEMBL
  ENSSSCT00070056576 UniProtKB/TrEMBL
  ENSSSCT00070056577 UniProtKB/TrEMBL
InterPro Calmodulin UniProtKB/TrEMBL
  EF-hand-dom_pair UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/TrEMBL
  SHIPPO-rpt UniProtKB/TrEMBL
  STPG4 UniProtKB/TrEMBL
KEGG Report ssc:100154056 UniProtKB/TrEMBL
  ssc:100522926 UniProtKB/TrEMBL
  ssc:396838 UniProtKB/TrEMBL
NCBI Gene CALM2 ENTREZGENE
PANTHER PTHR23050:SF401 UniProtKB/TrEMBL
  PTHR35678 UniProtKB/TrEMBL
Pfam EF-hand_7 UniProtKB/TrEMBL
  SHIPPO-rpt UniProtKB/TrEMBL
PROSITE EF_HAND_1 UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/TrEMBL
SMART EFh UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/TrEMBL
UniProt A0A287B857_PIG UniProtKB/TrEMBL
  A0A4X1SG58_PIG UniProtKB/TrEMBL
  A0A4X1SGS5_PIG UniProtKB/TrEMBL
  A0A4X1SGT9_PIG UniProtKB/TrEMBL
  A0A4X1SGU3_PIG UniProtKB/TrEMBL
  A0A5G2QDI9_PIG UniProtKB/TrEMBL
  A0A5G2QEH3_PIG UniProtKB/TrEMBL
  F2Z5G3 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A287BCG9 UniProtKB/TrEMBL