CNTF (ciliary neurotrophic factor)

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Gene: CNTF (ciliary neurotrophic factor) Sus scrofa

Analyze

Symbol:

CNTF

Name:

ciliary neurotrophic factor

RGD ID:

14184492

Description:

ENCODES a protein that exhibits interleukin-6 receptor binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN membrane hyperpolarization (ortholog); muscle organ morphogenesis (ortholog); negative regulation of neuron death (ortholog); ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); amyotrophic lateral sclerosis type 1 (ortholog); Cerebral Hemorrhage (ortholog); FOUND IN cytosol (ortholog); neuronal cell body (ortholog); nucleus (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Also known as:

LOW QUALITY PROTEIN: ciliary neurotrophic factor

RGD Orthologs

Human

Mouse

Rat

Chinchilla

Bonobo

Dog

Squirrel

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	2	12,492,777 - 12,495,401 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	12,129,497 - 12,133,389 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

amyotrophic lateral sclerosis (ISO)

amyotrophic lateral sclerosis type 1 (ISO)

Cerebral Hemorrhage (ISO)

disease of mental health (ISO)

glaucoma (ISO)

Huntington's disease (ISO)

hyperglycemia (ISO)

keratoconus (ISO)

multiple sclerosis (ISO)

Nerve Degeneration (ISO)

obesity (ISO)

Retina Reperfusion Injury (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

astrocyte activation (IBA)

ciliary neurotrophic factor-mediated signaling pathway (IBA)

membrane hyperpolarization (ISO)

muscle organ morphogenesis (ISO)

negative regulation of neuron apoptotic process (IBA)

negative regulation of neuron death (ISO)

negative regulation of photoreceptor cell differentiation (ISO)

nervous system development (ISO)

neuron development (ISO)

positive regulation of axon extension involved in regeneration (ISO)

positive regulation of axon regeneration (IBA)

positive regulation of cell growth (ISO)

positive regulation of cell population proliferation (IBA)

positive regulation of gene expression (ISO)

positive regulation of hormone secretion (ISO)

positive regulation of MAPK cascade (ISO)

positive regulation of phosphatidylinositol 3-kinase signaling (ISO)

positive regulation of receptor signaling pathway via JAK-STAT (ISO)

positive regulation of tyrosine phosphorylation of STAT protein (IBA)

receptor signaling pathway via JAK-STAT (ISO)

regulation of resting membrane potential (ISO)

regulation of retinal cell programmed cell death (ISO)

response to electrical stimulus (ISO)

response to light intensity (ISO)

Cellular Component

axon (IBA)

cytoplasm (IEA)

cytosol (ISO)

extracellular space (IBA)

neuronal cell body (ISO)

nucleus (ISO)

plasma membrane bounded cell projection cytoplasm (ISO)

Molecular Function

ciliary neurotrophic factor receptor binding (IBA)

cytokine activity (IBA)

growth factor activity (IBA)

interleukin-6 receptor binding (ISO)

protein binding (ISO)

protein-containing complex binding (ISO)

References

Genomics

Comparative Map Data

CNTF
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	2	12,492,777 - 12,495,401 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	12,129,497 - 12,133,389 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CNTF
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	11	58,622,665 - 58,625,733 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	11	58,622,665 - 58,625,733 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	11	58,390,146 - 58,393,206 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	58,146,721 - 58,149,778 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	11	58,146,720 - 58,149,778	NCBI
Celera	11	55,749,246 - 55,752,306 (+)	NCBI
Cytogenetic Map	11	q12.1	NCBI
HuRef	11	54,738,219 - 54,741,279 (+)	NCBI		HuRef
CHM1_1	11	58,255,656 - 58,258,716 (+)	NCBI		CHM1_1

Cntf
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	19	12,740,892 - 12,742,996 (-)	NCBI	GRCm39		mm39
GRCm38	19	12,763,528 - 12,765,632 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	19	12,763,660 - 12,765,632 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	19	12,838,018 - 12,840,122 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	19	12,830,679 - 12,845,972 (-)	NCBI			mm8
Celera	19	13,428,744 - 13,430,848 (-)	NCBI		Celera
Cytogenetic Map	19	A	NCBI
cM Map	19	8.73	NCBI

Cntf
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	1	229,599,009 - 229,601,032 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	229,599,009 - 229,601,032 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	236,752,366 - 236,754,389 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	215,842,668 - 215,844,691 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	1	216,001,097 - 216,003,121 (-)	NCBI
Celera	1	207,298,120 - 207,300,143 (-)	NCBI		Celera
Cytogenetic Map	1	q43	NCBI
RH 3.4 Map	1	1492.6	RGD

Cntf
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955511	3,527,552 - 3,534,348 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955511	3,527,552 - 3,531,275 (+)	NCBI	ChiLan1.0	ChiLan1.0

CNTF
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	11	57,336,792 - 57,341,127 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	57,336,792 - 57,341,121 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	11	53,876,081 - 53,882,870 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

CNTF
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	18	37,758,148 - 37,765,698 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Cntf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936581	3,710,171 - 3,715,753 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CNTF
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1 Ensembl	1	14,728,383 - 14,730,150 (-)	Ensembl
ChlSab1.1	1	14,724,562 - 14,730,698 (-)	NCBI

Cntf
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624864	1,785,215 - 1,788,608 (-)	NCBI

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003122707	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CU694851	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CU929527	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GU329007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GU329008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GU329009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GU329010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GU329011	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GU329012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GU329013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GU329014	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GU329015	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GU329016	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GU329017	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GU329018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GU329019	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GU329020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GU329021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GU329022	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GU329023	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GU329024	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GU329025	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GU329026	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GU329027	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GU329028	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GU329029	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GU329030	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GU329031	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GU329032	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GU329033	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GU329034	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GU329035	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U57644	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

XM_003122707 ⟹ XP_003122755

RefSeq Status:

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	2	12,492,777 - 12,495,401 (-)	NCBI

Sequence:

show sequence

AAATGTGTATATAAAATAGATTACATTAGGCAAGGGTGTCATGGGATTAGTGTGACAGTGACCT
TGTTGCTAAGAGCAAAAGCAAAACAATGACTTAAAAACAAGTACACTAGGCACTGAGTGGAGGA
GAGAGATGGAGGCAGACGCTACAGGAAAAAAGCTGATTAAAAAGGGGCCTTTGATTCCACAGGC
ACAAAAATCCACAGCCAGGAATTTGCTGCCACCTCTGAGTCAGGCAGGGGGTGGGGGTGCACAA
TTCCATTAGTAGAGAAATGCCCAGTGGATTTAGTCTGAGAGTCACATTGCTTATTTGGACCAGT
ATAGACAGAAACAAACCCAGCTCACTTGTTTCCTGGGACAGTTGAGTTAGGGGATGGCTTTTGC
AGAGCATTCACCGCTGACCCCTCACCGCCGGGACCTCTGTAGCCGCTCTATCTGGCTAGCAAGG
AAGATTCGTTCAGACCTGACTGCTCTTATGGAAGCTTATGTGAAGCATCAAGGTCTGAACGAGA
ACATCAACCTGGACTCTGTGGATGGTGTGCCAATGGCAAGCACTGATCGATGGAGTGAGCTGAC
GGAGGCAGAGCGACTCCAAGAGAACCTCCGAGCTTACCGTACCTTCCATGTTATGTTGGCCAGG
CTGTTAGAAGACCAGCGGGAACATTTTACTCCAGCTGAAGATGACNTTCATCAAGCAATACACA
CCATTGTCCTCCAAGTCGCTGCCTTTGCTTACCAGCTGGAAGAATTAATGGTGCTCCTGGAGCA
CAAGGTCCCCCCCAGTGAGGCTGATGGTACGCCCCTCAGCGTTGGAGGTGGTGGTCTCTTTGAG
AAGAAGCTGTGGGGCCTGAAGGTGCTGCAAGAGCTTTCACAGTGGACAGTGAGGTCCATCCGTG
ACCTTCGAGTCATCTCCTCTCATCAGGCTGGGGTCCCAGCACACGGGAGCCATCATGTCGCTAA
GGACAAGAAAATGTAGCAGTTACCTCCCTTCTTTCTTAGTTGCCTTCTATTCTAATGGAATAGA
CAGTTCTCTGAGGCCTCACTTCCCATTCTTATTTTTGAAAAAAAGACTGCAAGCATTTTTGTAA
CTAGGGTTGGAGACATGGACAAATGGGCATGCAGGTTTAGTGTGAGAGTGTGTGTGCGTTGGGG
CCATGAGAGAGCGAGGGCAGGGACGCCCCCACAGTGCACTAACCTCTCCCTACCCACTAAATAC
CCTTTACAGACATTTAACAGCCGCACAGGATAAATATATTTTTAACTCTAGTTCTGGATGACTC
GTCTGAGAAGACTTAAATAGTGAATTAAAAATCACAGAGTCTAGCCAGTTCAAACCCTTGGACA
ATAAAAATAGTAACTAAACATTTA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003122755	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAC27342	(Get FASTA)	NCBI Sequence Viewer
	ADU04445	(Get FASTA)	NCBI Sequence Viewer
	ADU04446	(Get FASTA)	NCBI Sequence Viewer
	ADU04447	(Get FASTA)	NCBI Sequence Viewer
	ADU04448	(Get FASTA)	NCBI Sequence Viewer
	ADU04449	(Get FASTA)	NCBI Sequence Viewer
	ADU04450	(Get FASTA)	NCBI Sequence Viewer
	ADU04451	(Get FASTA)	NCBI Sequence Viewer
	ADU04452	(Get FASTA)	NCBI Sequence Viewer
	ADU04453	(Get FASTA)	NCBI Sequence Viewer
	ADU04454	(Get FASTA)	NCBI Sequence Viewer
	ADU04455	(Get FASTA)	NCBI Sequence Viewer
	ADU04456	(Get FASTA)	NCBI Sequence Viewer
	ADU04457	(Get FASTA)	NCBI Sequence Viewer
	ADU04458	(Get FASTA)	NCBI Sequence Viewer
	ADU04459	(Get FASTA)	NCBI Sequence Viewer
	ADU04460	(Get FASTA)	NCBI Sequence Viewer
	ADU04461	(Get FASTA)	NCBI Sequence Viewer
	ADU04462	(Get FASTA)	NCBI Sequence Viewer
	ADU04463	(Get FASTA)	NCBI Sequence Viewer
	ADU04464	(Get FASTA)	NCBI Sequence Viewer
	ADU04465	(Get FASTA)	NCBI Sequence Viewer
	ADU04466	(Get FASTA)	NCBI Sequence Viewer
	ADU04467	(Get FASTA)	NCBI Sequence Viewer
	ADU04468	(Get FASTA)	NCBI Sequence Viewer
	ADU04469	(Get FASTA)	NCBI Sequence Viewer
	ADU04470	(Get FASTA)	NCBI Sequence Viewer
	ADU04471	(Get FASTA)	NCBI Sequence Viewer
	ADU04472	(Get FASTA)	NCBI Sequence Viewer
	ADU04473	(Get FASTA)	NCBI Sequence Viewer
	O02732	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

XP_003122755 ⟸ XM_003122707

- Sequence:

show sequence

MAFAEHSPLTPHRRDLCSRSIWLARKIRSDLTALMEAYVKHQGLNENINLDSVDGVPMASTDRW
SELTEAERLQENLRAYRTFHVMLARLLEDQREHFTPAEDDXHQAIHTIVLQVAAFAYQLEELMV
LLEHKVPPSEADGTPLSVGGGGLFEKKLWGLKVLQELSQWTVRSIRDLRVISSHQAGVPAHGSH
HVAKDKKM

hide sequence

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00005007790	UniProtKB/Swiss-Prot
	ENSSSCG00015009195	UniProtKB/Swiss-Prot
	ENSSSCG00025028324	UniProtKB/Swiss-Prot
	ENSSSCG00030027394	UniProtKB/Swiss-Prot
	ENSSSCG00035031991	UniProtKB/Swiss-Prot
	ENSSSCG00040003304	UniProtKB/Swiss-Prot
	ENSSSCG00050028640	UniProtKB/Swiss-Prot
	ENSSSCG00060050507	UniProtKB/Swiss-Prot
Ensembl Protein	ENSSSCP00005007150	UniProtKB/Swiss-Prot
	ENSSSCP00015004765	UniProtKB/Swiss-Prot
	ENSSSCP00025016226	UniProtKB/Swiss-Prot
	ENSSSCP00030017640	UniProtKB/Swiss-Prot
	ENSSSCP00035016940	UniProtKB/Swiss-Prot
	ENSSSCP00040001294	UniProtKB/Swiss-Prot
	ENSSSCP00050015952	UniProtKB/Swiss-Prot
	ENSSSCP00060029509	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSSSCT00005012220	UniProtKB/Swiss-Prot
	ENSSSCT00015012115	UniProtKB/Swiss-Prot
	ENSSSCT00025038433	UniProtKB/Swiss-Prot
	ENSSSCT00030038384	UniProtKB/Swiss-Prot
	ENSSSCT00035042389	UniProtKB/Swiss-Prot
	ENSSSCT00040004135	UniProtKB/Swiss-Prot
	ENSSSCT00050038513	UniProtKB/Swiss-Prot
	ENSSSCT00060068667	UniProtKB/Swiss-Prot
InterPro	4_helix_cytokine-like_core	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ciliary_neurotrophic_fac_CNTF	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene	CNTF	ENTREZGENE
PANTHER	PTHR15196	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	CNTF	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF47266	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	CNTF_PIG	UniProtKB/Swiss-Prot
	G8ABW7_PIG	UniProtKB/TrEMBL
	O02732	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD