CALM3 (calmodulin 3) - Rat Genome Database
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Gene: CALM3 (calmodulin 3) Sus scrofa
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Symbol: CALM3
Name: calmodulin 3
RGD ID: 14224288
Description: ENCODES a protein that exhibits adenylate cyclase binding (ortholog); calcium channel inhibitor activity (ortholog); calcium ion binding (ortholog); INVOLVED IN activation of adenylate cyclase activity (ortholog); autophagosome membrane docking (ortholog); calcium-mediated signaling (ortholog); PARTICIPATES IN adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; calcium/calcium-mediated signaling pathway; calcium/calmodulin dependent kinase 2 signaling pathway; ASSOCIATED WITH familial hypertrophic cardiomyopathy (ortholog); long QT syndrome 1 (ortholog); Long QT Syndrome 16 (ortholog); FOUND IN cytoplasm (ortholog); growth cone (ortholog); mitochondrial membrane (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: calmodulin; calmodulin-3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl652,506,674 - 52,516,703 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1652,506,979 - 52,516,704 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2647,824,454 - 47,834,181 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of adenylate cyclase activity  (ISO)
autophagosome membrane docking  (ISO)
calcium-mediated signaling  (IEA,ISO)
detection of calcium ion  (IEA)
establishment of protein localization to membrane  (ISO)
establishment of protein localization to mitochondrial membrane  (ISO)
G2/M transition of mitotic cell cycle  (IEA,ISO)
mitochondrion-endoplasmic reticulum membrane tethering  (ISO)
negative regulation of high voltage-gated calcium channel activity  (IEA)
negative regulation of ryanodine-sensitive calcium-release channel activity  (ISO)
organelle localization by membrane tethering  (ISO)
positive regulation of cyclic-nucleotide phosphodiesterase activity  (IEA)
positive regulation of DNA binding  (IEA)
positive regulation of nitric-oxide synthase activity  (ISO)
positive regulation of phosphoprotein phosphatase activity  (IEA)
positive regulation of protein dephosphorylation  (ISO)
positive regulation of ryanodine-sensitive calcium-release channel activity  (IEA)
regulation of cardiac muscle cell action potential  (IEA)
regulation of cardiac muscle contraction  (IEA)
regulation of cytokinesis  (IEA)
regulation of heart rate  (IEA)
regulation of high voltage-gated calcium channel activity  (ISO)
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  (IEA)
regulation of ryanodine-sensitive calcium-release channel activity  (ISO)
regulation of synaptic vesicle endocytosis  (ISO)
regulation of synaptic vesicle exocytosis  (ISO)
response to amphetamine  (ISO)
response to calcium ion  (ISO)
substantia nigra development  (ISO)

References
Additional References at PubMed
PMID:1520270   PMID:14681463   PMID:15147211   PMID:16199479   PMID:17407547   PMID:19839601   PMID:20815817  


Genomics

Comparative Map Data
CALM3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl652,506,674 - 52,516,703 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1652,506,979 - 52,516,704 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2647,824,454 - 47,834,181 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CALM3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1946,601,074 - 46,610,782 (+)EnsemblGRCh38hg38GRCh38
GRCh381946,601,074 - 46,610,782 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371947,104,331 - 47,114,039 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361951,796,352 - 51,805,879 (+)NCBINCBI36hg18NCBI36
Build 341951,796,351 - 51,805,878NCBI
Celera1943,908,038 - 43,917,566 (+)NCBI
Cytogenetic Map19q13.32NCBI
HuRef1943,529,569 - 43,539,096 (+)NCBIHuRef
CHM1_11947,106,370 - 47,115,897 (+)NCBICHM1_1
Calm3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39716,649,304 - 16,657,957 (-)NCBIGRCm39mm39
GRCm39 Ensembl716,649,304 - 16,658,039 (-)Ensembl
GRCm38716,915,379 - 16,924,032 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl716,915,379 - 16,924,114 (-)EnsemblGRCm38mm10GRCm38
MGSCv37717,500,728 - 17,509,381 (-)NCBIGRCm37mm9NCBIm37
MGSCv36716,073,901 - 16,082,476 (-)NCBImm8
Celera714,121,809 - 14,130,463 (-)NCBICelera
Cytogenetic Map7A2NCBI
cM Map79.15NCBI
Calm3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2177,590,668 - 77,597,776 (-)NCBI
Rnor_6.0 Ensembl178,843,080 - 78,851,719 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0178,844,520 - 78,851,628 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0180,092,078 - 80,099,186 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4177,245,609 - 77,252,717 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1177,322,279 - 77,330,919 (-)NCBI
Celera172,075,982 - 72,079,075 (-)NCBICelera
RH 3.4 Map1793.6RGD
Cytogenetic Map1q21NCBI
Calm3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955574672,300 - 680,924 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955574672,441 - 680,924 (+)NCBIChiLan1.0ChiLan1.0
CALM3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11952,121,687 - 52,131,135 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1952,121,687 - 52,131,135 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01943,593,069 - 43,602,550 (+)NCBIMhudiblu_PPA_v0panPan3
CALM3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1109,286,155 - 109,294,391 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11109,284,729 - 109,294,491 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Calm3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936664471,446 - 480,858 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CALM3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1639,957,012 - 39,966,562 (+)NCBI
ChlSab1.1 Ensembl639,957,320 - 39,966,581 (+)Ensembl
ChlSab1.1 Ensembl1460,027,801 - 60,044,951 (+)Ensembl
ChlSab1.1 Ensembl2468,133,428 - 68,145,180 (+)Ensembl
Calm3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248326,957,775 - 6,966,505 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000032084   ⟹   ENSSSCP00000028062
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl652,506,674 - 52,516,702 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000038935   ⟹   ENSSSCP00000043442
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl652,511,598 - 52,515,135 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000068935   ⟹   ENSSSCP00000072892
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl652,510,471 - 52,516,699 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000075163   ⟹   ENSSSCP00000068530
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl652,506,988 - 52,516,702 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000076501   ⟹   ENSSSCP00000059835
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl652,507,039 - 52,516,703 (+)Ensembl
RefSeq Acc Id: NM_001244209   ⟹   NP_001231138
RefSeq Status: VALIDATED
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1652,506,979 - 52,516,704 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001231138 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB87698 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001231138   ⟸   NM_001244209
- UniProtKB: F2Z5G3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000072892   ⟸   ENSSSCT00000068935
RefSeq Acc Id: ENSSSCP00000068530   ⟸   ENSSSCT00000075163
RefSeq Acc Id: ENSSSCP00000059835   ⟸   ENSSSCT00000076501
RefSeq Acc Id: ENSSSCP00000028062   ⟸   ENSSSCT00000032084
RefSeq Acc Id: ENSSSCP00000043442   ⟸   ENSSSCT00000038935
Protein Domains
EF-hand


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000008433 UniProtKB/TrEMBL
  ENSSSCG00000022545 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00000025768 UniProtKB/TrEMBL
  ENSSSCG00070000755 UniProtKB/TrEMBL
  ENSSSCG00070003824 UniProtKB/TrEMBL
  ENSSSCG00070028203 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000009000 UniProtKB/TrEMBL
  ENSSSCP00000022607 UniProtKB/TrEMBL
  ENSSSCP00000028062 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000043442 UniProtKB/TrEMBL
  ENSSSCP00000053816 UniProtKB/TrEMBL
  ENSSSCP00000059835 UniProtKB/TrEMBL
  ENSSSCP00000068530 UniProtKB/TrEMBL
  ENSSSCP00000072892 UniProtKB/TrEMBL
  ENSSSCP00070001223 UniProtKB/TrEMBL
  ENSSSCP00070005878 UniProtKB/TrEMBL
  ENSSSCP00070048067 UniProtKB/TrEMBL
  ENSSSCP00070048068 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000009234 UniProtKB/TrEMBL
  ENSSSCT00000031940 UniProtKB/TrEMBL
  ENSSSCT00000032084 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000038935 UniProtKB/TrEMBL
  ENSSSCT00000043548 UniProtKB/TrEMBL
  ENSSSCT00000068935 UniProtKB/TrEMBL
  ENSSSCT00000075163 UniProtKB/TrEMBL
  ENSSSCT00000076501 UniProtKB/TrEMBL
  ENSSSCT00070001414 UniProtKB/TrEMBL
  ENSSSCT00070007183 UniProtKB/TrEMBL
  ENSSSCT00070056576 UniProtKB/TrEMBL
  ENSSSCT00070056577 UniProtKB/TrEMBL
InterPro Calmodulin UniProtKB/TrEMBL
  EF-hand-dom_pair UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/TrEMBL
KEGG Report ssc:100154056 UniProtKB/TrEMBL
  ssc:100522926 UniProtKB/TrEMBL
  ssc:396838 UniProtKB/TrEMBL
NCBI Gene CALM3 ENTREZGENE
PANTHER PTHR23050:SF401 UniProtKB/TrEMBL
Pfam EF-hand_1 UniProtKB/TrEMBL
  EF-hand_7 UniProtKB/TrEMBL
PROSITE EF_HAND_1 UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/TrEMBL
SMART EFh UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/TrEMBL
UniProt A0A287AHS0_PIG UniProtKB/TrEMBL
  A0A4X1SGS5_PIG UniProtKB/TrEMBL
  A0A5G2Q7N5_PIG UniProtKB/TrEMBL
  A0A5G2QWK6_PIG UniProtKB/TrEMBL
  F2Z5G3 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A287BCG9 UniProtKB/TrEMBL