CALM1 (calmodulin 1) - Rat Genome Database

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Gene: CALM1 (calmodulin 1) Sus scrofa
Analyze
Symbol: CALM1
Name: calmodulin 1
RGD ID: 14031372
Description: ENCODES a protein that exhibits adenylate cyclase binding (ortholog); calcium ion binding (ortholog); calcium-dependent protein binding (ortholog); INVOLVED IN activation of adenylate cyclase activity (ortholog); calcium-mediated signaling (ortholog); establishment of protein localization to membrane (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); cannabis abuse (ortholog); catecholaminergic polymorphic ventricular tachycardia (ortholog); FOUND IN cytoplasm (ortholog); growth cone (ortholog); mitochondrial membrane (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: calmodulin; calmodulin-1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7112,154,880 - 112,171,744 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17112,160,823 - 112,171,754 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27118,728,008 - 118,738,940 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of adenylate cyclase activity  (ISO)
autophagosome membrane docking  (IEA)
calcium-mediated signaling  (ISO)
detection of calcium ion  (IEA)
establishment of protein localization to membrane  (ISO)
establishment of protein localization to mitochondrial membrane  (ISO)
G2/M transition of mitotic cell cycle  (IEA,ISO)
mitochondrion-endoplasmic reticulum membrane tethering  (IEA)
negative regulation of calcium ion export across plasma membrane  (IEA)
negative regulation of high voltage-gated calcium channel activity  (IEA)
negative regulation of ryanodine-sensitive calcium-release channel activity  (IEA)
organelle localization by membrane tethering  (ISO)
positive regulation of cyclic-nucleotide phosphodiesterase activity  (IEA)
positive regulation of DNA binding  (IEA,ISO)
positive regulation of nitric-oxide synthase activity  (ISO)
positive regulation of phosphoprotein phosphatase activity  (IEA)
positive regulation of protein dephosphorylation  (ISO)
positive regulation of ryanodine-sensitive calcium-release channel activity  (IEA)
regulation of calcium-mediated signaling  (IEA)
regulation of cardiac muscle cell action potential  (IEA)
regulation of cardiac muscle contraction  (IEA)
regulation of cyclase activity  (IEA)
regulation of cytokinesis  (IEA)
regulation of heart rate  (IEA)
regulation of high voltage-gated calcium channel activity  (ISO)
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  (IEA)
regulation of ryanodine-sensitive calcium-release channel activity  (ISO)
regulation of synaptic vesicle endocytosis  (ISO)
regulation of synaptic vesicle exocytosis  (ISO)
response to amphetamine  (ISO)
response to calcium ion  (ISO)
substantia nigra development  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway  (ISO)
adenosine monophosphate-activated protein kinase (AMPK) signaling pathway  (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
calcium/calcium-mediated signaling pathway  (ISO)
calcium/calmodulin dependent kinase 2 signaling pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
glycogen degradation pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
insulin responsive facilitative sugar transporter mediated glucose transport pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
N-cadherin signaling pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
p38 MAPK signaling pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
type II interferon signaling pathway  (ISO)
vascular endothelial growth factor signaling pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References
Additional References at PubMed
PMID:7929586   PMID:14681463   PMID:15679890   PMID:17145712   PMID:17407547  


Genomics

Comparative Map Data
CALM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7112,154,880 - 112,171,744 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17112,160,823 - 112,171,754 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27118,728,008 - 118,738,940 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CALM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1490,396,502 - 90,408,268 (+)EnsemblGRCh38hg38GRCh38
GRCh381490,396,502 - 90,408,268 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371490,862,846 - 90,874,612 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361489,933,126 - 89,944,363 (+)NCBINCBI36hg18NCBI36
Build 341489,933,129 - 89,944,148NCBI
Celera1470,910,477 - 70,921,767 (+)NCBI
Cytogenetic Map14q32.11NCBI
HuRef1471,038,153 - 71,049,443 (+)NCBIHuRef
CHM1_11490,801,276 - 90,812,578 (+)NCBICHM1_1
Calm1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912100,165,694 - 100,176,083 (+)NCBIGRCm39mm39
GRCm39 Ensembl12100,165,694 - 100,176,073 (+)Ensembl
GRCm3812100,199,435 - 100,209,824 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12100,199,435 - 100,209,814 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712101,437,751 - 101,448,016 (+)NCBIGRCm37mm9NCBIm37
MGSCv3612100,600,591 - 100,610,856 (+)NCBImm8
Celera12101,426,181 - 101,436,442 (+)NCBICelera
Cytogenetic Map12ENCBI
Calm1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.26119,487,691 - 119,495,759 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl6119,487,621 - 119,498,227 (+)Ensembl
Rnor_6.06124,217,241 - 124,225,292 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6124,217,241 - 124,225,292 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06133,444,207 - 133,452,258 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46124,477,601 - 124,485,669 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.16124,481,414 - 124,491,549 (+)NCBI
Celera6117,015,915 - 117,023,918 (+)NCBICelera
Cytogenetic Map6q32NCBI
Calm1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543812,842,437 - 12,854,028 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543812,842,437 - 12,854,028 (+)NCBIChiLan1.0ChiLan1.0
CALM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11490,367,086 - 90,378,361 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1952,121,687 - 52,131,135 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01471,015,099 - 71,026,322 (+)NCBIMhudiblu_PPA_v0panPan3
CALM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1861,398,231 - 61,408,874 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl861,398,244 - 61,406,195 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha860,978,989 - 60,989,622 (+)NCBI
ROS_Cfam_1.0861,672,887 - 61,680,835 (+)NCBI
UMICH_Zoey_3.1861,353,922 - 61,364,539 (+)NCBI
UNSW_CanFamBas_1.0861,402,765 - 61,413,376 (+)NCBI
UU_Cfam_GSD_1.0861,731,734 - 61,739,644 (+)NCBI
Calm1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864014,480,463 - 14,488,619 (-)NCBI
SpeTri2.0NW_00493648817,580,425 - 17,588,480 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CALM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12468,133,446 - 68,145,117 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2468,133,428 - 68,145,180 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605355,415,057 - 55,426,335 (+)NCBIVero_WHO_p1.0
Calm1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473412,030,264 - 12,041,682 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High 8
Medium 30 11 9 15 6 61 6 9 8
Low 1 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000031940   ⟹   ENSSSCP00000022607
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl7112,160,806 - 112,171,744 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000039600   ⟹   ENSSSCP00000047574
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl7112,160,804 - 112,168,024 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000043548   ⟹   ENSSSCP00000053816
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl7112,154,880 - 112,171,744 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000076440   ⟹   ENSSSCP00000068186
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl7112,162,897 - 112,171,744 (+)Ensembl
RefSeq Acc Id: NM_001244210   ⟹   NP_001231139
RefSeq Status: VALIDATED
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.17112,160,823 - 112,171,754 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001231139 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAQ14324 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001231139   ⟸   NM_001244210
- UniProtKB: F2Z5G3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000047574   ⟸   ENSSSCT00000039600
RefSeq Acc Id: ENSSSCP00000022607   ⟸   ENSSSCT00000031940
RefSeq Acc Id: ENSSSCP00000068186   ⟸   ENSSSCT00000076440
RefSeq Acc Id: ENSSSCP00000053816   ⟸   ENSSSCT00000043548
Protein Domains
EF-hand


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000008433 UniProtKB/TrEMBL
  ENSSSCG00000022545 UniProtKB/TrEMBL
  ENSSSCG00000025768 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070000755 UniProtKB/TrEMBL
  ENSSSCG00070003824 UniProtKB/TrEMBL
  ENSSSCG00070028203 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000009000 UniProtKB/TrEMBL
  ENSSSCP00000022607 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000028062 UniProtKB/TrEMBL
  ENSSSCP00000047574 UniProtKB/TrEMBL
  ENSSSCP00000053816 UniProtKB/TrEMBL
  ENSSSCP00000068186 UniProtKB/TrEMBL
  ENSSSCP00000072892 UniProtKB/TrEMBL
  ENSSSCP00070001223 UniProtKB/TrEMBL
  ENSSSCP00070005878 UniProtKB/TrEMBL
  ENSSSCP00070005894 UniProtKB/TrEMBL
  ENSSSCP00070005896 UniProtKB/TrEMBL
  ENSSSCP00070005899 UniProtKB/TrEMBL
  ENSSSCP00070005907 UniProtKB/TrEMBL
  ENSSSCP00070048062 UniProtKB/TrEMBL
  ENSSSCP00070048063 UniProtKB/TrEMBL
  ENSSSCP00070048067 UniProtKB/TrEMBL
  ENSSSCP00070048068 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000009234 UniProtKB/TrEMBL
  ENSSSCT00000031940 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000032084 UniProtKB/TrEMBL
  ENSSSCT00000039600 UniProtKB/TrEMBL
  ENSSSCT00000043548 UniProtKB/TrEMBL
  ENSSSCT00000068935 UniProtKB/TrEMBL
  ENSSSCT00000076440 UniProtKB/TrEMBL
  ENSSSCT00070001414 UniProtKB/TrEMBL
  ENSSSCT00070007183 UniProtKB/TrEMBL
  ENSSSCT00070007204 UniProtKB/TrEMBL
  ENSSSCT00070007206 UniProtKB/TrEMBL
  ENSSSCT00070007211 UniProtKB/TrEMBL
  ENSSSCT00070007218 UniProtKB/TrEMBL
  ENSSSCT00070056571 UniProtKB/TrEMBL
  ENSSSCT00070056572 UniProtKB/TrEMBL
  ENSSSCT00070056576 UniProtKB/TrEMBL
  ENSSSCT00070056577 UniProtKB/TrEMBL
InterPro Calmodulin UniProtKB/TrEMBL
  EF-hand-dom_pair UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/TrEMBL
KEGG Report ssc:100154056 UniProtKB/TrEMBL
  ssc:100522926 UniProtKB/TrEMBL
  ssc:396838 UniProtKB/TrEMBL
NCBI Gene CALM1 ENTREZGENE
PANTHER PTHR23050:SF401 UniProtKB/TrEMBL
Pfam EF-hand_1 UniProtKB/TrEMBL
  EF-hand_7 UniProtKB/TrEMBL
PROSITE EF_HAND_1 UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/TrEMBL
SMART EFh UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/TrEMBL
UniProt A0A287AUG4_PIG UniProtKB/TrEMBL
  A0A4X1SGS5_PIG UniProtKB/TrEMBL
  A0A4X1ST02_PIG UniProtKB/TrEMBL
  A0A4X1ST06_PIG UniProtKB/TrEMBL
  A0A4X1SUB1_PIG UniProtKB/TrEMBL
  A0A4X1SUD7_PIG UniProtKB/TrEMBL
  A0A4X1W1P6_PIG UniProtKB/TrEMBL
  A0A4X1W3F5_PIG UniProtKB/TrEMBL
  A0A5G2QTD3_PIG UniProtKB/TrEMBL
  B4DCU2_PIG UniProtKB/TrEMBL
  F2Z5G3 ENTREZGENE, UniProtKB/TrEMBL
  O46391_PIG UniProtKB/TrEMBL
UniProt Secondary A0A287BCG9 UniProtKB/TrEMBL