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ONTOLOGY REPORT - ANNOTATIONS

Term:protein targeting to ER
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Accession:GO:0045047 term browser browse the term
Definition:The process of directing proteins towards the endoplasmic reticulum (ER) using signals contained within the protein. One common mechanism uses a 16- to 30-residue signal sequence, typically located at the N-terminus of the protein and containing positively charged amino acids followed by a continuous stretch of hydrophobic residues, which directs the ribosome to the ER membrane and initiates transport of the growing polypeptide across the ER membrane.
Synonyms:exact_synonym: protein targeting to endoplasmic reticulum;   protein-ER targeting;   protein-endoplasmic reticulum targeting


show annotations for term's descendants           Sort by:
protein targeting to ER term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arxes1 adipocyte-related X-chromosome expressed sequence 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr  X:98,950,530...98,952,049
Ensembl chr  X:98,950,528...98,952,045 		JBrowse link
G Arxes2 adipocyte-related X-chromosome expressed sequence 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr  X:98,985,844...98,987,425
Ensembl chr  X:98,985,959...98,986,501
Ensembl chr  X:98,985,959...98,986,501 		JBrowse link
G Edem1 ER degradation enhancing alpha-mannosidase like protein 1 involved_in ISO (PMID:23233672) RGD PMID:23233672 NCBI chr 4:141,797,631...141,829,717
Ensembl chr 4:141,797,701...141,829,717 		JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 involved_in ISO (MGI:6467687|PMID:24478453) RGD PMID:24478453 MGI:6467687 NCBI chr19:10,598,411...10,609,002
Ensembl chr19:10,598,417...10,618,424 		JBrowse link
G Man1a1 mannosidase, alpha, class 1A, member 1 involved_in ISO (PMID:27108681) RGD PMID:27108681 NCBI chr20:33,202,509...33,385,747
Ensembl chr20:33,202,517...33,385,824 		JBrowse link
G Sec61a1 SEC61 translocon subunit alpha 1 involved_in ISO (PMID:18480044) RGD PMID:18480044 NCBI chr 4:120,973,519...120,987,871
Ensembl chr 4:120,960,626...120,987,925 		JBrowse link
G Sec61g Sec61 translocon subunit gamma involved_in ISO UniProtKB:P35179 (PMID:8107851) RGD PMID:8107851 NCBI chr14:90,899,766...90,906,143
Ensembl chr14:90,899,768...90,906,162 		JBrowse link
G Spcs1 signal peptidase complex subunit 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr16:6,190,208...6,191,776
Ensembl chr16:6,190,262...6,192,000 		JBrowse link
G Spcs2 signal peptidase complex subunit 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:154,163,724...154,183,152
Ensembl chr 1:154,163,724...154,183,186 		JBrowse link
G Spcs3 signal peptidase complex subunit 3 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr16:37,305,358...37,310,792
Ensembl chr16:37,305,305...37,331,746 		JBrowse link
G Srp14 signal recognition particle 14 involved_in ISO
IBA		 (PMID:18089836)
GO_REF:0000033		 RGD
GO_Central		 PMID:18089836 GO_REF:0000033 NCBI chr 3:105,442,184...105,445,875
Ensembl chr 3:105,442,198...105,445,859 		JBrowse link
G Srp54a signal recognition particle 54A involved_in ISO (PMID:18089836)
(PMID:16469117)		 RGD PMID:16469117 PMID:18089836 NCBI chr 6:72,587,584...72,626,878
Ensembl chr 6:72,587,605...72,625,189 		JBrowse link
G Srpra SRP receptor subunit alpha involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:33,560,365...33,566,458
Ensembl chr 8:33,560,348...33,566,470 		JBrowse link
G Srprb SRP receptor subunit beta involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:103,768,685...103,782,632 JBrowse link
G Vps54 VPS54 subunit of GARP complex involved_in IEA
ISO		 GO_REF:0000107
MGI:1857091 (PMID:28658628), (PMID:32345721)		 Ensembl
RGD		 PMID:28658628 PMID:32345721 GO_REF:0000107 NCBI chr14:95,378,821...95,455,871
Ensembl chr14:95,378,012...95,455,857 		JBrowse link
G Zfand2a zinc finger AN1-type containing 2A involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr12:15,161,601...15,172,679
Ensembl chr12:15,161,639...15,172,677 		JBrowse link
G Zfand2b zinc finger AN1-type containing 2B involved_in ISO
IBA		 (PMID:26692333)
(MGI:5780912|PMID:26692333)
GO_REF:0000033		 RGD
GO_Central		 PMID:26692333 GO_REF:0000033 MGI:5780912 NCBI chr 9:76,665,466...76,668,447
Ensembl chr 9:76,665,546...76,668,445 		JBrowse link
post-translational protein targeting to endoplasmic reticulum membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bag6 BAG cochaperone 6 involved_in ISO
IEA		 (PMID:25535373)
GO_REF:0000107		 RGD
Ensembl		 PMID:25535373 GO_REF:0000107 NCBI chr20:3,675,938...3,690,414
Ensembl chr20:3,675,938...3,688,657 		JBrowse link
G Chmp4b charged multivesicular body protein 4B involved_in ISO (PMID:21975012) RGD PMID:21975012 NCBI chr 3:143,170,859...143,211,376
Ensembl chr 3:143,170,902...143,210,844 		JBrowse link
G Get1 guided entry of tail-anchored proteins factor 1 acts_upstream_of_or_within ISO MGI:5911419|MGI:6117117 (PMID:27458190) RGD PMID:27458190 NCBI chr11:35,438,555...35,460,156
Ensembl chr11:35,445,815...35,459,973 		JBrowse link
G Get4 guided entry of tail-anchored proteins factor 4 involved_in ISO (PMID:25535373) RGD PMID:25535373 NCBI chr12:15,377,009...15,394,238
Ensembl chr12:15,377,009...15,394,053 		JBrowse link
G Macf1 microtubule-actin crosslinking factor 1 acts_upstream_of_or_within ISO (PMID:16815997) RGD PMID:16815997 NCBI chr 5:135,623,734...135,949,097
Ensembl chr 5:135,623,742...135,945,905 		JBrowse link
G Sec61a1 SEC61 translocon subunit alpha 1 acts_upstream_of_or_within ISO (PMID:22375059) RGD PMID:22375059 NCBI chr 4:120,973,519...120,987,871
Ensembl chr 4:120,960,626...120,987,925 		JBrowse link
G Sec62 SEC62 homolog, preprotein translocation factor acts_upstream_of_or_within ISO (PMID:22375059) RGD PMID:22375059 NCBI chr 2:112,570,810...112,598,198
Ensembl chr 2:112,570,819...112,601,814 		JBrowse link
G Sec63 SEC63 homolog, protein translocation regulator acts_upstream_of_or_within
involved_in		 ISO
IBA		 (PMID:22375059)
MGI:5442171 (PMID:22375059)
GO_REF:0000033		 RGD
GO_Central		 PMID:22375059 GO_REF:0000033 NCBI chr20:46,245,101...46,314,055
Ensembl chr20:46,245,101...46,314,055 		JBrowse link
G Sgta small glutamine rich tetratricopeptide repeat co-chaperone alpha involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:8,653,681...8,670,460
Ensembl chr 7:8,653,778...8,670,458 		JBrowse link
G Sgtb small glutamine rich tetratricopeptide repeat co-chaperone beta involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:35,233,045...35,269,527
Ensembl chr 2:35,233,042...35,269,518 		JBrowse link
G Ubl4a ubiquitin-like 4A involved_in ISO
IBA
IEA		 (PMID:25535373)
GO_REF:0000033
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:25535373 GO_REF:0000033 GO_REF:0000107 NCBI chr  X:152,151,242...152,154,094
Ensembl chr  X:152,151,460...152,154,069 		JBrowse link
post-translational protein targeting to membrane, translocation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Glp1r glucagon-like peptide 1 receptor involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2150310 (PMID:23542788)		 Ensembl
RGD		 PMID:23542788 GO_REF:0000107 NCBI chr20:8,972,004...9,010,241
Ensembl chr20:8,972,004...9,010,241 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:29719251)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:29719251 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Sec61a1 SEC61 translocon subunit alpha 1 involved_in ISS
IBA
IEA
ISO		 GO_REF:0000024
GO_REF:0000033
GO_REF:0000107
(PMID:29719251)		 UniProt
GO_Central
Ensembl
RGD		 PMID:29719251 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 4:120,973,519...120,987,871
Ensembl chr 4:120,960,626...120,987,925 		JBrowse link
G Sec61a2 SEC61 translocon subunit alpha 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr17:72,407,574...72,445,630
Ensembl chr17:72,407,671...72,434,494 		JBrowse link
G Sec61b SEC61 translocon subunit beta involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:61,773,594...61,781,804
Ensembl chr 5:61,773,594...61,781,804 		JBrowse link
G Sec61g Sec61 translocon subunit gamma involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr14:90,899,766...90,906,143
Ensembl chr14:90,899,768...90,906,162 		JBrowse link
G Sec61g-ps4 Sec61 translocon subunit gamma, pseudogene 4 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr  X:113,427,370...113,427,696
Ensembl chr  X:113,427,440...113,427,646 		JBrowse link
G Sec61gl2 Sec61 translocon subunit gamma like 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr17:75,638,449...75,638,655
Ensembl chr17:75,638,449...75,638,655 		JBrowse link
G Sec62 SEC62 homolog, preprotein translocation factor involved_in ISO
IBA		 (PMID:29719251)
GO_REF:0000033		 RGD
GO_Central		 PMID:29719251 GO_REF:0000033 NCBI chr 2:112,570,810...112,598,198
Ensembl chr 2:112,570,819...112,601,814 		JBrowse link
G Sec63 SEC63 homolog, protein translocation regulator involved_in ISO (PMID:29719251) RGD PMID:29719251 NCBI chr20:46,245,101...46,314,055
Ensembl chr20:46,245,101...46,314,055 		JBrowse link
SRP-dependent cotranslational protein targeting to membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ENSRNOG00000062486 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 Ensembl chr18:25,931,666...25,951,758 JBrowse link
G ENSRNOG00000065388 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 Ensembl chr14:18,768,039...18,769,105 JBrowse link
G LOC120099767 signal recognition particle subunit SRP72-like involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:75,982,366...75,984,490 JBrowse link
G Sec61a1 SEC61 translocon subunit alpha 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:22375059)
GO_REF:0000107		 RGD
Ensembl		 PMID:22375059 GO_REF:0000107 NCBI chr 4:120,973,519...120,987,871
Ensembl chr 4:120,960,626...120,987,925 		JBrowse link
G Sec63 SEC63 homolog, protein translocation regulator acts_upstream_of_or_within
involved_in		 ISO
IBA		 (PMID:22375059)
MGI:5442171 (PMID:22375059)
GO_REF:0000033		 RGD
GO_Central		 PMID:22375059 GO_REF:0000033 NCBI chr20:46,245,101...46,314,055
Ensembl chr20:46,245,101...46,314,055 		JBrowse link
G Srp14 signal recognition particle 14 involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 3:105,442,184...105,445,875
Ensembl chr 3:105,442,198...105,445,859 		JBrowse link
G Srp14l1 signal recognition particle 14 like 1 involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 9:86,645,829...86,649,077 JBrowse link
G Srp54a signal recognition particle 54A involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 6:72,587,584...72,626,878
Ensembl chr 6:72,587,605...72,625,189 		JBrowse link
G Srp68 signal recognition particle 68 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:101,481,213...101,508,035
Ensembl chr10:101,481,212...101,508,035 		JBrowse link
G Srp72 signal recognition particle 72 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr14:31,168,175...31,195,717
Ensembl chr14:31,168,293...31,195,729 		JBrowse link
G Srp9 signal recognition particle 9 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr13:93,832,580...93,840,720
Ensembl chr13:93,832,580...93,840,720 		JBrowse link
G Srpra SRP receptor subunit alpha involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 8:33,560,365...33,566,458
Ensembl chr 8:33,560,348...33,566,470 		JBrowse link
G Ssr3 signal sequence receptor subunit 3 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 2:149,605,005...149,625,069
Ensembl chr 2:149,605,005...149,625,132 		JBrowse link
SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Srp19 signal recognition particle 19 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr18:25,931,734...25,937,974
Ensembl chr18:25,931,589...25,938,017 		JBrowse link
G Srp54a signal recognition particle 54A involved_in ISO (PMID:16469117) RGD PMID:16469117 NCBI chr 6:72,587,584...72,626,878
Ensembl chr 6:72,587,605...72,625,189 		JBrowse link
SRP-dependent cotranslational protein targeting to membrane, translocation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sec61a1 SEC61 translocon subunit alpha 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:120,973,519...120,987,871
Ensembl chr 4:120,960,626...120,987,925 		JBrowse link
G Sec61a2 SEC61 translocon subunit alpha 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr17:72,407,574...72,445,630
Ensembl chr17:72,407,671...72,434,494 		JBrowse link
G Sec61b SEC61 translocon subunit beta involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:61,773,594...61,781,804
Ensembl chr 5:61,773,594...61,781,804 		JBrowse link
G Srp54a signal recognition particle 54A involved_in ISO
IBA		 (PMID:8521805)
GO_REF:0000033		 RGD
GO_Central		 PMID:8521805 GO_REF:0000033 NCBI chr 6:72,587,584...72,626,878
Ensembl chr 6:72,587,605...72,625,189 		JBrowse link
G Tram1 translocation associated membrane protein 1 involved_in IEA
ISO		 GO_REF:0000002
(PMID:8698819)		 InterPro
RGD		 PMID:8698819 GO_REF:0000002 NCBI chr 5:5,642,579...5,667,666
Ensembl chr 5:5,642,546...5,686,971 		JBrowse link
G Tram2 translocation associated membrane protein 2 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 9:23,419,204...23,498,745
Ensembl chr 9:23,424,232...23,498,689 		JBrowse link
G Zfand2b zinc finger AN1-type containing 2B acts_upstream_of_or_within ISO (PMID:24160817) RGD PMID:24160817 NCBI chr 9:76,665,466...76,668,447
Ensembl chr 9:76,665,546...76,668,445 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19692
    localization 5613
      establishment of localization 4924
        establishment of protein localization 1762
          protein targeting 338
            protein targeting to ER 44
              SRP-dependent cotranslational protein targeting to membrane + 19
              post-translational protein targeting to endoplasmic reticulum membrane + 18
Path 2
Term Annotations click to browse term
  biological_process 19692
    localization 5613
      cellular localization 3656
        cellular macromolecule localization 2682
          protein localization 2670
            protein localization to organelle 1043
              protein localization to endoplasmic reticulum 84
                establishment of protein localization to endoplasmic reticulum 48
                  protein targeting to ER 44
                    SRP-dependent cotranslational protein targeting to membrane + 19
                    post-translational protein targeting to endoplasmic reticulum membrane + 18
paths to the root