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ONTOLOGY REPORT - ANNOTATIONS


Term:posttranslational protein targeting to endoplasmic reticulum membrane
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Accession:GO:0006620 term browser browse the term
Definition:The targeting of proteins to a membrane that occurs after their translation. Some secretory proteins exhibit posttranslational transport into the endoplasmic reticulum (ER) lumen: they are synthesized in their entirety on free cytosolic ribosomes and then released into the cytosol, where they are bound by chaperones which keep them in an unfolded state, and subsequently are translocated across the ER membrane.
Synonyms:exact_synonym: SRP-independent endoplasmic reticulum protein-membrane targeting;   posttranslational endoplasmic reticulum membrane targeting;   posttranslational endoplasmic reticulum protein-membrane targeting;   posttranslational protein targeting to ER membrane


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posttranslational protein targeting to endoplasmic reticulum membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chmp4b charged multivesicular body protein 4B involved_in ISO (PMID:21975012) RGD PMID:21975012 NCBI chr 3:143,170,822...143,211,376
Ensembl chr 3:143,170,902...143,210,844
JBrowse link
G Get1 guided entry of tail-anchored proteins factor 1 acts_upstream_of_or_within ISO MGI:5911419|MGI:6117117 (MGI:5817553|PMID:27458190) RGD PMID:27458190 MGI:5817553 NCBI chr11:35,438,555...35,460,156
Ensembl chr11:35,445,815...35,459,973
JBrowse link
G Get3 guided entry of tail-anchored proteins factor 3, ATPase involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr19:23,130,109...23,138,196
Ensembl chr19:23,130,109...23,138,193
JBrowse link
G Macf1 microtubule-actin crosslinking factor 1 acts_upstream_of_or_within ISO (MGI:3640889|PMID:16815997) RGD PMID:16815997 MGI:3640889 NCBI chr 5:135,623,729...135,949,097
Ensembl chr 5:135,623,742...135,945,905
JBrowse link
G Sec61a1 SEC61 translocon subunit alpha 1 acts_upstream_of_or_within ISO (PMID:22375059) RGD PMID:22375059 NCBI chr 4:120,973,519...120,987,871
Ensembl chr 4:120,960,626...120,987,925
JBrowse link
G Sec62 SEC62 homolog, preprotein translocation factor acts_upstream_of_or_within ISO (PMID:22375059) RGD PMID:22375059 NCBI chr 2:112,570,810...112,607,576
Ensembl chr 2:112,570,819...112,601,814
JBrowse link
G Sec63 SEC63 homolog, protein translocation regulator involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(PMID:22375059)
MGI:5442171 (MGI:5494355|PMID:22375059)
RGD PMID:22375059 PMID:21873635 MGI:5494355, RGD:13792537 NCBI chr20:46,245,101...46,314,055
Ensembl chr20:46,245,101...46,314,055
JBrowse link
G Sgta small glutamine rich tetratricopeptide repeat co-chaperone alpha involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:8,653,681...8,670,460
Ensembl chr 7:8,653,778...8,670,458
JBrowse link
G Sgtb small glutamine rich tetratricopeptide repeat co-chaperone beta involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:35,233,045...35,269,527
Ensembl chr 2:35,233,042...35,269,518
JBrowse link
posttranslational protein targeting to membrane, translocation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07028668.1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537
G AABR07041141.1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537
G AABR07048012.1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537
G AABR07048013.1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537
G Hspa5 heat shock protein family A (Hsp70) member 5 involved_in ISS
ISO
GO_REF:0000024
(PMID:29719251)
UniProt
RGD
PMID:29719251 GO_REF:0000024 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G LOC100362376 LRRGT00025-like involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:113,427,370...113,427,696 JBrowse link
G LOC108348617 protein transport protein Sec61 subunit gamma pseudogene involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:75,638,449...75,638,655
Ensembl chr17:75,638,449...75,638,655
JBrowse link
G LOC499136 LRRGT00021 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:92,752,704...92,754,388
Ensembl chr 1:92,752,704...92,754,388
JBrowse link
G Sec61a1 SEC61 translocon subunit alpha 1 involved_in ISS
IBA
ISO
GO_REF:0000024
PMID:21873635
(PMID:29719251)
UniProt
RGD
PMID:29719251 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 4:120,973,519...120,987,871
Ensembl chr 4:120,960,626...120,987,925
JBrowse link
G Sec61a2 SEC61 translocon subunit alpha 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:72,407,574...72,445,630
Ensembl chr17:72,407,671...72,434,494
JBrowse link
G Sec61b SEC61 translocon subunit beta involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:61,773,594...61,781,804
Ensembl chr 5:61,773,594...61,781,804
JBrowse link
G Sec61g SEC61 translocon subunit gamma involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr14:90,899,766...90,906,143
Ensembl chr14:90,899,768...90,906,162
JBrowse link
G Sec62 SEC62 homolog, preprotein translocation factor involved_in ISO
IBA
(PMID:29719251)
PMID:21873635
RGD PMID:29719251 PMID:21873635 RGD:13792537 NCBI chr 2:112,570,810...112,607,576
Ensembl chr 2:112,570,819...112,601,814
JBrowse link
G Sec63 SEC63 homolog, protein translocation regulator involved_in ISO (PMID:29719251) RGD PMID:29719251 NCBI chr20:46,245,101...46,314,055
Ensembl chr20:46,245,101...46,314,055
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19492
    localization 6447
      establishment of localization 4864
        establishment of protein localization 1696
          establishment of protein localization to membrane 266
            protein targeting to membrane 126
              posttranslational protein targeting to endoplasmic reticulum membrane 20
                posttranslational protein targeting to membrane, docking 0
                posttranslational protein targeting to membrane, translocation + 14
Path 2
Term Annotations click to browse term
  biological_process 19492
    localization 6447
      macromolecule localization 3016
        protein localization 2574
          cellular protein localization 1842
            protein localization to organelle 939
              protein localization to endoplasmic reticulum 74
                establishment of protein localization to endoplasmic reticulum 46
                  protein targeting to ER 42
                    posttranslational protein targeting to endoplasmic reticulum membrane 20
                      posttranslational protein targeting to membrane, docking 0
                      posttranslational protein targeting to membrane, translocation + 14
paths to the root