Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

Ontology Browser
Term:
SRP-dependent cotranslational protein targeting to membrane, translocation (GO:0006616)
Annotations: Rat: (7) Mouse: (10) Human: (8) Chinchilla: (3) Bonobo: (8) Dog: (7) Squirrel: (8) Pig: (8) Naked Mole-rat: (7) Green Monkey: (7)
Parent Terms Term With Siblings Child Terms
post-translational protein targeting to membrane, translocation +   
protein import into peroxisome matrix +   
protein import into peroxisome matrix, translocation  
SRP-dependent cotranslational protein targeting to membrane, docking 
SRP-dependent cotranslational protein targeting to membrane, signal sequence processing 
SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition  
SRP-dependent cotranslational protein targeting to membrane, translocation  
The process during cotranslational membrane targeting wherein proteins move across a membrane. SRP and its receptor initiate the transfer of the nascent chain across the endoplasmic reticulum (ER) membrane; they then dissociate from the chain, which is transferred to a set of transmembrane proteins, collectively called the translocon. Once the nascent chain translocon complex is assembled, the elongating chain passes directly from the large ribosomal subunit into the centers of the translocon, a protein-lined channel within the membrane. The growing chain is never exposed to the cytosol and does not fold until it reaches the ER lumen.

Synonyms
Exact Synonyms: SRP-dependent cotranslational membrane targeting, translocation ;   SRP-dependent cotranslational protein-membrane targeting, translocation ;   translocation during SRP-dependent cotranslational protein targeting to membrane
Broad Synonyms: ER translocation
Definition Sources: ISBN:0716731363

paths to the root