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ONTOLOGY REPORT - ANNOTATIONS

Term:neurotrophin signaling pathway
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Accession:GO:0038179 term browser browse the term
Definition:The series of molecular signals initiated by neurotrophin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Neurotrophins are a family of secreted growth factors that induce the survival, development, and function of neurons.
Comment:There are two classes of receptors for neurotrophins: p75 and the Trk family of tyrosine kinase receptors.
Synonyms:exact_synonym: neurotrophin receptor signaling pathway


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neurotrophin signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD2AP CD2 associated protein involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:27076424) Ensembl
MGI		 PMID:27076424 GO_REF:0000107 NCBI chr 6:47,477,789...47,627,263
Ensembl chr 6:47,477,789...47,627,263 		JBrowse link
G GFRA1 GDNF family receptor alpha 1 involved_in IEA GOC GO_REF:0000108 NCBI chr10:116,056,925...116,274,705
Ensembl chr10:116,056,925...116,276,803 		JBrowse link
G NTRK1 neurotrophic receptor tyrosine kinase 1 involved_in IEA GOC GO_REF:0000108 NCBI chr 1:156,815,750...156,881,850
Ensembl chr 1:156,815,636...156,881,850 		JBrowse link
G NTRK2 neurotrophic receptor tyrosine kinase 2 involved_in IEA GOC GO_REF:0000108 NCBI chr 9:84,668,522...85,027,054
Ensembl chr 9:84,668,375...85,095,751 		JBrowse link
G NTRK3 neurotrophic receptor tyrosine kinase 3 involved_in IEA GOC GO_REF:0000108 NCBI chr15:87,859,751...88,256,739
Ensembl chr15:87,859,751...88,256,791 		JBrowse link
negative regulation of neurotrophin TRK receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen involved_in IDA (PMID:10406457) BHF-UCL PMID:10406457 NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,690,776...230,745,576 		JBrowse link
G AGTR2 angiotensin II receptor type 2 involved_in IMP (PMID:10406457) BHF-UCL PMID:10406457 NCBI chr  X:116,170,744...116,174,974
Ensembl chr  X:116,170,744...116,174,974 		JBrowse link
G PTPRF protein tyrosine phosphatase receptor type F ISO NGF stimulated neurite outgrowth in PC12 cells RGD PMID:10699984 RGD:1642748 NCBI chr 1:43,522,051...43,623,666
Ensembl chr 1:43,525,187...43,623,666 		JBrowse link
G SPRY1 sprouty RTK signaling antagonist 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11585837) Ensembl
MGI		 PMID:11585837 GO_REF:0000107 NCBI chr 4:123,396,795...123,403,760
Ensembl chr 4:123,396,795...123,403,760 		JBrowse link
G SPRY2 sprouty RTK signaling antagonist 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11585837) Ensembl
MGI		 PMID:11585837 GO_REF:0000107 NCBI chr13:80,335,976...80,341,126
Ensembl chr13:80,335,976...80,341,126 		JBrowse link
nerve growth factor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BDNF brain derived neurotrophic factor involved_in IBA GO_Central GO_REF:0000033 NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058 		JBrowse link
G CD2AP CD2 associated protein involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:27076424) Ensembl
MGI		 PMID:27076424 GO_REF:0000107 NCBI chr 6:47,477,789...47,627,263
Ensembl chr 6:47,477,789...47,627,263 		JBrowse link
G CORO1A coronin 1A involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:24270184) Ensembl
MGI		 PMID:24270184 GO_REF:0000107 NCBI chr16:30,183,602...30,189,076
Ensembl chr16:30,182,827...30,189,076 		JBrowse link
G KIDINS220 kinase D interacting substrate 220 involved_in ISS
IBA		 UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000033 NCBI chr 2:8,721,081...8,837,613
Ensembl chr 2:8,721,081...8,837,630 		JBrowse link
G MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 involved_in ISS UniProt GO_REF:0000024 NCBI chr 7:78,017,055...79,453,667
Ensembl chr 7:78,017,055...79,453,667 		JBrowse link
G NGF nerve growth factor involved_in
acts_upstream_of_or_within		 IBA
ISO		 (PMID:7854358)
(PMID:24270184)		 GO_Central
MGI		 PMID:7854358 PMID:24270184 GO_REF:0000033 NCBI chr 1:115,285,917...115,338,249
Ensembl chr 1:115,285,904...115,338,770 		JBrowse link
G NTF3 neurotrophin 3 involved_in IBA GO_Central GO_REF:0000033 NCBI chr12:5,430,332...5,495,299
Ensembl chr12:5,432,108...5,521,536 		JBrowse link
G NTF4 neurotrophin 4 involved_in IBA GO_Central GO_REF:0000033 NCBI chr19:49,058,284...49,065,035
Ensembl chr19:49,061,066...49,065,076 		JBrowse link
G NTRK1 neurotrophic receptor tyrosine kinase 1 involved_in
acts_upstream_of_or_within		 IMP
ISO
IBA
IEA		 (PMID:1281417)
(PMID:7854358)
(PMID:24270184)		 UniProt
MGI
GO_Central
Ensembl		 PMID:1281417 PMID:7854358 PMID:24270184 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:156,815,750...156,881,850
Ensembl chr 1:156,815,636...156,881,850 		JBrowse link
G RAP1A RAP1A, member of RAS oncogene family involved_in ISS UniProt GO_REF:0000024 NCBI chr 1:111,542,009...111,716,691
Ensembl chr 1:111,542,218...111,716,691 		JBrowse link
G RAPGEF1 Rap guanine nucleotide exchange factor 1 involved_in IDA (PMID:17724123) UniProt PMID:17724123 NCBI chr 9:131,576,775...131,740,076
Ensembl chr 9:131,576,770...131,740,076 		JBrowse link
G RAPGEF2 Rap guanine nucleotide exchange factor 2 involved_in ISS UniProt GO_REF:0000024 NCBI chr 4:159,103,079...159,360,173
Ensembl chr 4:159,103,013...159,360,174 		JBrowse link
G SHOC2 SHOC2 leucine rich repeat scaffold protein involved_in ISO
IEA		 RGD
Ensembl		 PMID:25514808 GO_REF:0000107 RGD:155804270 NCBI chr10:110,919,370...111,013,665
Ensembl chr10:110,919,367...111,017,307 		JBrowse link
G SORT1 sortilin 1 involved_in IEA GOC GO_REF:0000108 NCBI chr 1:109,309,575...109,397,918
Ensembl chr 1:109,309,568...109,397,918 		JBrowse link
neurotrophin TRK receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1S1 AKT1 substrate 1 involved_in IEA InterPro GO_REF:0000002 NCBI chr19:49,869,033...49,878,356
Ensembl chr19:49,869,033...49,878,459 		JBrowse link
G BCAR1 BCAR1 scaffold protein, Cas family member involved_in ISS UniProt GO_REF:0000024 NCBI chr16:75,228,181...75,268,007
Ensembl chr16:75,228,181...75,268,053 		JBrowse link
G CASP3 caspase 3 acts_upstream_of_or_within IDA (PMID:23954828) MGI PMID:23954828 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CD2AP CD2 associated protein involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:27076424) Ensembl
MGI		 PMID:27076424 GO_REF:0000107 NCBI chr 6:47,477,789...47,627,263
Ensembl chr 6:47,477,789...47,627,263 		JBrowse link
G DDIT4 DNA damage inducible transcript 4 involved_in ISS UniProt GO_REF:0000024 NCBI chr10:72,273,924...72,276,036
Ensembl chr10:72,273,919...72,276,036 		JBrowse link
G DOCK3 dedicator of cytokinesis 3 involved_in TAS Reactome Reactome:R-HSA-9032500 NCBI chr 3:50,674,927...51,384,198
Ensembl chr 3:50,674,927...51,384,198 		JBrowse link
G HAP1 huntingtin associated protein 1 involved_in ISS
IBA
IEA		 UniProt
GO_Central
Ensembl		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr17:41,717,739...41,734,646
Ensembl chr17:41,717,742...41,734,644 		JBrowse link
G NDN necdin, MAGE family member involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16049186) Ensembl
MGI		 PMID:16049186 GO_REF:0000107 NCBI chr15:23,685,400...23,687,305
Ensembl chr15:23,685,400...23,687,305 		JBrowse link
G NTRK1 neurotrophic receptor tyrosine kinase 1 involved_in IDA (PMID:15488758) UniProt PMID:15488758 NCBI chr 1:156,815,750...156,881,850
Ensembl chr 1:156,815,636...156,881,850 		JBrowse link
G PTPN11 protein tyrosine phosphatase non-receptor type 11 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12482708) Ensembl
MGI		 PMID:12482708 GO_REF:0000107 NCBI chr12:112,418,947...112,509,918
Ensembl chr12:112,418,351...112,509,918 		JBrowse link
G RAF1 Raf-1 proto-oncogene, serine/threonine kinase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9852579) Ensembl
MGI		 PMID:9852579 GO_REF:0000107 NCBI chr 3:12,583,601...12,664,117
Ensembl chr 3:12,582,101...12,664,201 		JBrowse link
G SORT1 sortilin 1 involved_in IMP (PMID:14985763) BHF-UCL PMID:14985763 NCBI chr 1:109,309,575...109,397,918
Ensembl chr 1:109,309,568...109,397,918 		JBrowse link
G SOS1 SOS Ras/Rac guanine nucleotide exchange factor 1 involved_in ISO
IEA		 RGD
Ensembl		 PMID:15728722 GO_REF:0000107 RGD:1581104 NCBI chr 2:38,981,549...39,124,868
Ensembl chr 2:38,962,206...39,124,345 		JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase involved_in ISO
IEA		 RGD
Ensembl		 PMID:15546918 GO_REF:0000107 RGD:1580675 NCBI chr20:37,344,699...37,406,050
Ensembl chr20:37,344,685...37,406,050 		JBrowse link
G ZFYVE27 zinc finger FYVE-type containing 27 involved_in ISS
IBA		 UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000033 NCBI chr10:97,737,128...97,760,895
Ensembl chr10:97,737,121...97,760,907 		JBrowse link
positive regulation of neurotrophin TRK receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYFIP1 cytoplasmic FMR1 interacting protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:22,867,052...22,980,898
Ensembl chr15:22,867,052...22,981,063 		JBrowse link
G CYFIP2 cytoplasmic FMR1 interacting protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:157,266,123...157,395,594
Ensembl chr 5:157,266,079...157,395,595 		JBrowse link
G NGF nerve growth factor acts_upstream_of_or_within ISO PMID:19029245 MGI PMID:19029245 RGD:8553977 NCBI chr 1:115,285,917...115,338,249
Ensembl chr 1:115,285,904...115,338,770 		JBrowse link
G PPP2R5B protein phosphatase 2 regulatory subunit B'beta acts_upstream_of_or_within
involved_in		 ISO
IEA		 PMID:19029245 MGI
Ensembl		 PMID:19029245 GO_REF:0000107 RGD:8553977 NCBI chr11:64,917,573...64,934,475
Ensembl chr11:64,917,553...64,934,475 		JBrowse link
G SH3GLB1 SH3 domain containing GRB2 like, endophilin B1 ISO RGD PMID:18768694 RGD:13504749 NCBI chr 1:86,704,576...86,748,184
Ensembl chr 1:86,704,570...86,748,184 		JBrowse link
G TMEM108 transmembrane protein 108 involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:133,038,391...133,397,775
Ensembl chr 3:133,038,391...133,397,775 		JBrowse link
G WASF1 WASP family member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:110,099,819...110,179,670
Ensembl chr 6:110,099,819...110,180,004 		JBrowse link
regulation of neurotrophin TRK receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DOK5 docking protein 5 acts_upstream_of_or_within IMP (PMID:23954828) MGI PMID:23954828 NCBI chr20:54,475,593...54,651,169
Ensembl chr20:54,475,593...54,651,169 		JBrowse link
G SLC9A6 solute carrier family 9 member A6 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:24035762) Ensembl
MGI		 PMID:24035762 GO_REF:0000107 NCBI chr  X:135,973,837...136,047,269
Ensembl chr  X:135,973,841...136,047,269 		JBrowse link
G ULK1 unc-51 like autophagy activating kinase 1 acts_upstream_of_or_within ISO (PMID:17389358) MGI PMID:17389358 NCBI chr12:131,894,622...131,923,150
Ensembl chr12:131,894,622...131,923,150 		JBrowse link
G ZDHHC17 zinc finger DHHC-type palmitoyltransferase 17 involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr12:76,764,115...76,853,701
Ensembl chr12:76,764,103...76,853,696 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20482
    cellular process 19724
      signal transduction 6631
        cell surface receptor signaling pathway 3201
          neurotrophin signaling pathway 44
            nerve growth factor signaling pathway 14
            neurotrophin TRK receptor signaling pathway + 31
Path 2
Term Annotations click to browse term
  biological_process 20482
    biological regulation 13634
      regulation of biological process 13232
        signaling 7230
          signal transduction 6631
            cell surface receptor signaling pathway 3201
              neurotrophin signaling pathway 44
                nerve growth factor signaling pathway 14
                neurotrophin TRK receptor signaling pathway + 31
paths to the root