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Gene: RAPGEF2 (Rap guanine nucleotide exchange factor 2) Homo sapiens
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Symbol: RAPGEF2
Name: Rap guanine nucleotide exchange factor 2
Description: Exhibits several functions, including anion binding activity; molecular function regulator; and protein domain specific binding activity. Involved in several processes, including intracellular signal transduction; positive regulation of protein phosphorylation; and response to purine-containing compound. Localizes to several cellular components, including apical plasma membrane; bicellular tight junction; and cytoplasmic vesicle. Implicated in familial adult myoclonic epilepsy 7.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CNrasGEF; cyclic nucleotide ras GEF; neural RAP guanine nucleotide exchange protein; nRap GEP; NRAPGEP; PDZ domain containing guanine nucleotide exchange factor (GEF) 1; PDZ domain-containing guanine nucleotide exchange factor 1; PDZ-GEF1; PDZGEF1; RA(Ras/Rap1A-associating)-GEF; RA-GEF; RA-GEF-1; RAGEF; Rap guanine nucleotide exchange factor (GEF) 2; Rap-GEP; ras/Rap1-associating GEF-1
Orthologs:
Mus musculus (house mouse) : Rapgef2 (Rap guanine nucleotide exchange factor (GEF) 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Rapgef2 (Rap guanine nucleotide exchange factor 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rapgef2 (Rap guanine nucleotide exchange factor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : RAPGEF2 (Rap guanine nucleotide exchange factor 2)
Canis lupus familiaris (dog) : RAPGEF2 (Rap guanine nucleotide exchange factor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rapgef2 (Rap guanine nucleotide exchange factor 2)
Sus scrofa (pig) : RAPGEF2 (Rap guanine nucleotide exchange factor 2)
Chlorocebus sabaeus (African green monkey) : RAPGEF2 (Rap guanine nucleotide exchange factor 2)
Heterocephalus glaber (naked mole-rat) : Rapgef2 (Rap guanine nucleotide exchange factor 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl4159,103,013 - 159,360,174 (+)EnsemblGRCh38hg38GRCh38
GRCh384159,104,051 - 159,360,173 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh374160,025,224 - 160,281,314 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364160,408,448 - 160,500,752 (+)NCBINCBI36hg18NCBI36
Celera4157,529,482 - 157,621,655 (+)NCBI
Cytogenetic Map4q32.1NCBI
HuRef4155,939,342 - 156,031,440 (+)NCBIHuRef
CHM1_14160,165,501 - 160,257,796 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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Nucleotide Sequences
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Nomenclature History
 
More on RAPGEF2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1315047
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-06-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.