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ONTOLOGY REPORT - ANNOTATIONS


Term:neurotrophin TRK receptor signaling pathway
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Accession:GO:0048011 term browser browse the term
Definition:A series of molecular signals initiated by the binding of a neurotrophin to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription.
Synonyms:exact_synonym: tropomyosin-receptor-kinase signaling
 narrow_synonym: TrkA signaling pathway;   TrkB signaling pathway;   TrkC signaling pathway


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neurotrophin TRK receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1s1 AKT1 substrate 1 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 1:100,845,443...100,851,961
Ensembl chr 1:100,845,563...100,851,960
JBrowse link
G Bcar1 BCAR1 scaffold protein, Cas family member involved_in IDA PMID:8631760 UniProt PMID:8631760 RGD:8553306 NCBI chr19:43,932,543...43,967,452
Ensembl chr19:43,932,554...43,955,783
JBrowse link
G Bex1 brain expressed, X-linked 1 acts_upstream_of_or_within IGI PMID:16498402 MGI PMID:16498402 RGD:8554704 NCBI chr  X:106,761,388...106,771,656 JBrowse link
G Casp3 caspase 3 acts_upstream_of_or_within ISO (PMID:23954828) RGD PMID:23954828 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 involved_in IMP PMID:21368030 UniProt PMID:21368030 RGD:8554300 NCBI chr20:29,509,283...29,511,382
Ensembl chr20:29,509,289...29,511,382
JBrowse link
G Hap1 huntingtin-associated protein 1 involved_in IEA
ISO
ISS
IBA
GO_REF:0000107
(MGI:5560429|PMID:24355921)
GO_REF:0000024
PMID:21873635
Ensembl
RGD
UniProt
PMID:24355921, PMID:21873635 GO_REF:0000024 GO_REF:0000107 MGI:5560429, RGD:13792537 NCBI chr10:88,257,975...88,266,210
Ensembl chr10:88,257,976...88,266,210
JBrowse link
G Mageh1 MAGE family member H1 NAS RGD PMID:12414813 RGD:729117 NCBI chr  X:19,243,759...19,245,015
Ensembl chr  X:19,243,759...19,245,007
JBrowse link
G Ndn necdin, MAGE family member acts_upstream_of_or_within NAS
ISO
MGI:3586988 (MGI:3586399|PMID:16049186) RGD PMID:16049186, PMID:12414813 MGI:3586399, RGD:729117 NCBI chr 1:122,981,755...122,983,354
Ensembl chr 1:122,981,755...122,983,351
JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 involved_in ISS
ISO
GO_REF:0000024
(PMID:15488758)
UniProt
RGD
PMID:15488758 GO_REF:0000024 NCBI chr 2:187,143,568...187,160,373
Ensembl chr 2:187,143,568...187,160,373
JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 acts_upstream_of_or_within ISO (MGI:2447085|PMID:12482708) RGD PMID:12482708 MGI:2447085 NCBI chr12:40,895,515...40,955,999
Ensembl chr12:40,895,515...40,955,999
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase acts_upstream_of_or_within ISO (MGI:1933753|PMID:9852579) RGD PMID:9852579 MGI:1933753 NCBI chr 4:147,532,040...147,592,769
Ensembl chr 4:147,532,042...147,592,699
JBrowse link
G Sort1 sortilin 1 involved_in ISO (PMID:14985763) RGD PMID:14985763 NCBI chr 2:211,078,092...211,156,312
Ensembl chr 2:211,078,334...211,156,312
JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 IMP RGD PMID:15728722 RGD:1581104 NCBI chr 6:3,105,443...3,182,977
Ensembl chr 6:3,104,861...3,182,996
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase IDA RGD PMID:15546918 RGD:1580675 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Zfyve27 zinc finger FYVE-type containing 27 involved_in IBA
IMP
PMID:21873635
PMID:17082457
GO_Central
UniProt
PMID:21873635, PMID:17082457 RGD:13792537, RGD:8554602 NCBI chr 1:261,415,172...261,438,539
Ensembl chr 1:261,415,191...261,438,539
JBrowse link
negative regulation of neurotrophin TRK receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen involved_in ISO (PMID:10406457) RGD PMID:10406457 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Agtr2 angiotensin II receptor, type 2 involved_in ISO (PMID:10406457) RGD PMID:10406457 NCBI chr  X:119,389,480...119,393,845
Ensembl chr  X:119,390,013...119,393,842
JBrowse link
G Ptprf protein tyrosine phosphatase, receptor type, F IMP NGF stimulated neurite outgrowth in PC12 cells RGD PMID:10699984 RGD:1642748 NCBI chr 5:137,036,936...137,112,930
Ensembl chr 5:137,036,935...137,112,927
JBrowse link
G Spry1 sprouty RTK signaling antagonist 1 acts_upstream_of_or_within ISO (MGI:2154590|PMID:11585837) RGD PMID:11585837 MGI:2154590 NCBI chr 2:124,400,689...124,405,331
Ensembl chr 2:124,400,679...124,405,331
JBrowse link
G Spry2 sprouty RTK signaling antagonist 2 acts_upstream_of_or_within ISO (MGI:2154590|PMID:11585837) RGD PMID:11585837 MGI:2154590 NCBI chr15:90,172,769...90,177,823
Ensembl chr15:90,172,975...90,175,802
JBrowse link
positive regulation of neurotrophin TRK receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyfip1 cytoplasmic FMR1 interacting protein 1 involved_in ISO (MGI:5825407|PMID:27605705) RGD PMID:27605705 MGI:5825407 NCBI chr 1:114,258,773...114,347,138
Ensembl chr 1:114,258,719...114,347,137
JBrowse link
G Cyfip2 cytoplasmic FMR1 interacting protein 2 involved_in ISO (MGI:5825407|PMID:27605705) RGD PMID:27605705 MGI:5825407 NCBI chr10:31,278,746...31,419,235
Ensembl chr10:31,278,746...31,419,235
JBrowse link
G Ngf nerve growth factor acts_upstream_of_or_within IDA PMID:19029245 MGI PMID:19029245 RGD:8553977 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Ppp2r5b protein phosphatase 2, regulatory subunit B', beta acts_upstream_of_or_within IMP PMID:19029245 MGI PMID:19029245 RGD:8553977 NCBI chr 1:221,597,294...221,605,467
Ensembl chr 1:221,597,296...221,605,400
JBrowse link
G Sh3glb1 SH3 domain -containing GRB2-like endophilin B1 IMP RGD PMID:18768694 RGD:13504749 NCBI chr 2:250,709,812...250,744,216
Ensembl chr 2:250,709,439...250,744,196
JBrowse link
G Tmem108 transmembrane protein 108 involved_in ISO (MGI:5825407|PMID:27605705), (MGI:5825424|PMID:21849472) RGD PMID:21849472 PMID:27605705 MGI:5825407 MGI:5825424 NCBI chr 8:111,968,568...112,265,623
Ensembl chr 8:111,970,288...111,984,572
JBrowse link
G Wasf1 WASP family member 1 involved_in ISO (MGI:5825407|PMID:27605705) RGD PMID:27605705 MGI:5825407 NCBI chr20:48,456,191...48,503,768
Ensembl chr20:48,455,705...48,503,898
JBrowse link
regulation of neurotrophin TRK receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dok5 docking protein 5 acts_upstream_of_or_within ISO (PMID:23954828) RGD PMID:23954828 NCBI chr 3:168,345,116...168,482,445
Ensembl chr 3:168,345,152...168,482,441
JBrowse link
G Slc9a6 solute carrier family 9 member A6 acts_upstream_of_or_within ISO MGI:3604561 (MGI:5515840|PMID:24035762) RGD PMID:24035762 MGI:5515840 NCBI chr  X:158,979,081...159,045,019
Ensembl chr  X:158,978,755...159,045,044
JBrowse link
G Ulk1 unc-51 like autophagy activating kinase 1 acts_upstream_of_or_within ISO (MGI:3706258|PMID:17389358) RGD PMID:17389358 MGI:3706258 NCBI chr12:51,908,105...51,934,704
Ensembl chr12:51,908,448...51,934,702
JBrowse link
G Zdhhc17 zinc finger DHHC-type palmitoyltransferase 17 involved_in ISS
ISO
GO_REF:0000024
(MGI:5775247|PMID:26232532)
UniProt
RGD
PMID:26232532 GO_REF:0000024 MGI:5775247 NCBI chr 7:53,651,529...53,715,007
Ensembl chr 7:53,653,116...53,714,879
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19491
    signaling 7458
      signal transduction 6881
        cell surface receptor signaling pathway 2774
          neurotrophin signaling pathway 43
            neurotrophin TRK receptor signaling pathway 31
              negative regulation of neurotrophin TRK receptor signaling pathway 5
              positive regulation of neurotrophin TRK receptor signaling pathway 7
              regulation of neurotrophin TRK receptor signaling pathway + 16
Path 2
Term Annotations click to browse term
  biological_process 19491
    biological regulation 13514
      regulation of biological process 12772
        regulation of cellular process 12273
          signal transduction 6881
            cell surface receptor signaling pathway 2774
              enzyme linked receptor protein signaling pathway 978
                transmembrane receptor protein tyrosine kinase signaling pathway 613
                  neurotrophin TRK receptor signaling pathway 31
                    negative regulation of neurotrophin TRK receptor signaling pathway 5
                    positive regulation of neurotrophin TRK receptor signaling pathway 7
                    regulation of neurotrophin TRK receptor signaling pathway + 16
paths to the root