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Gene: CYFIP1 (cytoplasmic FMR1 interacting protein 1) Homo sapiens
Symbol: CYFIP1
Name: cytoplasmic FMR1 interacting protein 1
Description: This gene encodes a protein that regulates cytoskeletal dynamics and protein translation. The encoded protein is a component of the WAVE regulatory complex (WRC), which promotes actin polymerization.This protein also interacts with the Fragile X mental retardation protein (FMRP) and translation initiation factor 4E to inhibit protein translation. A large chromosomal deletion including this gene is associated with increased risk of schizophrenia and epilepsy in human patients. Reduced expression of this gene has been observed in various human cancers and the encoded protein may inhibit tumor invasion. [provided by RefSeq, May 2017]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: cytoplasmic FMR1-interacting protein 1; cytoplasmic FMRP interacting protein 1; FLJ45151; P140SRA-1; selective hybridizing clone; SHYC; specifically Rac1-associated protein 1; SRA-1; SRA1
Mus musculus (house mouse) : Cyfip1 (cytoplasmic FMR1 interacting protein 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cyfip1 (cytoplasmic FMR1 interacting protein 1)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : CYFIP1 (cytoplasmic FMR1 interacting protein 1)
Canis lupus familiaris (dog) : CYFIP1 (cytoplasmic FMR1 interacting protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cyfip1 (cytoplasmic FMR1 interacting protein 1)
Sus scrofa (pig) : CYFIP1 (cytoplasmic FMR1 interacting protein 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381522,867,052 - 22,980,898 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371522,892,667 - 23,003,603 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361520,444,125 - 20,555,044 (+)NCBINCBI36hg18NCBI36
Build 341520,444,124 - 20,555,043NCBI
Celera151,376,209 - 1,487,232 (-)NCBI
Cytogenetic Map15q11.2NCBI
HuRef151,205,387 - 1,315,987 (+)NCBIHuRef
CHM1_11522,841,211 - 22,952,892 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on CYFIP1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1321175
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.