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ONTOLOGY REPORT - ANNOTATIONS

Term:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
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Accession:GO:0032436 term browser browse the term
Definition:Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
Synonyms:exact_synonym: up regulation of proteasomal ubiquitin-dependent protein catabolic process;   upregulation of proteasomal ubiquitin-dependent protein catabolic process
 narrow_synonym: activation of proteasomal ubiquitin-dependent protein catabolic process;   stimulation of proteasomal ubiquitin-dependent protein catabolic process


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positive regulation of proteasomal ubiquitin-dependent protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15937334) Ensembl
MGI		 PMID:15937334 GO_REF:0000107 NCBI chr14:85,417,229...85,444,722
Ensembl chr14:105,208,128...105,236,756 		JBrowse link
G ATG7 autophagy related 7 acts_upstream_of_or_within ISO (PMID:23152632) MGI PMID:23152632 NCBI chr 3:11,208,600...11,488,757
Ensembl chr 3:11,554,100...11,833,398 		JBrowse link
G AURKA aurora kinase A acts_upstream_of_or_within ISO (PMID:17060449) MGI PMID:17060449 NCBI chr20:52,707,757...52,730,579
Ensembl chr20:53,994,881...54,017,339 		JBrowse link
G AXIN1 axin 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16601693) Ensembl
TreeGrafter
MGI		 PMID:16601693 GO_REF:0000107 GO_REF:0000118 Ensembl chr16:278,239...337,891 JBrowse link
G AXIN2 axin 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr17:59,476,336...59,509,358
Ensembl chr17:64,688,416...64,720,086 		JBrowse link
G BAG2 BAG cochaperone 2 NOT|involved_in ISO (PMID:19228967) ARUK-UCL PMID:19228967 NCBI chr 6:56,730,297...56,743,123
Ensembl chr 6:58,360,889...58,373,733 		JBrowse link
G BBS7 Bardet-Biedl syndrome 7 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:22302990) MGI
Ensembl		 PMID:22302990 GO_REF:0000107 NCBI chr 4:114,024,949...114,072,000
Ensembl chr 4:125,161,804...125,208,350 		JBrowse link
G CBFA2T3 CBFA2/RUNX1 partner transcriptional co-repressor 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:69,592,293...69,662,321
Ensembl chr16:89,246,545...89,347,435 		JBrowse link
G CHFR checkpoint with forkhead and ring finger domains involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22285184) Ensembl
MGI		 PMID:22285184 GO_REF:0000107 NCBI chr12:130,318,971...130,366,282
Ensembl chr12:134,923,458...134,968,832
Ensembl chr12:134,923,458...134,968,832 		JBrowse link
G CLU clusterin involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 8:26,867,973...26,884,838
Ensembl chr 8:24,070,053...24,083,523 		JBrowse link
G COP1 COP1 E3 ubiquitin ligase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:151,459,354...151,727,131
Ensembl chr 1:155,156,185...155,425,156 		JBrowse link
G CSNK1A1 casein kinase 1 alpha 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:144,919,775...144,977,105
Ensembl chr 5:150,929,420...150,985,912 		JBrowse link
G CSNK1D casein kinase 1 delta involved_in ISO (PMID:19414593) UniProt PMID:19414593 NCBI chr17:76,648,677...76,683,054
Ensembl chr17:82,462,467...82,494,348 		JBrowse link
G CSNK1E casein kinase 1 epsilon involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:19,202,599...19,229,344
Ensembl chr22:37,027,094...37,072,942 		JBrowse link
G DAB2 DAB adaptor protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:70,951,198...71,004,836
Ensembl chr 5:76,022,143...76,041,443 		JBrowse link
G DDA1 DET1 and DDB1 associated 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr19:16,797,750...16,808,427
Ensembl chr19:17,771,925...17,785,267 		JBrowse link
G DDRGK1 DDRGK domain containing 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:3,276,292...3,290,433
Ensembl chr20:3,038,779...3,052,789 		JBrowse link
G DET1 DET1 partner of COP1 E3 ubiquitin ligase involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr15:67,203,101...67,238,185
Ensembl chr15:86,411,937...86,444,789 		JBrowse link
G DNAJB2 DnaJ heat shock protein family (Hsp40) member B2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr2B:106,536,846...106,544,430
Ensembl chr2B:225,127,967...225,135,556 		JBrowse link
G DVL1 dishevelled segment polarity protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:92,469...106,748
Ensembl chr 1:1,292,052...1,301,008 		JBrowse link
G FBXO22 F-box protein 22 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:19319192) MGI
TreeGrafter		 PMID:19319192 GO_REF:0000118 NCBI chr15:54,817,076...54,849,271
Ensembl chr15:74,410,213...74,441,609 		JBrowse link
G FBXW8 F-box and WD repeat domain containing 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:114,487,476...114,607,384
Ensembl chr12:117,863,254...117,983,269 		JBrowse link
G GABARAP GABA type A receptor-associated protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:7,270,316...7,272,365
Ensembl chr17:7,257,659...7,260,276 		JBrowse link
G GBA1 glucosylceramidase beta 1 acts_upstream_of_or_within ISO (PMID:23707074) ParkinsonsUK-UCL PMID:23707074 NCBI chr 1:130,579,300...130,589,560
Ensembl chr 1:134,185,385...134,194,851 		JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17189825) Ensembl
MGI		 PMID:17189825 GO_REF:0000107 NCBI chr 6:53,052,145...53,102,794
Ensembl chr 6:54,687,315...54,734,994 		JBrowse link
G GSK3A glycogen synthase kinase 3 alpha involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr19:39,118,330...39,130,768
Ensembl chr19:47,710,197...47,726,948 		JBrowse link
G GSK3B glycogen synthase kinase 3 beta involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22660580) Ensembl
TreeGrafter
MGI		 PMID:22660580 GO_REF:0000107 GO_REF:0000118 NCBI chr 3:116,943,205...117,215,001
Ensembl chr 3:123,861,379...124,126,771 		JBrowse link
G HAMP hepcidin antimicrobial peptide involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:32,228,701...32,231,494
Ensembl chr19:40,964,445...40,968,861 		JBrowse link
G HSPA1A heat shock protein family A (Hsp70) member 1A involved_in ISO (PMID:24613385) UniProt PMID:24613385 NCBI chr 6:31,476,710...31,491,411 JBrowse link
G HSPA1B heat shock protein family A (Hsp70) member 1B involved_in ISO (PMID:24613385) UniProt PMID:24613385 NCBI chr 6:31,488,882...31,491,412 JBrowse link
G HSPBP1 HSPA (Hsp70) binding protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:52,303,121...52,322,771
Ensembl chr19:60,995,202...61,013,756 		JBrowse link
G IL33 interleukin 33 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22660580) Ensembl
MGI		 PMID:22660580 GO_REF:0000107 NCBI chr 9:6,027,014...6,069,540
Ensembl chr 9:6,234,178...6,248,624 		JBrowse link
G KLHL40 kelch like family member 40 involved_in ISO (PMID:25940086) UniProt PMID:25940086 NCBI chr 3:42,592,977...42,600,100
Ensembl chr 3:43,657,128...43,664,055 		JBrowse link
G LRRK2 leucine rich repeat kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:48,343,621...48,488,337
Ensembl chr12:49,205,930...49,350,462 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 involved_in ISO (PMID:29153991) UniProt PMID:29153991 NCBI chr10:45,806,748...45,936,362 JBrowse link
G MAPK9 mitogen-activated protein kinase 9 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:175,437,167...175,495,469
Ensembl chr 5:182,748,381...182,795,135 		JBrowse link
G MDM2 MDM2 proto-oncogene involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:66,322,340...66,357,010
Ensembl chr12:69,102,084...69,133,278 		JBrowse link
G NKD2 NKD inhibitor of WNT signaling pathway 2 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr 5:1,075,172...1,081,664 JBrowse link
G NOP53 NOP53 ribosome biogenesis factor involved_in ISO (PMID:25818168), (PMID:27323397)
(PMID:21804542)		 UniProt PMID:21804542 PMID:25818168 PMID:27323397 NCBI chr19:44,739,739...44,751,303 JBrowse link
G NUB1 negative regulator of ubiquitin like proteins 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:142,927,730...142,964,475
Ensembl chr 7:155,079,243...155,114,676 		JBrowse link
G PABIR1 PP2A Aalpha (PPP2R1A) and B55A (PPP2R2A) interacting phosphatase regulator 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:56,007,323...56,011,655
Ensembl chr 9:67,544,489...67,545,352 		JBrowse link
G PAQR3 progestin and adipoQ receptor family member 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:45,255,403...45,279,319
Ensembl chr 4:51,102,305...51,123,506 		JBrowse link
G PIAS1 protein inhibitor of activated STAT 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:47,006,718...47,141,035
Ensembl chr15:65,276,530...65,410,105 		JBrowse link
G PLK1 polo like kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:14,420,972...14,432,821
Ensembl chr16:23,928,773...23,940,779 		JBrowse link
G PLK2 polo like kinase 2 ISO RGD PMID:18723513 RGD:7241135 NCBI chr 5:55,543,828...55,550,116
Ensembl chr 5:57,177,836...57,184,793 		JBrowse link
G PLK3 polo like kinase 3 involved_in ISO (PMID:20889502) UniProt PMID:20889502 NCBI chr 1:44,104,564...44,110,162
Ensembl chr 1:45,470,016...45,476,021 		JBrowse link
G PRICKLE1 prickle planar cell polarity protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:46,127,673...46,262,333
Ensembl chr12:47,100,393...47,126,102 		JBrowse link
G PRKN parkin RBR E3 ubiquitin protein ligase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:159,293,016...160,679,106
Ensembl chr 6:164,314,990...165,678,770 		JBrowse link
G PSEN1 presenilin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:53,718,299...53,802,684
Ensembl chr14:72,579,024...72,663,876 		JBrowse link
G PSEN2 presenilin 2 involved_in ISO (PMID:20208556) BHF-UCL PMID:20208556 NCBI chr 1:202,328,987...202,354,440
Ensembl chr 1:207,320,937...207,346,295 		JBrowse link
G PSMD10 proteasome 26S subunit, non-ATPase 10 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:97,182,090...97,189,523
Ensembl chr  X:107,552,186...107,559,616 		JBrowse link
G RACK1 receptor for activated C kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:176,462,991...176,470,153
Ensembl chr 5:183,712,665...183,720,128 		JBrowse link
G RAD23A RAD23 homolog A, nucleotide excision repair protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:12,508,232...12,516,068
Ensembl chr19:13,250,718...13,258,482 		JBrowse link
G RBX1 ring-box 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:21,845,351...21,866,627
Ensembl chr22:39,941,405...39,962,175 		JBrowse link
G RCHY1 ring finger and CHY zinc finger domain containing 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:48,691,213...48,725,979
Ensembl chr 4:54,526,202...54,561,048 		JBrowse link
G RFPL1 ret finger protein like 1 involved_in ISO (PMID:20725088) UniProt PMID:20725088
G RNF180 ring finger protein 180 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18363970), (PMID:23926250) Ensembl
TreeGrafter
MGI		 PMID:18363970 PMID:23926250 GO_REF:0000107 GO_REF:0000118 NCBI chr 5:49,624,452...49,841,741
Ensembl chr 5:51,280,064...51,454,750 		JBrowse link
G SH3RF2 SH3 domain containing ring finger 2 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 5:141,386,060...141,530,993
Ensembl chr 5:147,401,188...147,545,703 		JBrowse link
G SIRT1 sirtuin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:64,368,878...64,401,684
Ensembl chr10:66,681,598...66,715,069 		JBrowse link
G SIRT2 sirtuin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:35,984,453...36,005,582
Ensembl chr19:44,533,965...44,554,799 		JBrowse link
G SIRT6 sirtuin 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:3,196,092...3,204,602
Ensembl chr19:4,146,057...4,154,126 		JBrowse link
G SOCS4 suppressor of cytokine signaling 4 involved_in IEA InterPro GO_REF:0000002 NCBI chr14:35,614,238...35,636,531
Ensembl chr14:53,904,783...53,906,105 		JBrowse link
G SOCS5 suppressor of cytokine signaling 5 involved_in IEA Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000107 NCBI chr2A:46,813,589...46,878,102
Ensembl chr2A:47,804,431...47,806,041 		JBrowse link
G STUB1 STIP1 homology and U-box containing protein 1 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr16:694,414...696,682 JBrowse link
G SUMO1 small ubiquitin like modifier 1 involved_in ISO (PMID:18408734) UniProt PMID:18408734 NCBI chr2B:89,461,773...89,493,879
Ensembl chr2B:207,613,654...207,645,590 		JBrowse link
G SUMO2 small ubiquitin like modifier 2 involved_in ISO (PMID:18408734) UniProt PMID:18408734 NCBI chr17:69,115,433...69,130,065 JBrowse link
G TAF1 TATA-box binding protein associated factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:60,630,137...60,729,904
Ensembl chr  X:70,684,217...70,782,323 		JBrowse link
G TF transferrin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:130,799,063...130,830,227
Ensembl chr 3:138,274,159...138,305,476 		JBrowse link
G TRIB1 tribbles pseudokinase 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 8:122,115,194...122,123,319
Ensembl chr 8:124,867,359...124,872,924 		JBrowse link
G TRIB2 tribbles pseudokinase 2 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr2A:12,705,043...12,730,932
Ensembl chr2A:12,847,631...12,873,499 		JBrowse link
G TRIB3 tribbles pseudokinase 3 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr20:583,267...605,416
Ensembl chr20:359,879...375,486 		JBrowse link
G UBE2V2 ubiquitin conjugating enzyme E2 V2 ISO RGD PMID:12750002 RGD:1299567 NCBI chr 8:44,435,496...44,488,517
Ensembl chr 8:41,856,429...41,878,320 		JBrowse link
G USP5 ubiquitin specific peptidase 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:6,983,941...6,998,469
Ensembl chr12:6,895,416...6,909,936 		JBrowse link
G VCP valosin containing protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:34,907,147...34,923,227
Ensembl chr 9:35,712,937...35,729,588 		JBrowse link
G ZER1 zyg-11 related cell cycle regulator involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:99,853,433...99,895,399
Ensembl chr 9:128,519,972...128,560,098 		JBrowse link
G ZFAND2A zinc finger AN1-type containing 2A acts_upstream_of_or_within ISO (PMID:16973439) MGI PMID:16973439 NCBI chr 7:1,392,979...1,401,283
Ensembl chr 7:1,518,912...1,526,107 		JBrowse link
G ZYG11B zyg-11 family member B, cell cycle regulator involved_in ISO (PMID:31273098) UniProt PMID:31273098 NCBI chr 1:51,987,678...52,087,093 JBrowse link
positive regulation of anaphase-promoting complex-dependent catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDC20 cell division cycle 20 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 1:42,660,338...42,664,618
Ensembl chr 1:44,039,971...44,044,497 		JBrowse link
G CDC20B cell division cycle 20B involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 5:58,856,370...58,918,463
Ensembl chr 5:60,478,977...60,538,264 		JBrowse link
G FZR1 fizzy and cell division cycle 20 related 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr19:2,533,172...2,564,301
Ensembl chr19:3,500,117...3,510,867 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16644
    cellular process 16207
      metabolic process 10770
        catabolic process 2488
          positive regulation of catabolic process 543
            positive regulation of ubiquitin-dependent protein catabolic process 103
              positive regulation of proteasomal ubiquitin-dependent protein catabolic process 80
                positive regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process 0
                positive regulation of anaphase-promoting complex-dependent catabolic process 3
Path 2
Term Annotations click to browse term
  biological_process 16644
    cellular process 16207
      metabolic process 10770
        macromolecule metabolic process 8862
          protein metabolic process 4592
            proteolysis 1513
              proteolysis involved in protein catabolic process 738
                modification-dependent protein catabolic process 575
                  ubiquitin-dependent protein catabolic process 569
                    proteasome-mediated ubiquitin-dependent protein catabolic process 382
                      regulation of proteasomal ubiquitin-dependent protein catabolic process 133
                        positive regulation of proteasomal ubiquitin-dependent protein catabolic process 80
                          positive regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process 0
                          positive regulation of anaphase-promoting complex-dependent catabolic process 3
paths to the root