SOCS4 (suppressor of cytokine signaling 4) - Rat Genome Database

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Pathways
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Gene: SOCS4 (suppressor of cytokine signaling 4) Pan paniscus
Analyze
Symbol: SOCS4
Name: suppressor of cytokine signaling 4
RGD ID: 11991162
Description: ENCODES a protein that exhibits 1-phosphatidylinositol-3-kinase regulator activity (inferred); INVOLVED IN intracellular signal transduction (inferred); negative regulation of signal transduction (inferred); phosphatidylinositol phosphate biosynthetic process (inferred); PARTICIPATES IN Jak-Stat signaling pathway; ASSOCIATED WITH pre-malignant neoplasm (ortholog); Reperfusion Injury (ortholog); FOUND IN phosphatidylinositol 3-kinase complex (inferred)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21556,148,799 - 56,171,201 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11455,365,332 - 55,387,709 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01435,614,238 - 35,636,531 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11453,890,043 - 53,911,227 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1453,904,783 - 53,906,105 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SOCS4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21556,148,799 - 56,171,201 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11455,365,332 - 55,387,709 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01435,614,238 - 35,636,531 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11453,890,043 - 53,911,227 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1453,904,783 - 53,906,105 (+)Ensemblpanpan1.1panPan2
SOCS4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381455,027,236 - 55,049,489 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1455,027,230 - 55,049,489 (+)EnsemblGRCh38hg38GRCh38
GRCh371455,493,954 - 55,516,207 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361454,563,594 - 54,585,960 (+)NCBINCBI36Build 36hg18NCBI36
Build 341454,563,593 - 54,585,957NCBI
Celera1435,543,338 - 35,565,701 (+)NCBICelera
Cytogenetic Map14q22.3NCBI
HuRef1435,656,555 - 35,678,835 (+)NCBIHuRef
CHM1_11455,432,461 - 55,454,827 (+)NCBICHM1_1
T2T-CHM13v2.01449,232,425 - 49,254,678 (+)NCBIT2T-CHM13v2.0
Socs4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391447,514,377 - 47,533,559 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1447,514,388 - 47,533,559 (+)EnsemblGRCm39 Ensembl
GRCm381447,276,920 - 47,296,102 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1447,276,931 - 47,296,102 (+)EnsemblGRCm38mm10GRCm38
MGSCv371447,896,818 - 47,911,266 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361446,199,020 - 46,213,468 (+)NCBIMGSCv36mm8
Celera1443,463,746 - 43,478,181 (+)NCBICelera
Cytogenetic Map14C1NCBI
cM Map1424.6NCBI
Socs4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81523,003,130 - 23,017,615 (+)NCBIGRCr8
mRatBN7.21520,523,406 - 20,537,889 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1520,523,183 - 20,542,494 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1523,304,045 - 23,318,530 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01524,262,007 - 24,276,492 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01522,512,018 - 22,526,496 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01524,056,383 - 24,070,868 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1524,056,383 - 24,070,857 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01527,997,125 - 28,011,610 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41523,229,083 - 23,243,568 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11523,244,704 - 23,258,735 (+)NCBI
Celera1520,917,934 - 20,932,419 (+)NCBICelera
Cytogenetic Map15p14NCBI
Socs4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554098,527,291 - 8,528,616 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554098,522,540 - 8,539,551 (-)NCBIChiLan1.0ChiLan1.0
SOCS4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1830,892,663 - 30,898,896 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha830,648,526 - 30,667,659 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0831,139,073 - 31,158,412 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl831,139,292 - 31,155,995 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1830,742,868 - 30,761,975 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0830,819,420 - 30,838,823 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0831,184,322 - 31,203,430 (+)NCBIUU_Cfam_GSD_1.0
Socs4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864074,336,511 - 74,355,624 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936697110,952 - 129,686 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936697110,637 - 129,767 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SOCS4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1184,379,086 - 184,398,898 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11184,379,017 - 184,398,902 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21204,886,200 - 204,906,104 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SOCS4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12432,198,438 - 32,227,240 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2432,220,800 - 32,222,122 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605320,442,274 - 20,463,992 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Socs4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473114,359,837 - 14,382,738 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473114,356,719 - 14,382,738 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000010071   ⟹   ENSPPAP00000002048
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1453,904,783 - 53,906,105 (+)Ensembl
RefSeq Acc Id: XM_003831690   ⟹   XP_003831738
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21556,148,835 - 56,171,201 (+)NCBI
NHGRI_mPanPan11455,365,343 - 55,387,709 (+)NCBI
Mhudiblu_PPA_v01435,614,238 - 35,636,531 (+)NCBI
PanPan1.11453,890,049 - 53,911,227 (+)NCBI
Sequence:
RefSeq Acc Id: XM_003831691   ⟹   XP_003831739
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21556,148,823 - 56,171,201 (+)NCBI
NHGRI_mPanPan11455,365,397 - 55,387,709 (+)NCBI
Mhudiblu_PPA_v01435,614,239 - 35,636,531 (+)NCBI
PanPan1.11453,890,043 - 53,911,227 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008957048   ⟹   XP_008955296
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21556,148,799 - 56,171,201 (+)NCBI
NHGRI_mPanPan11455,365,344 - 55,387,709 (+)NCBI
Mhudiblu_PPA_v01435,614,238 - 35,636,531 (+)NCBI
PanPan1.11453,890,049 - 53,911,227 (+)NCBI
Sequence:
RefSeq Acc Id: XM_055097609   ⟹   XP_054953584
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21556,148,824 - 56,171,201 (+)NCBI
NHGRI_mPanPan11455,365,332 - 55,387,709 (+)NCBI
Protein Sequences
Protein RefSeqs XP_003831738 (Get FASTA)   NCBI Sequence Viewer  
  XP_003831739 (Get FASTA)   NCBI Sequence Viewer  
  XP_008955296 (Get FASTA)   NCBI Sequence Viewer  
  XP_054953584 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000002048.1
Reference Protein Sequences
RefSeq Acc Id: XP_003831739   ⟸   XM_003831691
- UniProtKB: A0A2R8ZAJ6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003831738   ⟸   XM_003831690
- UniProtKB: A0A2R8ZAJ6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008955296   ⟸   XM_008957048
- UniProtKB: A0A2R8ZAJ6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSPPAP00000002048   ⟸   ENSPPAT00000010071
RefSeq Acc Id: XP_054953584   ⟸   XM_055097609
- UniProtKB: A0A2R8ZAJ6 (UniProtKB/TrEMBL)
Protein Domains
SH2   SOCS box


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000009240 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000010071.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.505.10 UniProtKB/TrEMBL
InterPro SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  SOCS4/SOCS5_dom UniProtKB/TrEMBL
  SOCS4_SH2 UniProtKB/TrEMBL
  SOCS4_SOCS UniProtKB/TrEMBL
  SOCS_box UniProtKB/TrEMBL
  SOCS_box-like_dom_sf UniProtKB/TrEMBL
KEGG Report pps:100989690 UniProtKB/TrEMBL
NCBI Gene SOCS4 ENTREZGENE
PANTHER PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT UniProtKB/TrEMBL
  PTHR10155:SF21 UniProtKB/TrEMBL
Pfam SH2 UniProtKB/TrEMBL
  SOCS UniProtKB/TrEMBL
  SOCS_box UniProtKB/TrEMBL
PROSITE SH2 UniProtKB/TrEMBL
  SOCS UniProtKB/TrEMBL
SMART SH2 UniProtKB/TrEMBL
  SOCS UniProtKB/TrEMBL
  SOCS_box UniProtKB/TrEMBL
Superfamily-SCOP SSF158235 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
UniProt A0A2R8ZAJ6 ENTREZGENE, UniProtKB/TrEMBL