SOCS4 (suppressor of cytokine signaling 4) - Rat Genome Database

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Gene: SOCS4 (suppressor of cytokine signaling 4) Chlorocebus sabaeus
Analyze
Symbol: SOCS4
Name: suppressor of cytokine signaling 4
RGD ID: 18396077
Description: ENCODES a protein that exhibits 1-phosphatidylinositol-3-kinase regulator activity (inferred); INVOLVED IN intracellular signal transduction (inferred); negative regulation of signal transduction (inferred); phosphatidylinositol phosphate biosynthetic process (inferred); PARTICIPATES IN Jak-Stat signaling pathway; ASSOCIATED WITH pre-malignant neoplasm (ortholog); Reperfusion Injury (ortholog); FOUND IN phosphatidylinositol 3-kinase complex (inferred)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12432,198,438 - 32,227,240 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2432,220,800 - 32,222,122 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605320,442,274 - 20,463,992 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SOCS4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12432,198,438 - 32,227,240 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2432,220,800 - 32,222,122 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605320,442,274 - 20,463,992 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
SOCS4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381455,027,236 - 55,049,489 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1455,027,230 - 55,049,489 (+)EnsemblGRCh38hg38GRCh38
GRCh371455,493,954 - 55,516,207 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361454,563,594 - 54,585,960 (+)NCBINCBI36Build 36hg18NCBI36
Build 341454,563,593 - 54,585,957NCBI
Celera1435,543,338 - 35,565,701 (+)NCBICelera
Cytogenetic Map14q22.3NCBI
HuRef1435,656,555 - 35,678,835 (+)NCBIHuRef
CHM1_11455,432,461 - 55,454,827 (+)NCBICHM1_1
T2T-CHM13v2.01449,232,425 - 49,254,678 (+)NCBIT2T-CHM13v2.0
Socs4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391447,514,377 - 47,533,559 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1447,514,388 - 47,533,559 (+)EnsemblGRCm39 Ensembl
GRCm381447,276,920 - 47,296,102 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1447,276,931 - 47,296,102 (+)EnsemblGRCm38mm10GRCm38
MGSCv371447,896,818 - 47,911,266 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361446,199,020 - 46,213,468 (+)NCBIMGSCv36mm8
Celera1443,463,746 - 43,478,181 (+)NCBICelera
Cytogenetic Map14C1NCBI
cM Map1424.6NCBI
Socs4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81523,003,130 - 23,017,615 (+)NCBIGRCr8
mRatBN7.21520,523,406 - 20,537,889 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1520,523,183 - 20,542,494 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1523,304,045 - 23,318,530 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01524,262,007 - 24,276,492 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01522,512,018 - 22,526,496 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01524,056,383 - 24,070,868 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1524,056,383 - 24,070,857 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01527,997,125 - 28,011,610 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41523,229,083 - 23,243,568 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11523,244,704 - 23,258,735 (+)NCBI
Celera1520,917,934 - 20,932,419 (+)NCBICelera
Cytogenetic Map15p14NCBI
Socs4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554098,527,291 - 8,528,616 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554098,522,540 - 8,539,551 (-)NCBIChiLan1.0ChiLan1.0
SOCS4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21556,148,799 - 56,171,201 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11455,365,332 - 55,387,709 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01435,614,238 - 35,636,531 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11453,890,043 - 53,911,227 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1453,904,783 - 53,906,105 (+)Ensemblpanpan1.1panPan2
SOCS4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1830,892,663 - 30,898,896 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha830,648,526 - 30,667,659 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0831,139,073 - 31,158,412 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl831,139,292 - 31,155,995 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1830,742,868 - 30,761,975 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0830,819,420 - 30,838,823 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0831,184,322 - 31,203,430 (+)NCBIUU_Cfam_GSD_1.0
Socs4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864074,336,511 - 74,355,624 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936697110,952 - 129,686 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936697110,637 - 129,767 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SOCS4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1184,379,086 - 184,398,898 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11184,379,017 - 184,398,902 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21204,886,200 - 204,906,104 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Socs4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473114,359,837 - 14,382,738 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473114,356,719 - 14,382,738 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 9 5 42
Low 27 15 18
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_007986742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACDXN010000021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCSAT00000019499   ⟹   ENSCSAP00000018917
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2432,220,800 - 32,222,122 (+)Ensembl
RefSeq Acc Id: XM_007986742   ⟹   XP_007984933
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12432,198,438 - 32,227,240 (+)NCBI
Vero_WHO_p1.0NW_02366605320,442,274 - 20,463,992 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007984933 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000018917
  ENSCSAP00000018917.1
Reference Protein Sequences
RefSeq Acc Id: XP_007984933   ⟸   XM_007986742
- UniProtKB: A0A0D9SDH8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000018917   ⟸   ENSCSAT00000019499


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000019409 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000019499.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.505.10 UniProtKB/TrEMBL
InterPro SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  SOCS4/SOCS5_dom UniProtKB/TrEMBL
  SOCS4_SH2 UniProtKB/TrEMBL
  SOCS4_SOCS UniProtKB/TrEMBL
  SOCS_box UniProtKB/TrEMBL
  SOCS_box-like_dom_sf UniProtKB/TrEMBL
KEGG Report csab:103229025 UniProtKB/TrEMBL
NCBI Gene SOCS4 ENTREZGENE
PANTHER PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT UniProtKB/TrEMBL
  PTHR10155:SF21 UniProtKB/TrEMBL
Pfam SH2 UniProtKB/TrEMBL
  SOCS UniProtKB/TrEMBL
  SOCS_box UniProtKB/TrEMBL
PROSITE SH2 UniProtKB/TrEMBL
  SOCS UniProtKB/TrEMBL
SMART SH2 UniProtKB/TrEMBL
  SOCS UniProtKB/TrEMBL
  SOCS_box UniProtKB/TrEMBL
Superfamily-SCOP SSF158235 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
UniProt A0A0D9SDH8 ENTREZGENE, UniProtKB/TrEMBL