SIRT2 (sirtuin 2) - Rat Genome Database

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Gene: SIRT2 (sirtuin 2) Pan paniscus
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Symbol: SIRT2
Name: sirtuin 2
RGD ID: 11745051
Description: ENCODES a protein that exhibits beta-tubulin binding (ortholog); chromatin binding (ortholog); DNA-binding transcription factor binding (ortholog); INVOLVED IN cellular lipid catabolic process (ortholog); cellular response to caloric restriction (ortholog); cellular response to epinephrine stimulus (ortholog); PARTICIPATES IN histone modification pathway; Sirtuin mediated pathway; ASSOCIATED WITH high grade glioma (ortholog); intermittent claudication (ortholog); non-alcoholic fatty liver disease (ortholog); FOUND IN centriole (ortholog); centrosome (ortholog); chromosome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: NAD-dependent protein deacetylase sirtuin-2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11944,533,965 - 44,554,838 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1944,533,965 - 44,554,799 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01935,984,453 - 36,005,582 (-)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular lipid catabolic process  (ISO)
cellular response to caloric restriction  (ISO)
cellular response to epinephrine stimulus  (ISO)
cellular response to hepatocyte growth factor stimulus  (ISO)
cellular response to hypoxia  (ISO)
cellular response to molecule of bacterial origin  (ISO)
cellular response to oxidative stress  (ISO)
central nervous system development  (ISO)
hepatocyte growth factor receptor signaling pathway  (ISO)
histone deacetylation  (ISO)
histone H3 deacetylation  (ISO)
histone H4 deacetylation  (ISO)
myelination in peripheral nervous system  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of autophagy  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of defense response to bacterium  (ISO)
negative regulation of fat cell differentiation  (ISO)
negative regulation of NLRP3 inflammasome complex assembly  (ISO)
negative regulation of oligodendrocyte differentiation  (ISO)
negative regulation of oligodendrocyte progenitor proliferation  (ISO)
negative regulation of peptidyl-threonine phosphorylation  (ISO)
negative regulation of protein catabolic process  (ISO)
negative regulation of reactive oxygen species metabolic process  (ISO)
negative regulation of striated muscle tissue development  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of transcription from RNA polymerase II promoter in response to hypoxia  (ISO)
negative regulation of transcription, DNA-templated  (ISO)
peptidyl-lysine deacetylation  (ISO)
phosphatidylinositol 3-kinase signaling  (ISO)
positive regulation of attachment of spindle microtubules to kinetochore  (ISO)
positive regulation of cell division  (ISO)
positive regulation of DNA binding  (ISO)
positive regulation of execution phase of apoptosis  (ISO)
positive regulation of meiotic nuclear division  (ISO)
positive regulation of oocyte maturation  (ISO)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (ISO)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
proteasome-mediated ubiquitin-dependent protein catabolic process  (ISO)
protein ADP-ribosylation  (ISO)
protein deacetylation  (ISO)
protein kinase B signaling  (ISO)
regulation of cell cycle  (ISO)
regulation of fat cell differentiation  (ISO)
regulation of myelination  (ISO)
regulation of postsynaptic neurotransmitter receptor internalization  (ISO)
substantia nigra development  (ISO)
tubulin deacetylation  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
SIRT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11944,533,965 - 44,554,838 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1944,533,965 - 44,554,799 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01935,984,453 - 36,005,582 (-)NCBIMhudiblu_PPA_v0panPan3
SIRT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1938,878,555 - 38,899,862 (-)EnsemblGRCh38hg38GRCh38
GRCh381938,878,555 - 38,899,733 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371939,369,195 - 39,390,258 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361944,061,040 - 44,082,201 (-)NCBINCBI36hg18NCBI36
Build 341944,061,039 - 44,082,193NCBI
Celera1936,171,632 - 36,192,939 (-)NCBI
Cytogenetic Map19q13.2NCBI
HuRef1935,815,856 - 35,837,294 (-)NCBIHuRef
CHM1_11939,369,665 - 39,390,970 (-)NCBICHM1_1
Sirt2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39728,466,177 - 28,488,090 (+)NCBIGRCm39mm39
GRCm39 Ensembl728,466,160 - 28,488,086 (+)Ensembl
GRCm38728,766,752 - 28,788,665 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl728,766,735 - 28,788,661 (+)EnsemblGRCm38mm10GRCm38
MGSCv37729,551,771 - 29,573,684 (+)NCBIGRCm37mm9NCBIm37
MGSCv36728,475,543 - 28,497,420 (+)NCBImm8
Celera723,327,529 - 23,349,457 (+)NCBICelera
Cytogenetic Map7B1NCBI
Sirt2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2184,053,883 - 84,076,975 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl184,052,903 - 84,076,975 (+)Ensembl
Rnor_6.0186,948,866 - 86,971,954 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl186,948,918 - 86,971,952 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0188,130,012 - 88,153,086 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4183,873,578 - 83,896,121 (+)NCBIRGSC3.4rn4RGSC3.4
Celera178,446,589 - 78,469,133 (+)NCBICelera
Cytogenetic Map1q21NCBI
Sirt2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955468626,365 - 644,441 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955468626,365 - 644,441 (+)NCBIChiLan1.0ChiLan1.0
SIRT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11114,224,922 - 114,235,041 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1114,224,900 - 114,234,583 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1113,618,889 - 113,636,581 (+)NCBI
ROS_Cfam_1.01114,817,111 - 114,834,816 (+)NCBI
UMICH_Zoey_3.11114,375,328 - 114,392,089 (+)NCBI
UNSW_CanFamBas_1.01114,008,029 - 114,025,710 (+)NCBI
UU_Cfam_GSD_1.01115,003,788 - 115,021,492 (+)NCBI
Sirt2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934913,400,802 - 13,421,980 (-)NCBI
SpeTri2.0NW_0049366611,828,868 - 1,849,892 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SIRT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl647,682,424 - 47,703,529 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1647,682,427 - 47,703,408 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2643,218,298 - 43,228,967 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SIRT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1633,493,106 - 33,518,793 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl633,493,079 - 33,518,647 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607311,514,410 - 11,540,709 (-)NCBIVero_WHO_p1.0
Sirt2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462479412,239,363 - 12,259,561 (-)NCBIHetGla_female_1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000048804   ⟹   ENSPPAP00000025973
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1944,533,965 - 44,554,799 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000048807   ⟹   ENSPPAP00000025976
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1944,534,560 - 44,548,512 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000048809   ⟹   ENSPPAP00000025978
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1944,534,882 - 44,548,806 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000048811   ⟹   ENSPPAP00000025980
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1944,544,301 - 44,548,512 (-)Ensembl
RefSeq Acc Id: XM_003812256   ⟹   XP_003812304
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.11944,533,965 - 44,554,838 (-)NCBI
Mhudiblu_PPA_v01935,984,453 - 36,005,562 (-)NCBI
Sequence:
RefSeq Acc Id: XM_003812257   ⟹   XP_003812305
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.11944,533,965 - 44,554,799 (-)NCBI
Mhudiblu_PPA_v01935,984,453 - 36,005,570 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008964657   ⟹   XP_008962905
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.11944,533,976 - 44,554,709 (-)NCBI
Mhudiblu_PPA_v01935,985,028 - 36,005,582 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034944928   ⟹   XP_034800819
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v01935,985,059 - 36,005,535 (-)NCBI
Protein Sequences
Protein RefSeqs XP_003812304 (Get FASTA)   NCBI Sequence Viewer  
  XP_003812305 (Get FASTA)   NCBI Sequence Viewer  
  XP_008962905 (Get FASTA)   NCBI Sequence Viewer  
  XP_034800819 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_003812304   ⟸   XM_003812256
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_003812305   ⟸   XM_003812257
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008962905   ⟸   XM_008964657
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_034800819   ⟸   XM_034944928
- Peptide Label: isoform X4
RefSeq Acc Id: ENSPPAP00000025976   ⟸   ENSPPAT00000048807
RefSeq Acc Id: ENSPPAP00000025973   ⟸   ENSPPAT00000048804
RefSeq Acc Id: ENSPPAP00000025978   ⟸   ENSPPAT00000048809
RefSeq Acc Id: ENSPPAP00000025980   ⟸   ENSPPAT00000048811


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000036095 Ensembl, ENTREZGENE
NCBI Gene SIRT2 ENTREZGENE