SIRT6 (sirtuin 6) - Rat Genome Database

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Gene: SIRT6 (sirtuin 6) Pan paniscus
Analyze
Symbol: SIRT6
Name: sirtuin 6
RGD ID: 11906129
Description: ENCODES a protein that exhibits enzyme regulator activity (ortholog); histone deacetylase regulator activity (ortholog); histone H3K9 deacetylase activity, hydrolytic mechanism (ortholog); INVOLVED IN base-excision repair (ortholog); cardiac muscle cell differentiation (ortholog); cellular response to angiotensin (ortholog); PARTICIPATES IN histone modification pathway; Sirtuin mediated pathway; ASSOCIATED WITH amenorrhea (ortholog); Cardiomegaly (ortholog); Cardiotoxicity (ortholog); FOUND IN chromatin (ortholog); endoplasmic reticulum (ortholog); nucleolus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: NAD-dependent protein deacetylase sirtuin-6; NAD-dependent protein deacylase sirtuin-6
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2208,570,110 - 8,578,621 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1197,800,265 - 7,808,774 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0193,196,092 - 3,204,602 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1194,146,057 - 4,154,132 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl194,146,057 - 4,154,126 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
base-excision repair  (ISO)
cardiac muscle cell differentiation  (ISO)
cellular response to angiotensin  (ISO)
cellular response to endothelin  (ISO)
cellular response to hydrogen peroxide  (ISO)
chromatin remodeling  (IEA)
circadian regulation of gene expression  (ISO)
determination of adult lifespan  (IEA)
DNA repair-dependent chromatin remodeling  (ISO)
double-strand break repair  (IEA)
glucose homeostasis  (ISO)
ketone biosynthetic process  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of cellular senescence  (IEA)
negative regulation of D-glucose import  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of gene expression, epigenetic  (IEA)
negative regulation of gluconeogenesis  (IEA)
negative regulation of glycolytic process  (IEA)
negative regulation of protein import into nucleus  (ISO)
negative regulation of protein localization to chromatin  (IEA)
negative regulation of transcription by RNA polymerase II  (IEA)
negative regulation of transcription elongation by RNA polymerase II  (ISO)
pericentric heterochromatin formation  (IEA)
positive regulation of blood vessel branching  (IEA)
positive regulation of chondrocyte proliferation  (IEA)
positive regulation of cold-induced thermogenesis  (ISO)
positive regulation of double-strand break repair  (IEA)
positive regulation of fat cell differentiation  (ISO)
positive regulation of fibroblast proliferation  (ISO)
positive regulation of insulin secretion  (ISO)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (IEA)
positive regulation of protein export from nucleus  (IEA)
positive regulation of protein localization to chromatin  (ISO)
positive regulation of stem cell differentiation  (IEA)
positive regulation of stem cell population maintenance  (IEA)
positive regulation of stem cell proliferation  (ISO)
positive regulation of telomere maintenance  (IEA)
positive regulation of vascular endothelial cell proliferation  (IEA)
post-embryonic cardiac muscle cell growth involved in heart morphogenesis  (ISO)
post-translational protein modification  (IEA)
protein deacetylation  (ISO)
protein delipidation  (ISO)
protein destabilization  (IEA)
protein import into nucleus  (IEA)
protein localization to site of double-strand break  (IEA)
regulation of circadian rhythm  (ISO)
regulation of double-strand break repair via homologous recombination  (IEA)
regulation of lipid catabolic process  (ISO)
regulation of lipid metabolic process  (ISO)
regulation of protein localization to plasma membrane  (IEA)
regulation of protein secretion  (IEA)
response to nutrient levels  (ISO)
response to UV  (IEA)
subtelomeric heterochromatin formation  (IEA)
transposable element silencing  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SIRT6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2208,570,110 - 8,578,621 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1197,800,265 - 7,808,774 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0193,196,092 - 3,204,602 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1194,146,057 - 4,154,132 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl194,146,057 - 4,154,126 (-)Ensemblpanpan1.1panPan2
SIRT6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38194,174,109 - 4,182,563 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl194,174,109 - 4,182,566 (-)EnsemblGRCh38hg38GRCh38
GRCh37194,174,106 - 4,182,560 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36194,125,106 - 4,133,596 (-)NCBINCBI36Build 36hg18NCBI36
Build 34194,125,105 - 4,133,596NCBI
Celera194,113,565 - 4,122,051 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef193,937,486 - 3,945,942 (-)NCBIHuRef
CHM1_1194,173,652 - 4,182,142 (-)NCBICHM1_1
T2T-CHM13v2.0194,157,416 - 4,165,866 (-)NCBIT2T-CHM13v2.0
Sirt6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391081,457,621 - 81,463,631 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1081,457,619 - 81,463,631 (-)EnsemblGRCm39 Ensembl
GRCm381081,621,787 - 81,627,792 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1081,621,785 - 81,627,797 (-)EnsemblGRCm38mm10GRCm38
MGSCv371081,084,531 - 81,090,353 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361081,024,916 - 81,030,687 (-)NCBIMGSCv36mm8
Celera1082,644,967 - 82,650,787 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Sirt6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr878,733,056 - 8,738,543 (+)NCBIGRCr8
mRatBN7.278,082,312 - 8,087,776 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl78,082,364 - 8,098,914 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx710,968,768 - 10,974,195 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0712,844,434 - 12,849,861 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0710,711,823 - 10,717,248 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0710,937,622 - 10,943,048 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl710,937,599 - 10,943,063 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0711,106,748 - 11,112,174 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.479,555,269 - 9,560,695 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.179,555,269 - 9,560,695 (+)NCBI
Celera76,273,425 - 6,278,851 (+)NCBICelera
Cytogenetic Map7q11NCBI
Sirt6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554954,644,023 - 4,650,083 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554954,641,883 - 4,650,518 (+)NCBIChiLan1.0ChiLan1.0
SIRT6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12055,412,989 - 55,424,944 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2055,412,646 - 55,424,944 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2055,140,555 - 55,152,607 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02056,071,820 - 56,083,846 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2056,072,611 - 56,083,837 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12055,131,653 - 55,143,673 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02055,612,837 - 55,624,841 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02055,811,751 - 55,823,816 (+)NCBIUU_Cfam_GSD_1.0
Sirt6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118215,440,673 - 215,447,621 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365882,386,977 - 2,394,096 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365882,387,162 - 2,394,066 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SIRT6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl274,568,493 - 74,577,772 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1274,568,539 - 74,577,774 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2275,063,186 - 75,071,642 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SIRT6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.163,924,230 - 3,932,583 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl63,924,230 - 3,932,590 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660814,286,733 - 4,295,705 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sirt6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248285,442,057 - 5,451,520 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248285,441,973 - 5,449,549 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000045221   ⟹   ENSPPAP00000022411
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl194,146,057 - 4,154,126 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000045227   ⟹   ENSPPAP00000022417
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl194,146,565 - 4,154,067 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000045232   ⟹   ENSPPAP00000022422
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl194,146,846 - 4,154,067 (-)Ensembl
RefSeq Acc Id: XM_003819271   ⟹   XP_003819319
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2208,570,110 - 8,578,621 (-)NCBI
NHGRI_mPanPan1197,800,265 - 7,808,774 (-)NCBI
Mhudiblu_PPA_v0193,196,092 - 3,204,602 (-)NCBI
PanPan1.1194,146,057 - 4,154,126 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008972625   ⟹   XP_008970873
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2208,570,110 - 8,578,621 (-)NCBI
NHGRI_mPanPan1197,800,265 - 7,808,774 (-)NCBI
Mhudiblu_PPA_v0193,196,092 - 3,204,602 (-)NCBI
PanPan1.1194,146,057 - 4,154,126 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024926726   ⟹   XP_024782494
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2208,570,110 - 8,578,609 (-)NCBI
NHGRI_mPanPan1197,800,265 - 7,808,762 (-)NCBI
Mhudiblu_PPA_v0193,196,092 - 3,204,590 (-)NCBI
PanPan1.1194,146,057 - 4,154,132 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024926727   ⟹   XP_024782495
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2208,570,110 - 8,578,611 (-)NCBI
NHGRI_mPanPan1197,800,265 - 7,808,774 (-)NCBI
Mhudiblu_PPA_v0193,196,092 - 3,204,602 (-)NCBI
PanPan1.1194,146,057 - 4,154,126 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024926728   ⟹   XP_024782496
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2208,570,110 - 8,578,621 (-)NCBI
NHGRI_mPanPan1197,800,265 - 7,808,746 (-)NCBI
Mhudiblu_PPA_v0193,196,092 - 3,204,602 (-)NCBI
PanPan1.1194,146,057 - 4,154,126 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034946767   ⟹   XP_034802658
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2208,570,110 - 8,578,611 (-)NCBI
NHGRI_mPanPan1197,800,265 - 7,808,774 (-)NCBI
Mhudiblu_PPA_v0193,196,092 - 3,204,602 (-)NCBI
RefSeq Acc Id: XP_003819319   ⟸   XM_003819271
- Peptide Label: isoform X1
- UniProtKB: A0A2R9B4Q4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008970873   ⟸   XM_008972625
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_024782494   ⟸   XM_024926726
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_024782496   ⟸   XM_024926728
- Peptide Label: isoform X6
- UniProtKB: A0A2R9B2P3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_024782495   ⟸   XM_024926727
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_034802658   ⟸   XM_034946767
- Peptide Label: isoform X3
Ensembl Acc Id: ENSPPAP00000022417   ⟸   ENSPPAT00000045227
Ensembl Acc Id: ENSPPAP00000022411   ⟸   ENSPPAT00000045221
Ensembl Acc Id: ENSPPAP00000022422   ⟸   ENSPPAT00000045232
Protein Domains
Deacetylase sirtuin-type


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000034387 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000045221.1 UniProtKB/TrEMBL
  ENSPPAT00000045227.1 UniProtKB/TrEMBL
  ENSPPAT00000045232.1 UniProtKB/TrEMBL
Gene3D-CATH 2.20.28.200 UniProtKB/TrEMBL
  TPP-binding domain UniProtKB/TrEMBL
InterPro DHS-like_NAD/FAD-binding_dom UniProtKB/TrEMBL
  NAD-dep_sirtuin_deacylases UniProtKB/TrEMBL
  Sirtuin UniProtKB/TrEMBL
  Ssirtuin_cat_dom UniProtKB/TrEMBL
KEGG Report pps:100995305 UniProtKB/TrEMBL
NCBI Gene SIRT6 ENTREZGENE
PANTHER NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED UniProtKB/TrEMBL
  NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-6 UniProtKB/TrEMBL
Pfam SIR2 UniProtKB/TrEMBL
PROSITE SIRTUIN UniProtKB/TrEMBL
Superfamily-SCOP SSF52467 UniProtKB/TrEMBL
UniProt A0A2R9B2N8_PANPA UniProtKB/TrEMBL
  A0A2R9B2P3 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9B4Q4 ENTREZGENE, UniProtKB/TrEMBL