SIRT6 (sirtuin 6) - Rat Genome Database

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Gene: SIRT6 (sirtuin 6) Homo sapiens
Analyze
Symbol: SIRT6
Name: sirtuin 6
RGD ID: 1313110
HGNC Page HGNC:14934
Description: Enables several functions, including acyltransferase activity, transferring groups other than amino-acyl groups; histone H3K deacetylase activity; and nucleic acid binding activity. Involved in several processes, including constitutive heterochromatin formation; regulation of primary metabolic process; and regulation of protein localization. Located in chromosome, subtelomeric region and nucleoplasm. Is active in chromosome; endoplasmic reticulum; and nucleus.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: hSIRT6; NAD-dependent deacetylase sirtuin-6; NAD-dependent protein deacetylase sirtuin-6; NAD-dependent protein deacylase sirtuin-6; regulatory protein SIR2 homolog 6; SIR2-like protein 6; sir2-related protein type 6; SIR2L6; sirtuin; sirtuin type 6
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38194,174,109 - 4,182,563 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl194,174,109 - 4,182,566 (-)EnsemblGRCh38hg38GRCh38
GRCh37194,174,106 - 4,182,560 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36194,125,106 - 4,133,596 (-)NCBINCBI36Build 36hg18NCBI36
Build 34194,125,105 - 4,133,596NCBI
Celera194,113,565 - 4,122,051 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef193,937,486 - 3,945,942 (-)NCBIHuRef
CHM1_1194,173,652 - 4,182,142 (-)NCBICHM1_1
T2T-CHM13v2.0194,157,416 - 4,165,866 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
base-excision repair  (IEA)
cardiac muscle cell differentiation  (IEA,ISS)
cellular response to angiotensin  (ISO)
cellular response to endothelin  (ISO)
cellular response to hydrogen peroxide  (ISO)
chromatin organization  (IEA)
chromatin remodeling  (IDA)
circadian regulation of gene expression  (IEA,ISS)
determination of adult lifespan  (IEA,IMP)
DNA repair  (IEA)
DNA repair-dependent chromatin remodeling  (IEA)
double-strand break repair  (IDA)
glucose homeostasis  (IEA)
ketone biosynthetic process  (IEA,ISS)
negative regulation of cell population proliferation  (IEA)
negative regulation of cellular senescence  (IDA,IMP)
negative regulation of D-glucose import  (IEA)
negative regulation of DNA-templated transcription  (IEA)
negative regulation of gene expression, epigenetic  (IMP)
negative regulation of gluconeogenesis  (IDA)
negative regulation of glycolytic process  (IDA,IEA)
negative regulation of protein import into nucleus  (IEA,ISS)
negative regulation of protein localization to chromatin  (IDA)
negative regulation of transcription by RNA polymerase II  (IBA,IDA,IEA,ISS)
negative regulation of transcription elongation by RNA polymerase II  (IEA,ISS)
pericentric heterochromatin formation  (IDA)
positive regulation of blood vessel branching  (IMP)
positive regulation of chondrocyte proliferation  (IMP)
positive regulation of cold-induced thermogenesis  (IEA,ISS)
positive regulation of double-strand break repair  (IDA,IEA)
positive regulation of fat cell differentiation  (IEA,ISS)
positive regulation of fibroblast proliferation  (IEA)
positive regulation of insulin secretion  (IEA,ISS)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (IMP)
positive regulation of protein export from nucleus  (IDA,IEA)
positive regulation of protein localization to chromatin  (IEA,ISS)
positive regulation of stem cell differentiation  (IDA,IEA,ISS)
positive regulation of stem cell population maintenance  (IDA)
positive regulation of stem cell proliferation  (IEA)
positive regulation of telomere maintenance  (IMP)
positive regulation of vascular endothelial cell proliferation  (IMP)
post-embryonic cardiac muscle cell growth involved in heart morphogenesis  (ISO)
post-translational protein modification  (IEA)
protein deacetylation  (IMP)
protein delipidation  (IDA)
protein destabilization  (IDA,IEA,IMP)
protein import into nucleus  (IDA,IMP)
protein localization to site of double-strand break  (IDA)
regulation of circadian rhythm  (IEA,ISS)
regulation of double-strand break repair via homologous recombination  (IDA)
regulation of lipid catabolic process  (IEA,ISS)
regulation of lipid metabolic process  (IEA,ISS)
regulation of protein localization to plasma membrane  (IDA)
regulation of protein secretion  (IDA)
response to nutrient levels  (ISO)
response to UV  (IDA)
subtelomeric heterochromatin formation  (IMP)
transposable element silencing  (IEA,ISS)

Cellular Component

Molecular Function
acyltransferase activity  (IEA)
chromatin binding  (IDA,IEA,IMP)
chromatin DNA binding  (IDA)
damaged DNA binding  (IDA)
DNA binding  (IEA,IMP)
DNA damage sensor activity  (IDA)
enzyme regulator activity  (IDA)
glycosyltransferase activity  (IEA)
histone deacetylase activity, NAD-dependent  (IDA,ISS)
histone deacetylase regulator activity  (IDA)
histone H3K14 deacetylase activity, NAD-dependent  (IEA)
histone H3K18 deacetylase activity, NAD-dependent  (IDA,IEA)
histone H3K4 deacetylase activity, NAD-dependent  (IEA)
histone H3K56 deacetylase activity, NAD-dependent  (IDA,IEA)
histone H3K9 deacetylase activity, hydrolytic mechanism  (EXP)
histone H3K9 deacetylase activity, NAD-dependent  (IBA,IDA,IEA,IMP)
histone H4K16 deacetylase activity, NAD-dependent  (IEA)
lncRNA binding  (IDA)
metal ion binding  (IEA)
NAD+ binding  (IBA,IEA,ISS)
NAD+-protein ADP-ribosyltransferase activity  (IDA,IEA,TAS)
NAD+-protein poly-ADP-ribosyltransferase activity  (TAS)
NAD+-protein-arginine ADP-ribosyltransferase activity  (IEA,ISS)
NAD+-protein-lysine ADP-ribosyltransferase activity  (IEA)
NAD-dependent protein demyristoylase activity  (IDA,IEA)
NAD-dependent protein depalmitoylase activity  (IDA,IEA,IMP)
NAD-dependent protein lysine deacetylase activity  (IDA,IEA,TAS)
nucleosome binding  (IDA,IMP)
nucleotidyltransferase activity  (IEA)
protein binding  (IPI,ISO)
protein homodimerization activity  (IDA)
protein lysine deacetylase activity  (ISO)
RNA binding  (IEA)
TORC2 complex binding  (IEA,ISS)
transcription corepressor activity  (IBA,IEA)
transferase activity  (IEA)
zinc ion binding  (ISS)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Endothelial SIRT6 Is Vital to Prevent Hypertension and Associated Cardiorenal Injury Through Targeting Nkx3.2-GATA5 Signaling. Guo J, etal., Circ Res. 2019 May 10;124(10):1448-1461. doi: 10.1161/CIRCRESAHA.118.314032.
2. Decreased expression of sirtuin 6 is associated with release of high mobility group box-1 after cerebral ischemia. Lee OH, etal., Biochem Biophys Res Commun. 2013 Aug 23;438(2):388-94. doi: 10.1016/j.bbrc.2013.07.085. Epub 2013 Jul 27.
3. Physical and functional HAT/HDAC interplay regulates protein acetylation balance. Peserico A and Simone C, J Biomed Biotechnol. 2011;2011:371832. doi: 10.1155/2011/371832. Epub 2010 Dec 5.
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. NAD(+) in aging, metabolism, and neurodegeneration. Verdin E Science. 2015 Dec 4;350(6265):1208-13. doi: 10.1126/science.aac4854.
7. Obesity accelerates ovarian follicle development and follicle loss in rats. Wang N, etal., Metabolism. 2014 Jan;63(1):94-103. doi: 10.1016/j.metabol.2013.09.001. Epub 2013 Oct 14.
8. Activation of peroxisome proliferator-activated receptor gamma by rosiglitazone increases sirt6 expression and ameliorates hepatic steatosis in rats. Yang SJ, etal., PLoS One. 2011 Feb 23;6(2):e17057.
9. Sirtuin 6 protects cardiomyocytes from hypertrophy in vitro via inhibition of NF-kappaB-dependent transcriptional activity. Yu SS, etal., Br J Pharmacol. 2013 Jan;168(1):117-28. doi: 10.1111/j.1476-5381.2012.01903.x.
Additional References at PubMed
PMID:8125298   PMID:10873683   PMID:12477932   PMID:14702039   PMID:15057824   PMID:15146197   PMID:15489334   PMID:15719057   PMID:16079181   PMID:16169070   PMID:16189514   PMID:17131381  
PMID:17456799   PMID:18242175   PMID:18337721   PMID:18388907   PMID:19109893   PMID:19135889   PMID:19625767   PMID:20117128   PMID:20157594   PMID:20375098   PMID:21224216   PMID:21349544  
PMID:21362626   PMID:21502801   PMID:21680843   PMID:21847107   PMID:21873635   PMID:21900206   PMID:21900744   PMID:21981042   PMID:22087257   PMID:22700961   PMID:22743824   PMID:22753495  
PMID:22770219   PMID:22792191   PMID:22939629   PMID:23041974   PMID:23075334   PMID:23086953   PMID:23132960   PMID:23136298   PMID:23142079   PMID:23201774   PMID:23217706   PMID:23240041  
PMID:23514751   PMID:23526469   PMID:23552949   PMID:23653361   PMID:23860128   PMID:23892288   PMID:23911928   PMID:23928404   PMID:23982738   PMID:24043303   PMID:24052263   PMID:24163442  
PMID:24169447   PMID:24171769   PMID:24366394   PMID:24367027   PMID:24438746   PMID:24607900   PMID:24638860   PMID:24782448   PMID:24842653   PMID:25009184   PMID:25074979   PMID:25083875  
PMID:25162034   PMID:25175731   PMID:25181338   PMID:25197348   PMID:25227832   PMID:25304127   PMID:25320180   PMID:25325735   PMID:25361925   PMID:25400728   PMID:25503141   PMID:25541994  
PMID:25607651   PMID:25660418   PMID:25683165   PMID:25713071   PMID:25777360   PMID:25807436   PMID:25808624   PMID:25816777   PMID:25819580   PMID:26063178   PMID:26114387   PMID:26180037  
PMID:26183563   PMID:26186194   PMID:26332421   PMID:26456828   PMID:26496610   PMID:26549451   PMID:26639398   PMID:26648570   PMID:26657850   PMID:26675349   PMID:26701732   PMID:26711340  
PMID:26768768   PMID:26787900   PMID:26802595   PMID:26803106   PMID:26861461   PMID:26886147   PMID:26898756   PMID:26983852   PMID:26987016   PMID:27041572   PMID:27043296   PMID:27101740  
PMID:27118880   PMID:27156849   PMID:27180906   PMID:27249230   PMID:27322069   PMID:27457971   PMID:27496874   PMID:27534902   PMID:27536992   PMID:27568560   PMID:27746184   PMID:27766571  
PMID:27777384   PMID:27794562   PMID:27824900   PMID:27912097   PMID:27923994   PMID:28196907   PMID:28215636   PMID:28215707   PMID:28228253   PMID:28238784   PMID:28250020   PMID:28296196  
PMID:28355558   PMID:28393212   PMID:28399814   PMID:28406396   PMID:28443459   PMID:28478957   PMID:28514442   PMID:28653878   PMID:28656307   PMID:28661724   PMID:28677777   PMID:28685526  
PMID:28723567   PMID:28786706   PMID:28871079   PMID:28887543   PMID:28921546   PMID:28935467   PMID:28983623   PMID:29025907   PMID:29197589   PMID:29215322   PMID:29217762   PMID:29227545  
PMID:29233643   PMID:29317652   PMID:29352194   PMID:29363378   PMID:29387864   PMID:29465379   PMID:29474172   PMID:29476161   PMID:29555651   PMID:29599436   PMID:29659670   PMID:29686974  
PMID:29698567   PMID:29957460   PMID:29966233   PMID:30032073   PMID:30230565   PMID:30250025   PMID:30256390   PMID:30374165   PMID:30402853   PMID:30409187   PMID:30419336   PMID:30429089  
PMID:30483801   PMID:30514106   PMID:30542728   PMID:30587342   PMID:30641770   PMID:30651359   PMID:30700227   PMID:30787391   PMID:30858544   PMID:30987683   PMID:30989475   PMID:31004738  
PMID:31113929   PMID:31149050   PMID:31257493   PMID:31265839   PMID:31295533   PMID:31321952   PMID:31399344   PMID:31437090   PMID:31442424   PMID:31477582   PMID:31541078   PMID:31551254  
PMID:31591350   PMID:31603249   PMID:31626739   PMID:31696978   PMID:31759967   PMID:31842909   PMID:31965997   PMID:31970415   PMID:31972266   PMID:31995034   PMID:32002721   PMID:32124950  
PMID:32236974   PMID:32305562   PMID:32329825   PMID:32360514   PMID:32416067   PMID:32460013   PMID:32483423   PMID:32538779   PMID:32573339   PMID:32619399   PMID:32621766   PMID:32642006  
PMID:32649901   PMID:32681437   PMID:32711549   PMID:32789493   PMID:33067423   PMID:33087267   PMID:33098511   PMID:33123950   PMID:33143333   PMID:33171439   PMID:33238266   PMID:33251641  
PMID:33282964   PMID:33308014   PMID:33325563   PMID:33436551   PMID:33464650   PMID:33568575   PMID:33600943   PMID:33631165   PMID:33742100   PMID:33903120   PMID:33961781   PMID:33993657  
PMID:34021216   PMID:34033225   PMID:34051221   PMID:34073604   PMID:34077730   PMID:34148121   PMID:34240732   PMID:34244565   PMID:34348649   PMID:34359939   PMID:34530350   PMID:34535875  
PMID:34573442   PMID:34731617   PMID:34750509   PMID:34787870   PMID:34793336   PMID:34927546   PMID:34950960   PMID:35167876   PMID:35195783   PMID:35224092   PMID:35235147   PMID:35249460  
PMID:35443857   PMID:35686673   PMID:35840633   PMID:35842903   PMID:35896220   PMID:35915188   PMID:35944360   PMID:36172813   PMID:36215696   PMID:36252808   PMID:36278398   PMID:36301499  
PMID:36327468   PMID:36367517   PMID:36396113   PMID:36443316   PMID:36496445   PMID:36534275   PMID:36593966   PMID:36607699   PMID:36631993   PMID:36720357   PMID:36813148   PMID:36831330  
PMID:36880305   PMID:36924820   PMID:37023208   PMID:37047732   PMID:37058572   PMID:37099691   PMID:37134154   PMID:37298604   PMID:37343371   PMID:37394473   PMID:37499928   PMID:37544377  
PMID:37566087   PMID:37566546   PMID:37626845   PMID:37754211   PMID:37819455   PMID:37851128   PMID:37860888   PMID:37876546   PMID:37897855   PMID:37914087   PMID:38016337   PMID:38078876  
PMID:38081972   PMID:38135684   PMID:38154209   PMID:38222451   PMID:38389322   PMID:38415718   PMID:38430021   PMID:38490134   PMID:38548549   PMID:38649362   PMID:38749754   PMID:38789630  
PMID:38819446   PMID:38904337   PMID:38967361   PMID:38986922   PMID:39033117   PMID:39183280   PMID:39259343  


Genomics

Comparative Map Data
SIRT6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38194,174,109 - 4,182,563 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl194,174,109 - 4,182,566 (-)EnsemblGRCh38hg38GRCh38
GRCh37194,174,106 - 4,182,560 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36194,125,106 - 4,133,596 (-)NCBINCBI36Build 36hg18NCBI36
Build 34194,125,105 - 4,133,596NCBI
Celera194,113,565 - 4,122,051 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef193,937,486 - 3,945,942 (-)NCBIHuRef
CHM1_1194,173,652 - 4,182,142 (-)NCBICHM1_1
T2T-CHM13v2.0194,157,416 - 4,165,866 (-)NCBIT2T-CHM13v2.0
Sirt6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391081,457,621 - 81,463,631 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1081,457,619 - 81,463,631 (-)EnsemblGRCm39 Ensembl
GRCm381081,621,787 - 81,627,792 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1081,621,785 - 81,627,797 (-)EnsemblGRCm38mm10GRCm38
MGSCv371081,084,531 - 81,090,353 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361081,024,916 - 81,030,687 (-)NCBIMGSCv36mm8
Celera1082,644,967 - 82,650,787 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Sirt6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr878,733,056 - 8,738,543 (+)NCBIGRCr8
mRatBN7.278,082,312 - 8,087,776 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl78,082,364 - 8,098,914 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx710,968,768 - 10,974,195 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0712,844,434 - 12,849,861 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0710,711,823 - 10,717,248 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0710,937,622 - 10,943,048 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl710,937,599 - 10,943,063 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0711,106,748 - 11,112,174 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.479,555,269 - 9,560,695 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.179,555,269 - 9,560,695 (+)NCBI
Celera76,273,425 - 6,278,851 (+)NCBICelera
Cytogenetic Map7q11NCBI
Sirt6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554954,644,023 - 4,650,083 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554954,641,883 - 4,650,518 (+)NCBIChiLan1.0ChiLan1.0
SIRT6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2208,570,110 - 8,578,621 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1197,800,265 - 7,808,774 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0193,196,092 - 3,204,602 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1194,146,057 - 4,154,132 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl194,146,057 - 4,154,126 (-)Ensemblpanpan1.1panPan2
SIRT6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12055,412,989 - 55,424,944 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2055,412,646 - 55,424,944 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2055,140,555 - 55,152,607 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02056,071,820 - 56,083,846 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2056,072,611 - 56,083,837 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12055,131,653 - 55,143,673 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02055,612,837 - 55,624,841 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02055,811,751 - 55,823,816 (+)NCBIUU_Cfam_GSD_1.0
Sirt6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118215,440,673 - 215,447,621 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365882,386,977 - 2,394,096 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365882,387,162 - 2,394,066 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SIRT6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl274,568,493 - 74,577,772 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1274,568,539 - 74,577,774 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2275,063,186 - 75,071,642 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SIRT6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.163,924,230 - 3,932,583 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl63,924,230 - 3,932,590 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660814,286,733 - 4,295,705 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sirt6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248285,442,057 - 5,451,520 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248285,441,973 - 5,449,549 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SIRT6
41 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 19p13.3-13.2(chr19:1972245-9648879)x3 copy number gain See cases [RCV000052879] Chr19:1972245..9648879 [GRCh38]
Chr19:1972244..9759555 [GRCh37]
Chr19:1923244..9620555 [NCBI36]
Chr19:19p13.3-13.2		 pathogenic
GRCh38/hg38 19p13.3(chr19:4008560-4763159)x3 copy number gain See cases [RCV000052880] Chr19:4008560..4763159 [GRCh38]
Chr19:4008558..4763171 [GRCh37]
Chr19:3959558..4714171 [NCBI36]
Chr19:19p13.3		 pathogenic
GRCh38/hg38 19p13.3-13.2(chr19:4039158-9176125)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052881]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052881]|See cases [RCV000052881] Chr19:4039158..9176125 [GRCh38]
Chr19:4039156..9286801 [GRCh37]
Chr19:3990156..9147801 [NCBI36]
Chr19:19p13.3-13.2		 pathogenic
GRCh38/hg38 19p13.3-13.2(chr19:265917-8564134)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052876]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052876]|See cases [RCV000052876] Chr19:265917..8564134 [GRCh38]
Chr19:265917..8629018 [GRCh37]
Chr19:216917..8535018 [NCBI36]
Chr19:19p13.3-13.2		 pathogenic
GRCh38/hg38 19p13.3(chr19:233565-4699472)x3 copy number gain See cases [RCV000052575] Chr19:233565..4699472 [GRCh38]
Chr19:233565..4699484 [GRCh37]
Chr19:184565..4650484 [NCBI36]
Chr19:19p13.3		 pathogenic
GRCh38/hg38 19p13.3(chr19:3554635-4690965)x1 copy number loss See cases [RCV000053943] Chr19:3554635..4690965 [GRCh38]
Chr19:3554633..4690977 [GRCh37]
Chr19:3505633..4641977 [NCBI36]
Chr19:19p13.3		 pathogenic
GRCh38/hg38 19p13.3(chr19:3947934-5196676)x3 copy number gain See cases [RCV000134164] Chr19:3947934..5196676 [GRCh38]
Chr19:3947932..5196687 [GRCh37]
Chr19:3898932..5147687 [NCBI36]
Chr19:19p13.3		 pathogenic|uncertain significance
GRCh38/hg38 19p13.3(chr19:3338024-4833139)x1 copy number loss See cases [RCV000134482] Chr19:3338024..4833139 [GRCh38]
Chr19:3338022..4833151 [GRCh37]
Chr19:3289022..4784151 [NCBI36]
Chr19:19p13.3		 pathogenic
GRCh38/hg38 19p13.3(chr19:1549144-4288720)x1 copy number loss See cases [RCV000134795] Chr19:1549144..4288720 [GRCh38]
Chr19:1549143..4288717 [GRCh37]
Chr19:1500143..4239717 [NCBI36]
Chr19:19p13.3		 pathogenic
GRCh38/hg38 19p13.3(chr19:3080621-4912622)x3 copy number gain See cases [RCV000137713] Chr19:3080621..4912622 [GRCh38]
Chr19:3080619..4912634 [GRCh37]
Chr19:3031619..4863634 [NCBI36]
Chr19:19p13.3		 likely pathogenic
GRCh38/hg38 19p13.3(chr19:259395-6795611)x3 copy number gain See cases [RCV000142627] Chr19:259395..6795611 [GRCh38]
Chr19:259395..6795622 [GRCh37]
Chr19:210395..6746622 [NCBI36]
Chr19:19p13.3		 pathogenic
GRCh38/hg38 19p13.3(chr19:3788727-5147354)x1 copy number loss See cases [RCV000143614] Chr19:3788727..5147354 [GRCh38]
Chr19:3788725..5147365 [GRCh37]
Chr19:3739725..5098365 [NCBI36]
Chr19:19p13.3		 likely pathogenic
NM_016539.4(SIRT6):c.742C>T (p.Arg248Cys) single nucleotide variant Long QT syndrome [RCV000190172] Chr19:4174943 [GRCh38]
Chr19:4174940 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_016539.4(SIRT6):c.29C>A (p.Ser10Ter) single nucleotide variant not provided [RCV000731233] Chr19:4182511 [GRCh38]
Chr19:4182508 [GRCh37]
Chr19:19p13.3		 uncertain significance
GRCh37/hg19 19p13.3(chr19:4153714-4179574)x1 copy number loss See cases [RCV000448007] Chr19:4153714..4179574 [GRCh37]
Chr19:19p13.3		 uncertain significance
GRCh37/hg19 19p13.3(chr19:2652901-4342179)x3 copy number gain See cases [RCV000448078] Chr19:2652901..4342179 [GRCh37]
Chr19:19p13.3		 uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888) copy number gain See cases [RCV000512296] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
NM_016539.4(SIRT6):c.791G>A (p.Arg264Gln) single nucleotide variant not specified [RCV004321584] Chr19:4174894 [GRCh38]
Chr19:4174891 [GRCh37]
Chr19:19p13.3		 uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888)x3 copy number gain See cases [RCV000511289] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic|uncertain significance
GRCh37/hg19 19p13.3-13.2(chr19:3120160-9732820)x3 copy number gain not provided [RCV000684096] Chr19:3120160..9732820 [GRCh37]
Chr19:19p13.3-13.2		 pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-59097160)x3 copy number gain not provided [RCV000752444] Chr19:260912..59097160 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
Single allele duplication Primary amenorrhea [RCV000754469] Chr19:3718839..4604407 [GRCh37]
Chr19:19p13.3		 uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:68029-59110290)x3 copy number gain not provided [RCV000752439] Chr19:68029..59110290 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
NM_016539.4(SIRT6):c.882C>T (p.Thr294=) single nucleotide variant not provided [RCV000921646] Chr19:4174803 [GRCh38]
Chr19:4174800 [GRCh37]
Chr19:19p13.3		 likely benign
GRCh37/hg19 19p13.3(chr19:3076808-4796782) copy number loss not provided [RCV000767742] Chr19:3076808..4796782 [GRCh37]
Chr19:19p13.3		 pathogenic
NM_016539.4(SIRT6):c.264C>T (p.Ser88=) single nucleotide variant not provided [RCV000898502] Chr19:4179217 [GRCh38]
Chr19:4179214 [GRCh37]
Chr19:19p13.3		 likely benign
NM_016539.4(SIRT6):c.444C>T (p.Tyr148=) single nucleotide variant not provided [RCV000919342] Chr19:4175931 [GRCh38]
Chr19:4175928 [GRCh37]
Chr19:19p13.3		 likely benign
NM_016539.4(SIRT6):c.924C>G (p.Asn308Lys) single nucleotide variant not provided [RCV000973161] Chr19:4174761 [GRCh38]
Chr19:4174758 [GRCh37]
Chr19:19p13.3		 likely benign
GRCh37/hg19 19p13.3(chr19:260911-4788357)x3 copy number gain not provided [RCV000846988] Chr19:260911..4788357 [GRCh37]
Chr19:19p13.3		 pathogenic
GRCh37/hg19 19p13.3(chr19:260912-4384674)x3 copy number gain See cases [RCV001007443] Chr19:260912..4384674 [GRCh37]
Chr19:19p13.3		 pathogenic
NC_000019.9:g.(?_589946)_(4818389_?)dup duplication not provided [RCV003105391] Chr19:589946..4818389 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_016539.4(SIRT6):c.1003C>T (p.Arg335Trp) single nucleotide variant not specified [RCV004319362] Chr19:4174682 [GRCh38]
Chr19:4174679 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_016539.4(SIRT6):c.937G>T (p.Ala313Ser) single nucleotide variant not provided [RCV000973160] Chr19:4174748 [GRCh38]
Chr19:4174745 [GRCh37]
Chr19:19p13.3		 likely benign
NM_016539.4(SIRT6):c.823G>A (p.Ala275Thr) single nucleotide variant not provided [RCV000957840] Chr19:4174862 [GRCh38]
Chr19:4174859 [GRCh37]
Chr19:19p13.3		 benign
NM_016539.4(SIRT6):c.739-7T>C single nucleotide variant not provided [RCV001615544] Chr19:4174953 [GRCh38]
Chr19:4174950 [GRCh37]
Chr19:19p13.3		 benign
GRCh37/hg19 19p13.3(chr19:3976203-4345430) copy number loss Obesity [RCV001352661] Chr19:3976203..4345430 [GRCh37]
Chr19:19p13.3		 pathogenic
NM_016539.4(SIRT6):c.362G>A (p.Arg121His) single nucleotide variant Premature ovarian failure [RCV001270238] Chr19:4179119 [GRCh38]
Chr19:4179116 [GRCh37]
Chr19:19p13.3		 likely pathogenic
GRCh37/hg19 19p13.3(chr19:3501624-5357124)x1 copy number loss not provided [RCV001834187] Chr19:3501624..5357124 [GRCh37]
Chr19:19p13.3		 pathogenic
NM_016539.4(SIRT6):c.615-8G>A single nucleotide variant Syndromic complex neurodevelopmental disorder [RCV004801975] Chr19:4175159 [GRCh38]
Chr19:4175156 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_016539.4(SIRT6):c.701G>A (p.Gly234Asp) single nucleotide variant Syndromic complex neurodevelopmental disorder [RCV004801974] Chr19:4175065 [GRCh38]
Chr19:4175062 [GRCh37]
Chr19:19p13.3		 uncertain significance
GRCh37/hg19 19p13.3(chr19:3788725-4225547)x1 copy number loss not provided [RCV001827741] Chr19:3788725..4225547 [GRCh37]
Chr19:19p13.3		 uncertain significance
NC_000019.9:g.(?_589946)_(5696788_?)dup duplication not provided [RCV003113597] Chr19:589946..5696788 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_016539.4(SIRT6):c.937G>A (p.Ala313Thr) single nucleotide variant not specified [RCV004161918] Chr19:4174748 [GRCh38]
Chr19:4174745 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_016539.4(SIRT6):c.961G>A (p.Ala321Thr) single nucleotide variant not specified [RCV004129743] Chr19:4174724 [GRCh38]
Chr19:4174721 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_016539.4(SIRT6):c.863C>A (p.Pro288His) single nucleotide variant not specified [RCV004130959] Chr19:4174822 [GRCh38]
Chr19:4174819 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_016539.4(SIRT6):c.715G>A (p.Val239Ile) single nucleotide variant not specified [RCV004239919] Chr19:4175051 [GRCh38]
Chr19:4175048 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_016539.4(SIRT6):c.985G>A (p.Ala329Thr) single nucleotide variant not specified [RCV004227475] Chr19:4174700 [GRCh38]
Chr19:4174697 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_016539.4(SIRT6):c.871C>T (p.Arg291Cys) single nucleotide variant not specified [RCV004184281] Chr19:4174814 [GRCh38]
Chr19:4174811 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_016539.4(SIRT6):c.258T>G (p.Phe86Leu) single nucleotide variant not specified [RCV004093333] Chr19:4179223 [GRCh38]
Chr19:4179220 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_016539.4(SIRT6):c.703C>T (p.Arg235Cys) single nucleotide variant not specified [RCV004115557] Chr19:4175063 [GRCh38]
Chr19:4175060 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_016539.4(SIRT6):c.872G>A (p.Arg291His) single nucleotide variant not specified [RCV004148581] Chr19:4174813 [GRCh38]
Chr19:4174810 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_016539.4(SIRT6):c.960C>G (p.Cys320Trp) single nucleotide variant not specified [RCV004113976] Chr19:4174725 [GRCh38]
Chr19:4174722 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_016539.4(SIRT6):c.659G>A (p.Arg220Gln) single nucleotide variant not specified [RCV004207909] Chr19:4175107 [GRCh38]
Chr19:4175104 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_016539.4(SIRT6):c.955C>A (p.Pro319Thr) single nucleotide variant not specified [RCV004122115] Chr19:4174730 [GRCh38]
Chr19:4174727 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_016539.4(SIRT6):c.445G>A (p.Val149Ile) single nucleotide variant not specified [RCV004083004] Chr19:4175930 [GRCh38]
Chr19:4175927 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_016539.4(SIRT6):c.998G>A (p.Arg333Gln) single nucleotide variant not specified [RCV004122601] Chr19:4174687 [GRCh38]
Chr19:4174684 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_016539.4(SIRT6):c.268C>T (p.Arg90Trp) single nucleotide variant not specified [RCV004221427] Chr19:4179213 [GRCh38]
Chr19:4179210 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_016539.4(SIRT6):c.290C>T (p.Ala97Val) single nucleotide variant not specified [RCV004309065] Chr19:4179191 [GRCh38]
Chr19:4179188 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_016539.4(SIRT6):c.778G>A (p.Glu260Lys) single nucleotide variant not specified [RCV004333938] Chr19:4174907 [GRCh38]
Chr19:4174904 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_016539.4(SIRT6):c.785T>A (p.Met262Lys) single nucleotide variant not specified [RCV004359849] Chr19:4174900 [GRCh38]
Chr19:4174897 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_016539.4(SIRT6):c.601G>A (p.Asp201Asn) single nucleotide variant not specified [RCV004341650] Chr19:4175693 [GRCh38]
Chr19:4175690 [GRCh37]
Chr19:19p13.3		 uncertain significance
GRCh37/hg19 19p13.3-13.2(chr19:260912-7246777)x3 copy number gain not provided [RCV003485190] Chr19:260912..7246777 [GRCh37]
Chr19:19p13.3-13.2		 pathogenic
NM_016539.4(SIRT6):c.72C>T (p.Phe24=) single nucleotide variant not provided [RCV003421745] Chr19:4180904 [GRCh38]
Chr19:4180901 [GRCh37]
Chr19:19p13.3		 likely benign
GRCh37/hg19 19p13.3(chr19:3788725-4881494)x1 copy number loss not specified [RCV003986118] Chr19:3788725..4881494 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_016539.4(SIRT6):c.704G>A (p.Arg235His) single nucleotide variant not specified [RCV004455948] Chr19:4175062 [GRCh38]
Chr19:4175059 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_016539.4(SIRT6):c.547G>A (p.Asp183Asn) single nucleotide variant not specified [RCV004455947] Chr19:4175747 [GRCh38]
Chr19:4175744 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_016539.4(SIRT6):c.1022C>T (p.Pro341Leu) single nucleotide variant not specified [RCV004455946] Chr19:4174663 [GRCh38]
Chr19:4174660 [GRCh37]
Chr19:19p13.3		 uncertain significance
NC_000019.9:g.(?_3917720)_(4818389_?)dup duplication not provided [RCV004579723] Chr19:3917720..4818389 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_016539.4(SIRT6):c.917G>A (p.Arg306Gln) single nucleotide variant not specified [RCV004669945] Chr19:4174768 [GRCh38]
Chr19:4174765 [GRCh37]
Chr19:19p13.3		 likely benign
NM_016539.4(SIRT6):c.955C>T (p.Pro319Ser) single nucleotide variant not specified [RCV004669946] Chr19:4174730 [GRCh38]
Chr19:4174727 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_016539.4(SIRT6):c.1019C>T (p.Ala340Val) single nucleotide variant not specified [RCV004669948] Chr19:4174666 [GRCh38]
Chr19:4174663 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_016539.4(SIRT6):c.772G>A (p.Val258Ile) single nucleotide variant not specified [RCV004676454] Chr19:4174913 [GRCh38]
Chr19:4174910 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_016539.4(SIRT6):c.1048G>C (p.Ala350Pro) single nucleotide variant not specified [RCV004676455] Chr19:4174637 [GRCh38]
Chr19:4174634 [GRCh37]
Chr19:19p13.3		 uncertain significance
NM_016539.4(SIRT6):c.929C>G (p.Ser310Cys) single nucleotide variant not specified [RCV004676456] Chr19:4174756 [GRCh38]
Chr19:4174753 [GRCh37]
Chr19:19p13.3		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:7548
Count of miRNA genes:918
Interacting mature miRNAs:1129
Transcripts:ENST00000305232, ENST00000337491, ENST00000381935, ENST00000594279, ENST00000594341, ENST00000595670, ENST00000596119, ENST00000596298, ENST00000597896, ENST00000599365, ENST00000599394, ENST00000600540, ENST00000600938, ENST00000601069, ENST00000601488, ENST00000601571
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298499UAE1_HUrinary albumin excretion QTL 1 (human)2.730.0009Urinary albumin excretionurine albumin:creatinine ratio (ACR)19116075902Human
1643451SLIPL6_HSerum lipid level QTL 6 (human)2.190.0008Lipid level19116075902Human
1581534BP76_HBlood pressure QTL 76 (human)20.001Blood pressurepulse pressure19116075902Human
1581535BP65_HBlood pressure QTL 65 (human)3.10.001Blood pressurepulse pressure19116075902Human
2314591INSUL4_HInsulin level QTL 4 (human)3.80.000038Insulin levelfasting19116075902Human
1298476BP3_HBlood pressure QTL 3 (human)2.4Blood pressuresystolic19116075902Human

Markers in Region
RH93156  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37194,174,182 - 4,174,360UniSTSGRCh37
Build 36194,125,182 - 4,125,360RGDNCBI36
Celera194,113,641 - 4,113,819RGD
Cytogenetic Map19p13.3UniSTS
HuRef193,937,562 - 3,937,740UniSTS
GeneMap99-GB4 RH Map1931.19UniSTS
SIRT6_244  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37194,174,068 - 4,174,914UniSTSGRCh37
Build 36194,125,068 - 4,125,914RGDNCBI36
Celera194,113,527 - 4,114,373RGD
HuRef193,937,448 - 3,938,294UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2439 2788 2253 4974 1726 2351 6 624 1950 465 2270 7305 6471 53 3734 1 852 1744 1617 175 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_047153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001193285 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001321058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001321059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001321060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001321061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001321062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001321063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001321064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_016539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024451539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024451540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054321190 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC005620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC006930 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC016586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF233396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK074810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK225567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK293348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK299420 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK301247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK315048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL365375 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL559383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC004218 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC005026 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC028220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE281103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP418952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ060703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN364175 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN364177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR457200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CS330066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000305232   ⟹   ENSP00000305310
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl194,174,109 - 4,182,550 (-)Ensembl
Ensembl Acc Id: ENST00000337491   ⟹   ENSP00000337332
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl194,174,109 - 4,182,563 (-)Ensembl
Ensembl Acc Id: ENST00000594279   ⟹   ENSP00000472023
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl194,174,141 - 4,182,279 (-)Ensembl
Ensembl Acc Id: ENST00000594341
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl194,180,612 - 4,182,546 (-)Ensembl
Ensembl Acc Id: ENST00000595670
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl194,174,704 - 4,182,534 (-)Ensembl
Ensembl Acc Id: ENST00000596119
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl194,174,620 - 4,182,530 (-)Ensembl
Ensembl Acc Id: ENST00000596298
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl194,175,572 - 4,182,534 (-)Ensembl
Ensembl Acc Id: ENST00000597896   ⟹   ENSP00000470215
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl194,174,636 - 4,182,500 (-)Ensembl
Ensembl Acc Id: ENST00000599365   ⟹   ENSP00000473085
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl194,174,109 - 4,182,544 (-)Ensembl
Ensembl Acc Id: ENST00000599394
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl194,175,791 - 4,179,503 (-)Ensembl
Ensembl Acc Id: ENST00000600540
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl194,174,704 - 4,182,565 (-)Ensembl
Ensembl Acc Id: ENST00000600938   ⟹   ENSP00000471123
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl194,174,110 - 4,182,565 (-)Ensembl
Ensembl Acc Id: ENST00000601069
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl194,174,878 - 4,182,566 (-)Ensembl
Ensembl Acc Id: ENST00000601488   ⟹   ENSP00000469001
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl194,174,109 - 4,182,547 (-)Ensembl
Ensembl Acc Id: ENST00000601571   ⟹   ENSP00000471837
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl194,174,861 - 4,182,533 (-)Ensembl
RefSeq Acc Id: NM_001193285   ⟹   NP_001180214
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38194,174,109 - 4,182,563 (-)NCBI
GRCh37194,174,106 - 4,182,596 (-)ENTREZGENE
HuRef193,937,486 - 3,945,942 (-)ENTREZGENE
CHM1_1194,173,652 - 4,182,147 (-)NCBI
T2T-CHM13v2.0194,157,416 - 4,165,866 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001321058   ⟹   NP_001307987
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38194,174,109 - 4,182,563 (-)NCBI
CHM1_1194,173,652 - 4,182,147 (-)NCBI
T2T-CHM13v2.0194,157,416 - 4,165,866 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001321059   ⟹   NP_001307988
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38194,174,109 - 4,182,563 (-)NCBI
CHM1_1194,173,652 - 4,182,147 (-)NCBI
T2T-CHM13v2.0194,157,416 - 4,165,866 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001321060   ⟹   NP_001307989
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38194,174,109 - 4,182,563 (-)NCBI
CHM1_1194,173,652 - 4,182,147 (-)NCBI
T2T-CHM13v2.0194,157,416 - 4,165,866 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001321061   ⟹   NP_001307990
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38194,174,109 - 4,182,563 (-)NCBI
CHM1_1194,173,652 - 4,182,147 (-)NCBI
T2T-CHM13v2.0194,157,416 - 4,165,866 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001321062   ⟹   NP_001307991
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38194,174,109 - 4,182,563 (-)NCBI
CHM1_1194,173,652 - 4,182,147 (-)NCBI
T2T-CHM13v2.0194,157,416 - 4,165,866 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001321063   ⟹   NP_001307992
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38194,174,109 - 4,182,563 (-)NCBI
CHM1_1194,173,652 - 4,182,147 (-)NCBI
T2T-CHM13v2.0194,157,416 - 4,165,866 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001321064   ⟹   NP_001307993
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38194,174,109 - 4,182,306 (-)NCBI
CHM1_1194,173,652 - 4,181,849 (-)NCBI
T2T-CHM13v2.0194,157,416 - 4,165,609 (-)NCBI
Sequence:
RefSeq Acc Id: NM_016539   ⟹   NP_057623
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38194,174,109 - 4,182,563 (-)NCBI
GRCh37194,174,106 - 4,182,596 (-)ENTREZGENE
Build 36194,125,106 - 4,133,596 (-)NCBI Archive
HuRef193,937,486 - 3,945,942 (-)ENTREZGENE
CHM1_1194,173,652 - 4,182,147 (-)NCBI
T2T-CHM13v2.0194,157,416 - 4,165,866 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024451539   ⟹   XP_024307307
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38194,174,109 - 4,180,909 (-)NCBI
Sequence:
RefSeq Acc Id: XM_054321190   ⟹   XP_054177165
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0194,157,416 - 4,164,212 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001180214 (Get FASTA)   NCBI Sequence Viewer  
  NP_001307987 (Get FASTA)   NCBI Sequence Viewer  
  NP_001307988 (Get FASTA)   NCBI Sequence Viewer  
  NP_001307989 (Get FASTA)   NCBI Sequence Viewer  
  NP_001307990 (Get FASTA)   NCBI Sequence Viewer  
  NP_001307991 (Get FASTA)   NCBI Sequence Viewer  
  NP_001307992 (Get FASTA)   NCBI Sequence Viewer  
  NP_001307993 (Get FASTA)   NCBI Sequence Viewer  
  NP_057623 (Get FASTA)   NCBI Sequence Viewer  
  XP_024307307 (Get FASTA)   NCBI Sequence Viewer  
  XP_054177165 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC34468 (Get FASTA)   NCBI Sequence Viewer  
  AAD15478 (Get FASTA)   NCBI Sequence Viewer  
  AAF43432 (Get FASTA)   NCBI Sequence Viewer  
  AAH04218 (Get FASTA)   NCBI Sequence Viewer  
  AAH05026 (Get FASTA)   NCBI Sequence Viewer  
  AAH28220 (Get FASTA)   NCBI Sequence Viewer  
  BAC11222 (Get FASTA)   NCBI Sequence Viewer  
  BAG37527 (Get FASTA)   NCBI Sequence Viewer  
  BAG56864 (Get FASTA)   NCBI Sequence Viewer  
  BAG62814 (Get FASTA)   NCBI Sequence Viewer  
  BAH13027 (Get FASTA)   NCBI Sequence Viewer  
  CAG33481 (Get FASTA)   NCBI Sequence Viewer  
  CAL00161 (Get FASTA)   NCBI Sequence Viewer  
  EAW69251 (Get FASTA)   NCBI Sequence Viewer  
  EAW69252 (Get FASTA)   NCBI Sequence Viewer  
  EAW69253 (Get FASTA)   NCBI Sequence Viewer  
  EAW69254 (Get FASTA)   NCBI Sequence Viewer  
  EAW69255 (Get FASTA)   NCBI Sequence Viewer  
  EAW69256 (Get FASTA)   NCBI Sequence Viewer  
  EAW69257 (Get FASTA)   NCBI Sequence Viewer  
  EAW69258 (Get FASTA)   NCBI Sequence Viewer  
  EAW69259 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000305310
  ENSP00000305310.5
  ENSP00000337332
  ENSP00000337332.1
  ENSP00000469001
  ENSP00000469001.1
  ENSP00000470215
  ENSP00000470215.1
  ENSP00000471123.1
  ENSP00000471837.1
  ENSP00000472023
  ENSP00000472023.1
  ENSP00000473085.1
GenBank Protein Q8N6T7 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001180214   ⟸   NM_001193285
- Peptide Label: isoform 2
- UniProtKB: Q8N6T7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_057623   ⟸   NM_016539
- Peptide Label: isoform 1
- UniProtKB: Q9NRC7 (UniProtKB/Swiss-Prot),   Q9BWP3 (UniProtKB/Swiss-Prot),   Q9BSI5 (UniProtKB/Swiss-Prot),   Q8NCD2 (UniProtKB/Swiss-Prot),   Q6PK99 (UniProtKB/Swiss-Prot),   Q6IAF5 (UniProtKB/Swiss-Prot),   O75291 (UniProtKB/Swiss-Prot),   B2RCD0 (UniProtKB/Swiss-Prot),   Q9UQD1 (UniProtKB/Swiss-Prot),   Q8N6T7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001307991   ⟸   NM_001321062
- Peptide Label: isoform 7
- UniProtKB: Q8N6T7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001307990   ⟸   NM_001321061
- Peptide Label: isoform 6
- UniProtKB: Q8N6T7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001307987   ⟸   NM_001321058
- Peptide Label: isoform 3
- UniProtKB: B4DDV3 (UniProtKB/TrEMBL),   M0QZ09 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001307992   ⟸   NM_001321063
- Peptide Label: isoform 8
- UniProtKB: M0QXA0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001307988   ⟸   NM_001321059
- Peptide Label: isoform 4
- UniProtKB: M0QZ09 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001307989   ⟸   NM_001321060
- Peptide Label: isoform 5
- UniProtKB: Q8N6T7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001307993   ⟸   NM_001321064
- Peptide Label: isoform 9
- UniProtKB: M0R1N9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_024307307   ⟸   XM_024451539
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSP00000470215   ⟸   ENST00000597896
Ensembl Acc Id: ENSP00000473085   ⟸   ENST00000599365
Ensembl Acc Id: ENSP00000337332   ⟸   ENST00000337491
Ensembl Acc Id: ENSP00000471123   ⟸   ENST00000600938
Ensembl Acc Id: ENSP00000471837   ⟸   ENST00000601571
Ensembl Acc Id: ENSP00000469001   ⟸   ENST00000601488
Ensembl Acc Id: ENSP00000305310   ⟸   ENST00000305232
Ensembl Acc Id: ENSP00000472023   ⟸   ENST00000594279
RefSeq Acc Id: XP_054177165   ⟸   XM_054321190
- Peptide Label: isoform X1
Protein Domains
Deacetylase sirtuin-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8N6T7-F1-model_v2 AlphaFold Q8N6T7 1-355 view protein structure

Promoters
RGD ID:6796045
Promoter ID:HG_KWN:28562
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_2Hour,   HeLa_S3
Transcripts:ENST00000269860,   ENST00000305232,   ENST00000381935,   NM_016539,   UC002LZN.1,   UC002LZR.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36194,133,271 - 4,133,771 (-)MPROMDB
RGD ID:7238071
Promoter ID:EPDNEW_H24781
Type:initiation region
Name:SIRT6_1
Description:sirtuin 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38194,182,547 - 4,182,607EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:14934 AgrOrtholog
COSMIC SIRT6 COSMIC
Ensembl Genes ENSG00000077463 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000305232 ENTREZGENE
  ENST00000305232.10 UniProtKB/Swiss-Prot
  ENST00000337491 ENTREZGENE
  ENST00000337491.7 UniProtKB/Swiss-Prot
  ENST00000594279 ENTREZGENE
  ENST00000594279.5 UniProtKB/TrEMBL
  ENST00000597896 ENTREZGENE
  ENST00000597896.5 UniProtKB/TrEMBL
  ENST00000599365.5 UniProtKB/TrEMBL
  ENST00000600938.5 UniProtKB/TrEMBL
  ENST00000601488 ENTREZGENE
  ENST00000601488.5 UniProtKB/TrEMBL
  ENST00000601571.1 UniProtKB/TrEMBL
Gene3D-CATH 2.20.28.200 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPP-binding domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000077463 GTEx
HGNC ID HGNC:14934 ENTREZGENE
Human Proteome Map SIRT6 Human Proteome Map
InterPro DHS-like_NAD/FAD-binding_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD-dep_sirtuin_deacylases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sirtuin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ssirtuin_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:51548 UniProtKB/Swiss-Prot
NCBI Gene 51548 ENTREZGENE
OMIM 606211 OMIM
PANTHER NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam SIR2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA37939 PharmGKB
PROSITE SIRTUIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52467 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B2RCD0 ENTREZGENE
  B4DDV3 ENTREZGENE, UniProtKB/TrEMBL
  M0QXA0 ENTREZGENE, UniProtKB/TrEMBL
  M0QZ09 ENTREZGENE, UniProtKB/TrEMBL
  M0R0B2_HUMAN UniProtKB/TrEMBL
  M0R1F6_HUMAN UniProtKB/TrEMBL
  M0R1N9 ENTREZGENE, UniProtKB/TrEMBL
  O75291 ENTREZGENE
  Q6IAF5 ENTREZGENE
  Q6PK99 ENTREZGENE
  Q8N6T7 ENTREZGENE
  Q8NCD2 ENTREZGENE
  Q9BSI5 ENTREZGENE
  Q9BWP3 ENTREZGENE
  Q9NRC7 ENTREZGENE
  Q9UQD1 ENTREZGENE
  SIR6_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary B2RCD0 UniProtKB/Swiss-Prot
  O75291 UniProtKB/Swiss-Prot
  Q6IAF5 UniProtKB/Swiss-Prot
  Q6PK99 UniProtKB/Swiss-Prot
  Q8NCD2 UniProtKB/Swiss-Prot
  Q9BSI5 UniProtKB/Swiss-Prot
  Q9BWP3 UniProtKB/Swiss-Prot
  Q9NRC7 UniProtKB/Swiss-Prot
  Q9UQD1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-27 SIRT6  sirtuin 6  SIRT6  sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae)  Symbol and/or name change 5135510 APPROVED