RGD Reference Report - Decreased expression of sirtuin 6 is associated with release of high mobility group box-1 after cerebral ischemia. - Rat Genome Database

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Decreased expression of sirtuin 6 is associated with release of high mobility group box-1 after cerebral ischemia.

Authors: Lee, OH  Kim, J  Kim, JM  Lee, H  Kim, EH  Bae, SK  Choi, Y  Nam, HS  Heo, JH 
Citation: Lee OH, etal., Biochem Biophys Res Commun. 2013 Aug 23;438(2):388-94. doi: 10.1016/j.bbrc.2013.07.085. Epub 2013 Jul 27.
RGD ID: 9586062
Pubmed: PMID:23899523   (View Abstract at PubMed)
DOI: DOI:10.1016/j.bbrc.2013.07.085   (Journal Full-text)

Sirtuin 6 (SIRT6) belongs to the sirtuin family of NAD(+)-dependent deacetylases and has been implicated in the regulation of metabolism, inflammation, and aging. Here, we found that SIRT6 was predominantly expressed in neuronal cells throughout the entire brain. Ischemia models using transient middle cerebral artery occlusion in rats and oxygen/glucose deprivation (OGD) in SH-SY5Y neuronal cells showed that ischemia reduced SIRT6 expression and induced the release of high mobility group box-1 (HMGB1) from cell nuclei. The reduced expression of SIRT6 via treatment with SIRT6 siRNA dramatically enhanced the OGD-induced release of HMGB1 in SH-SY5Y cells. Together, our data suggest that SIRT6 may serve as a potential therapeutic target for HMGB1-mediated inflammation after cerebral ischemia.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
transient cerebral ischemia  ISOSirt6 (Rattus norvegicus)9586062; 9586062mRNA and protein:decreased expression:brainRGD 
transient cerebral ischemia  IEP 9586062mRNA and protein:decreased expression:brainRGD 

Objects Annotated

Genes (Rattus norvegicus)
Sirt6  (sirtuin 6)

Genes (Mus musculus)
Sirt6  (sirtuin 6)

Genes (Homo sapiens)
SIRT6  (sirtuin 6)


Additional Information