SIRT6 (sirtuin 6) - Rat Genome Database

Name: SIRT6
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: SIRT6 (sirtuin 6) Sus scrofa

Analyze

Symbol:

SIRT6

Name:

sirtuin 6

RGD ID:

13877717

Description:

ENCODES a protein that exhibits chromatin binding (ortholog); chromatin DNA binding (ortholog); damaged DNA binding (ortholog); INVOLVED IN base-excision repair (ortholog); cardiac muscle cell differentiation (ortholog); cellular response to angiotensin (ortholog); PARTICIPATES IN histone modification pathway; Sirtuin mediated pathway; ASSOCIATED WITH amenorrhea (ortholog); Cardiomegaly (ortholog); Cardiotoxicity (ortholog); FOUND IN chromatin (ortholog); chromosome, subtelomeric region (ortholog); endoplasmic reticulum (ortholog); INTERACTS WITH deoxynivalenol

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

NAD-dependent protein deacetylase sirtuin-6; NAD-dependent protein deacylase sirtuin-6

RGD Orthologs

Human

Mouse

Rat

Chinchilla

Bonobo

Dog

Squirrel

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SIRT6 (sirtuin 6)	HGNC	EggNOG, Ensembl, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Sirt6 (sirtuin 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Sirt6 (sirtuin 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Sirt6 (sirtuin 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SIRT6 (sirtuin 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SIRT6 (sirtuin 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Sirt6 (sirtuin 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SIRT6 (sirtuin 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Sirt6 (sirtuin 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	74,568,493 - 74,577,772 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	74,568,539 - 74,577,774 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	75,063,186 - 75,071,642 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

amenorrhea (ISO)

Cardiomegaly (ISO)

Cardiotoxicity (ISO)

endomyocardial fibrosis (ISO)

fatty liver disease (ISO)

Fibrosis (ISO)

genetic disease (ISO)

hypertension (ISO)

Hypertensive Nephropathy (ISO)

Left Ventricular Hypertrophy (ISO)

long QT syndrome (ISO)

non-alcoholic fatty liver disease (ISO)

obesity (ISO)

primary ovarian insufficiency (ISO)

progeria (ISO)

transient cerebral ischemia (ISO)

Ventricular Dysfunction, Left (ISO)

Ventricular Remodeling (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

deoxynivalenol (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

base-excision repair (ISO)

cardiac muscle cell differentiation (ISO)

cellular response to angiotensin (ISO)

cellular response to endothelin (ISO)

cellular response to hydrogen peroxide (ISO)

chromatin remodeling (IEA)

circadian regulation of gene expression (ISO)

determination of adult lifespan (ISO)

DNA repair-dependent chromatin remodeling (ISO)

double-strand break repair (ISO)

glucose homeostasis (ISO)

histone deacetylation (ISO)

ketone biosynthetic process (ISO)

negative regulation of cell population proliferation (ISO)

negative regulation of cellular senescence (ISO)

negative regulation of DNA-templated transcription (ISO)

negative regulation of gene expression, epigenetic (ISO)

negative regulation of gluconeogenesis (ISO)

negative regulation of glucose import (ISO)

negative regulation of glycolytic process (ISO)

negative regulation of protein import into nucleus (ISO)

negative regulation of protein localization to chromatin (ISO)

negative regulation of transcription by RNA polymerase II (IBA)

negative regulation of transcription elongation by RNA polymerase II (ISO)

pericentric heterochromatin formation (ISO)

positive regulation of blood vessel branching (ISO)

positive regulation of chondrocyte proliferation (ISO)

positive regulation of cold-induced thermogenesis (ISO)

positive regulation of double-strand break repair (ISO)

positive regulation of fat cell differentiation (ISO)

positive regulation of fibroblast proliferation (ISO)

positive regulation of histone deacetylase activity (ISO)

positive regulation of insulin secretion (ISO)

positive regulation of protein export from nucleus (ISO)

positive regulation of protein localization to chromatin (ISO)

positive regulation of stem cell differentiation (ISO)

positive regulation of stem cell population maintenance (ISO)

positive regulation of stem cell proliferation (ISO)

positive regulation of telomere maintenance (ISO)

positive regulation of transcription factor catabolic process (ISO)

positive regulation of vascular endothelial cell proliferation (ISO)

post-embryonic cardiac muscle cell growth involved in heart morphogenesis (ISO)

protein deacetylation (ISO)

protein delipidation (ISO)

protein destabilization (ISO)

protein localization to site of double-strand break (ISO)

regulation of circadian rhythm (ISO)

regulation of double-strand break repair via homologous recombination (ISO)

regulation of lipid catabolic process (ISO)

regulation of lipid metabolic process (ISO)

regulation of protein localization to plasma membrane (ISO)

regulation of protein secretion (ISO)

response to nutrient levels (ISO)

response to UV (ISO)

retrotransposon silencing (ISO)

subtelomeric heterochromatin formation (ISO)

Cellular Component

chromatin (ISO)

chromosome, subtelomeric region (ISO)

endoplasmic reticulum (ISO)

intracellular membrane-bounded organelle (ISO)

nucleolus (ISO)

nucleoplasm (ISO)

nucleus (IBA,ISO)

pericentric heterochromatin (ISO)

site of DNA damage (ISO)

site of double-strand break (ISO)

Molecular Function

chromatin binding (ISO)

chromatin DNA binding (ISO)

damaged DNA binding (ISO)

DNA damage sensor activity (ISO)

enzyme activator activity (ISO)

histone deacetylase regulator activity (ISO)

lncRNA binding (ISO)

molecular function activator activity (ISO)

NAD+ binding (IBA,IEA)

NAD+-protein ADP-ribosyltransferase activity (ISO)

NAD+-protein-arginine ADP-ribosyltransferase activity (ISO)

NAD-dependent histone deacetylase activity (ISO)

NAD-dependent histone H3K18 deacetylase activity (ISO)

NAD-dependent histone H3K56 deacetylase activity (ISO)

NAD-dependent histone H3K9 deacetylase activity (IBA)

NAD-dependent protein deacetylase activity (ISO)

NAD-dependent protein demyristoylase activity (ISO)

NAD-dependent protein depalmitoylase activity (ISO)

nucleosome binding (ISO)

protein binding (ISO)

protein homodimerization activity (ISO)

protein lysine deacetylase activity (ISO)

TORC2 complex binding (ISO)

transcription corepressor activity (IBA)

transcription regulator inhibitor activity (ISO)

transferase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

histone modification pathway (ISO)

Sirtuin mediated pathway (ISO)

References

Additional References at PubMed

PMID:14681463	PMID:19389481	PMID:31593883

Genomics

Comparative Map Data

SIRT6
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	74,568,493 - 74,577,772 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	74,568,539 - 74,577,774 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	75,063,186 - 75,071,642 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SIRT6
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	4,174,109 - 4,182,563 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	19	4,174,109 - 4,182,566 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	4,174,106 - 4,182,560 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	4,125,106 - 4,133,596 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	19	4,125,105 - 4,133,596	NCBI
Celera	19	4,113,565 - 4,122,051 (-)	NCBI		Celera
Cytogenetic Map	19	p13.3	NCBI
HuRef	19	3,937,486 - 3,945,942 (-)	NCBI		HuRef
CHM1_1	19	4,173,652 - 4,182,142 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	4,157,416 - 4,165,866 (-)	NCBI		T2T-CHM13v2.0

Sirt6
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	81,457,621 - 81,463,631 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	81,457,619 - 81,463,631 (-)	Ensembl		GRCm39 Ensembl
GRCm38	10	81,621,787 - 81,627,792 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	81,621,785 - 81,627,797 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	81,084,531 - 81,090,353 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	81,024,916 - 81,030,687 (-)	NCBI		MGSCv36	mm8
Celera	10	82,644,967 - 82,650,787 (-)	NCBI		Celera
Cytogenetic Map	10	C1	NCBI
cM Map	10	39.72	NCBI

Sirt6
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	7	8,082,312 - 8,087,776 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	8,082,364 - 8,098,914 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	10,968,768 - 10,974,195 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	7	12,844,434 - 12,849,861 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	7	10,711,823 - 10,717,248 (+)	NCBI	Rnor_WKY
Rnor_6.0	7	10,937,622 - 10,943,048 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	10,937,599 - 10,943,063 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	11,106,748 - 11,112,174 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	9,555,269 - 9,560,695 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	9,555,269 - 9,560,695 (+)	NCBI
Celera	7	6,273,425 - 6,278,851 (+)	NCBI		Celera
Cytogenetic Map	7	q11	NCBI

Sirt6
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955495	4,644,023 - 4,650,083 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955495	4,641,883 - 4,650,518 (+)	NCBI	ChiLan1.0	ChiLan1.0

SIRT6
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	19	7,800,265 - 7,808,774 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	3,196,092 - 3,204,602 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	4,146,057 - 4,154,132 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	4,146,057 - 4,154,126 (-)	Ensembl	panpan1.1		panPan2

SIRT6
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	55,412,989 - 55,424,944 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	55,412,646 - 55,424,944 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	55,140,555 - 55,152,607 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	56,071,820 - 56,083,846 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	56,072,611 - 56,083,837 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	55,131,653 - 55,143,673 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	55,612,837 - 55,624,841 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	55,811,751 - 55,823,816 (+)	NCBI		UU_Cfam_GSD_1.0

Sirt6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	215,440,673 - 215,447,621 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936588	2,386,977 - 2,394,096 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936588	2,387,162 - 2,394,066 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SIRT6
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	3,924,230 - 3,932,583 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	3,924,230 - 3,932,590 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666081	4,286,733 - 4,295,705 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Sirt6
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624828	5,442,057 - 5,451,520 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624828	5,441,973 - 5,449,549 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	hemolymphoid system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system
High
Medium
Low	10	4	3	5	2	23	2	2	3
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001114273	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK235213	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK236953	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK390975	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CU929466	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	EU127893	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	EU357902	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FJ457624	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FJ457625	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GFLN01074720	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HQ242712	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSSSCT00000014742 ⟹ ENSSSCP00000014344

RefSeq Status:

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	2	74,568,493 - 74,577,772 (+)	Ensembl

RefSeq Acc Id:

ENSSSCT00000014748 ⟹ ENSSSCP00000014350

RefSeq Status:

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	2	74,568,493 - 74,577,420 (+)	Ensembl

RefSeq Acc Id:

ENSSSCT00000094799 ⟹ ENSSSCP00000081105

RefSeq Status:

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	2	74,568,507 - 74,577,772 (+)	Ensembl

RefSeq Acc Id:

NM_001114273 ⟹ NP_001107745

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	2	74,568,539 - 74,577,774 (+)	NCBI

Sequence:

show sequence

GCGGTGAGGATGTCGGTGAATTATGCGGCTGGCCTGTCGCCGTACGCAGACAAGGGCAAGTGCG
GTCTCCCCGAGGTGTTTGACCCCCCTGAGGAATTGGAGCAGAAGGTATGGGAGCTGGCACAGCT
GGTCTGGCAGTCCTCCAACGTGGTGTTCCACACGGGCGCGGGCATCAGCACCGCCTCAGGCATC
CCTGACTTCAGGGGTCCCCATGGTGTCTGGACAATGGAGGAGCGAGGCCTGGCCCCCAAGTTCG
ACACCACCTTCGAGAACGCGAGGCCCACGAAGACCCACATGGCACTGGTGCAGCTGGAGCGCGT
GGGCCTCCTCCGCTTCCTGGTCAGCCAGAACGTGGATGGGCTGCATGTGCGATCCGGCTTCCCC
AGGGACAAGCTGGCAGAGCTTCATGGAAACATGTTCGTAGAAGAATGTGTCAAGTGTAAGACGC
AATACGTCCGGGACACCGTGGTGGGGAGCATGGGCCTGAAGGCTACCGGCCGCCTCTGCACCGT
GGCCAAGTCAAGGGGGCTACGGGCCTGCAGGGTGGAGCTGAGAGACACCATCCTAGACTGGGAG
GATGCCCTGCCTGACCGAGACCTCACCCTCGCTGACGAGGCCAGCAGGAACGCCGACCTGTCCA
TCACGCTGGGCACCTCCCTGCAAATCCGGCCCAGCGGGAACCTGCCGCTCACCACCAAACGCCG
GGGGGGCCGGCTGGTCATTGTCAACCTTCAGCCCACCAAGCACGACCGCCATGCAGACCTGCGT
ATCCACGGCTACGTAGATGAGGTCATGACCCGGCTCATGAAGCACCTGGGCCTGGAGATCCCGG
CCTGGGACGGCCCCCGTGTCCTAGAGCTCACTTTATTACTCGTCTCTGCCCTTGTGGGGAGACC
TCAGGACTCTGAGAGCTGGGCTCCAGGCCCACATTACACCTCCCTTAGCTTGGGGCCTCTGGAG
GGGGCCTGGCAAGGGGCATCCCTGCCCTGGGCCTAACCTTGGAGCTGACACTCCTGACACCTGC
TCCACCCTTAGGCCCCAGCCCTGACTCAGGATGTTTTTGGGAGGTGTGGCCAGGCCCTCTCTGG
TTTCCAGCCTAAACAGGAATTGACCCCCTCTGCCCTCTGGACCCTCACACTCCCCATCTCTTGC
CTACCCCAGAATTGCCTCACAGTCCCTCCAGGAGGGAAGGGAGGCAGAGTCACCATTTAGGAGC
CAAACATCATGCCAGGACAGGCAATAGAGGCTTGCACTGCCTTTGGGGCTGGAGGGAGAAAGAG
ATGAGGCCACCTGGCTTCCTCCAGGCTTCCAGAAAAGCCTTCAATGCAATAAAAAGCAACGTTT
CTTGCAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001107745	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	ABV48770	(Get FASTA)	NCBI Sequence Viewer
	ABY65336	(Get FASTA)	NCBI Sequence Viewer
	ACK38355	(Get FASTA)	NCBI Sequence Viewer
	ACK38356	(Get FASTA)	NCBI Sequence Viewer
	ADZ44547	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001107745 ⟸ NM_001114273

- UniProtKB:

B0FWP8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSVNYAAGLSPYADKGKCGLPEVFDPPEELEQKVWELAQLVWQSSNVVFHTGAGISTASGIPDF
RGPHGVWTMEERGLAPKFDTTFENARPTKTHMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDK
LAELHGNMFVEECVKCKTQYVRDTVVGSMGLKATGRLCTVAKSRGLRACRVELRDTILDWEDAL
PDRDLTLADEASRNADLSITLGTSLQIRPSGNLPLTTKRRGGRLVIVNLQPTKHDRHADLRIHG
YVDEVMTRLMKHLGLEIPAWDGPRVLELTLLLVSALVGRPQDSESWAPGPHYTSLSLGPLEGAW
QGASLPWA

hide sequence

RefSeq Acc Id:

ENSSSCP00000014344 ⟸ ENSSSCT00000014742

RefSeq Acc Id:

ENSSSCP00000014350 ⟸ ENSSSCT00000014748

RefSeq Acc Id:

ENSSSCP00000081105 ⟸ ENSSSCT00000094799

Protein Domains

Deacetylase sirtuin-type

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00000013496	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSSSCP00000014344.5	UniProtKB/TrEMBL
	ENSSSCP00000014350	ENTREZGENE
	ENSSSCP00000014350.4	UniProtKB/TrEMBL
	ENSSSCP00000081105.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSSSCT00000014742.5	UniProtKB/TrEMBL
	ENSSSCT00000014748	ENTREZGENE
	ENSSSCT00000014748.5	UniProtKB/TrEMBL
	ENSSSCT00000094799.1	UniProtKB/TrEMBL
Gene3D-CATH	2.20.28.200	UniProtKB/TrEMBL
	TPP-binding domain	UniProtKB/TrEMBL
InterPro	DHS-like_NAD/FAD-binding_dom	UniProtKB/TrEMBL
	Sirtuin	UniProtKB/TrEMBL
	Ssirtuin_cat_dom	UniProtKB/TrEMBL
KEGG Report	ssc:100126274	UniProtKB/TrEMBL
NCBI Gene	SIRT6	ENTREZGENE
PANTHER	NAD-DEPENDENT HISTONE DEACETYLASE HST4	UniProtKB/TrEMBL
	NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-6	UniProtKB/TrEMBL
Pfam	SIR2	UniProtKB/TrEMBL
PROSITE	SIRTUIN	UniProtKB/TrEMBL
Superfamily-SCOP	SSF52467	UniProtKB/TrEMBL
UniProt	A0A8W4FP14_PIG	UniProtKB/TrEMBL
	A0A8X9AEU7_PIG	UniProtKB/TrEMBL
	B0FWP8	ENTREZGENE, UniProtKB/TrEMBL
	B7U9B1_PIG	UniProtKB/TrEMBL
	B7U9B2_PIG	UniProtKB/TrEMBL
	F1S7M5_PIG	UniProtKB/TrEMBL
UniProt Secondary	F1S7P1	UniProtKB/TrEMBL
VGNC ID	VGNC:92889	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

RGD Manual Annotations

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

RGD Manual Annotations