RGD Reference Report - Dietary restriction increases site-specific histone H3 acetylation in rat liver: possible modulation by sirtuins. - Rat Genome Database

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Dietary restriction increases site-specific histone H3 acetylation in rat liver: possible modulation by sirtuins.

Authors: Kawakami, K  Nakamura, A  Goto, S 
Citation: Kawakami K, etal., Biochem Biophys Res Commun. 2012 Feb 24;418(4):836-40. doi: 10.1016/j.bbrc.2012.01.120. Epub 2012 Jan 31.
RGD ID: 9586063
Pubmed: PMID:22321393   (View Abstract at PubMed)
DOI: DOI:10.1016/j.bbrc.2012.01.120   (Journal Full-text)

We studied dietary restriction (DR) related changes of site-specific acetylation of histone H3 in rat livers to explore a possible link to histone modifications and sirtuin levels with anti-aging effects of DR. The acetylation at lysine residue 9, 27 and 56 in H3 was 20-30% higher in DR animals compared with ad libitum fed counterparts. SIRT6, one of histone deacetylases, was significantly decreased by DR and thereby may be involved in an increase in the histone acetylation. Our findings suggest that upregulation of chromatin activities through increased histone acetylation is a mechanism of anti-aging effects of DR.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
response to nutrient levels  IEP 9586063 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Sirt6  (sirtuin 6)


Additional Information