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ONTOLOGY REPORT - ANNOTATIONS

Term:SH3 domain binding
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Accession:GO:0017124 term browser browse the term
Definition:Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins.

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SH3 domain binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABI1 abl interactor 1 enables IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 9:26,377,822...26,495,665
Ensembl chr 9:26,379,516...26,495,676 		JBrowse link
G ABI2 abl interactor 2 enables IEA TreeGrafter GO_REF:0000118 NCBI chr10:89,074,333...89,314,144
Ensembl chr10:89,075,798...89,181,235 		JBrowse link
G ABI3 ABI family member 3 enables IEA TreeGrafter GO_REF:0000118 Ensembl chr16:69,613,801...69,625,377 JBrowse link
G ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase enables ISO (PMID:7590236) UniProt PMID:7590236 NCBI chr12:7,258,932...7,435,658
Ensembl chr12:7,256,648...7,312,734 		JBrowse link
G ACP1 acid phosphatase 1 ISO RGD PMID:11971983 RGD:1625292 NCBI chr14:107,449,327...107,465,478 JBrowse link
G ADAM10 ADAM metallopeptidase domain 10 enables IEA UniProt GO_REF:0000043 NCBI chr26:24,768,827...24,921,169
Ensembl chr26:24,768,915...24,919,009 		JBrowse link
G ADAM12 ADAM metallopeptidase domain 12 enables ISO (PMID:15280379) BHF-UCL PMID:15280379 NCBI chr 9:118,641,551...119,014,280
Ensembl chr 9:118,646,539...118,749,351 		JBrowse link
G ADAM15 ADAM metallopeptidase domain 15 enables ISO (PMID:10531379) BHF-UCL PMID:10531379 NCBI chr20:8,767,836...8,779,399
Ensembl chr20:8,768,112...8,779,311 		JBrowse link
G ADAM19 ADAM metallopeptidase domain 19 enables ISO (MGI:6158822|PMID:12615925) UniProt PMID:12615925 MGI:6158822 NCBI chr23:59,867,949...59,966,873
Ensembl chr23:59,867,596...59,966,802 		JBrowse link
G ADAM9 ADAM metallopeptidase domain 9 enables IEA Ensembl GO_REF:0000107 NCBI chr 8:37,017,827...37,131,462
Ensembl chr 8:37,017,545...37,131,615 		JBrowse link
G AFAP1 actin filament associated protein 1 enables ISO
IEA		 RGD
TreeGrafter		 PMID:12114187 GO_REF:0000118 RGD:625602 NCBI chr27:43,715,242...43,892,127
Ensembl chr27:43,715,243...43,892,220 		JBrowse link
G AFAP1L1 actin filament associated protein 1 like 1 enables IEA TreeGrafter GO_REF:0000118 NCBI chr23:51,893,641...51,959,949
Ensembl chr23:51,920,796...51,963,359 		JBrowse link
G AFAP1L2 actin filament associated protein 1 like 2 enables IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 9:107,164,687...107,274,433
Ensembl chr 9:107,162,963...107,273,307 		JBrowse link
G AKAP5 A-kinase anchoring protein 5 enables ISO (PMID:10939335) SynGO-UCL PMID:10939335 RGD:2313285 NCBI chr24:41,669,206...41,678,205
Ensembl chr24:41,672,098...41,673,381 		JBrowse link
G ARHGAP27 Rho GTPase activating protein 27 enables ISO PMID:15147912 HGNC-UCL PMID:15147912 RGD:1302833 NCBI chr16:60,984,171...61,020,579
Ensembl chr16:60,985,548...61,020,220 		JBrowse link
G ARHGAP31 Rho GTPase activating protein 31 enables ISO (PMID:11744688) MGI PMID:11744688 NCBI chr22:61,415,805...61,543,679
Ensembl chr22:61,415,804...61,543,834 		JBrowse link
G CASP9 caspase 9 enables ISO (PMID:15657060) UniProt PMID:15657060 NCBI chr20:116,772,819...116,798,402
Ensembl chr20:116,772,155...116,798,930 		JBrowse link
G CBL Cbl proto-oncogene enables ISO
IEA		 RGD
TreeGrafter
Ensembl		 PMID:9259313 PMID:17675467 GO_REF:0000107 GO_REF:0000118 RGD:11038829 RGD:11576315 NCBI chr 1:110,581,049...110,679,284
Ensembl chr 1:110,581,143...110,674,481 		JBrowse link
G CBLB Cbl proto-oncogene B enables IEA TreeGrafter GO_REF:0000118 NCBI chr22:74,961,831...75,181,307
Ensembl chr22:74,961,859...75,178,548 		JBrowse link
G CBLC Cbl proto-oncogene C enables IEA TreeGrafter GO_REF:0000118 NCBI chr 6:38,257,418...38,285,534
Ensembl chr 6:38,257,672...38,280,051 		JBrowse link
G CD2AP CD2 associated protein enables IEA Ensembl GO_REF:0000107 NCBI chr17:24,664,245...24,815,786
Ensembl chr17:24,663,872...24,815,829 		JBrowse link
G CD3E CD3e molecule enables ISO (PMID:12110186) UniProt PMID:12110186 NCBI chr 1:109,681,142...109,692,835
Ensembl chr 1:109,681,065...109,692,839 		JBrowse link
G CNTNAP1 contactin associated protein 1 ISO RGD PMID:9118959 RGD:70689 NCBI chr16:63,590,043...63,606,805
Ensembl chr16:63,591,119...63,607,579 		JBrowse link
G CRB3 crumbs cell polarity complex component 3 enables IEA Ensembl GO_REF:0000107 NCBI chr 6:6,062,459...6,070,989
Ensembl chr 6:6,068,459...6,070,771 		JBrowse link
G CRK CRK proto-oncogene, adaptor protein enables IEA Ensembl GO_REF:0000107 NCBI chr16:1,102,485...1,135,225
Ensembl chr16:1,102,348...1,135,166 		JBrowse link
G CTTNBP2 cortactin binding protein 2 ISO RGD PMID:9813110 RGD:632437 NCBI chr21:86,376,005...86,539,662
Ensembl chr21:86,376,011...86,527,223 		JBrowse link
G DAB2IP DAB2 interacting protein enables ISO (PMID:19033661) UniProt PMID:19033661 NCBI chr12:17,802,030...18,017,648
Ensembl chr12:17,801,831...17,830,890 		JBrowse link
G DENND1A DENN domain containing 1A enables IEA Ensembl GO_REF:0000107 NCBI chr12:14,211,743...14,756,063
Ensembl chr12:14,212,606...14,758,953 		JBrowse link
G DNM1 dynamin 1 ISO RGD PMID:9348539 PMID:16648848 RGD:13504740 RGD:631926 NCBI chr12:9,874,098...9,927,737
Ensembl chr12:9,878,966...9,927,744 		JBrowse link
G DNM2 dynamin 2 enables ISO
IEA		 RGD
Ensembl		 PMID:19122684 GO_REF:0000107 RGD:9685149 NCBI chr 6:9,718,014...9,830,061
Ensembl chr 6:9,718,244...9,831,206 		JBrowse link
G DPYSL3 dihydropyrimidinase like 3 ISO RGD PMID:12684468 RGD:1298810 NCBI chr23:49,941,799...50,060,696
Ensembl chr23:49,945,023...50,060,392 		JBrowse link
G DRD4 dopamine receptor D4 enables IEA Ensembl GO_REF:0000107 NCBI chr 1:454,018...459,582 JBrowse link
G EFS embryonal Fyn-associated substrate enables IEA Ensembl GO_REF:0000107 NCBI chr29:23,727,820...23,737,585
Ensembl chr29:23,726,245...23,736,157 		JBrowse link
G ELMO1 engulfment and cell motility 1 enables IEA Ensembl
UniProt		 GO_REF:0000043 GO_REF:0000107 NCBI chr21:21,066,910...21,639,149
Ensembl chr21:21,066,924...21,640,705 		JBrowse link
G ELMO2 engulfment and cell motility 2 enables IEA UniProt GO_REF:0000043 NCBI chr 2:17,477,425...17,518,814
Ensembl chr 2:17,489,658...17,518,843 		JBrowse link
G ELMO3 engulfment and cell motility 3 enables IEA UniProt GO_REF:0000043 NCBI chr 5:60,253,105...60,257,804
Ensembl chr 5:60,253,252...60,257,478 		JBrowse link
G ENAH ENAH actin regulator enables IEA UniProt
TreeGrafter		 GO_REF:0000043 GO_REF:0000118 NCBI chr25:4,134,853...4,264,392
Ensembl chr25:4,134,852...4,260,928 		JBrowse link
G ERRFI1 ERBB receptor feedback inhibitor 1 ISO RGD PMID:11003669 RGD:9685556 NCBI chr20:123,738,971...123,753,575
Ensembl chr20:123,738,973...123,755,809 		JBrowse link
G ESPN espin enables ISO PMID:12598619 UniProt PMID:12598619 RGD:632657 NCBI chr20:125,282,283...125,320,436
Ensembl chr20:125,278,313...125,320,365 		JBrowse link
G EVL Enah/Vasp-like enables IEA UniProt
TreeGrafter		 GO_REF:0000043 GO_REF:0000118 NCBI chr24:77,937,319...78,113,011
Ensembl chr24:78,029,684...78,112,664 		JBrowse link
G FMN1 formin 1 enables IEA Ensembl GO_REF:0000107 NCBI chr26:49,700,309...50,117,799
Ensembl chr26:49,734,553...49,996,405 		JBrowse link
G FUT8 fucosyltransferase 8 enables IEA UniProt GO_REF:0000043 NCBI chr24:42,627,340...42,965,505
Ensembl chr24:42,788,132...42,968,124 		JBrowse link
G GJA1 gap junction protein alpha 1 enables ISO dependent on acidic pH
PMID:15492000
PMID:14699011		 RGD
DisProt
CAFA		 PMID:14699011 PMID:15492000 RGD:12793032 RGD:1582694 NCBI chr13:52,397,291...52,410,341
Ensembl chr13:52,396,109...52,410,339 		JBrowse link
G GPX1 glutathione peroxidase 1 enables ISO (PMID:12893824) BHF-UCL PMID:12893824 NCBI chr22:10,754,976...10,756,617 JBrowse link
G GPX1 glutathione peroxidase 1 enables IEA Ensembl GO_REF:0000107 Ensembl chr22:10,754,970...10,757,057 JBrowse link
G GRB2 growth factor receptor bound protein 2 enables ISO (PMID:19509291) UniProt PMID:19509291 NCBI chr16:46,264,818...46,346,426
Ensembl chr16:46,264,825...46,347,156 		JBrowse link
G GRIK5 glutamate ionotropic receptor kainate type subunit 5 enables ISO PMID:1127911 UniProt PMID:1127911 RGD:8553546 NCBI chr 6:36,199,358...36,273,355
Ensembl chr 6:36,199,349...36,269,591 		JBrowse link
G HCLS1 hematopoietic cell-specific Lyn substrate 1 enables ISO (PMID:9126384)
(PMID:19064729)		 MGI PMID:9126384 PMID:19064729 NCBI chr22:59,225,768...59,255,744
Ensembl chr22:59,225,750...59,256,243 		JBrowse link
G HIP1R huntingtin interacting protein 1 related enables IEA Ensembl GO_REF:0000107 NCBI chr11:118,173,302...118,202,840
Ensembl chr11:118,173,544...118,202,985 		JBrowse link
G ILK integrin linked kinase ISO SH3 domain of c-src (unknown species) RGD PMID:18252715 RGD:2301742 NCBI chr 1:58,214,630...58,221,770
Ensembl chr 1:58,213,310...58,221,217 		JBrowse link
G INPP5D inositol polyphosphate-5-phosphatase D enables IEA UniProt GO_REF:0000043 NCBI chr10:119,093,160...119,244,128
Ensembl chr10:119,093,781...119,244,123 		JBrowse link
G INPPL1 inositol polyphosphate phosphatase like 1 enables IEA UniProt GO_REF:0000043 NCBI chr 1:63,443,819...63,459,067
Ensembl chr 1:63,444,713...63,459,776 		JBrowse link
G KHDRBS1 KH RNA binding domain containing, signal transduction associated 1 enables ISO
IEA		 RGD
UniProt		 PMID:12112020 GO_REF:0000043 RGD:634064 NCBI chr20:100,831,307...100,859,609
Ensembl chr20:100,832,461...100,859,630 		JBrowse link
G KHDRBS2 KH RNA binding domain containing, signal transduction associated 2 enables ISO (PMID:10077576) MGI PMID:10077576 NCBI chr17:12,522,386...13,150,784
Ensembl chr17:12,522,531...12,898,201 		JBrowse link
G KHDRBS3 KH RNA binding domain containing, signal transduction associated 3 enables IEA UniProt GO_REF:0000043 NCBI chr 8:129,814,228...130,044,479
Ensembl chr 8:129,911,686...130,035,258 		JBrowse link
G LANCL1 LanC like glutathione S-transferase 1 enables IEA Ensembl GO_REF:0000107 NCBI chr10:96,144,156...96,191,023
Ensembl chr10:96,144,541...96,191,030 		JBrowse link
G LOC103223283 pyridoxal phosphate phosphatase enables ISO (PMID:8438166) MGI PMID:8438166 NCBI chr19:20,340,535...20,357,426
Ensembl chr19:20,360,108...20,368,247
Ensembl chr19:20,360,108...20,368,247 		JBrowse link
G LOC103233451 cytochrome b-245 light chain enables IEA Ensembl GO_REF:0000107 NCBI chr 5:74,023,134...74,030,793
Ensembl chr 5:74,023,082...74,030,750 		JBrowse link
G LYN LYN proto-oncogene, Src family tyrosine kinase enables ISO (PMID:19064729) MGI PMID:19064729 NCBI chr 8:51,919,656...52,057,376
Ensembl chr 8:51,919,808...52,057,959 		JBrowse link
G MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 ISO RGD PMID:11384986 RGD:727317 NCBI chr14:67,931,906...68,121,640
Ensembl chr14:67,931,940...68,122,556 		JBrowse link
G MAPT microtubule associated protein tau enables ISO (PMID:9763511) UniProt PMID:9763511 NCBI chr16:59,894,400...60,020,723
Ensembl chr16:59,890,221...59,955,612 		JBrowse link
G MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1 enables IEA Ensembl GO_REF:0000107 NCBI chr13:64,400,908...64,424,096
Ensembl chr13:64,400,152...64,427,366 		JBrowse link
G MVB12A multivesicular body subunit 12A enables IEA UniProt GO_REF:0000043 NCBI chr 6:15,917,568...15,923,168
Ensembl chr 6:15,917,539...15,923,361 		JBrowse link
G MYPN myopalladin enables IEA Ensembl GO_REF:0000107 NCBI chr 9:63,173,243...63,279,777
Ensembl chr 9:63,174,804...63,279,133 		JBrowse link
G NCF1 neutrophil cytosolic factor 1 enables ISO (PMID:7938008) BHF-UCL PMID:7938008 NCBI chr28:8,334,172...8,349,828
Ensembl chr28:8,332,772...8,349,804 		JBrowse link
G NOXA1 NADPH oxidase activator 1 enables ISO (PMID:19755710) UniProt PMID:19755710 NCBI chr12:758,107...769,252
Ensembl chr12:758,152...769,095 		JBrowse link
G OSTF1 osteoclast stimulating factor 1 enables ISO (PMID:9630982) MGI PMID:9630982 NCBI chr12:86,140,711...86,197,474
Ensembl chr12:86,140,588...86,198,572 		JBrowse link
G PDCD6IP programmed cell death 6 interacting protein ISO RGD PMID:10858458 RGD:68284 NCBI chr15:78,265,099...78,339,307
Ensembl chr15:78,265,252...78,339,873 		JBrowse link
G PICALM phosphatidylinositol binding clathrin assembly protein ISO RGD PMID:10926122 RGD:1600757 NCBI chr 1:77,214,391...77,325,626
Ensembl chr 1:77,213,836...77,324,875 		JBrowse link
G PLSCR1 phospholipid scramblase 1 enables IEA Ensembl GO_REF:0000107 NCBI chr15:44,160,017...44,189,056
Ensembl chr15:44,160,200...44,188,195 		JBrowse link
G PRKCE protein kinase C epsilon ISO RGD PMID:17084383 RGD:2326120 NCBI chr14:61,022,903...61,570,390
Ensembl chr14:61,026,017...61,242,343 		JBrowse link
G PRRT2 proline rich transmembrane protein 2 enables ISO PMID:26797119 MGI PMID:26797119 RGD:11528976 NCBI chr 5:26,838,280...26,841,918
Ensembl chr 5:26,839,454...26,841,916 		JBrowse link
G PTPN12 protein tyrosine phosphatase non-receptor type 12 enables IEA Ensembl GO_REF:0000107 NCBI chr21:71,285,917...71,389,645
Ensembl chr21:71,285,736...71,389,926 		JBrowse link
G PTPN22 protein tyrosine phosphatase non-receptor type 22 enables IEA Ensembl GO_REF:0000107 NCBI chr20:19,792,807...19,855,784
Ensembl chr20:19,793,083...19,855,827 		JBrowse link
G PTPN6 protein tyrosine phosphatase non-receptor type 6 enables IEA Ensembl GO_REF:0000107 NCBI chr11:6,977,480...6,994,525
Ensembl chr11:6,984,710...6,994,545 		JBrowse link
G RAD9A RAD9 checkpoint clamp component A enables IEA Ensembl GO_REF:0000107 NCBI chr 1:6,865,990...6,945,179
Ensembl chr 1:6,866,840...6,941,486 		JBrowse link
G REPS1 RALBP1 associated Eps domain containing 1 enables ISO (PMID:20946875) UniProt PMID:20946875 NCBI chr13:34,402,172...34,488,994
Ensembl chr13:34,402,127...34,491,919 		JBrowse link
G RIMS1 regulating synaptic membrane exocytosis 1 ISO RGD PMID:10748113 RGD:633421 NCBI chr17:2,690,430...3,176,794
Ensembl chr17:2,690,418...3,176,738 		JBrowse link
G RUFY1 RUN and FYVE domain containing 1 enables IEA Ensembl GO_REF:0000107 NCBI chr23:81,260,109...81,326,818
Ensembl chr23:81,269,663...81,330,154 		JBrowse link
G RUFY2 RUN and FYVE domain containing 2 enables ISO (PMID:11877430) UniProt PMID:11877430 NCBI chr 9:62,993,151...63,050,274
Ensembl chr 9:62,993,856...63,049,981 		JBrowse link
G SGIP1 SH3GL interacting endocytic adaptor 1 enables ISO (PMID:20946875) UniProt PMID:20946875 NCBI chr20:66,349,378...66,565,216
Ensembl chr20:66,357,440...66,473,483 		JBrowse link
G SH3BGRL2 SH3 domain binding glutamate rich protein like 2 enables IEA UniProt GO_REF:0000043 NCBI chr13:4,342,588...4,416,054
Ensembl chr13:4,363,387...4,413,063 		JBrowse link
G SH3BP2 SH3 domain binding protein 2 enables IEA TreeGrafter GO_REF:0000118 NCBI chr27:45,919,717...45,961,355
Ensembl chr27:45,920,171...45,942,425 		JBrowse link
G SH3BP5 SH3 domain binding protein 5 enables IEA UniProt GO_REF:0000104 NCBI chr15:60,098,901...60,175,421
Ensembl chr15:60,100,132...60,175,349 		JBrowse link
G SH3BP5L SH3 binding domain protein 5 like enables IEA UniProt GO_REF:0000104 NCBI chr25:85,654,598...85,669,989
Ensembl chr25:85,653,098...85,669,960 		JBrowse link
G SH3GL1 SH3 domain containing GRB2 like 1, endophilin A2 ISO RGD PMID:22750032 RGD:13463484 NCBI chr 6:4,090,800...4,130,566
Ensembl chr 6:4,091,359...4,130,578 		JBrowse link
G SHANK1 SH3 and multiple ankyrin repeat domains 1 enables ISO PMID:15496675 BHF-UCL PMID:15496675 RGD:8553458 NCBI chr 6:43,718,904...43,776,814
Ensembl chr 6:43,716,714...43,773,945 		JBrowse link
G SHANK2 SH3 and multiple ankyrin repeat domains 2 ISO RGD PMID:15014124 RGD:1599734 NCBI chr 1:3,453,268...4,104,515 JBrowse link
G SHANK3 SH3 and multiple ankyrin repeat domains 3 ISO RGD PMID:15014124 RGD:1599734 NCBI chr19:33,155,695...33,209,679
Ensembl chr19:33,155,770...33,208,224 		JBrowse link
G SOS1 SOS Ras/Rac guanine nucleotide exchange factor 1 ISO RGD PMID:10913276 RGD:1581107 NCBI chr14:68,259,509...68,404,167
Ensembl chr14:68,259,360...68,399,895 		JBrowse link
G SYNJ1 synaptojanin 1 enables ISO
IEA		 also binds SH3 domain of endophilins RGD
TreeGrafter		 PMID:8552192 PMID:11498538 PMID:17097615 GO_REF:0000118 RGD:13513210 RGD:628465 RGD:69388 NCBI chr 2:59,421,561...59,523,076
Ensembl chr 2:59,422,110...59,523,176 		JBrowse link
G SYNJ2 synaptojanin 2 enables ISO
IEA		 also binds SH3 domain of endophilins RGD
TreeGrafter		 PMID:11498538 GO_REF:0000118 RGD:628465 NCBI chr13:85,579,457...85,695,694
Ensembl chr13:85,580,392...85,692,908 		JBrowse link
G UVRAG UV radiation resistance associated enables IEA Ensembl GO_REF:0000107 NCBI chr 1:67,032,575...67,353,207
Ensembl chr 1:67,032,436...67,353,166 		JBrowse link
G VASP vasodilator stimulated phosphoprotein enables IEA InterPro
TreeGrafter
UniProt		 GO_REF:0000002 GO_REF:0000043 GO_REF:0000118 NCBI chr 6:38,954,212...38,974,680
Ensembl chr 6:38,954,014...38,975,108 		JBrowse link
G WAS WASP actin nucleation promoting factor enables IEA Ensembl GO_REF:0000107 NCBI chr  X:45,809,418...45,817,165
Ensembl chr  X:45,809,189...45,817,667 		JBrowse link
G WASF2 WASP family member 2 enables ISO (PMID:19798448) UniProt PMID:19798448 NCBI chr20:105,300,429...105,387,246
Ensembl chr20:105,300,368...105,383,314 		JBrowse link
G WIPF1 WAS/WASL interacting protein family member 1 enables ISO (PMID:19798448) UniProt PMID:19798448 NCBI chr10:60,067,384...60,188,234
Ensembl chr10:60,067,015...60,142,823 		JBrowse link
G WIPF3 WAS/WASL interacting protein family member 3 ISO RGD PMID:8906616 RGD:1302419 NCBI chr21:28,459,605...28,570,438
Ensembl chr21:28,471,971...28,501,063 		JBrowse link
G ZNF106 zinc finger protein 106 enables IEA TreeGrafter GO_REF:0000118 NCBI chr26:40,486,801...40,567,811
Ensembl chr26:40,486,913...40,563,332 		JBrowse link
G ZNF384 zinc finger protein 384 ISO RGD PMID:10669742 RGD:1299381 NCBI chr11:6,699,988...6,725,282
Ensembl chr11:6,697,989...6,713,322 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 18050
    binding 16493
      protein binding 14613
        protein domain specific binding 804
          SH3 domain binding 100
paths to the root