EFS (embryonal Fyn-associated substrate) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: EFS (embryonal Fyn-associated substrate) Chlorocebus sabaeus
Analyze
Symbol: EFS
Name: embryonal Fyn-associated substrate
RGD ID: 18783773
Description: ENCODES a protein that exhibits protein domain specific binding (inferred); SH3 domain binding (inferred); INVOLVED IN cell adhesion (inferred); cell migration (inferred); cell surface receptor protein tyrosine kinase signaling pathway (inferred); ASSOCIATED WITH Brain-Lung-Thyroid Syndrome (ortholog); Crohn's disease (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (inferred); focal adhesion (inferred); plasma membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12923,727,820 - 23,737,585 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2923,726,245 - 23,736,157 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605922,681,718 - 22,690,780 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
EFS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12923,727,820 - 23,737,585 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2923,726,245 - 23,736,157 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605922,681,718 - 22,690,780 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
EFS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381423,356,406 - 23,365,172 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1423,356,403 - 23,365,752 (-)EnsemblGRCh38hg38GRCh38
GRCh371423,825,615 - 23,834,381 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361422,895,451 - 22,904,682 (-)NCBINCBI36Build 36hg18NCBI36
Build 341422,895,451 - 22,904,682NCBI
Celera143,688,322 - 3,697,553 (-)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef143,942,027 - 3,951,261 (-)NCBIHuRef
CHM1_11423,824,281 - 23,833,514 (-)NCBICHM1_1
T2T-CHM13v2.01417,557,422 - 17,566,188 (-)NCBIT2T-CHM13v2.0
Efs
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391455,154,087 - 55,164,222 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1455,153,992 - 55,163,583 (-)EnsemblGRCm39 Ensembl
GRCm381454,916,543 - 54,926,788 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1454,916,535 - 54,926,126 (-)EnsemblGRCm38mm10GRCm38
MGSCv371455,535,380 - 55,545,625 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361453,870,752 - 53,880,123 (-)NCBIMGSCv36mm8
Celera1452,722,855 - 52,732,967 (-)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1427.99NCBI
Efs
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81532,362,401 - 32,374,490 (-)NCBIGRCr8
mRatBN7.21528,392,417 - 28,403,016 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1528,392,187 - 28,401,902 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1530,238,121 - 30,247,469 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01531,385,323 - 31,394,671 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01529,628,004 - 29,637,348 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01533,579,952 - 33,590,217 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1533,578,381 - 33,589,522 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01537,466,898 - 37,477,213 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41533,018,805 - 33,028,147 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11533,034,947 - 33,038,747 (-)NCBI
Celera1527,970,221 - 27,979,564 (-)NCBICelera
Cytogenetic Map15p13NCBI
Efs
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540936,973,522 - 36,981,079 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540936,973,522 - 36,981,079 (+)NCBIChiLan1.0ChiLan1.0
EFS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21524,788,084 - 24,798,115 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11424,004,574 - 24,014,315 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0144,174,676 - 4,185,215 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11422,270,126 - 22,278,930 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1422,270,952 - 22,278,732 (-)Ensemblpanpan1.1panPan2
EFS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.183,600,597 - 3,612,563 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl83,600,589 - 3,613,947 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha83,551,417 - 3,560,679 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.083,710,916 - 3,720,179 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl83,712,246 - 3,720,176 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.183,402,512 - 3,411,771 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.083,463,787 - 3,473,050 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.083,725,967 - 3,735,229 (-)NCBIUU_Cfam_GSD_1.0
Efs
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864035,369,899 - 35,379,628 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367221,010,904 - 1,019,334 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367221,009,966 - 1,019,093 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EFS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl775,722,183 - 75,731,610 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1775,720,033 - 75,731,615 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2781,009,512 - 81,020,818 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Efs
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248209,200,287 - 9,207,263 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248209,200,383 - 9,206,387 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 21 26
Low 15 11 34
Below cutoff 6

Sequence


RefSeq Acc Id: ENSCSAT00000014112   ⟹   ENSCSAP00000012092
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2923,726,245 - 23,736,157 (-)Ensembl
RefSeq Acc Id: XM_007990859   ⟹   XP_007989050
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12923,727,820 - 23,737,584 (-)NCBI
Vero_WHO_p1.0NW_02366605922,681,836 - 22,690,780 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007990860   ⟹   XP_007989051
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12923,727,820 - 23,737,585 (-)NCBI
Vero_WHO_p1.0NW_02366605922,682,126 - 22,690,780 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007990861   ⟹   XP_007989052
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12923,727,820 - 23,737,584 (-)NCBI
Vero_WHO_p1.0NW_02366605922,682,126 - 22,690,778 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007990862   ⟹   XP_007989053
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12923,727,820 - 23,737,584 (-)NCBI
Vero_WHO_p1.0NW_02366605922,682,126 - 22,690,780 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007990863   ⟹   XP_007989054
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12923,727,820 - 23,737,585 (-)NCBI
Vero_WHO_p1.0NW_02366605922,681,718 - 22,690,780 (+)NCBI
Sequence:
RefSeq Acc Id: XM_037987537   ⟹   XP_037843465
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366605922,682,126 - 22,690,780 (+)NCBI
RefSeq Acc Id: XP_007989054   ⟸   XM_007990863
- Peptide Label: isoform X5
RefSeq Acc Id: XP_007989051   ⟸   XM_007990860
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RU03 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007989053   ⟸   XM_007990862
- Peptide Label: isoform X4
- UniProtKB: A0A0D9RU03 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007989052   ⟸   XM_007990861
- Peptide Label: isoform X3
- UniProtKB: A0A0D9RU03 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007989050   ⟸   XM_007990859
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RU03 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000012092   ⟸   ENSCSAT00000014112
RefSeq Acc Id: XP_037843465   ⟸   XM_037987537
- Peptide Label: isoform X6


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000016019 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000014112.1 UniProtKB/TrEMBL
Gene3D-CATH Alpha-catenin/vinculin-like UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro CAS_C UniProtKB/TrEMBL
  CAS_fam UniProtKB/TrEMBL
  EFS_SH3 UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
NCBI Gene EFS ENTREZGENE
PANTHER EMBRYONAL FYN-ASSOCIATED SUBSTRATE UniProtKB/TrEMBL
  PTHR10654 UniProtKB/TrEMBL
Pfam CAS_C UniProtKB/TrEMBL
  SH3_9 UniProtKB/TrEMBL
PRINTS SH3DOMAIN UniProtKB/TrEMBL
PROSITE SH3 UniProtKB/TrEMBL
SMART SH3 UniProtKB/TrEMBL
Superfamily-SCOP SSF50044 UniProtKB/TrEMBL
UniProt A0A0D9RU03 ENTREZGENE, UniProtKB/TrEMBL