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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of tumor necrosis factor-mediated signaling pathway
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Accession:GO:0010804 term browser browse the term
Definition:Any process that decreases the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor.
Synonyms:exact_synonym: negative regulation of TNF signaling;   negative regulation of TNF-mediated signaling pathway;   negative regulation of tumor necrosis factor-mediated signalling pathway


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negative regulation of tumor necrosis factor-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADIPOQ adiponectin, C1Q and collagen domain containing involved_in IDA (PMID:10604883) BHF-UCL PMID:10604883 NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463 		JBrowse link
G APOA1 apolipoprotein A1 involved_in IDA (PMID:21571275) BHF-UCL PMID:21571275 NCBI chr11:116,835,751...116,837,950
Ensembl chr11:116,835,751...116,837,622 		JBrowse link
G BIRC7 baculoviral IAP repeat containing 7 involved_in IDA (PMID:11865055) UniProt PMID:11865055 NCBI chr20:63,235,905...63,240,495
Ensembl chr20:63,235,883...63,240,495 		JBrowse link
G CARD16 caspase recruitment domain family member 16 involved_in IMP (PMID:16920334) UniProt PMID:16920334 NCBI chr11:105,041,563...105,045,335
Ensembl chr11:105,041,326...105,101,431 		JBrowse link
G CARD8 caspase recruitment domain family member 8 involved_in IMP (PMID:11821383) UniProt PMID:11821383 NCBI chr19:48,179,825...48,255,946
Ensembl chr19:48,180,770...48,255,946 		JBrowse link
G CCDC3 coiled-coil domain containing 3 involved_in IMP (PMID:25193116) UniProt PMID:25193116 NCBI chr10:12,896,625...13,099,989
Ensembl chr10:12,896,625...13,099,652 		JBrowse link
G CLDN18 claudin 18 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22437732) Ensembl
MGI		 PMID:22437732 GO_REF:0000107 NCBI chr 3:137,998,816...138,033,649
Ensembl chr 3:137,998,735...138,033,655 		JBrowse link
G DICER1 dicer 1, ribonuclease III acts_upstream_of IDA (PMID:26435691) ARUK-UCL PMID:26435691 NCBI chr14:95,086,228...95,158,010
Ensembl chr14:95,086,228...95,158,010 		JBrowse link
G F2RL1 F2R like trypsin receptor 1 involved_in IDA (PMID:19781631) UniProt PMID:19781631 NCBI chr 5:76,819,030...76,835,315
Ensembl chr 5:76,818,933...76,835,315 		JBrowse link
G GAS6 growth arrest specific 6 involved_in IDA (PMID:19657094) UniProt PMID:19657094 NCBI chr13:113,820,549...113,864,076
Ensembl chr13:113,820,549...113,864,076 		JBrowse link
G GPS2 G protein pathway suppressor 2 involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr17:7,312,661...7,315,360
Ensembl chr17:7,311,324...7,315,564 		JBrowse link
G GSTP1 glutathione S-transferase pi 1 involved_in IC (PMID:16636664) BHF-UCL PMID:16636664 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656 		JBrowse link
G H2BC11 H2B clustered histone 11 involved_in IDA (PMID:11859126) UniProt PMID:11859126 NCBI chr 6:27,132,316...27,132,795
Ensembl chr 6:27,125,897...27,132,795 		JBrowse link
G MIR125B1 microRNA 125b-1 acts_upstream_of IDA (PMID:26435691) ARUK-UCL PMID:26435691 NCBI chr11:122,099,757...122,099,844
Ensembl chr11:122,099,757...122,099,844 		JBrowse link
G MIR125B2 microRNA 125b-2 acts_upstream_of IDA (PMID:26435691) ARUK-UCL PMID:26435691 NCBI chr21:16,590,237...16,590,325
Ensembl chr21:16,590,237...16,590,325 		JBrowse link
G MIR130A microRNA 130a acts_upstream_of IDA (PMID:26435691) ARUK-UCL PMID:26435691 NCBI chr11:57,641,198...57,641,286
Ensembl chr11:57,641,198...57,641,286 		JBrowse link
G MIR152 microRNA 152 involved_in IDA (PMID:24813629) BHF-UCL PMID:24813629 NCBI chr17:48,037,161...48,037,247
Ensembl chr17:48,037,161...48,037,247 		JBrowse link
G MIR24-1 microRNA 24-1 involved_in ISS ARUK-UCL GO_REF:0000024 NCBI chr 9:95,086,021...95,086,088
Ensembl chr 9:95,086,021...95,086,088 		JBrowse link
G MIR24-2 microRNA 24-2 involved_in ISS ARUK-UCL GO_REF:0000024 NCBI chr19:13,836,287...13,836,359
Ensembl chr19:13,836,287...13,836,359 		JBrowse link
G MIR27B microRNA 27b acts_upstream_of_or_within IGI (PMID:31124343) ARUK-UCL PMID:31124343 NCBI chr 9:95,085,445...95,085,541
Ensembl chr 9:95,085,445...95,085,541 		JBrowse link
G NAIP NLR family apoptosis inhibitory protein involved_in IDA (PMID:11865055) UniProt PMID:11865055 NCBI chr 5:70,968,166...71,025,339
Ensembl chr 5:70,968,166...71,025,339 		JBrowse link
G NLRP2B NLR family pyrin domain containing 2B involved_in IMP (PMID:24871464) UniProt PMID:24871464 NCBI chr  X:57,677,067...57,680,260
Ensembl chr  X:57,677,067...57,680,260 		JBrowse link
G NOL3 nucleolar protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:67,170,538...67,175,737
Ensembl chr16:67,170,154...67,175,737 		JBrowse link
G NR1H4 nuclear receptor subfamily 1 group H member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:100,473,866...100,564,414
Ensembl chr12:100,473,708...100,564,414 		JBrowse link
G PELI3 pellino E3 ubiquitin protein ligase family member 3 acts_upstream_of_or_within IMP (PMID:24113711) MGI PMID:24113711 NCBI chr11:66,466,327...66,477,337
Ensembl chr11:66,466,327...66,477,337 		JBrowse link
G PIAS4 protein inhibitor of activated STAT 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20054338) Ensembl
MGI		 PMID:20054338 GO_REF:0000107 NCBI chr19:4,007,736...4,039,386
Ensembl chr19:4,007,736...4,039,386 		JBrowse link
G PPP2CB protein phosphatase 2 catalytic subunit beta acts_upstream_of IGI (PMID:28159925) ARUK-UCL PMID:28159925 NCBI chr 8:30,785,616...30,812,818
Ensembl chr 8:30,774,457...30,814,314 		JBrowse link
G PTPN2 protein tyrosine phosphatase non-receptor type 2 involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr18:12,785,478...12,884,237
Ensembl chr18:12,785,478...12,929,643 		JBrowse link
G PYDC1 pyrin domain containing 1 involved_in IMP
IDA		 (PMID:24871464)
(PMID:12656673)		 UniProt
HGNC-UCL		 PMID:12656673 PMID:24871464 NCBI chr16:31,215,962...31,217,135
Ensembl chr16:31,215,962...31,217,135 		JBrowse link
G PYDC2 pyrin domain containing 2 involved_in IMP (PMID:17339483), (PMID:24871464) UniProt PMID:17339483 PMID:24871464 NCBI chr 3:191,461,163...191,461,456
Ensembl chr 3:191,461,163...191,461,456 		JBrowse link
G RFFL ring finger and FYVE like domain containing E3 ubiquitin protein ligase involved_in IMP (PMID:18450452) UniProt PMID:18450452 NCBI chr17:35,005,990...35,089,226
Ensembl chr17:35,005,990...35,089,319 		JBrowse link
G TANK TRAF family member associated NFKB activator involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:161,136,963...161,236,230
Ensembl chr 2:161,136,908...161,236,230 		JBrowse link
G TJP2 tight junction protein 2 acts_upstream_of_or_within ISO (PMID:22437732) MGI PMID:22437732 NCBI chr 9:69,121,264...69,255,208
Ensembl chr 9:69,121,264...69,274,615 		JBrowse link
G TNFRSF11B TNF receptor superfamily member 11b involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:29415886) Ensembl
MGI		 PMID:29415886 GO_REF:0000107 NCBI chr 8:118,923,557...118,951,885
Ensembl chr 8:118,923,557...118,951,885 		JBrowse link
G TRAIP TRAF interacting protein involved_in IDA (PMID:19151749) CACAO PMID:19151749 NCBI chr 3:49,828,601...49,856,564
Ensembl chr 3:49,828,601...49,856,574 		JBrowse link
G XIAP X-linked inhibitor of apoptosis involved_in IDA (PMID:11865055) UniProt PMID:11865055 NCBI chr  X:123,859,708...123,913,972
Ensembl chr  X:123,859,712...123,913,972 		JBrowse link
G ZNF675 zinc finger protein 675 involved_in IDA (PMID:11751921) BHF-UCL PMID:11751921 NCBI chr19:23,652,801...23,687,212
Ensembl chr19:23,525,631...23,687,220 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19613
    negative regulation of biological process 6432
      negative regulation of response to stimulus 2026
        negative regulation of response to cytokine stimulus 117
          negative regulation of cytokine-mediated signaling pathway 111
            negative regulation of tumor necrosis factor-mediated signaling pathway 37
Path 2
Term Annotations click to browse term
  biological_process 19613
    biological regulation 13363
      regulation of biological process 12979
        signaling 7170
          signal transduction 6566
            cell surface receptor signaling pathway 3201
              cytokine-mediated signaling pathway 569
                regulation of cytokine-mediated signaling pathway 196
                  negative regulation of cytokine-mediated signaling pathway 111
                    negative regulation of tumor necrosis factor-mediated signaling pathway 37
paths to the root