Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of cytokine-mediated signaling pathway
go back to main search page
Accession:GO:0001960 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of the cytokine mediated signaling pathway.
Synonyms:exact_synonym: down-regulation of cytokine mediated signaling pathway;   downregulation of cytokine mediated signaling pathway;   negative regulation of cytokine and chemokine mediated signaling pathway;   negative regulation of cytokine mediated signalling pathway
 narrow_synonym: inhibition of cytokine mediated signaling pathway


show annotations for term's descendants           Sort by:
 
negative regulation of cytokine-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cav1 caveolin 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2180364 (MGI:3703676|PMID:12388746)
Ensembl
RGD
PMID:12388746 GO_REF:0000107 MGI:3703676 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200
JBrowse link
G Ecm1 extracellular matrix protein 1 acts_upstream_of_or_within ISO (MGI:4887510|PMID:21217760) RGD PMID:21217760 MGI:4887510 NCBI chr 2:197,855,468...197,860,973
Ensembl chr 2:197,855,460...197,860,699
JBrowse link
G Il36rn interleukin 36 receptor antagonist involved_in ISO (PMID:23147407) RGD PMID:23147407 NCBI chr 3:1,385,256...1,392,275
Ensembl chr 3:1,385,654...1,392,275
JBrowse link
G Palm3 paralemmin 3 involved_in ISO
IBA
(PMID:21187075)
PMID:21873635
RGD PMID:21187075, PMID:21873635 RGD:13792537 NCBI chr19:25,143,464...25,152,275
Ensembl chr19:25,143,428...25,151,891
JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C involved_in ISS
ISO
GO_REF:0000024
(MGI:2386427|PMID:11201744)
UniProt
RGD
PMID:11201744 GO_REF:0000024 MGI:2386427 NCBI chr13:55,061,561...55,174,150
Ensembl chr13:55,061,562...55,173,692
JBrowse link
G Ptprf protein tyrosine phosphatase, receptor type, F IMP hepatocyte growth factor/Met signaling RGD PMID:16415345 RGD:1642742 NCBI chr 5:137,036,936...137,112,930
Ensembl chr 5:137,036,935...137,112,927
JBrowse link
G Sigirr single Ig and TIR domain containing involved_in ISS
ISO
GO_REF:0000024
(MGI:2673012|PMID:12925853)
HGNC-UCL
RGD
PMID:12925853 GO_REF:0000024 MGI:2673012 NCBI chr 1:213,898,395...213,907,697
Ensembl chr 1:213,898,401...213,907,144
JBrowse link
negative regulation of chemokine-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl5 C-C motif chemokine ligand 5 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Padi2 peptidyl arginine deiminase 2 involved_in ISO
IEA
(PMID:18645041)
GO_REF:0000107
RGD
Ensembl
PMID:18645041 GO_REF:0000107 NCBI chr 5:159,428,479...159,471,113
Ensembl chr 5:159,428,515...159,471,144
JBrowse link
G Rnf113a1 ring finger protein 113A1 involved_in ISO (PMID:28978524) RGD PMID:28978524 NCBI chr  X:123,806,922...123,808,049
Ensembl chr  X:124,516,949...124,518,077
Ensembl chr  X:124,516,949...124,518,077
JBrowse link
G Robo1 roundabout guidance receptor 1 involved_in ISO
IEA
(PMID:18829537)
GO_REF:0000107
RGD
Ensembl
PMID:18829537 GO_REF:0000107 NCBI chr11:9,079,291...10,146,302
Ensembl chr11:9,642,365...10,143,317
JBrowse link
G Sh2b3 SH2B adaptor protein 3 involved_in IEA
ISO
GO_REF:0000107
(MGI:3510267|PMID:15337790)
Ensembl
RGD
PMID:15337790 GO_REF:0000107 MGI:3510267 NCBI chr12:40,261,990...40,265,757
Ensembl chr12:40,244,081...40,265,757
JBrowse link
G Slit2 slit guidance ligand 2 involved_in ISO
IEA
(PMID:18829537)
GO_REF:0000107
RGD
Ensembl
PMID:18829537 GO_REF:0000107 NCBI chr14:66,831,848...67,171,491
Ensembl chr14:66,831,848...67,170,361
JBrowse link
G Slit3 slit guidance ligand 3 involved_in ISO
IEA
(PMID:18829537)
GO_REF:0000107
RGD
Ensembl
PMID:18829537 GO_REF:0000107 NCBI chr10:19,924,200...20,517,918
Ensembl chr10:20,320,878...20,518,518
JBrowse link
negative regulation of interferon-gamma-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arg1 arginase 1 involved_in ISO (PMID:16709924) RGD PMID:16709924 NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863
JBrowse link
G Dnaja3 DnaJ heat shock protein family (Hsp40) member A3 involved_in ISO (PMID:11679576) RGD PMID:11679576 NCBI chr10:11,059,701...11,085,186
Ensembl chr10:11,060,313...11,085,210
JBrowse link
G Otop1 otopetrin 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:5750846|PMID:24379350)
UniProt
RGD
PMID:24379350 GO_REF:0000024 MGI:5750846 NCBI chr14:77,236,278...77,263,729
Ensembl chr14:77,236,278...77,263,729
JBrowse link
G Parp14 poly (ADP-ribose) polymerase family, member 14 involved_in ISO (PMID:27796300)
(MGI:5905929|PMID:27796300)
RGD PMID:27796300 MGI:5905929 NCBI chr11:68,105,442...68,137,509
Ensembl chr11:68,105,369...68,137,535
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma involved_in ISO (PMID:21268089) RGD PMID:21268089 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 involved_in ISS
ISO
GO_REF:0000024
(MGI:5493216|PMID:12138178)
UniProt
RGD
PMID:12138178 GO_REF:0000024 MGI:5493216 NCBI chr18:63,415,298...63,489,240
Ensembl chr18:63,415,306...63,488,027
JBrowse link
negative regulation of interleukin-1-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1r2 interleukin 1 receptor type 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
PR:000045525 (MGI:5468848|PMID:23395675)
Ensembl
RGD
PMID:23395675 GO_REF:0000107 MGI:5468848 NCBI chr 9:46,840,646...46,881,241
Ensembl chr 9:46,840,992...46,881,264
JBrowse link
G Il1rn interleukin 1 receptor antagonist involved_in IBA
IEA
ISO
PMID:21873635
GO_REF:0000107
(PMID:2137200), (PMID:2139180)
Ensembl
RGD
PMID:2137200 PMID:2139180, PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614
JBrowse link
G Il6 interleukin 6 involved_in ISO (MGI:5795829|PMID:11159963) RGD PMID:11159963 MGI:5795829 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Otud4 OTU deubiquitinase 4 involved_in ISO
IBA
(PMID:29395066)
PMID:21873635
(MGI:6120140|PMID:29395066)
RGD PMID:29395066, PMID:21873635 MGI:6120140, RGD:13792537 NCBI chr19:31,895,753...31,942,509
Ensembl chr19:31,899,087...31,942,180
JBrowse link
negative regulation of interleukin-2-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 involved_in ISS
ISO
GO_REF:0000024
(MGI:3691503|PMID:11909529)
(PMID:11909529)
UniProt
RGD
PMID:11909529 GO_REF:0000024 MGI:3691503 NCBI chr18:63,415,298...63,489,240
Ensembl chr18:63,415,306...63,488,027
JBrowse link
negative regulation of interleukin-4-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 involved_in ISO
ISS
(PMID:17210636)
(MGI:5493214|PMID:17210636)
GO_REF:0000024
RGD
UniProt
PMID:17210636 GO_REF:0000024 MGI:5493214 NCBI chr18:63,415,298...63,489,240
Ensembl chr18:63,415,306...63,488,027
JBrowse link
negative regulation of interleukin-6-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il6st interleukin 6 cytokine family signal transducer involved_in ISO (PMID:8353278) RGD PMID:8353278 NCBI chr 2:44,279,199...44,319,427
Ensembl chr 2:44,289,393...44,314,944
JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 involved_in ISO
ISS
(PMID:12359225)
(MGI:4941441|PMID:20484139)
GO_REF:0000024
RGD
UniProt
PMID:12359225 PMID:20484139 GO_REF:0000024 MGI:4941441 NCBI chr18:63,415,298...63,489,240
Ensembl chr18:63,415,306...63,488,027
JBrowse link
negative regulation of Kit signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rabgef1 RAB guanine nucleotide exchange factor 1 acts_upstream_of_or_within ISO MGI:3051384 (MGI:3620385|PMID:16533754) RGD PMID:16533754 MGI:3620385 NCBI chr12:29,960,132...30,004,727
Ensembl chr12:29,961,120...29,988,959
JBrowse link
G Sh2b3 SH2B adaptor protein 3 involved_in IEA
ISO
GO_REF:0000107
GO:1990782 (MGI:3041996|PMID:14612394)
Ensembl
RGD
PMID:14612394 GO_REF:0000107 MGI:3041996 NCBI chr12:40,261,990...40,265,757
Ensembl chr12:40,244,081...40,265,757
JBrowse link
negative regulation of macrophage colony-stimulating factor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 involved_in ISS
ISO
GO_REF:0000024
(MGI:3629372|PMID:16705167)
UniProt
RGD
PMID:16705167 GO_REF:0000024 MGI:3629372 NCBI chr18:63,415,298...63,489,240
Ensembl chr18:63,415,306...63,488,027
JBrowse link
G Stap1 signal transducing adaptor family member 1 involved_in ISO (MGI:3831067|PMID:19100238) RGD PMID:19100238 MGI:3831067 NCBI chr14:23,575,400...23,604,984
Ensembl chr14:23,576,085...23,604,834
JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO (PMID:33097708) RGD PMID:33097708 NCBI chr 9:14,611,541...14,618,076
Ensembl chr 9:14,611,561...14,618,013
JBrowse link
negative regulation of tumor necrosis factor-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing involved_in ISS
ISO
GO_REF:0000024
(PMID:10604883)
UniProt
RGD
PMID:10604883 GO_REF:0000024 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Apoa1 apolipoprotein A1 involved_in ISO (PMID:21571275) RGD PMID:21571275 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875
JBrowse link
G Ccdc3 coiled-coil domain containing 3 involved_in ISO (PMID:25193116) RGD PMID:25193116 NCBI chr17:76,991,722...77,093,515
Ensembl chr17:76,995,043...77,093,308
JBrowse link
G F2rl1 F2R like trypsin receptor 1 involved_in ISO (PMID:19781631) RGD PMID:19781631 NCBI chr 2:25,222,324...25,235,275
Ensembl chr 2:25,222,328...25,235,275
JBrowse link
G Gas6 growth arrest specific 6 involved_in ISO
ISS
(PMID:19657094)
GO_REF:0000024
RGD
UniProt
PMID:19657094 GO_REF:0000024 NCBI chr16:81,213,364...81,243,824
Ensembl chr16:81,213,364...81,243,757
JBrowse link
G Gps2 G protein pathway suppressor 2 involved_in ISO (MGI:6148454|PMID:22424771) RGD PMID:22424771 MGI:6148454 NCBI chr10:56,524,327...56,527,447
Ensembl chr10:56,524,468...56,526,987
JBrowse link
G Hist2h2be histone cluster 2 H2B family member E involved_in ISO (PMID:11859126) RGD PMID:11859126 NCBI chr 2:198,360,837...198,363,399
Ensembl chr 2:198,360,998...198,361,378
JBrowse link
G Nlrp1b NLR family, pyrin domain containing 1B involved_in ISO (PMID:11821383) RGD PMID:11821383 NCBI chr10:57,755,957...57,847,867 JBrowse link
G Nol3 nucleolar protein 3 involved_in IEA
ISO
GO_REF:0000107
(MGI:5617337|PMID:24440909)
Ensembl
RGD
PMID:24440909 GO_REF:0000107 MGI:5617337 NCBI chr19:37,232,567...37,236,668
Ensembl chr19:37,235,001...37,236,649
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 involved_in ISO (MGI:5707586|PMID:18972444) RGD PMID:18972444 MGI:5707586 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Peli3 pellino E3 ubiquitin protein ligase family member 3 acts_upstream_of_or_within ISO MGI:5441750 (MGI:5546581|PMID:23950925)
(PMID:24113711)
RGD PMID:23950925 PMID:24113711 MGI:5546581 NCBI chr 1:220,191,209...220,204,032
Ensembl chr 1:220,190,067...220,204,032
JBrowse link
G Pias4 protein inhibitor of activated STAT, 4 acts_upstream_of_or_within ISO (MGI:4453084|PMID:20054338) RGD PMID:20054338 MGI:4453084 NCBI chr 7:11,414,565...11,428,090
Ensembl chr 7:11,414,446...11,428,552
JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 involved_in ISS
ISO
GO_REF:0000024
(MGI:3530208|PMID:15696169)
UniProt
RGD
PMID:15696169 GO_REF:0000024 MGI:3530208 NCBI chr18:63,415,298...63,489,240
Ensembl chr18:63,415,306...63,488,027
JBrowse link
G Rffl ring finger and FYVE-like domain containing E3 ubiquitin protein ligase involved_in ISO
ISS
(PMID:18450452)
GO_REF:0000024
RGD
UniProt
PMID:18450452 GO_REF:0000024 NCBI chr10:70,157,621...70,220,618
Ensembl chr10:70,157,621...70,220,582
JBrowse link
G Traip TRAF-interacting protein involved_in ISO (PMID:19151749) RGD PMID:19151749 NCBI chr 8:116,730,170...116,750,528
Ensembl chr 8:116,730,641...116,750,709
JBrowse link
negative regulation of type I interferon-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adar adenosine deaminase, RNA-specific involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:3828307 (MGI:3821394|PMID:19060901)
Ensembl
RGD
PMID:19060901 GO_REF:0000107 MGI:3821394 NCBI chr 2:189,045,551...189,085,448
Ensembl chr 2:189,062,443...189,083,236
JBrowse link
G Cactin cactin, spliceosome C complex subunit involved_in ISO (PMID:20829348) RGD PMID:20829348 NCBI chr 7:11,258,526...11,266,509
Ensembl chr 7:11,261,201...11,266,630
JBrowse link
G Cnot7 CCR4-NOT transcription complex, subunit 7 involved_in ISO (PMID:23386060) RGD PMID:23386060 NCBI chr16:54,899,452...54,918,616
Ensembl chr16:54,899,452...54,918,613
JBrowse link
G Dcst1 DC-STAMP domain containing 1 involved_in ISO (PMID:27782195) RGD PMID:27782195 NCBI chr 2:188,672,549...188,690,004
Ensembl chr 2:188,672,405...188,689,392
JBrowse link
G Isg15 ISG15 ubiquitin-like modifier involved_in ISO (PMID:28724761) RGD PMID:28724761 NCBI chr 5:173,624,862...173,629,124
Ensembl chr 5:173,624,310...173,626,248
JBrowse link
G Mettl3 methyltransferase-like 3 involved_in ISO (PMID:30559377) RGD PMID:30559377 NCBI chr15:28,710,299...28,721,491
Ensembl chr15:28,710,300...28,721,127
JBrowse link
G Mmp12 matrix metallopeptidase 12 involved_in IEA
ISO
GO_REF:0000107
(MGI:5583923|PMID:24784232)
Ensembl
RGD
PMID:24784232 GO_REF:0000107 MGI:5583923 NCBI chr 8:5,594,717...5,616,494
Ensembl chr 8:5,606,592...5,616,493
JBrowse link
G Mul1 mitochondrial E3 ubiquitin protein ligase 1 involved_in ISO (PMID:23399697) RGD PMID:23399697 NCBI chr 5:156,855,105...156,864,517
Ensembl chr 5:156,850,206...156,864,517
JBrowse link
G Nlrc5 NLR family, CARD domain containing 5 involved_in ISO
IBA
(PMID:20434986)
(MGI:4454346|PMID:20434986)
PMID:21873635
RGD PMID:20434986, PMID:21873635 MGI:4454346, RGD:13792537 NCBI chr19:10,904,381...11,006,202
Ensembl chr19:10,905,542...10,976,396
JBrowse link
G Oas1a 2'-5' oligoadenylate synthetase 1A involved_in ISO (PMID:30078389) RGD PMID:30078389 NCBI chr12:41,200,680...41,211,393
Ensembl chr12:41,200,718...41,211,909
JBrowse link
G Oas3 2'-5'-oligoadenylate synthetase 3 involved_in ISO
IEA
(PMID:30078389)
GO_REF:0000107
RGD
Ensembl
PMID:30078389 GO_REF:0000107 NCBI chr12:41,313,081...41,368,217
Ensembl chr12:41,316,764...41,336,562
JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 involved_in ISO
ISS
(PMID:11909529)
(MGI:3691503|PMID:11909529), (MGI:5493216|PMID:12138178)
GO_REF:0000024
RGD
UniProt
PMID:11909529 PMID:12138178 GO_REF:0000024 MGI:3691503 MGI:5493216 NCBI chr18:63,415,298...63,489,240
Ensembl chr18:63,415,306...63,488,027
JBrowse link
G Samhd1 SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 involved_in ISO (PMID:29670289)
(MGI:5521417|PMID:23972988)
RGD PMID:23972988 PMID:29670289 MGI:5521417 NCBI chr 3:153,210,829...153,250,705
Ensembl chr 3:153,210,829...153,250,641
JBrowse link
G Stat2 signal transducer and activator of transcription 2 involved_in ISO (PMID:28165510)
(MGI:6508512|PMID:28165510)
RGD PMID:28165510 MGI:6508512 NCBI chr 7:2,691,064...2,707,530
Ensembl chr 7:2,691,369...2,707,741
JBrowse link
G Trex1 three prime repair exonuclease 1 acts_upstream_of_or_within ISO MGI:3052754 (MGI:3834787|PMID:18724932) RGD PMID:18724932 MGI:3834787 NCBI chr 8:117,796,127...117,797,427
Ensembl chr 8:117,796,128...117,797,427
JBrowse link
G Ttll12 tubulin tyrosine ligase like 12 involved_in ISO (PMID:28011935) RGD PMID:28011935 NCBI chr 7:124,472,758...124,491,004
Ensembl chr 7:124,472,758...124,491,004
JBrowse link
G Usp18 ubiquitin specific peptidase 18 involved_in ISO (PMID:28165510) RGD PMID:28165510 NCBI chr 4:153,812,312...153,834,374
Ensembl chr 4:153,805,993...153,834,430
JBrowse link
G Ythdf2 YTH N(6)-methyladenosine RNA binding protein 2 involved_in ISO (PMID:30559377) RGD PMID:30559377 NCBI chr 5:150,364,490...150,390,173
Ensembl chr 5:150,365,101...150,390,099
JBrowse link
G Ythdf3 YTH N(6)-methyladenosine RNA binding protein 3 involved_in ISO (MGI:6316470|PMID:30591559) RGD PMID:30591559 MGI:6316470 NCBI chr 2:100,677,388...100,711,365
Ensembl chr 2:100,677,411...100,710,417
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19491
    cellular process 18343
      signal transduction 6881
        negative regulation of signal transduction 1265
          negative regulation of cytokine-mediated signaling pathway 60
            negative regulation of Kit signaling pathway 2
            negative regulation of chemokine-mediated signaling pathway + 7
            negative regulation of interferon-gamma-mediated signaling pathway 6
            negative regulation of interleukin-1-mediated signaling pathway 4
            negative regulation of interleukin-17-mediated signaling pathway 0
            negative regulation of interleukin-18-mediated signaling pathway 0
            negative regulation of interleukin-2-mediated signaling pathway 1
            negative regulation of interleukin-27-mediated signaling pathway 0
            negative regulation of interleukin-35-mediated signaling pathway 0
            negative regulation of interleukin-4-mediated signaling pathway 1
            negative regulation of interleukin-6-mediated signaling pathway 2
            negative regulation of macrophage colony-stimulating factor signaling pathway 3
            negative regulation of macrophage migration inhibitory factor signaling pathway 0
            negative regulation of prolactin signaling pathway 0
            negative regulation of tumor necrosis factor-mediated signaling pathway 15
            negative regulation of type I interferon-mediated signaling pathway + 19
Path 2
Term Annotations click to browse term
  biological_process 19491
    biological regulation 13515
      regulation of biological process 12773
        regulation of cellular process 12275
          signal transduction 6881
            cell surface receptor signaling pathway 2774
              cytokine-mediated signaling pathway 424
                regulation of cytokine-mediated signaling pathway 124
                  negative regulation of cytokine-mediated signaling pathway 60
                    negative regulation of Kit signaling pathway 2
                    negative regulation of chemokine-mediated signaling pathway + 7
                    negative regulation of interferon-gamma-mediated signaling pathway 6
                    negative regulation of interleukin-1-mediated signaling pathway 4
                    negative regulation of interleukin-17-mediated signaling pathway 0
                    negative regulation of interleukin-18-mediated signaling pathway 0
                    negative regulation of interleukin-2-mediated signaling pathway 1
                    negative regulation of interleukin-27-mediated signaling pathway 0
                    negative regulation of interleukin-35-mediated signaling pathway 0
                    negative regulation of interleukin-4-mediated signaling pathway 1
                    negative regulation of interleukin-6-mediated signaling pathway 2
                    negative regulation of macrophage colony-stimulating factor signaling pathway 3
                    negative regulation of macrophage migration inhibitory factor signaling pathway 0
                    negative regulation of prolactin signaling pathway 0
                    negative regulation of tumor necrosis factor-mediated signaling pathway 15
                    negative regulation of type I interferon-mediated signaling pathway + 19
paths to the root