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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:3-Nitrofluoranthene
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Accession:CHEBI:34345 term browser browse the term
Definition:A nitronaphthalene that has formula C16H9NO2.
Synonyms:related_synonym: Formula=C16H9NO2;   InChI=1S/C16H9NO2/c18-17(19)15-9-8-13-11-5-2-1-4-10(11)12-6-3-7-14(15)16(12)13/h1-9H;   InChIKey=PIHGQKMEAMSUNA-UHFFFAOYSA-N;   SMILES=[O-][N+](=O)c1ccc2-c3ccccc3-c3cccc1c23
 xref: CAS:892-21-7;   KEGG:C14406
 xref_mesh: MESH:C033643


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3-Nitrofluoranthene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor multiple interactions EXP 3-nitrofluoranthene binds to and results in increased activity of AHR protein CTD PMID:28186253 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152 		JBrowse link
G AKT1 AKT serine/threonine kinase 1 increases phosphorylation ISO 3-nitrofluoranthene results in increased phosphorylation of AKT1 protein CTD PMID:19041363 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751 		JBrowse link
G CASP3 caspase 3 increases activity ISO 3-nitrofluoranthene results in increased activity of CASP3 protein CTD PMID:19041363 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CASP8 caspase 8 increases activity ISO 3-nitrofluoranthene results in increased activity of CASP8 protein CTD PMID:19041363 NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836 		JBrowse link
G CASP9 caspase 9 increases activity ISO 3-nitrofluoranthene results in increased activity of CASP9 protein CTD PMID:19041363 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534 		JBrowse link
G CCL20 C-C motif chemokine ligand 20 increases expression EXP 3-nitrofluoranthene results in increased expression of CCL20 mRNA CTD PMID:19879285 NCBI chr 2:227,813,842...227,817,556
Ensembl chr 2:227,805,739...227,817,564 		JBrowse link
G CXCL1 C-X-C motif chemokine ligand 1 increases expression EXP 3-nitrofluoranthene results in increased expression of CXCL1 mRNA CTD PMID:19879285 NCBI chr 4:73,869,393...73,871,308
Ensembl chr 4:73,869,393...73,871,308 		JBrowse link
G CXCL10 C-X-C motif chemokine ligand 10 increases expression EXP 3-nitrofluoranthene results in increased expression of CXCL10 mRNA CTD PMID:19879285 NCBI chr 4:76,021,118...76,023,497
Ensembl chr 4:76,021,118...76,023,497 		JBrowse link
G CXCL3 C-X-C motif chemokine ligand 3 increases expression EXP 3-nitrofluoranthene results in increased expression of CXCL3 mRNA CTD PMID:19879285 NCBI chr 4:74,036,589...74,038,689
Ensembl chr 4:74,036,589...74,038,807 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 increases secretion
increases expression		 EXP 3-nitrofluoranthene results in increased secretion of CXCL8 protein
3-nitrofluoranthene results in increased expression of CXCL8 mRNA		 CTD PMID:19879285 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 increases expression ISO
EXP		 3-nitrofluoranthene results in increased expression of CYP1A1 protein
3-nitrofluoranthene results in increased expression of CYP1A1 mRNA		 CTD PMID:12107646 PMID:19041363 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536 		JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 increases expression EXP 3-nitrofluoranthene results in increased expression of CYP1A2 mRNA CTD PMID:12107646 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607 		JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 multiple interactions EXP [CYP1B1 protein co-treated with POR protein] results in decreased metabolism of 3-nitrofluoranthene CTD PMID:11113705 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902 		JBrowse link
G HMOX1 heme oxygenase 1 increases expression EXP 3-nitrofluoranthene results in increased expression of HMOX1 protein CTD PMID:28633978 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214 		JBrowse link
G IL6 interleukin 6 increases expression EXP 3-nitrofluoranthene results in increased expression of IL6 mRNA CTD PMID:19879285 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G LTB lymphotoxin beta increases expression EXP 3-nitrofluoranthene results in increased expression of LTB mRNA CTD PMID:19879285 NCBI chr 6:31,580,558...31,582,425
Ensembl chr 6:31,580,525...31,582,522 		JBrowse link
G MAP1LC3B microtubule associated protein 1 light chain 3 beta increases expression ISO 3-nitrofluoranthene results in increased expression of MAP1LC3B protein CTD PMID:19041363 NCBI chr16:87,392,336...87,404,774
Ensembl chr16:87,383,953...87,404,779 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 increases phosphorylation ISO 3-nitrofluoranthene results in increased phosphorylation of MAPK1 protein CTD PMID:19041363 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 increases phosphorylation ISO 3-nitrofluoranthene results in increased phosphorylation of MAPK3 protein CTD PMID:19041363 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions EXP 3-nitrofluoranthene results in increased expression of and affects the localization of and results in increased activity of NFE2L2 protein CTD PMID:28633978 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 increases cleavage ISO 3-nitrofluoranthene results in increased cleavage of PARP1 protein CTD PMID:19041363 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154 		JBrowse link
G POR cytochrome p450 oxidoreductase multiple interactions EXP [CYP1B1 protein co-treated with POR protein] results in decreased metabolism of 3-nitrofluoranthene CTD PMID:11113705 NCBI chr 7:75,915,155...75,986,855
Ensembl chr 7:75,899,200...75,986,855 		JBrowse link
G PRKDC protein kinase, DNA-activated, catalytic subunit increases expression EXP 3-nitrofluoranthene results in increased expression of PRKDC protein CTD PMID:28633978 NCBI chr 8:47,773,111...47,960,136
Ensembl chr 8:47,773,111...47,960,178 		JBrowse link
G TNF tumor necrosis factor increases expression
multiple interactions		 EXP 3-nitrofluoranthene results in increased expression of TNF mRNA
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [3-nitrofluoranthene results in increased expression of TNF mRNA]; MK 2206 inhibits the reaction [3-nitrofluoranthene results in increased expression of TNF mRNA]		 CTD PMID:19879285 PMID:28633978 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TP53 tumor protein p53 multiple interactions ISO 3-nitrofluoranthene results in increased phosphorylation of and affects the localization of TRP53 protein CTD PMID:19041363 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26041
    role 25957
      chemical role 24249
        environmental contaminant 20879
          naphthalene 2350
            nitronaphthalene 27
              3-Nitrofluoranthene 25
Path 2
Term Annotations click to browse term
  CHEBI ontology 26041
    subatomic particle 26016
      composite particle 26016
        hadron 26016
          baryon 26016
            nucleon 26016
              atomic nucleus 26016
                atom 26016
                  main group element atom 25841
                    main group molecular entity 25841
                      s-block molecular entity 25162
                        hydrogen molecular entity 24761
                          hydrides 22974
                            organic hydride 21936
                              organic fundamental parent 21936
                                hydrocarbon 21359
                                  cyclic hydrocarbon 20003
                                    arene 19983
                                      polycyclic arene 19679
                                        ortho-fused polycyclic arene 10295
                                          ortho-fused bicyclic arene 2407
                                            naphthalene 2350
                                              nitronaphthalene 27
                                                3-Nitrofluoranthene 25
paths to the root