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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:nitronaphthalene
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Accession:CHEBI:50631 term browser browse the term
Definition:A nitroarene that is naphthalene substituted by at least one nitro group.
Synonyms:related_synonym: nitronaphthalenes


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1-nitronaphthalene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2f4 cytochrome P450, family 2, subfamily f, polypeptide 4 increases abundance EXP
ISO
CYP2F4 protein results in increased abundance of 1-nitronaphthalene metabolite
CYP2F2 protein results in increased abundance of 1-nitronaphthalene metabolite
CTD PMID:15509722 NCBI chr 1:83,933,974...83,947,804
Ensembl chr 1:83,933,942...83,947,821
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 increases activity ISO 1-nitronaphthalene results in increased activity of TRPA1 protein CTD PMID:21591660 NCBI chr 5:3,783,247...3,836,485
Ensembl chr 5:3,783,247...3,836,485
JBrowse link
3-Nitrofluoranthene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO 3-nitrofluoranthene binds to and results in increased activity of AHR protein CTD PMID:28186253 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation ISO 3-nitrofluoranthene results in increased phosphorylation of AKT1 protein CTD PMID:19041363 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Casp3 caspase 3 increases activity ISO 3-nitrofluoranthene results in increased activity of CASP3 protein CTD PMID:19041363 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases activity ISO 3-nitrofluoranthene results in increased activity of CASP8 protein CTD PMID:19041363 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases activity ISO 3-nitrofluoranthene results in increased activity of CASP9 protein CTD PMID:19041363 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ccl20 C-C motif chemokine ligand 20 increases expression ISO 3-nitrofluoranthene results in increased expression of CCL20 mRNA CTD PMID:19879285 NCBI chr 9:88,918,359...88,921,017
Ensembl chr 9:88,918,433...88,921,001
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases expression ISO 3-nitrofluoranthene results in increased expression of CXCL1 mRNA CTD PMID:19879285 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 increases expression ISO 3-nitrofluoranthene results in increased expression of CXCL10 mRNA CTD PMID:19879285 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression ISO 3-nitrofluoranthene results in increased expression of CXCL1 mRNA CTD PMID:19879285 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO 3-nitrofluoranthene results in increased expression of CYP1A1 protein
3-nitrofluoranthene results in increased expression of CYP1A1 mRNA
CTD PMID:12107646, PMID:19041363 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO 3-nitrofluoranthene results in increased expression of CYP1A2 mRNA CTD PMID:12107646 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO [CYP1B1 protein co-treated with POR protein] results in decreased metabolism of 3-nitrofluoranthene CTD PMID:11113705 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO 3-nitrofluoranthene results in increased expression of HMOX1 protein CTD PMID:28633978 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Il6 interleukin 6 increases expression ISO 3-nitrofluoranthene results in increased expression of IL6 mRNA CTD PMID:19879285 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ltb lymphotoxin beta increases expression ISO 3-nitrofluoranthene results in increased expression of LTB mRNA CTD PMID:19879285 NCBI chr20:5,184,631...5,186,476
Ensembl chr20:5,184,515...5,186,503
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases expression ISO 3-nitrofluoranthene results in increased expression of MAP1LC3B protein CTD PMID:19041363 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO 3-nitrofluoranthene results in increased phosphorylation of MAPK1 protein CTD PMID:19041363 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO 3-nitrofluoranthene results in increased phosphorylation of MAPK3 protein CTD PMID:19041363 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO 3-nitrofluoranthene results in increased expression of and affects the localization of and results in increased activity of NFE2L2 protein CTD PMID:28633978 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO 3-nitrofluoranthene results in increased cleavage of PARP1 protein CTD PMID:19041363 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions ISO [CYP1B1 protein co-treated with POR protein] results in decreased metabolism of 3-nitrofluoranthene CTD PMID:11113705 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit increases expression ISO 3-nitrofluoranthene results in increased expression of PRKDC protein CTD PMID:28633978 NCBI chr11:89,293,547...89,510,948
Ensembl chr11:89,293,696...89,510,871
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
ISO 3-nitrofluoranthene results in increased expression of TNF mRNA
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [3-nitrofluoranthene results in increased expression of TNF mRNA]; MK 2206 inhibits the reaction [3-nitrofluoranthene results in increased expression of TNF mRNA]
CTD PMID:19879285, PMID:28633978 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO 3-nitrofluoranthene results in increased phosphorylation of and affects the localization of TRP53 protein CTD PMID:19041363 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
5-Nitroacenaphthene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO 5-nitroacenaphthene binds to and results in increased activity of AHR protein CTD PMID:28186253 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      chemical role 19248
        environmental contaminant 18574
          naphthalene 2342
            nitronaphthalene 26
              1-Nitro-5,6-dihydroxy-dihydronaphthalene 0
              1-Nitronaphthalene-5,6-oxide 0
              1-Nitronaphthalene-7,8-oxide 0
              3,7-Dinitrofluoranthene 0
              3,9-Dinitrofluoranthene 0
              3-(5,8-dinitro-1,3-dioxo-2-benzo[de]isoquinolinyl)benzoic acid 0
              3-(6-nitro-1,3-dioxo-2-benzo[de]isoquinolinyl)propanoic acid 0
              3-Nitrofluoranthene 24
              4-[(1-hydroxy-2-naphthalenyl)hydrazinylidene]-7-nitro-3-oxo-1-naphthalenesulfonic acid 0
              5-Nitroacenaphthene 1
              NS-102 0
              dinitronaphthalene + 0
              mononitronaphthalene + 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    main group molecular entity 19670
                      s-block molecular entity 19428
                        hydrogen molecular entity 19418
                          hydrides 18685
                            organic hydride 18248
                              organic fundamental parent 18248
                                hydrocarbon 17968
                                  cyclic hydrocarbon 17062
                                    arene 17058
                                      polycyclic arene 16879
                                        ortho-fused polycyclic arene 9641
                                          ortho-fused bicyclic arene 2395
                                            naphthalene 2342
                                              nitronaphthalene 26
                                                1-Nitro-5,6-dihydroxy-dihydronaphthalene 0
                                                1-Nitronaphthalene-5,6-oxide 0
                                                1-Nitronaphthalene-7,8-oxide 0
                                                3,7-Dinitrofluoranthene 0
                                                3,9-Dinitrofluoranthene 0
                                                3-(5,8-dinitro-1,3-dioxo-2-benzo[de]isoquinolinyl)benzoic acid 0
                                                3-(6-nitro-1,3-dioxo-2-benzo[de]isoquinolinyl)propanoic acid 0
                                                3-Nitrofluoranthene 24
                                                4-[(1-hydroxy-2-naphthalenyl)hydrazinylidene]-7-nitro-3-oxo-1-naphthalenesulfonic acid 0
                                                5-Nitroacenaphthene 1
                                                NS-102 0
                                                dinitronaphthalene + 0
                                                mononitronaphthalene + 2
paths to the root

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