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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:estrone 3-sulfate
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Accession:CHEBI:17474 term browser browse the term
Definition:A steroid sulfate that is the 3-sulfate of estrone.
Synonyms:exact_synonym: 17-oxoestra-1,3,5(10)-trien-3-yl hydrogen sulfate
 related_synonym: 3-hydroxyestra-1,3,5(10)-trien-17-one hydrogen sulphate;   Formula=C18H22O5S;   InChI=1S/C18H22O5S/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19/h3,5,10,14-16H,2,4,6-9H2,1H3,(H,20,21,22)/t14-,15-,16+,18+/m1/s1;   InChIKey=JKKFKPJIXZFSSB-CBZIJGRNSA-N;   SMILES=[H][C@]12CC[C@]3(C)C(=O)CC[C@@]3([H])[C@]1([H])CCc1cc(OS(O)(=O)=O)ccc21;   estrone hydrogen sulfate;   estrone sulfate;   estrone sulphate
 alt_id: CHEBI:14221;   CHEBI:23972;   CHEBI:4871
 xref: Beilstein:2399598;   CAS:481-97-0;   Drug_Central:4857;   HMDB:HMDB0001425;   KEGG:C02538;   LINCS:LSM-3126
 xref_mesh: MESH:C017296
 xref: PMID:15356081;   PMID:23717534;   Reaxys:2399598
 cyclic_relationship: is_conjugate_acid_of CHEBI:60050


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estrone 3-sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca8 ATP binding cassette subfamily A member 8 affects transport ISO ABCA8 protein affects the transport of estrone sulfate CTD PMID:12379217 NCBI chr10:94,917,520...94,991,199
Ensembl chr10:94,917,520...94,990,988 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 affects export
increases activity		 ISO
EXP		 ABCC2 protein affects the export of estrone sulfate
estrone sulfate results in increased activity of ABCC2 protein; estrone sulfate results in increased activity of ABCC2 protein modified form		 CTD PMID:15652233 PMID:15904671 PMID:16046661 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 affects export
increases export
increases uptake
multiple interactions
affects transport		 ISO ABCG2 protein affects the export of estrone sulfate
ABCG2 protein results in increased export of estrone sulfate
ABCG2 protein results in increased uptake of estrone sulfate
[Adenosine Triphosphate co-treated with ABCG2 protein] results in increased uptake of estrone sulfate; Androstenedione inhibits the reaction [ABCG2 protein results in increased uptake of estrone sulfate]; Estradiol inhibits the reaction [ABCG2 protein results in increased uptake of estrone sulfate]; hippuric acid inhibits the reaction [ABCG2 protein results in increased export of estrone sulfate]; Indican inhibits the reaction [ABCG2 protein results in increased export of estrone sulfate]; Kynurenic Acid inhibits the reaction [ABCG2 protein results in increased export of estrone sulfate]; Progesterone inhibits the reaction [ABCG2 protein results in increased uptake of estrone sulfate]; Risperidone inhibits the reaction [ABCG2 protein results in increased uptake of estrone sulfate]; Sulfasalazine inhibits the reaction [[Adenosine Triphosphate co-treated with ABCG2 protein] results in increased uptake of estrone sulfate]; Testosterone inhibits the reaction [ABCG2 protein results in increased uptake of estrone sulfate]
ABCG2 protein affects the transport of estrone sulfate		 CTD PMID:15901800 PMID:18834354 PMID:19505989 PMID:21483698 PMID:22581381 More... NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Dhrs11 dehydrogenase/reductase 11 increases reduction ISO DHRS11 protein results in increased reduction of estrone sulfate CTD PMID:30926317 NCBI chr10:69,698,214...69,708,294
Ensembl chr10:69,698,214...69,708,295 		JBrowse link
G Esr2 estrogen receptor 2 affects binding EXP Estrone-3-sulfate binds to Esr2 protein RGD PMID:9048584 RGD:8694130 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Il1a interleukin 1 alpha decreases expression ISO estrone sulfate results in decreased expression of IL1A mRNA CTD PMID:10731640 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il6 interleukin 6 decreases expression ISO estrone sulfate results in decreased expression of IL6 mRNA CTD PMID:10731640 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Pdgfa platelet derived growth factor subunit A decreases expression ISO estrone sulfate results in decreased expression of PDGFA mRNA CTD PMID:10731640 NCBI chr12:15,645,549...15,667,056
Ensembl chr12:15,645,541...15,666,497 		JBrowse link
G Slc10a1 solute carrier family 10 member 1 multiple interactions ISO daidzein metabolite inhibits the reaction [SLC10A1 protein results in increased transport of estrone sulfate]; daidzein metabolite promotes the reaction [SLC10A1 protein results in increased transport of estrone sulfate]; estrone sulfate inhibits the reaction [SLC10A1 protein results in increased transport of daidzein metabolite] CTD PMID:25319728 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670 		JBrowse link
G Slc10a6 solute carrier family 10 member 6 increases transport
increases uptake
increases response to substance
multiple interactions		 ISO SLC10A6 protein results in increased transport of estrone sulfate
SLC10A6 protein results in increased uptake of estrone sulfate
SLC10A6 protein results in increased susceptibility to estrone sulfate
daidzein inhibits the reaction [SLC10A6 protein results in increased transport of estrone sulfate]; daidzein metabolite inhibits the reaction [SLC10A6 protein results in increased transport of estrone sulfate]; estrone sulfate inhibits the reaction [SLC10A6 protein results in increased transport of daidzein metabolite]; Sodium promotes the reaction [SLC10A6 protein results in increased uptake of estrone sulfate]		 CTD PMID:23562556 PMID:25319728 PMID:30186172 NCBI chr14:6,080,716...6,102,037
Ensembl chr14:6,080,717...6,103,037 		JBrowse link
G Slc17a3 solute carrier family 17 member 3 affects transport ISO SLC17A3 gene SNP affects the transport of estrone sulfate CTD PMID:21282933 NCBI chr17:41,270,804...41,300,132
Ensembl chr17:41,270,812...41,295,256 		JBrowse link
G Slc22a20 solute carrier family 22 member 20 multiple interactions
increases uptake		 ISO 2,4-Dichlorophenoxyacetic Acid inhibits the reaction [SLC22A20 protein results in increased uptake of estrone sulfate]; Glutarates promotes the reaction [SLC22A20 protein results in increased uptake of estrone sulfate]; ochratoxin A inhibits the reaction [SLC22A20 protein results in increased uptake of estrone sulfate]; p-Aminohippuric Acid inhibits the reaction [SLC22A20 protein results in increased uptake of estrone sulfate]; Penicillin G inhibits the reaction [SLC22A20 protein results in increased uptake of estrone sulfate]; Probenecid inhibits the reaction [SLC22A20 protein results in increased uptake of estrone sulfate]; Salicylates inhibits the reaction [SLC22A20 protein results in increased uptake of estrone sulfate]; Uric Acid inhibits the reaction [SLC22A20 protein results in increased uptake of estrone sulfate] CTD PMID:16478971 NCBI chr 1:203,257,374...203,273,848
Ensembl chr 1:203,257,374...203,273,822 		JBrowse link
G Slc22a25 solute carrier family 22, member 25 affects transport
increases import
multiple interactions
increases uptake		 EXP
ISO		 SLC22A9 protein affects the transport of estrone sulfate
SLC22A9 protein results in increased import of estrone sulfate
candesartan cilexetil inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]; candesartan inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]; Dehydroepiandrosterone Sulfate inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]; losartan carboxylic acid inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]; Losartan inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]; pranlukast inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]; Probenecid inhibits the reaction [SLC22A9 protein results in increased import of estrone sulfate]; Probenecid inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]; Tobacco Smoke Pollution inhibits the reaction [SLC22A9 protein results in increased import of estrone sulfate]; Valsartan inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]
4-methylumbelliferyl sulfate inhibits the reaction [SLC22A9 protein affects the transport of estrone sulfate]; Glutarates affects the reaction [SLC22A9 protein affects the transport of estrone sulfate]; naphthyl sulfate inhibits the reaction [SLC22A9 protein affects the transport of estrone sulfate]; Succinic Acid inhibits the reaction [SLC22A9 protein affects the transport of estrone sulfate]		 CTD PMID:16079298 PMID:17132213 PMID:18441515 PMID:28629854 NCBI chr 1:205,338,698...205,498,486
Ensembl chr 1:205,338,699...205,433,085 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 increases uptake ISO SLC22A6 protein results in increased uptake of estrone sulfate CTD PMID:16098483 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173 		JBrowse link
G Slc22a7 solute carrier family 22 member 7 multiple interactions
increases uptake		 ISO Fumarates promotes the reaction [SLC22A7 protein results in increased uptake of estrone sulfate]; Succinates promotes the reaction [SLC22A7 protein results in increased uptake of estrone sulfate] CTD PMID:15901346 NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions
increases import
affects transport
increases uptake		 ISO
EXP		 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; aristolochic acid I inhibits the reaction [SLC22A8 results in increased uptake of estrone sulfate]; bis(4-hydroxyphenyl)sulfone inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; bisphenol A inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; bisphenol F inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Bumetanide inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]; Cefaclor inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Cefdinir inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; cefoselis inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Cefotiam inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Ceftibuten inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Ceftizoxime inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Cephaloridine inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Cholates inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]; Cimetidine inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]; cyazofamid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Dehydroepiandrosterone inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]; Diclofenac inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]; estrone sulfate inhibits the reaction [SLC22A8 protein results in increased uptake of Famotidine]; estrone sulfate promotes the reaction [SLC22A8 results in increased export of p-Aminohippuric Acid]; Famotidine inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]; Furosemide inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]; Ibuprofen inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]; Indomethacin inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]; Probenecid inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]; Probenecid inhibits the reaction [SLC22A8 protein results in increased import of estrone sulfate]; Probenecid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Quercetin inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; rhein inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; rhein metabolite inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; tetrabromobisphenol A inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Tobacco Smoke Pollution inhibits the reaction [SLC22A8 protein results in increased import of estrone sulfate]
SLC22A8 protein results in increased uptake of estrone sulfate; SLC22A8 results in increased uptake of estrone sulfate
3,4-dihydroxymandelic acid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; 3,4-Dihydroxyphenylacetic Acid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; 5-methoxyindoleacetic acid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Bumetanide inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; estrone sulfate inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]; Furosemide inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; hexadecafluoro-nonanoic acid inhibits the reaction [SLC22A8 protein results in increased import of estrone sulfate]; Homovanillic Acid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Indocyanine Green inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; methoxytryptophol inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Penicillin G inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; perfluoro-n-heptanoic acid inhibits the reaction [SLC22A8 protein results in increased import of estrone sulfate]; perfluorodecanoic acid inhibits the reaction [SLC22A8 protein results in increased import of estrone sulfate]; perfluorooctanoic acid inhibits the reaction [SLC22A8 protein results in increased import of estrone sulfate]; Piroxicam inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Probenecid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Sulfobromophthalein inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Vanilmandelic Acid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]		 CTD PMID:10224140 PMID:11306713 PMID:15100168 PMID:15319347 PMID:15496291 More... NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 affects uptake
multiple interactions
increases uptake
increases transport
increases import		 ISO SLCO1A4 protein affects the uptake of estrone sulfate
7-hydroxymethotrexate inhibits the reaction [SLCO1A2 mRNA results in increased import of estrone sulfate]; artemisinin inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; Chloroquine inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; Mefloquine inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; Methotrexate inhibits the reaction [SLCO1A2 mRNA results in increased import of estrone sulfate]; naringin inhibits the reaction [SLCO1A2 protein alternative form results in increased uptake of estrone sulfate]; naringin inhibits the reaction [SLCO1A2 protein results in increased transport of estrone sulfate]; perfluorodecanoic acid inhibits the reaction [SLCO1A2 protein results in increased import of estrone sulfate]; Pyrimethamine inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; Quinine inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]
SLCO1A2 protein alternative form results in increased uptake of estrone sulfate; SLCO1A2 protein results in increased uptake of estrone sulfate
SLCO1A2 mRNA results in increased import of estrone sulfate; SLCO1A2 protein results in increased import of estrone sulfate		 CTD PMID:16702441 PMID:20639259 PMID:21561886 PMID:25466967 PMID:27504015 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions ISO cyazofamid inhibits the reaction [SLCO1B3 protein results in increased uptake of estrone sulfate] CTD PMID:32003934 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981 		JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 increases import
increases uptake
multiple interactions		 ISO SLCO2B1 protein results in increased import of estrone sulfate; SLCO2B1 results in increased import of estrone sulfate
SLCO2B1 protein results in increased uptake of estrone sulfate
2,2',4,4',5,6'-hexabromodiphenyl ether inhibits the reaction [SLCO2B1 results in increased import of estrone sulfate]; 2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [SLCO2B1 results in increased import of estrone sulfate]; [icariin results in decreased activity of SLCO2B1 protein] which results in decreased uptake of estrone sulfate; daidzein inhibits the reaction [SLCO2B1 protein results in increased transport of estrone sulfate]; daidzein metabolite inhibits the reaction [SLCO2B1 protein results in increased transport of estrone sulfate]; estrone sulfate inhibits the reaction [SLCO2B1 protein results in increased transport of daidzein metabolite]; estrone sulfate inhibits the reaction [SLCO2B1 protein results in increased uptake of Quercetin]; Mefloquine affects the reaction [SLCO2B1 protein results in increased uptake of estrone sulfate]; pentabromodiphenyl ether inhibits the reaction [SLCO2B1 results in increased import of estrone sulfate]; Rutin promotes the reaction [SLCO2B1 protein results in increased uptake of estrone sulfate]; Sulfobromophthalein inhibits the reaction [SLCO2B1 protein results in increased import of estrone sulfate]; Tobacco Smoke Pollution inhibits the reaction [SLCO2B1 protein results in increased import of estrone sulfate]		 CTD PMID:16714376 PMID:20176623 PMID:24265111 PMID:24285294 PMID:24947867 More... NCBI chr 1:153,959,288...154,007,294
Ensembl chr 1:153,959,293...154,007,353 		JBrowse link
G Slco3a1 solute carrier organic anion transporter family, member 3a1 multiple interactions ISO estrone sulfate promotes the reaction [SLCO3A1 protein results in increased uptake of simvastatin acid] CTD PMID:28887287 NCBI chr 1:128,115,184...128,387,887
Ensembl chr 1:128,106,228...128,387,925 		JBrowse link
G Sts steroid sulfatase affects metabolic processing
decreases sulfation		 ISO STS protein affects the metabolism of estrone sulfate
STS protein results in decreased sulfation of estrone sulfate		 CTD PMID:15597397 PMID:16054388 NCBI chr  X:42,225,131...42,233,403
Ensembl chr  X:42,225,372...42,233,402 		JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 multiple interactions ISO [[Oxygen deficiency co-treated with Oxygen] results in increased expression of SULT1E1 protein] which results in increased abundance of estrone sulfate CTD PMID:25922074 NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275 		JBrowse link
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Term Annotations click to browse term
  CHEBI ontology 19795
    role 19746
      application 19492
        pharmaceutical 19351
          drug 19351
            antineoplastic agent 17359
              estrone 129
                estrone 3-sulfate 22
Path 2
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  CHEBI ontology 19795
    subatomic particle 19794
      composite particle 19794
        hadron 19794
          baryon 19794
            nucleon 19794
              atomic nucleus 19794
                atom 19794
                  main group element atom 19693
                    p-block element atom 19693
                      chalcogen 19445
                        oxygen atom 19418
                          oxygen molecular entity 19418
                            hydroxides 19152
                              oxoacid 18466
                                chalcogen oxoacid 11497
                                  sulfur oxoacid 11105
                                    sulfuric acid 8024
                                      sulfuric acid derivative 8024
                                        sulfates 8020
                                          organic sulfate 1946
                                            steroid sulfate 62
                                              estrone 3-sulfate 22
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