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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:steroid sulfate
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Accession:CHEBI:16158 term browser browse the term
Definition:A sulfuric ester obtained by the formal condensation of a hydroxy group of any steroid with sulfuric acid.
Synonyms:related_synonym: Phenolic steroid O-sulfate;   Steroid O-sulfate;   steroid O-sulfates;   steroid sulfates
 alt_id: CHEBI:15110;   CHEBI:26760;   CHEBI:9264
 xref: KEGG:C02590


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cholesterol sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases expression ISO cholesteryl sulfate results in decreased expression of CYP11A1 mRNA CTD PMID:18490834 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
JBrowse link
G Star steroidogenic acute regulatory protein decreases expression ISO cholesteryl sulfate results in decreased expression of STAR mRNA; cholesteryl sulfate results in decreased expression of STAR protein CTD PMID:18490834 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
JBrowse link
G Sult2b1 sulfotransferase family 2B member 1 increases abundance ISO SULT2B1 protein results in increased abundance of cholesteryl sulfate CTD PMID:27052460 NCBI chr 1:96,200,155...96,261,295
Ensembl chr 1:96,200,156...96,261,295
JBrowse link
dehydroepiandrosterone sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity
multiple interactions
ISO Dehydroepiandrosterone Sulfate results in decreased activity of ABCB11 protein
Dehydroepiandrosterone Sulfate inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
CTD PMID:24014644 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Acox1 acyl-CoA oxidase 1 increases expression
multiple interactions
ISO Dehydroepiandrosterone Sulfate results in increased expression of ACOX1 mRNA
PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of ACOX1 mRNA]
CTD PMID:8700121 NCBI chr10:101,406,197...101,431,242
Ensembl chr10:101,406,197...101,431,232
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
multiple interactions
EXP Dehydroepiandrosterone Sulfate results in increased expression of BCL2 protein
Pertussis Toxin inhibits the reaction [Dehydroepiandrosterone Sulfate results in increased expression of BCL2 protein]
CTD PMID:16407456 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression
multiple interactions
EXP Dehydroepiandrosterone Sulfate results in increased expression of BCL2L1 protein
Pertussis Toxin inhibits the reaction [Dehydroepiandrosterone Sulfate results in increased expression of BCL2L1 protein]
CTD PMID:16407456 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions
increases expression
EXP [Dehydroepiandrosterone Sulfate co-treated with Phenobarbital] results in increased expression of CPT1A protein
Dehydroepiandrosterone Sulfate results in increased expression of CPT1A protein
CTD PMID:25786523 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 multiple interactions EXP [Dehydroepiandrosterone Sulfate co-treated with Phenobarbital] results in increased expression of CYP2C11 protein CTD PMID:25786523 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions EXP [Dehydroepiandrosterone Sulfate co-treated with Phenobarbital] results in increased expression of CYP2C6V1 protein CTD PMID:25786523 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
affects metabolic processing
EXP
ISO
[Dehydroepiandrosterone Sulfate co-treated with Phenobarbital] results in increased expression of CYP3A2 protein
CYP3A4 protein affects the metabolism of Dehydroepiandrosterone Sulfate
CTD PMID:2271712 PMID:25786523 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 increases expression
multiple interactions
EXP Dehydroepiandrosterone Sulfate results in increased expression of CYP4A1 mRNA; Dehydroepiandrosterone Sulfate results in increased expression of CYP4A1 protein
[Dehydroepiandrosterone Sulfate co-treated with Phenobarbital] results in increased expression of CYP4A1 protein
CTD PMID:8700121 PMID:25786523 NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464
JBrowse link
G Cyp4a3 cytochrome P450, family 4, subfamily a, polypeptide 3 increases expression EXP Dehydroepiandrosterone Sulfate results in increased expression of CYP4A3 mRNA CTD PMID:8700121 NCBI chr 5:129,097,571...129,115,488
Ensembl chr 5:129,097,926...129,115,463
JBrowse link
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase increases expression
multiple interactions
ISO Dehydroepiandrosterone Sulfate results in increased expression of EHHADH mRNA
PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of EHHADH mRNA]
CTD PMID:8700121 NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188
JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression
multiple interactions
ISO Dehydroepiandrosterone Sulfate results in increased expression of FABP1 mRNA
PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of FABP1 mRNA]
CTD PMID:8700121 NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [Morphine co-treated with Dehydroepiandrosterone Sulfate] results in decreased expression of FOS protein CTD PMID:15196791 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases abundance
ISO Dexamethasone inhibits the reaction [IL1B protein results in increased abundance of Dehydroepiandrosterone Sulfate] CTD PMID:12548226 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [Morphine co-treated with Dehydroepiandrosterone Sulfate] results in decreased phosphorylation of MAPK1 protein CTD PMID:15196791 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Nat1 N-acetyltransferase 1 multiple interactions ISO Dehydroepiandrosterone Sulfate inhibits the reaction [NAT1 protein results in increased acetylation of 4-Aminobenzoic Acid]; Dehydroepiandrosterone Sulfate promotes the reaction [NAT1 protein results in increased acetylation of 4-Aminobenzoic Acid] CTD PMID:11470991 NCBI chr16:22,218,217...22,238,516 JBrowse link
G Pomc proopiomelanocortin increases abundance ISO POMC results in increased abundance of Dehydroepiandrosterone Sulfate CTD PMID:2161262 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
increases response to substance
ISO PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of ACOX1 mRNA]; PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of CYP4A1 mRNA]; PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of CYP4A3 mRNA]; PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of EHHADH mRNA]; PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of FABP1 mRNA]
PPARA protein results in increased susceptibility to Dehydroepiandrosterone Sulfate
CTD PMID:8700121 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Prl prolactin increases abundance ISO PRL protein results in increased abundance of Dehydroepiandrosterone Sulfate CTD PMID:2943108 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
JBrowse link
G Sirt1 sirtuin 1 increases expression EXP Dehydroepiandrosterone Sulfate results in increased expression of SIRT1 protein CTD PMID:25786523 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Sirt6 sirtuin 6 increases expression EXP Dehydroepiandrosterone Sulfate results in increased expression of SIRT6 protein CTD PMID:25786523 NCBI chr 7:8,082,312...8,087,776
Ensembl chr 7:8,082,364...8,098,914
JBrowse link
G Slc10a6 solute carrier family 10 member 6 increases transport ISO SLC10A6 protein results in increased transport of Dehydroepiandrosterone Sulfate CTD PMID:23562556 NCBI chr14:6,080,716...6,102,037
Ensembl chr14:6,080,717...6,103,037
JBrowse link
G Slc22a12 solute carrier family 22 member 12 multiple interactions ISO Potassium promotes the reaction [SLC22A12 protein results in increased uptake of Dehydroepiandrosterone Sulfate] CTD PMID:15284287 NCBI chr 1:203,845,039...203,852,496
Ensembl chr 1:203,845,048...203,853,555
JBrowse link
G Slc22a25 solute carrier family 22, member 25 increases uptake
multiple interactions
EXP
ISO
SLC22A9 protein results in increased uptake of Dehydroepiandrosterone Sulfate
Dehydroepiandrosterone Sulfate inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]
CTD PMID:17132213 PMID:18441515 NCBI chr 1:205,338,698...205,498,486
Ensembl chr 1:205,338,699...205,433,085
JBrowse link
G Slc22a7 solute carrier family 22 member 7 increases transport ISO SLC22A7 protein results in increased transport of Dehydroepiandrosterone Sulfate CTD PMID:15901346 NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921
JBrowse link
G Slc22a8 solute carrier family 22 member 8 affects transport
increases uptake
ISO SLC22A8 protein affects the transport of Dehydroepiandrosterone Sulfate
SLC22A8 protein results in increased uptake of Dehydroepiandrosterone Sulfate
CTD PMID:11306713 PMID:16098483 PMID:17255469 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions ISO Dehydroepiandrosterone Sulfate inhibits the reaction [SLCO1B3 protein results in increased susceptibility to cyanoginosin LR]; Dehydroepiandrosterone Sulfate inhibits the reaction [SLCO1B3 protein results in increased susceptibility to Okadaic Acid] CTD PMID:26134461 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase increases phosphorylation EXP Dehydroepiandrosterone Sulfate results in increased phosphorylation of SRC protein CTD PMID:16407456 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G Sts steroid sulfatase affects metabolic processing ISO STS protein affects the metabolism of Dehydroepiandrosterone Sulfate CTD PMID:16054388 NCBI chr  X:42,225,131...42,233,403
Ensembl chr  X:42,225,372...42,233,402
JBrowse link
estrone 3-sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca8 ATP binding cassette subfamily A member 8 affects transport ISO ABCA8 protein affects the transport of estrone sulfate CTD PMID:12379217 NCBI chr10:94,917,520...94,991,199
Ensembl chr10:94,917,520...94,990,988
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 affects export
increases activity
ISO
EXP
ABCC2 protein affects the export of estrone sulfate
estrone sulfate results in increased activity of ABCC2 protein; estrone sulfate results in increased activity of ABCC2 protein modified form
CTD PMID:15652233 PMID:15904671 PMID:16046661 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 affects export
increases export
increases uptake
multiple interactions
affects transport
ISO ABCG2 protein affects the export of estrone sulfate
ABCG2 protein results in increased export of estrone sulfate
ABCG2 protein results in increased uptake of estrone sulfate
[Adenosine Triphosphate co-treated with ABCG2 protein] results in increased uptake of estrone sulfate; Androstenedione inhibits the reaction [ABCG2 protein results in increased uptake of estrone sulfate]; Estradiol inhibits the reaction [ABCG2 protein results in increased uptake of estrone sulfate]; hippuric acid inhibits the reaction [ABCG2 protein results in increased export of estrone sulfate]; Indican inhibits the reaction [ABCG2 protein results in increased export of estrone sulfate]; Kynurenic Acid inhibits the reaction [ABCG2 protein results in increased export of estrone sulfate]; Progesterone inhibits the reaction [ABCG2 protein results in increased uptake of estrone sulfate]; Risperidone inhibits the reaction [ABCG2 protein results in increased uptake of estrone sulfate]; Sulfasalazine inhibits the reaction [[Adenosine Triphosphate co-treated with ABCG2 protein] results in increased uptake of estrone sulfate]; Testosterone inhibits the reaction [ABCG2 protein results in increased uptake of estrone sulfate]
ABCG2 protein affects the transport of estrone sulfate
CTD PMID:15901800 PMID:18834354 PMID:19505989 PMID:21483698 PMID:22581381 More... NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Dhrs11 dehydrogenase/reductase 11 increases reduction ISO DHRS11 protein results in increased reduction of estrone sulfate CTD PMID:30926317 NCBI chr10:69,698,214...69,708,294
Ensembl chr10:69,698,214...69,708,295
JBrowse link
G Esr2 estrogen receptor 2 affects binding EXP Estrone-3-sulfate binds to Esr2 protein RGD PMID:9048584 RGD:8694130 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Il1a interleukin 1 alpha decreases expression ISO estrone sulfate results in decreased expression of IL1A mRNA CTD PMID:10731640 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il6 interleukin 6 decreases expression ISO estrone sulfate results in decreased expression of IL6 mRNA CTD PMID:10731640 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Pdgfa platelet derived growth factor subunit A decreases expression ISO estrone sulfate results in decreased expression of PDGFA mRNA CTD PMID:10731640 NCBI chr12:15,645,549...15,667,056
Ensembl chr12:15,645,541...15,666,497
JBrowse link
G Slc10a1 solute carrier family 10 member 1 multiple interactions ISO daidzein metabolite inhibits the reaction [SLC10A1 protein results in increased transport of estrone sulfate]; daidzein metabolite promotes the reaction [SLC10A1 protein results in increased transport of estrone sulfate]; estrone sulfate inhibits the reaction [SLC10A1 protein results in increased transport of daidzein metabolite] CTD PMID:25319728 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
JBrowse link
G Slc10a6 solute carrier family 10 member 6 increases transport
increases uptake
increases response to substance
multiple interactions
ISO SLC10A6 protein results in increased transport of estrone sulfate
SLC10A6 protein results in increased uptake of estrone sulfate
SLC10A6 protein results in increased susceptibility to estrone sulfate
daidzein inhibits the reaction [SLC10A6 protein results in increased transport of estrone sulfate]; daidzein metabolite inhibits the reaction [SLC10A6 protein results in increased transport of estrone sulfate]; estrone sulfate inhibits the reaction [SLC10A6 protein results in increased transport of daidzein metabolite]; Sodium promotes the reaction [SLC10A6 protein results in increased uptake of estrone sulfate]
CTD PMID:23562556 PMID:25319728 PMID:30186172 NCBI chr14:6,080,716...6,102,037
Ensembl chr14:6,080,717...6,103,037
JBrowse link
G Slc17a3 solute carrier family 17 member 3 affects transport ISO SLC17A3 gene SNP affects the transport of estrone sulfate CTD PMID:21282933 NCBI chr17:41,270,804...41,300,132
Ensembl chr17:41,270,812...41,295,256
JBrowse link
G Slc22a20 solute carrier family 22 member 20 multiple interactions
increases uptake
ISO 2,4-Dichlorophenoxyacetic Acid inhibits the reaction [SLC22A20 protein results in increased uptake of estrone sulfate]; Glutarates promotes the reaction [SLC22A20 protein results in increased uptake of estrone sulfate]; ochratoxin A inhibits the reaction [SLC22A20 protein results in increased uptake of estrone sulfate]; p-Aminohippuric Acid inhibits the reaction [SLC22A20 protein results in increased uptake of estrone sulfate]; Penicillin G inhibits the reaction [SLC22A20 protein results in increased uptake of estrone sulfate]; Probenecid inhibits the reaction [SLC22A20 protein results in increased uptake of estrone sulfate]; Salicylates inhibits the reaction [SLC22A20 protein results in increased uptake of estrone sulfate]; Uric Acid inhibits the reaction [SLC22A20 protein results in increased uptake of estrone sulfate] CTD PMID:16478971 NCBI chr 1:203,257,374...203,273,848
Ensembl chr 1:203,257,374...203,273,822
JBrowse link
G Slc22a25 solute carrier family 22, member 25 affects transport
increases import
multiple interactions
increases uptake
EXP
ISO
SLC22A9 protein affects the transport of estrone sulfate
SLC22A9 protein results in increased import of estrone sulfate
candesartan cilexetil inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]; candesartan inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]; Dehydroepiandrosterone Sulfate inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]; losartan carboxylic acid inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]; Losartan inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]; pranlukast inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]; Probenecid inhibits the reaction [SLC22A9 protein results in increased import of estrone sulfate]; Probenecid inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]; Tobacco Smoke Pollution inhibits the reaction [SLC22A9 protein results in increased import of estrone sulfate]; Valsartan inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]
4-methylumbelliferyl sulfate inhibits the reaction [SLC22A9 protein affects the transport of estrone sulfate]; Glutarates affects the reaction [SLC22A9 protein affects the transport of estrone sulfate]; naphthyl sulfate inhibits the reaction [SLC22A9 protein affects the transport of estrone sulfate]; Succinic Acid inhibits the reaction [SLC22A9 protein affects the transport of estrone sulfate]
CTD PMID:16079298 PMID:17132213 PMID:18441515 PMID:28629854 NCBI chr 1:205,338,698...205,498,486
Ensembl chr 1:205,338,699...205,433,085
JBrowse link
G Slc22a6 solute carrier family 22 member 6 increases uptake ISO SLC22A6 protein results in increased uptake of estrone sulfate CTD PMID:16098483 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
JBrowse link
G Slc22a7 solute carrier family 22 member 7 multiple interactions
increases uptake
ISO Fumarates promotes the reaction [SLC22A7 protein results in increased uptake of estrone sulfate]; Succinates promotes the reaction [SLC22A7 protein results in increased uptake of estrone sulfate] CTD PMID:15901346 NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921
JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions
increases import
affects transport
increases uptake
ISO
EXP
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; aristolochic acid I inhibits the reaction [SLC22A8 results in increased uptake of estrone sulfate]; bis(4-hydroxyphenyl)sulfone inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; bisphenol A inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; bisphenol F inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Bumetanide inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]; Cefaclor inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Cefdinir inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; cefoselis inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Cefotiam inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Ceftibuten inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Ceftizoxime inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Cephaloridine inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Cholates inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]; Cimetidine inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]; cyazofamid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Dehydroepiandrosterone inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]; Diclofenac inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]; estrone sulfate inhibits the reaction [SLC22A8 protein results in increased uptake of Famotidine]; estrone sulfate promotes the reaction [SLC22A8 results in increased export of p-Aminohippuric Acid]; Famotidine inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]; Furosemide inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]; Ibuprofen inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]; Indomethacin inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]; Probenecid inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]; Probenecid inhibits the reaction [SLC22A8 protein results in increased import of estrone sulfate]; Probenecid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Quercetin inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; rhein inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; rhein metabolite inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; tetrabromobisphenol A inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Tobacco Smoke Pollution inhibits the reaction [SLC22A8 protein results in increased import of estrone sulfate]
SLC22A8 protein results in increased uptake of estrone sulfate; SLC22A8 results in increased uptake of estrone sulfate
3,4-dihydroxymandelic acid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; 3,4-Dihydroxyphenylacetic Acid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; 5-methoxyindoleacetic acid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Bumetanide inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; estrone sulfate inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]; Furosemide inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; hexadecafluoro-nonanoic acid inhibits the reaction [SLC22A8 protein results in increased import of estrone sulfate]; Homovanillic Acid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Indocyanine Green inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; methoxytryptophol inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Penicillin G inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; perfluoro-n-heptanoic acid inhibits the reaction [SLC22A8 protein results in increased import of estrone sulfate]; perfluorodecanoic acid inhibits the reaction [SLC22A8 protein results in increased import of estrone sulfate]; perfluorooctanoic acid inhibits the reaction [SLC22A8 protein results in increased import of estrone sulfate]; Piroxicam inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Probenecid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Sulfobromophthalein inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Vanilmandelic Acid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]
CTD PMID:10224140 PMID:11306713 PMID:15100168 PMID:15319347 PMID:15496291 More... NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 affects uptake
multiple interactions
increases uptake
increases transport
increases import
ISO SLCO1A4 protein affects the uptake of estrone sulfate
7-hydroxymethotrexate inhibits the reaction [SLCO1A2 mRNA results in increased import of estrone sulfate]; artemisinine inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; Chloroquine inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; Mefloquine inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; Methotrexate inhibits the reaction [SLCO1A2 mRNA results in increased import of estrone sulfate]; naringin inhibits the reaction [SLCO1A2 protein alternative form results in increased uptake of estrone sulfate]; naringin inhibits the reaction [SLCO1A2 protein results in increased transport of estrone sulfate]; perfluorodecanoic acid inhibits the reaction [SLCO1A2 protein results in increased import of estrone sulfate]; Pyrimethamine inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; Quinine inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]
SLCO1A2 protein alternative form results in increased uptake of estrone sulfate; SLCO1A2 protein results in increased uptake of estrone sulfate
SLCO1A2 mRNA results in increased import of estrone sulfate; SLCO1A2 protein results in increased import of estrone sulfate
CTD PMID:16702441 PMID:20639259 PMID:21561886 PMID:25466967 PMID:27504015 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions ISO cyazofamid inhibits the reaction [SLCO1B3 protein results in increased uptake of estrone sulfate] CTD PMID:32003934 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981
JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 increases import
increases uptake
multiple interactions
ISO SLCO2B1 protein results in increased import of estrone sulfate; SLCO2B1 results in increased import of estrone sulfate
SLCO2B1 protein results in increased uptake of estrone sulfate
2,2',4,4',5,6'-hexabromodiphenyl ether inhibits the reaction [SLCO2B1 results in increased import of estrone sulfate]; 2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [SLCO2B1 results in increased import of estrone sulfate]; [icariin results in decreased activity of SLCO2B1 protein] which results in decreased uptake of estrone sulfate; daidzein inhibits the reaction [SLCO2B1 protein results in increased transport of estrone sulfate]; daidzein metabolite inhibits the reaction [SLCO2B1 protein results in increased transport of estrone sulfate]; estrone sulfate inhibits the reaction [SLCO2B1 protein results in increased transport of daidzein metabolite]; estrone sulfate inhibits the reaction [SLCO2B1 protein results in increased uptake of Quercetin]; Mefloquine affects the reaction [SLCO2B1 protein results in increased uptake of estrone sulfate]; pentabromodiphenyl ether inhibits the reaction [SLCO2B1 results in increased import of estrone sulfate]; Rutin promotes the reaction [SLCO2B1 protein results in increased uptake of estrone sulfate]; Sulfobromophthalein inhibits the reaction [SLCO2B1 protein results in increased import of estrone sulfate]; Tobacco Smoke Pollution inhibits the reaction [SLCO2B1 protein results in increased import of estrone sulfate]
CTD PMID:16714376 PMID:20176623 PMID:24265111 PMID:24285294 PMID:24947867 More... NCBI chr 1:153,959,288...154,007,294
Ensembl chr 1:153,959,293...154,007,353
JBrowse link
G Slco3a1 solute carrier organic anion transporter family, member 3a1 multiple interactions ISO estrone sulfate promotes the reaction [SLCO3A1 protein results in increased uptake of simvastatin acid] CTD PMID:28887287 NCBI chr 1:128,115,184...128,387,887
Ensembl chr 1:128,106,228...128,387,925
JBrowse link
G Sts steroid sulfatase affects metabolic processing
decreases sulfation
ISO STS protein affects the metabolism of estrone sulfate
STS protein results in decreased sulfation of estrone sulfate
CTD PMID:15597397 PMID:16054388 NCBI chr  X:42,225,131...42,233,403
Ensembl chr  X:42,225,372...42,233,402
JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 multiple interactions ISO [[Oxygen deficiency co-treated with Oxygen] results in increased expression of SULT1E1 protein] which results in increased abundance of estrone sulfate CTD PMID:25922074 NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275
JBrowse link
lithocholic acid sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions ISO sulfolithocholic acid inhibits the reaction [ABCC1 protein results in increased export of 2',7'-bis-(carboxypropyl)-5(6)-carboxyfluorescein] CTD PMID:16101123 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Gsta4 glutathione S-transferase alpha 4 multiple interactions EXP sulfolithocholic acid binds to and results in decreased activity of GSTA4 protein CTD PMID:3954743 NCBI chr 8:79,066,967...79,084,193
Ensembl chr 8:79,066,934...79,084,182
JBrowse link
G Gstm1 glutathione S-transferase mu 1 multiple interactions EXP sulfolithocholic acid binds to and results in decreased activity of GSTM1 protein CTD PMID:3954743 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G Gstm2 glutathione S-transferase mu 2 multiple interactions EXP sulfolithocholic acid binds to and results in decreased activity of GSTM2 protein CTD PMID:3954743 NCBI chr 2:195,624,015...195,628,774 JBrowse link
pregnenolone sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions EXP pregnenolone sulfate inhibits the reaction [gamma-Aminobutyric Acid binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; pregnenolone sulfate results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein] CTD PMID:17054655 NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864
JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 multiple interactions EXP pregnenolone sulfate inhibits the reaction [gamma-Aminobutyric Acid binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; pregnenolone sulfate results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein] CTD PMID:17054655 NCBI chr10:26,936,592...27,156,141
Ensembl chr10:26,936,551...27,151,251
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions EXP pregnenolone sulfate inhibits the reaction [gamma-Aminobutyric Acid binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; pregnenolone sulfate results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein] CTD PMID:17054655 NCBI chr10:26,376,805...26,463,680
Ensembl chr10:26,374,694...26,464,346
JBrowse link
G Glra1 glycine receptor, alpha 1 decreases activity ISO pregnenolone sulfate results in decreased activity of GLRA1 protein CTD PMID:15081878 NCBI chr10:39,625,853...39,727,897
Ensembl chr10:39,629,459...39,727,162
JBrowse link
G Slc10a6 solute carrier family 10 member 6 increases transport ISO SLC10A6 protein results in increased transport of pregnenolone sulfate CTD PMID:23562556 NCBI chr14:6,080,716...6,102,037
Ensembl chr14:6,080,717...6,103,037
JBrowse link
G Trpm3 transient receptor potential cation channel, subfamily M, member 3 multiple interactions ISO pregnenolone sulfate binds to and results in increased activity of TRPM3 protein CTD PMID:30883612 NCBI chr 1:219,673,200...220,557,610
Ensembl chr 1:219,672,892...220,560,717
JBrowse link
sulfoglycolithocholic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc10a1 solute carrier family 10 member 1 increases uptake ISO SLC10A1 protein results in increased uptake of sulfolithocholylglycine CTD PMID:29024779 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
JBrowse link
taurolithocholic acid sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen multiple interactions
decreases response to substance
EXP AGT protein inhibits the reaction [taurolithocholic acid 3-sulfate results in increased activity of CASP3 protein]
AGT protein results in decreased susceptibility to taurolithocholic acid 3-sulfate
CTD PMID:23300732 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
EXP AGT protein inhibits the reaction [taurolithocholic acid 3-sulfate results in increased activity of CASP3 protein] CTD PMID:23300732 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cftr CF transmembrane conductance regulator decreases activity ISO taurolithocholic acid 3-sulfate results in decreased activity of CFTR protein CTD PMID:15634668 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 affects binding ISO taurolithocholic acid 3-sulfate binds to CHRM1 protein CTD PMID:12464352 NCBI chr 1:205,567,046...205,583,001
Ensembl chr 1:205,567,220...205,582,356
JBrowse link
G Ifng interferon gamma multiple interactions
increases expression
ISO Dantrolene inhibits the reaction [taurolithocholic acid 3-sulfate results in increased expression of IFNG mRNA] CTD PMID:22517774 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
ISO Dantrolene inhibits the reaction [taurolithocholic acid 3-sulfate results in increased expression of IL6 mRNA] CTD PMID:22517774 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      chemical role 19345
        catalyst 8052
          sulfuric acid 8012
            sulfuric acid derivative 8012
              organic sulfate 1945
                steroid sulfate 62
                  (24S)-hydroxycholesterol 24-sulfate 0
                  (24S)-hydroxycholesterol 3,24-disulfate 0
                  (24S)-hydroxycholesterol 3-sulfate 0
                  16alpha-hydroxydehydroepiandrosterone 3-sulfate 0
                  17-hydroxypregnenolone 3-sulfate 0
                  17alpha-ethynylestradiol 3-sulfate 0
                  17beta-estradiol 3-sulfate 0
                  17beta-estradiol 3-sulfate 17-(beta-D-glucosiduronic acid) 0
                  2,3-dihydro-3beta-O-sulfate withaferin A 0
                  2-Hydroxyestrone sulfate 0
                  2-hydroxy-17beta-estradiol 3-sulfate 0
                  2-methoxy-17beta-estradiol 3-sulfate 0
                  2-methoxyestrone 3-sulfate 0
                  21-hydroxypregnenolone disulfate 0
                  24-epi-cathasterone-22-O-sulfate 0
                  26-hydroxycholesterol 3-sulfate 0
                  3-Sulfodeoxycholic acid 0
                  3alpha,7alpha,12alpha-trihydroxy-5alpha-cholan-24-yl sulfate 0
                  3alpha-Hydroxy-5beta-pregnane-20-one sulfate 0
                  3b,16a-Dihydroxyandrostenone sulfate 0
                  4-Hydroxyestrone sulfate 0
                  4-androstene-3beta,17beta-diol disulfate 0
                  5alpha-dihydrotestosterone sulfate 0
                  5alpha-pregnane-3,20beta-diol disulfate 0
                  5alpha-pregnane-3beta,20alpha-diol disulfate 0
                  5beta-Androstan-3alpha-ol-17-one sulfate 0
                  5beta-cyprinol sulfate 0
                  5beta-scymnol sulfate 0
                  Abiraterone sulfate 0
                  Epitestosterone sulfate 0
                  Estra-1,3,5(10)-trien-3-yl hydrogen sulfate 0
                  Etiocholanolone sulfate 0
                  Steryl sulfate 0
                  androstane sulfate + 0
                  androsterone sulfate 0
                  beta-Estradiol 3-sulfate 0
                  cholesterol sulfate 3
                  clathsterol disulfonic acid 0
                  cortisol 21-sulfate 0
                  dehydroepiandrosterone sulfate 29
                  epiandrosterone sulfate 0
                  equilin sodium sulfate 0
                  estrone 3-sulfate 22
                  estrone sodium sulfate 0
                  estropipate 0
                  eurysterol A sulfonic acid 0
                  eurysterol B sulfonic acid 0
                  glycodeoxycholic acid 3-sulfate 0
                  halistanol sulfonic acid F 0
                  halistanol sulfonic acid G 0
                  lithocholic acid sulfate 4
                  phenolic steroid 3-O-sulfate(1-) 0
                  prasterone sodium sulfate 0
                  pregnenolone sulfate 6
                  sulfoglycochenodeoxycholic acid 0
                  sulfoglycolithocholic acid 1
                  sulfuric acid [(13S)-13-methyl-17-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-yl] ester 0
                  sulfuric acid [(8R,9R,13S,14R)-13-methyl-17-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-yl] ester 0
                  taurolithocholic acid sulfate 6
                  testosterone sulfate 0
                  withalongolide G 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      chalcogen 19469
                        oxygen atom 19445
                          oxygen molecular entity 19445
                            hydroxides 19180
                              oxoacid 18498
                                chalcogen oxoacid 11491
                                  sulfur oxoacid 11099
                                    sulfuric acid 8012
                                      sulfuric acid derivative 8012
                                        sulfates 8008
                                          organic sulfate 1945
                                            steroid sulfate 62
                                              (24S)-hydroxycholesterol 24-sulfate 0
                                              (24S)-hydroxycholesterol 3,24-disulfate 0
                                              (24S)-hydroxycholesterol 3-sulfate 0
                                              16alpha-hydroxydehydroepiandrosterone 3-sulfate 0
                                              17-hydroxypregnenolone 3-sulfate 0
                                              17alpha-ethynylestradiol 3-sulfate 0
                                              17beta-estradiol 3-sulfate 0
                                              17beta-estradiol 3-sulfate 17-(beta-D-glucosiduronic acid) 0
                                              2,3-dihydro-3beta-O-sulfate withaferin A 0
                                              2-Hydroxyestrone sulfate 0
                                              2-hydroxy-17beta-estradiol 3-sulfate 0
                                              2-methoxy-17beta-estradiol 3-sulfate 0
                                              2-methoxyestrone 3-sulfate 0
                                              21-hydroxypregnenolone disulfate 0
                                              24-epi-cathasterone-22-O-sulfate 0
                                              26-hydroxycholesterol 3-sulfate 0
                                              3-Sulfodeoxycholic acid 0
                                              3alpha,7alpha,12alpha-trihydroxy-5alpha-cholan-24-yl sulfate 0
                                              3alpha-Hydroxy-5beta-pregnane-20-one sulfate 0
                                              3b,16a-Dihydroxyandrostenone sulfate 0
                                              4-Hydroxyestrone sulfate 0
                                              4-androstene-3beta,17beta-diol disulfate 0
                                              5alpha-dihydrotestosterone sulfate 0
                                              5alpha-pregnane-3,20beta-diol disulfate 0
                                              5alpha-pregnane-3beta,20alpha-diol disulfate 0
                                              5beta-Androstan-3alpha-ol-17-one sulfate 0
                                              5beta-cyprinol sulfate 0
                                              5beta-scymnol sulfate 0
                                              Abiraterone sulfate 0
                                              Epitestosterone sulfate 0
                                              Estra-1,3,5(10)-trien-3-yl hydrogen sulfate 0
                                              Etiocholanolone sulfate 0
                                              Steryl sulfate 0
                                              androstane sulfate + 0
                                              androsterone sulfate 0
                                              beta-Estradiol 3-sulfate 0
                                              cholesterol sulfate 3
                                              clathsterol disulfonic acid 0
                                              cortisol 21-sulfate 0
                                              dehydroepiandrosterone sulfate 29
                                              epiandrosterone sulfate 0
                                              equilin sodium sulfate 0
                                              estrone 3-sulfate 22
                                              estrone sodium sulfate 0
                                              estropipate 0
                                              eurysterol A sulfonic acid 0
                                              eurysterol B sulfonic acid 0
                                              glycodeoxycholic acid 3-sulfate 0
                                              halistanol sulfonic acid F 0
                                              halistanol sulfonic acid G 0
                                              lithocholic acid sulfate 4
                                              phenolic steroid 3-O-sulfate(1-) 0
                                              prasterone sodium sulfate 0
                                              pregnenolone sulfate 6
                                              sulfoglycochenodeoxycholic acid 0
                                              sulfoglycolithocholic acid 1
                                              sulfuric acid [(13S)-13-methyl-17-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-yl] ester 0
                                              sulfuric acid [(8R,9R,13S,14R)-13-methyl-17-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-yl] ester 0
                                              taurolithocholic acid sulfate 6
                                              testosterone sulfate 0
                                              withalongolide G 0
paths to the root