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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:estrone
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Accession:CHEBI:17263 term browser browse the term
Definition:A 17-oxo steroid that is estra-1,3,5(10)-triene substituted by an hydroxy group at position 3 and an oxo group at position 17.
Synonyms:related_synonym: 3-Hydroxy-1,3,5(10)-estratrien-17-one;   3-Hydroxyestra-1,3,5(10)-trien-17-one;   Formula=C18H22O2;   InChI=1S/C18H22O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-16,19H,2,4,6-9H2,1H3/t14-,15-,16+,18+/m1/s1;   InChIKey=DNXHEGUUPJUMQT-CBZIJGRNSA-N;   SMILES=[H][C@]12CC[C@]3(C)C(=O)CC[C@@]3([H])[C@]1([H])CCc1cc(O)ccc21;   follicular hormone;   folliculin;   oestrone
 alt_id: CHEBI:14220;   CHEBI:23971;   CHEBI:4870
 xref: Beilstein:1915077;   CAS:53-16-7;   DrugBank:DB00655;   Drug_Central:3188;   Gmelin:542591;   HMDB:HMDB0000145;   KEGG:C00468;   KEGG:D00067;   KNApSAcK:C00003663;   LINCS:LSM-3837;   LIPID_MAPS_instance:LMST02010004
 xref_mesh: MESH:D004970
 xref: PDBeChem:J3Z;   PMID:11786692;   PMID:19610377;   PMID:23647561;   PMID:24390165;   PMID:24398390;   Patent:FR1305992;   Patent:US1967350;   Patent:US1967351;   Reaxys:1915077;   Wikipedia:Estrone


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estrone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases expression
decreases expression
increases export
ISO Elacridar inhibits the reaction [ABCB1 protein results in increased export of Estrone]
Estrone results in increased expression of ABCB1 mRNA; Estrone results in increased expression of ABCB1 protein
Estrone results in decreased expression of ABCB1 protein
CTD PMID:15290871, PMID:16925584 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc8 ATP binding cassette subfamily C member 8 increases response to substance EXP ABCC8 protein results in increased susceptibility to Estrone CTD PMID:19095654 NCBI chr 1:102,110,708...102,191,287
Ensembl chr 1:102,110,708...102,191,287
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 increases expression ISO Estrone results in increased expression of ABCG2 mRNA CTD PMID:16849015 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Abhd2 abhydrolase domain containing 2, acylglycerol lipase increases expression ISO Estrone results in increased expression of ABHD2 mRNA CTD PMID:26865669 NCBI chr 1:140,998,240...141,087,405
Ensembl chr 1:140,998,240...141,087,405
JBrowse link
G Afp alpha-fetoprotein affects binding EXP Estrone binds to AFP protein CTD PMID:23013281, PMID:25349334 NCBI chr14:19,141,755...19,159,919
Ensembl chr14:19,141,755...19,159,923
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 increases metabolic processing
increases reduction
multiple interactions
ISO AKR1C3 protein results in increased metabolism of Estrone
AKR1C3 protein results in increased reduction of Estrone
[AKR1C3 protein results in increased metabolism of Estrone] which results in increased chemical synthesis of Estradiol; [AKR1C3 protein results in increased reduction of Estrone] which results in increased chemical synthesis of Estradiol
CTD PMID:19010312, PMID:20036328 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions
ISO Estrone results in increased phosphorylation of AKT1 protein
wortmannin inhibits the reaction [Estrone results in increased phosphorylation of AKT1 protein]
CTD PMID:21767602 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alad aminolevulinate dehydratase decreases expression ISO Estrone results in decreased expression of ALAD mRNA CTD PMID:26865669 NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
JBrowse link
G Alpp alkaline phosphatase, placental increases chemical synthesis ISO ALPP protein results in increased chemical synthesis of Estrone CTD PMID:1495895 NCBI chr 9:94,189,961...94,193,054
Ensembl chr 9:94,190,067...94,192,813
JBrowse link
G Ar androgen receptor multiple interactions ISO Estrone binds to and results in increased activity of AR protein CTD PMID:12676605 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Areg amphiregulin increases expression ISO Estrone results in increased expression of AREG mRNA CTD PMID:26865669 NCBI chr14:18,521,921...18,531,179
Ensembl chr14:18,521,930...18,531,179
JBrowse link
G Arhgdia Rho GDP dissociation inhibitor alpha decreases expression ISO Estrone results in decreased expression of ARHGDIA mRNA CTD PMID:15159206 NCBI chr10:109,754,012...109,757,506
Ensembl chr10:109,754,004...109,757,550
JBrowse link
G Ca12 carbonic anhydrase 12 increases expression ISO Estrone results in increased expression of CA12 mRNA CTD PMID:26865669 NCBI chr 8:72,405,770...72,461,425
Ensembl chr 8:72,405,748...72,460,240
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO Palmitic Acid promotes the reaction [Estrone results in increased activity of CASP3 protein] CTD PMID:22700542 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 increases activity
multiple interactions
ISO Estrone results in increased activity of CASP7 protein
Palmitic Acid promotes the reaction [Estrone results in increased activity of CASP7 protein]
CTD PMID:22700542 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Ccng2 cyclin G2 decreases expression ISO Estrone results in decreased expression of CCNG2 mRNA CTD PMID:26865669 NCBI chr14:16,267,572...16,276,068
Ensembl chr14:16,267,573...16,276,068
JBrowse link
G Comt catechol-O-methyltransferase increases methylation ISO COMT protein results in increased methylation of Estrone metabolite CTD PMID:22285433 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 increases expression ISO Estrone results in increased expression of CXCL12 mRNA CTD PMID:26865669 NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 affects abundance ISO CYP17A1 protein affects the abundance of Estrone CTD PMID:21427057 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 affects chemical synthesis
multiple interactions
increases chemical synthesis
ISO CYP19A1 protein affects the chemical synthesis of Estrone
[Fluconazole results in decreased activity of CYP19A1 protein] which results in decreased chemical synthesis of Estrone; [Ketoconazole results in increased activity of CYP19A1 protein] which results in increased chemical synthesis of Estrone; Estrone analog binds to and results in decreased activity of CYP19A1 protein; TNF protein promotes the reaction [CYP19A1 protein affects the chemical synthesis of Estrone]
CYP19A1 protein results in increased chemical synthesis of Estrone
CTD PMID:16030167, PMID:16039845, PMID:16054388, PMID:31330226 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases hydroxylation
affects binding
multiple interactions
ISO CYP1A1 protein polymorphism results in increased hydroxylation of Estrone
CYP1A1 protein binds to Estrone
Estrone promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
CTD PMID:12093619, PMID:15805301, PMID:27966929 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
affects binding
ISO CYP1A2 protein promotes the reaction [Estrone binds to Deoxyguanosine]
CYP1A2 protein binds to Estrone
CTD PMID:21907773, PMID:27966929 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases hydroxylation
affects binding
multiple interactions
affects hydroxylation
ISO CYP1B1 protein results in increased hydroxylation of Estrone
CYP1B1 protein binds to Estrone
Estrone binds to and results in decreased activity of CYP1B1 protein
CYP1B1 protein polymorphism affects the hydroxylation of Estrone
CTD PMID:15763594, PMID:16207128, PMID:19563207, PMID:27966929 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression ISO Estrone results in increased expression of CYP2B10 mRNA CTD PMID:7771797, PMID:11075820, PMID:12948398 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO Estrone results in increased expression of CYP2B9 mRNA CTD PMID:7771797 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Dhrs11 dehydrogenase/reductase 11 increases reduction ISO DHRS11 protein results in increased reduction of Estrone CTD PMID:30926317 NCBI chr10:72,144,042...72,153,496
Ensembl chr10:72,144,042...72,153,375
JBrowse link
G Dhrs3 dehydrogenase/reductase 3 increases metabolic processing ISO DHRS3 protein results in increased metabolism of Estrone CTD PMID:25451588 NCBI chr 5:162,809,090...162,843,385
Ensembl chr 5:162,808,646...162,843,383
JBrowse link
G Dhrs7 dehydrogenase/reductase 7 increases reduction ISO DHRS7 protein results in increased reduction of Estrone CTD PMID:24246760 NCBI chr 6:95,522,577...95,541,393
Ensembl chr 6:95,522,577...95,541,393
JBrowse link
G Dmbt1 deleted in malignant brain tumors 1 increases expression
multiple interactions
EXP Estrone results in increased expression of DMBT1 mRNA
fulvestrant inhibits the reaction [Estrone results in increased expression of DMBT1 mRNA]
CTD PMID:15564322 NCBI chr 1:201,620,642...201,689,905
NCBI chr 1:203,149,414...203,228,705
JBrowse link
G Efna1 ephrin A1 decreases expression ISO Estrone results in decreased expression of EFNA1 mRNA CTD PMID:26865669 NCBI chr 2:188,588,808...188,596,156
Ensembl chr 2:188,588,796...188,596,222
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO Estrone inhibits the reaction [LEPR gene mutant form inhibits the reaction [EGFR protein results in increased phosphorylation of EGFR protein]]; Estrone inhibits the reaction [LEPR gene mutant form results in decreased expression of EGFR mRNA] CTD PMID:1753381 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Egr3 early growth response 3 increases expression ISO Estrone results in increased expression of EGR3 mRNA CTD PMID:15159206, PMID:26865669 NCBI chr15:51,756,683...51,762,080
Ensembl chr15:51,756,736...51,760,722
JBrowse link
G Eno2 enolase 2 decreases expression ISO Estrone results in decreased expression of ENO2 mRNA CTD PMID:15159206 NCBI chr 4:157,285,192...157,294,090
Ensembl chr 4:157,285,179...157,294,047
JBrowse link
G Epha4 Eph receptor A4 decreases expression ISO Estrone results in decreased expression of EPHA4 mRNA CTD PMID:26865669 NCBI chr 9:83,111,222...83,253,486
Ensembl chr 9:83,111,222...83,253,458
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
increases expression
affects binding
increases activity
ISO
EXP
Estrone binds to and results in increased activity of ESR1 protein; Estrone inhibits the reaction [16 alpha-iodoestradiol binds to ESR1 protein]; Estrone inhibits the reaction [ESR1 results in increased susceptibility to Cisplatin]; Estrone inhibits the reaction [Estradiol binds to ESR1 protein]; Estrone promotes the reaction [ESR1 protein alternative form binds to ESR1 protein alternative form]; Estrone promotes the reaction [ESR1 protein binds to ESR1 protein]; Estrone promotes the reaction [ESR1 protein modified form binds to NCOA1 protein modified form]; Estrone promotes the reaction [ESR1 protein modified form binds to NRIP1 protein modified form]; fulvestrant inhibits the reaction [Estrone results in increased activity of ESR1 protein]
Estrone results in increased expression of ESR1 mRNA
Estrone binds to ESR1 protein
CTD PMID:9048584, PMID:11162928, PMID:11331656, PMID:11518614, PMID:11750080, PMID:12127041, PMID:12598185, PMID:12676605, PMID:18026938, PMID:19233257, PMID:19913605, PMID:21767602, PMID:22562034, PMID:23383871, PMID:25012808, PMID:26865669, PMID:29162470, PMID:29783106 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
affects binding
affects localization
increases activity
EXP
ISO
Estrone inhibits the reaction [16 alpha-iodoestradiol binds to ESR2 protein]; Estrone inhibits the reaction [Estradiol binds to ESR2 protein alternative form]; Estrone inhibits the reaction [Estradiol binds to ESR2 protein]
Estrone binds to ESR2 protein
Estrone affects the localization of ESR2 protein
Estrone results in increased activity of ESR2 protein
CTD PMID:8650195, PMID:9048584, PMID:9492041, PMID:11518614, PMID:19913605, PMID:20950447 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Fhl2 four and a half LIM domains 2 increases expression ISO Estrone results in increased expression of FHL2 mRNA CTD PMID:26865669 NCBI chr 9:49,920,611...49,994,906
Ensembl chr 9:49,920,854...49,950,093
JBrowse link
G Foxc1 forkhead box C1 increases expression ISO Estrone results in increased expression of FOXC1 mRNA CTD PMID:26865669 NCBI chr17:33,947,501...33,951,484
Ensembl chr17:33,947,506...33,951,484
JBrowse link
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 affects metabolic processing
multiple interactions
increases chemical synthesis
ISO HSD17B1 protein affects the metabolism of Estrone
[HSD17B1 protein co-treated with NADP] results in increased reduction of Estrone; coumarin analog inhibits the reaction [[HSD17B1 protein co-treated with NADP] results in increased reduction of Estrone]
HSD17B1 protein results in increased chemical synthesis of Estrone
CTD PMID:16054388, PMID:21232530 NCBI chr10:88,987,558...88,989,758
Ensembl chr10:88,987,558...88,989,757
JBrowse link
G Hsd17b12 hydroxysteroid (17-beta) dehydrogenase 12 increases metabolic processing ISO HSD17B12 protein results in increased metabolism of Estrone CTD PMID:16166196, PMID:17641292 NCBI chr 3:82,924,699...83,048,465
Ensembl chr 3:82,924,687...83,048,435
JBrowse link
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 increases chemical synthesis
affects metabolic processing
ISO HSD17B2 protein results in increased chemical synthesis of Estrone
HSD17B2 protein affects the metabolism of Estrone
CTD PMID:16054388 NCBI chr19:50,246,404...50,317,892
Ensembl chr19:50,246,402...50,317,891
JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 increases chemical synthesis
affects metabolic processing
ISO HSD17B4 protein results in increased chemical synthesis of Estrone
HSD17B4 protein affects the metabolism of Estrone
CTD PMID:16054388 NCBI chr18:44,810,462...44,897,677
Ensembl chr18:44,810,388...44,897,640
JBrowse link
G Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 affects metabolic processing
increases chemical synthesis
ISO HSD17B7 protein affects the metabolism of Estrone
HSD17B7 protein results in increased chemical synthesis of Estrone
CTD PMID:16054388 NCBI chr13:88,288,116...88,308,019
Ensembl chr13:88,288,046...88,307,988
JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression EXP Estrone results in decreased expression of ICAM1 mRNA CTD PMID:22903158 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Id3 inhibitor of DNA binding 3, HLH protein decreases expression ISO Estrone results in decreased expression of ID3 mRNA CTD PMID:26865669 NCBI chr 5:154,489,603...154,491,172
Ensembl chr 5:154,489,590...154,491,223
JBrowse link
G Igf2 insulin-like growth factor 2 increases chemical synthesis ISO IGF2 protein results in increased chemical synthesis of Estrone CTD PMID:24055520 NCBI chr 1:215,828,102...215,839,081
Ensembl chr 1:215,828,102...215,846,911
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Estrone promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein] CTD PMID:8979148 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Itgam integrin subunit alpha M decreases expression
multiple interactions
EXP Estrone results in decreased expression of ITGAM protein
Estrone inhibits the reaction [Lipopolysaccharides results in increased expression of ITGAM protein]
CTD PMID:22903158 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
JBrowse link
G Itgax integrin subunit alpha X decreases expression
multiple interactions
EXP Estrone results in decreased expression of ITGAX protein
Estrone inhibits the reaction [Lipopolysaccharides results in increased expression of ITGAX protein]
CTD PMID:22903158 NCBI chr 1:199,555,560...199,576,948
Ensembl chr 1:199,555,722...199,576,932
JBrowse link
G Jak2 Janus kinase 2 increases expression ISO Estrone results in increased expression of JAK2 mRNA CTD PMID:26865669 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
JBrowse link
G Kynu kynureninase decreases expression ISO Estrone results in decreased expression of KYNU mRNA CTD PMID:26865669 NCBI chr 3:28,416,926...28,566,939
Ensembl chr 3:28,416,954...28,566,928
JBrowse link
G Lepr leptin receptor multiple interactions ISO Estrone inhibits the reaction [LEPR gene mutant form inhibits the reaction [EGFR protein results in increased phosphorylation of EGFR protein]]; Estrone inhibits the reaction [LEPR gene mutant form results in decreased expression of EGFR mRNA] CTD PMID:1753381 NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
affects phosphorylation
multiple interactions
ISO
EXP
Estrone results in increased phosphorylation of MAPK1 protein
Estrone affects the phosphorylation of MAPK1 protein
4,4,',4'',4'''-(carbonylbis(imino-5,1,3-benzenetriylbis(carbonylimino)))tetrakis(benzene-1,3-disulfonate) inhibits the reaction [Estrone results in increased phosphorylation of MAPK1 protein]; 4-ethylphenol analog affects the reaction [Estrone affects the phosphorylation of MAPK1 protein]; 4-nonylphenol analog affects the reaction [Estrone affects the phosphorylation of MAPK1 protein]; 4-octylphenol analog affects the reaction [Estrone affects the phosphorylation of MAPK1 protein]; 4-propylphenol affects the reaction [Estrone affects the phosphorylation of MAPK1 protein]; bisphenol A affects the reaction [Estrone affects the phosphorylation of MAPK1 protein]; NF023 inhibits the reaction [Estrone results in increased phosphorylation of MAPK1 protein]; Nystatin inhibits the reaction [Estrone results in increased phosphorylation of MAPK1 protein]; Pertussis Toxin inhibits the reaction [Estrone results in increased phosphorylation of MAPK1 protein]
4-ethylphenol inhibits the reaction [Estrone results in increased phosphorylation of MAPK1 protein]; 4-nonylphenol inhibits the reaction [Estrone results in increased phosphorylation of MAPK1 protein]; 4-octylphenol inhibits the reaction [Estrone results in increased phosphorylation of MAPK1 protein]; 4-propylphenol inhibits the reaction [Estrone results in increased phosphorylation of MAPK1 protein]; bisphenol A inhibits the reaction [Estrone results in increased phosphorylation of MAPK1 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Estrone results in increased phosphorylation of MAPK1 protein]
CTD PMID:20870566, PMID:20950447, PMID:21767602, PMID:22230296 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
affects phosphorylation
multiple interactions
ISO
EXP
Estrone results in increased phosphorylation of MAPK3 protein
Estrone affects the phosphorylation of MAPK3 protein
4,4,',4'',4'''-(carbonylbis(imino-5,1,3-benzenetriylbis(carbonylimino)))tetrakis(benzene-1,3-disulfonate) inhibits the reaction [Estrone results in increased phosphorylation of MAPK3 protein]; 4-ethylphenol analog affects the reaction [Estrone affects the phosphorylation of MAPK3 protein]; 4-nonylphenol analog affects the reaction [Estrone affects the phosphorylation of MAPK3 protein]; 4-octylphenol analog affects the reaction [Estrone affects the phosphorylation of MAPK3 protein]; 4-propylphenol affects the reaction [Estrone affects the phosphorylation of MAPK3 protein]; bisphenol A affects the reaction [Estrone affects the phosphorylation of MAPK3 protein]; NF023 inhibits the reaction [Estrone results in increased phosphorylation of MAPK3 protein]; Nystatin inhibits the reaction [Estrone results in increased phosphorylation of MAPK3 protein]; Pertussis Toxin inhibits the reaction [Estrone results in increased phosphorylation of MAPK3 protein]
4-ethylphenol inhibits the reaction [Estrone results in increased phosphorylation of MAPK3 protein]; 4-nonylphenol inhibits the reaction [Estrone results in increased phosphorylation of MAPK3 protein]; 4-octylphenol inhibits the reaction [Estrone results in increased phosphorylation of MAPK3 protein]; 4-propylphenol inhibits the reaction [Estrone results in increased phosphorylation of MAPK3 protein]; bisphenol A inhibits the reaction [Estrone results in increased phosphorylation of MAPK3 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Estrone results in increased phosphorylation of MAPK3 protein]
CTD PMID:20870566, PMID:20950447, PMID:21767602, PMID:22230296 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mical2 microtubule associated monooxygenase, calponin and LIM domain containing 2 increases expression ISO Estrone results in increased expression of MICAL2 mRNA CTD PMID:26865669 NCBI chr 1:177,048,607...177,173,729
Ensembl chr 1:177,048,655...177,173,995
JBrowse link
G Myb MYB proto-oncogene, transcription factor increases expression ISO Estrone results in increased expression of MYB mRNA CTD PMID:26865669 NCBI chr 1:16,658,178...16,690,135
Ensembl chr 1:16,659,442...16,687,817
JBrowse link
G Mybl1 MYB proto-oncogene like 1 increases expression ISO Estrone results in increased expression of MYBL1 mRNA CTD PMID:26865669 NCBI chr 5:9,279,756...9,315,112
Ensembl chr 5:9,279,970...9,315,114
JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO Estrone promotes the reaction [NR1I3 protein binds to NCOA1 protein]
Estrone promotes the reaction [ESR1 protein modified form binds to NCOA1 protein modified form]
CTD PMID:23015691, PMID:23383871 NCBI chr 6:28,677,563...28,931,844
Ensembl chr 6:28,677,540...28,931,843
JBrowse link
G Ncoa3 nuclear receptor coactivator 3 increases expression ISO Estrone results in increased expression of NCOA3 mRNA; Estrone results in increased expression of NCOA3 protein CTD PMID:21767602 NCBI chr 3:162,692,176...162,788,582
Ensembl chr 3:162,692,185...162,787,548
JBrowse link
G Nmrk1 nicotinamide riboside kinase 1 increases expression ISO Estrone results in increased expression of NMRK1 mRNA CTD PMID:26865669 NCBI chr 1:234,721,992...234,749,452
Ensembl chr 1:234,721,974...234,749,447
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases expression
increases activity
affects binding
multiple interactions
affects localization
ISO
EXP
Estrone results in increased expression of NR1I3 mRNA
Estrone results in increased activity of NR1I3 protein
Estrone binds to NR1I3 protein
Estrone inhibits the reaction [KN 62 results in decreased activity of NR1I3 protein]
Estrone binds to and results in increased activity of NR1I3 protein; Estrone inhibits the reaction [KN 62 results in decreased activity of NR1I3 protein]; Estrone inhibits the reaction [Progesterone results in decreased activity of NR1I3 protein]; Estrone promotes the reaction [NR1I3 protein binds to NCOA1 protein]
Estrone affects the localization of NR1I3 mRNA
CTD PMID:11075820, PMID:12948398, PMID:16929008, PMID:23015691, PMID:28927721 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Nrip1 nuclear receptor interacting protein 1 multiple interactions ISO Estrone promotes the reaction [ESR1 protein modified form binds to NRIP1 protein modified form] CTD PMID:23383871 NCBI chr11:14,658,225...14,742,478
Ensembl chr11:14,658,225...14,741,563
JBrowse link
G Olfm1 olfactomedin 1 increases expression ISO Estrone results in increased expression of OLFM1 mRNA CTD PMID:26865669 NCBI chr 3:6,761,031...6,798,739
Ensembl chr 3:6,773,813...6,798,737
JBrowse link
G Pdgfa platelet derived growth factor subunit A decreases expression ISO Estrone results in decreased expression of PDGFA mRNA CTD PMID:10731640 NCBI chr12:17,734,141...17,756,186
Ensembl chr12:17,734,133...17,755,285
JBrowse link
G Pdzk1 PDZ domain containing 1 increases expression ISO Estrone results in increased expression of PDZK1 mRNA CTD PMID:15159206, PMID:26865669 NCBI chr 2:198,965,685...198,999,323
Ensembl chr 2:198,965,685...198,999,323
JBrowse link
G Pgr progesterone receptor decreases expression
increases expression
multiple interactions
ISO Estrone results in decreased expression of PGR mRNA alternative form; Estrone results in decreased expression of PGR protein alternative form
Estrone results in increased expression of PGR mRNA
fulvestrant inhibits the reaction [Estrone results in decreased expression of PGR protein alternative form]
CTD PMID:15806153, PMID:26865669 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 decreases expression ISO Estrone results in decreased expression of PIK3R3 mRNA CTD PMID:26865669 NCBI chr 5:135,069,972...135,145,633
Ensembl chr 5:135,074,297...135,142,488
JBrowse link
G Prl prolactin increases expression
increases secretion
multiple interactions
EXP
ISO
Estrone results in increased expression of PRL protein
Estrone results in increased secretion of PRL protein
4-ethylphenol inhibits the reaction [Estrone results in increased secretion of PRL protein]; 4-nonylphenol inhibits the reaction [Estrone results in increased secretion of PRL protein]; 4-octylphenol affects the reaction [Estrone results in increased secretion of PRL protein]; 4-propylphenol affects the reaction [Estrone results in increased secretion of PRL protein]; bisphenol A inhibits the reaction [Estrone results in increased secretion of PRL protein]
CTD PMID:3780563, PMID:20950447 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Prss23 serine protease 23 increases expression ISO Estrone results in increased expression of PRSS23 mRNA CTD PMID:26865669 NCBI chr 1:153,732,528...153,742,111
Ensembl chr 1:153,732,532...153,752,541
JBrowse link
G Rapgefl1 Rap guanine nucleotide exchange factor like 1 increases expression ISO Estrone results in increased expression of RAPGEFL1 mRNA CTD PMID:26865669 NCBI chr10:86,749,220...86,765,677
Ensembl chr10:86,763,117...86,765,675
JBrowse link
G Rbbp8 RB binding protein 8, endonuclease increases expression ISO Estrone results in increased expression of RBBP8 mRNA CTD PMID:26865669 NCBI chr18:3,134,630...3,227,702
Ensembl chr18:3,162,543...3,227,688
JBrowse link
G Rcl1 RNA terminal phosphate cyclase-like 1 increases expression ISO Estrone results in increased expression of RCL1 mRNA CTD PMID:26865669 NCBI chr 1:247,228,012...247,272,369
Ensembl chr 1:247,228,061...247,305,693
JBrowse link
G Ret ret proto-oncogene increases expression ISO Estrone results in increased expression of RET mRNA CTD PMID:26865669 NCBI chr 4:150,202,170...150,249,196
Ensembl chr 4:150,202,058...150,244,372
JBrowse link
G Rhbdf1 rhomboid 5 homolog 1 decreases expression ISO Estrone results in decreased expression of RHBDF1 mRNA CTD PMID:26865669 NCBI chr10:15,672,370...15,685,285
Ensembl chr10:15,672,382...15,685,284
JBrowse link
G Selenbp1 selenium binding protein 1 decreases expression ISO Estrone results in decreased expression of SELENBP1 mRNA CTD PMID:15159206 NCBI chr 2:196,105,592...196,146,474
Ensembl chr 2:196,105,569...196,113,149
JBrowse link
G Selp selectin P increases expression EXP Estrone results in increased expression of SELP mRNA CTD PMID:22903158 NCBI chr13:82,428,914...82,464,629
Ensembl chr13:82,429,063...82,464,628
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 increases expression ISO Estrone results in increased expression of SGK1 mRNA CTD PMID:26865669 NCBI chr 1:24,185,451...24,302,309
Ensembl chr 1:24,185,435...24,302,298
JBrowse link
G Sgk3 serum/glucocorticoid regulated kinase family, member 3 increases expression ISO Estrone results in increased expression of SGK3 mRNA CTD PMID:26865669 NCBI chr 5:9,046,889...9,094,740
Ensembl chr 5:9,048,614...9,094,616
JBrowse link
G Shbg sex hormone binding globulin affects binding ISO Estrone binds to SHBG protein CTD PMID:25349334 NCBI chr10:56,219,861...56,237,354
Ensembl chr10:56,219,858...56,223,245
JBrowse link
G Siah2 siah E3 ubiquitin protein ligase 2 increases expression ISO Estrone results in increased expression of SIAH2 mRNA CTD PMID:26865669 NCBI chr 2:148,874,151...148,891,900
Ensembl chr 2:148,874,151...148,891,900
JBrowse link
G Slc12a2 solute carrier family 12 member 2 decreases expression ISO Estrone results in decreased expression of SLC12A2 mRNA CTD PMID:15159206 NCBI chr18:52,917,124...52,985,281
Ensembl chr18:52,917,124...52,985,261
JBrowse link
G Slc18a2 solute carrier family 18 member A2 multiple interactions ISO Estrone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SLC18A2 protein] CTD PMID:16011487 NCBI chr 1:280,397,831...280,457,968
Ensembl chr 1:280,423,079...280,457,148
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Estrone inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions ISO Estrone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased activity of SLC6A3 protein] CTD PMID:16011487 NCBI chr 1:32,323,011...32,363,983
Ensembl chr 1:32,321,580...32,363,983
JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO Estrone results in increased expression of SLC7A11 mRNA CTD PMID:15159206 NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162
JBrowse link
G Slc7a5 solute carrier family 7 member 5 increases expression ISO Estrone results in increased expression of SLC7A5 mRNA CTD PMID:26865669 NCBI chr19:54,693,959...54,722,563
Ensembl chr19:54,693,959...54,722,563
JBrowse link
G Smox spermine oxidase increases expression ISO Estrone results in increased expression of SMOX mRNA CTD PMID:26865669 NCBI chr 3:124,068,796...124,103,726
Ensembl chr 3:124,068,865...124,102,240
JBrowse link
G Sts steroid sulfatase increases chemical synthesis ISO STS protein results in increased chemical synthesis of Estrone CTD PMID:16054388 NCBI chr  X:45,420,418...45,428,748
Ensembl chr  X:45,420,596...45,428,750
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases metabolic processing ISO SULT1A1 protein results in increased metabolism of Estrone CTD PMID:10623578 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 multiple interactions
increases sulfation
decreases activity
affects sulfation
ISO [Estrone co-treated with SULT1E1 protein] results in decreased sulfation of Ethinyl Estradiol
SULT1E1 protein results in increased sulfation of Estrone
Estrone results in decreased activity of SULT1E1 protein
Estrone affects the sulfation of SULT1E1 protein
CTD PMID:8185618, PMID:11358677, PMID:15483196, PMID:16914110 NCBI chr14:22,070,861...22,089,264
Ensembl chr14:22,072,024...22,089,248
JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 increases metabolic processing ISO SULT2A1 protein results in increased metabolism of Estrone CTD PMID:10623578 NCBI chr 1:76,558,721...76,614,315
Ensembl chr 1:76,252,329...76,780,230
JBrowse link
G Sult4a1 sulfotransferase family 4A, member 1 increases metabolic processing ISO SULT4A1 protein results in increased metabolism of Estrone CTD PMID:12039030 NCBI chr 7:124,958,546...124,982,602
Ensembl chr 7:124,958,546...124,982,566
JBrowse link
G Svil supervillin increases expression ISO Estrone results in increased expression of SVIL mRNA CTD PMID:26865669 NCBI chr17:55,230,298...55,425,967
Ensembl chr17:55,230,298...55,346,279
JBrowse link
G Tfap2c transcription factor AP-2 gamma increases expression ISO Estrone results in increased expression of TFAP2C mRNA CTD PMID:26865669 NCBI chr 3:170,550,314...170,558,197
Ensembl chr 3:170,550,314...170,558,194
JBrowse link
G Tff1 trefoil factor 1 increases expression
multiple interactions
ISO Estrone results in increased expression of TFF1 mRNA
fulvestrant inhibits the reaction [Estrone results in increased expression of TFF1 mRNA]
CTD PMID:22562034 NCBI chr20:9,892,124...9,895,984
Ensembl chr20:9,892,124...9,895,984
JBrowse link
G Tfpi tissue factor pathway inhibitor decreases expression ISO Estrone results in decreased expression of TFPI mRNA CTD PMID:26865669 NCBI chr 3:71,852,738...71,902,127
Ensembl chr 3:71,852,744...71,893,618
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO TNF protein promotes the reaction [CYP19A1 protein affects the chemical synthesis of Estrone] CTD PMID:16030167 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of Estrone; UGT1A1 protein results in increased glucuronidation of Estrone analog CTD PMID:15117964, PMID:15472229 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of Estrone; UGT1A3 protein results in increased glucuronidation of Estrone analog CTD PMID:15117964, PMID:15472229 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation ISO UGT1A8 protein results in increased glucuronidation of Estrone; UGT1A8 protein results in increased glucuronidation of Estrone analog CTD PMID:15117964, PMID:15472229 NCBI chr 9:95,221,474...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of Estrone; UGT1A9 protein results in increased glucuronidation of Estrone analog CTD PMID:15472229 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 increases glucuronidation ISO UGT2B7 protein results in increased glucuronidation of Estrone; UGT2B7 protein results in increased glucuronidation of Estrone analog CTD PMID:15472229 NCBI chr14:22,597,103...22,619,968 JBrowse link
G Vcam1 vascular cell adhesion molecule 1 decreases expression EXP Estrone results in decreased expression of VCAM1 mRNA CTD PMID:22903158 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Wars1 tryptophanyl-tRNA synthetase 1 increases expression ISO Estrone results in increased expression of WARS1 mRNA CTD PMID:15159206 NCBI chr 6:132,771,026...132,802,262
Ensembl chr 6:132,771,021...132,802,210
JBrowse link
G Xiap X-linked inhibitor of apoptosis increases expression ISO Estrone results in increased expression of XIAP mRNA; Estrone results in increased expression of XIAP protein CTD PMID:21767602 NCBI chr  X:128,409,425...128,455,786
Ensembl chr  X:128,409,472...128,453,000
JBrowse link
2-hydroxyestrone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ckb creatine kinase B multiple interactions EXP 2-hydroxyestrone inhibits the reaction [Estradiol results in increased expression of CKB] CTD PMID:10030690 NCBI chr 6:136,142,956...136,145,838
Ensembl chr 6:136,142,956...136,145,837
JBrowse link
G Esr1 estrogen receptor 1 affects binding
multiple interactions
ISO 2-hydroxyestrone binds to ESR1 protein
2-hydroxyestrone binds to and results in increased activity of ESR1 protein
CTD PMID:16728493, PMID:17713618 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO 2-hydroxyestrone binds to and results in increased activity of ESR2 protein CTD PMID:17713618 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Fshb follicle stimulating hormone subunit beta decreases expression ISO 2-hydroxyestrone results in decreased expression of FSHB protein CTD PMID:6401747 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link
G Lhb luteinizing hormone subunit beta decreases expression ISO 2-hydroxyestrone results in decreased expression of LHB protein CTD PMID:6401747 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of 2-hydroxyestrone CTD PMID:15117964 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of 2-hydroxyestrone CTD PMID:15117964 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation ISO UGT1A8 protein results in increased glucuronidation of 2-hydroxyestrone CTD PMID:15117964 NCBI chr 9:95,221,474...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of 2-hydroxyestrone CTD PMID:15117964 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
2-methoxyestrone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 multiple interactions ISO [HSD17B2 protein results in increased metabolism of and results in decreased activity of 2-methoxyestradiol] which results in increased chemical synthesis of 2-methoxyestrone CTD PMID:16397246 NCBI chr19:50,246,404...50,317,892
Ensembl chr19:50,246,402...50,317,891
JBrowse link
4-hydroxyestrone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nfe2l2 nuclear factor, erythroid 2-like 2 decreases expression
decreases response to substance
ISO 4-hydroxyestrone results in decreased expression of NFE2L2 mRNA
NFE2L2 protein results in decreased susceptibility to 4-hydroxyestrone
CTD PMID:25231996 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of 4-hydroxyestrone CTD PMID:15117964 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of 4-hydroxyestrone CTD PMID:15117964 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation ISO UGT1A8 protein results in increased glucuronidation of 4-hydroxyestrone CTD PMID:15117964 NCBI chr 9:95,221,474...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of 4-hydroxyestrone CTD PMID:15117964 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 increases glucuronidation ISO UGT2B7 protein alternative form results in increased glucuronidation of 4-hydroxyestrone; UGT2B7 protein results in increased glucuronidation of 4-hydroxyestrone CTD PMID:8423545, PMID:8517101 NCBI chr14:22,597,103...22,619,968 JBrowse link
estrone 3-O-(beta-D-glucuronide) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kl Klotho increases hydrolysis
multiple interactions
ISO KL protein results in increased hydrolysis of estrone-3-glucuronide
estrone-3-glucuronide inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides]
CTD PMID:14701853 NCBI chr12:942,974...987,206
Ensembl chr12:943,006...987,551
JBrowse link
estrone 3-sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca8 ATP binding cassette subfamily A member 8 affects transport ISO ABCA8 protein affects the transport of estrone sulfate CTD PMID:12379217 NCBI chr10:98,236,919...98,308,288
Ensembl chr10:98,237,141...98,294,522
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 affects export
increases activity
ISO
EXP
ABCC2 protein affects the export of estrone sulfate
estrone sulfate results in increased activity of ABCC2 protein; estrone sulfate results in increased activity of ABCC2 protein modified form
CTD PMID:15652233, PMID:15904671, PMID:16046661 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 affects export
increases export
increases uptake
multiple interactions
affects transport
ISO ABCG2 protein affects the export of estrone sulfate
ABCG2 protein results in increased export of estrone sulfate
ABCG2 protein results in increased uptake of estrone sulfate
[Adenosine Triphosphate co-treated with ABCG2 protein] results in increased uptake of estrone sulfate; Androstenedione inhibits the reaction [ABCG2 protein results in increased uptake of estrone sulfate]; Estradiol inhibits the reaction [ABCG2 protein results in increased uptake of estrone sulfate]; hippuric acid inhibits the reaction [ABCG2 protein results in increased export of estrone sulfate]; Indican inhibits the reaction [ABCG2 protein results in increased export of estrone sulfate]; Kynurenic Acid inhibits the reaction [ABCG2 protein results in increased export of estrone sulfate]; Progesterone inhibits the reaction [ABCG2 protein results in increased uptake of estrone sulfate]; Risperidone inhibits the reaction [ABCG2 protein results in increased uptake of estrone sulfate]; Sulfasalazine inhibits the reaction [[Adenosine Triphosphate co-treated with ABCG2 protein] results in increased uptake of estrone sulfate]; Testosterone inhibits the reaction [ABCG2 protein results in increased uptake of estrone sulfate]
ABCG2 protein affects the transport of estrone sulfate
CTD PMID:15901800, PMID:18834354, PMID:19505989, PMID:21483698, PMID:22581381, PMID:32003934 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Dhrs11 dehydrogenase/reductase 11 increases reduction ISO DHRS11 protein results in increased reduction of estrone sulfate CTD PMID:30926317 NCBI chr10:72,144,042...72,153,496
Ensembl chr10:72,144,042...72,153,375
JBrowse link
G Il1a interleukin 1 alpha decreases expression ISO estrone sulfate results in decreased expression of IL1A mRNA CTD PMID:10731640 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il6 interleukin 6 decreases expression ISO estrone sulfate results in decreased expression of IL6 mRNA CTD PMID:10731640 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Pdgfa platelet derived growth factor subunit A decreases expression ISO estrone sulfate results in decreased expression of PDGFA mRNA CTD PMID:10731640 NCBI chr12:17,734,141...17,756,186
Ensembl chr12:17,734,133...17,755,285
JBrowse link
G Slc10a1 solute carrier family 10 member 1 multiple interactions ISO daidzein metabolite inhibits the reaction [SLC10A1 protein results in increased transport of estrone sulfate]; daidzein metabolite promotes the reaction [SLC10A1 protein results in increased transport of estrone sulfate]; estrone sulfate inhibits the reaction [SLC10A1 protein results in increased transport of daidzein metabolite] CTD PMID:25319728 NCBI chr 6:104,617,730...104,631,355
Ensembl chr 6:104,617,730...104,631,355
JBrowse link
G Slc10a6 solute carrier family 10 member 6 increases transport
increases uptake
increases response to substance
multiple interactions
ISO SLC10A6 protein results in increased transport of estrone sulfate
SLC10A6 protein results in increased uptake of estrone sulfate
SLC10A6 protein results in increased susceptibility to estrone sulfate
daidzein inhibits the reaction [SLC10A6 protein results in increased transport of estrone sulfate]; daidzein metabolite inhibits the reaction [SLC10A6 protein results in increased transport of estrone sulfate]; estrone sulfate inhibits the reaction [SLC10A6 protein results in increased transport of daidzein metabolite]; Sodium promotes the reaction [SLC10A6 protein results in increased uptake of estrone sulfate]
CTD PMID:23562556, PMID:25319728, PMID:30186172 NCBI chr14:7,618,022...7,682,377
Ensembl chr14:7,618,022...7,682,377
JBrowse link
G Slc17a3 solute carrier family 17 member 3 affects transport ISO SLC17A3 gene SNP affects the transport of estrone sulfate CTD PMID:21282933 NCBI chr17:43,518,760...43,545,160
Ensembl chr17:43,518,655...43,543,185
JBrowse link
G Slc22a20 solute carrier family 22 member 20 multiple interactions
increases uptake
ISO 2,4-Dichlorophenoxyacetic Acid inhibits the reaction [SLC22A20 protein results in increased uptake of estrone sulfate]; Glutarates promotes the reaction [SLC22A20 protein results in increased uptake of estrone sulfate]; ochratoxin A inhibits the reaction [SLC22A20 protein results in increased uptake of estrone sulfate]; p-Aminohippuric Acid inhibits the reaction [SLC22A20 protein results in increased uptake of estrone sulfate]; Penicillin G inhibits the reaction [SLC22A20 protein results in increased uptake of estrone sulfate]; Probenecid inhibits the reaction [SLC22A20 protein results in increased uptake of estrone sulfate]; Salicylates inhibits the reaction [SLC22A20 protein results in increased uptake of estrone sulfate]; Uric Acid inhibits the reaction [SLC22A20 protein results in increased uptake of estrone sulfate] CTD PMID:16478971 NCBI chr 1:221,327,608...221,344,367
Ensembl chr 1:221,328,711...221,343,889
JBrowse link
G Slc22a25 solute carrier family 22, member 25 affects transport
increases import
multiple interactions
increases uptake
EXP
ISO
SLC22A9 protein affects the transport of estrone sulfate
SLC22A9 protein results in increased import of estrone sulfate
candesartan cilexetil inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]; candesartan inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]; Dehydroepiandrosterone Sulfate inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]; losartan carboxylic acid inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]; Losartan inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]; pranlukast inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]; Probenecid inhibits the reaction [SLC22A9 protein results in increased import of estrone sulfate]; Probenecid inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]; Tobacco Smoke Pollution inhibits the reaction [SLC22A9 protein results in increased import of estrone sulfate]; Valsartan inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]
4-methylumbelliferyl sulfate inhibits the reaction [SLC22A9 protein affects the transport of estrone sulfate]; Glutarates affects the reaction [SLC22A9 protein affects the transport of estrone sulfate]; naphthyl sulfate inhibits the reaction [SLC22A9 protein affects the transport of estrone sulfate]; Succinic Acid inhibits the reaction [SLC22A9 protein affects the transport of estrone sulfate]
CTD PMID:16079298, PMID:17132213, PMID:18441515, PMID:28629854 NCBI chr 1:224,596,886...224,698,512
Ensembl chr 1:224,596,887...224,698,514
JBrowse link
G Slc22a6 solute carrier family 22 member 6 increases uptake ISO SLC22A6 protein results in increased uptake of estrone sulfate CTD PMID:16098483 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259
JBrowse link
G Slc22a7 solute carrier family 22 member 7 multiple interactions
increases uptake
ISO Fumarates promotes the reaction [SLC22A7 protein results in increased uptake of estrone sulfate]; Succinates promotes the reaction [SLC22A7 protein results in increased uptake of estrone sulfate] CTD PMID:15901346 NCBI chr 9:16,925,321...16,931,119
Ensembl chr 9:16,924,520...16,931,766
JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions
increases import
affects transport
increases uptake
ISO
EXP
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; aristolochic acid I inhibits the reaction [SLC22A8 results in increased uptake of estrone sulfate]; bis(4-hydroxyphenyl)sulfone inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; bisphenol A inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; bisphenol F inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Bumetanide inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]; Cefaclor inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Cefdinir inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; cefoselis inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Cefotiam inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Ceftibuten inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Ceftizoxime inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Cephaloridine inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Cholates inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]; Cimetidine inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]; cyazofamid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Dehydroepiandrosterone inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]; Diclofenac inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]; estrone sulfate inhibits the reaction [SLC22A8 protein results in increased uptake of Famotidine]; estrone sulfate promotes the reaction [SLC22A8 results in increased export of p-Aminohippuric Acid]; Famotidine inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]; Furosemide inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]; Ibuprofen inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]; Indomethacin inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]; Probenecid inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]; Probenecid inhibits the reaction [SLC22A8 protein results in increased import of estrone sulfate]; Probenecid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Quercetin inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; rhein inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; rhein metabolite inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; tetrabromobisphenol A inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Tobacco Smoke Pollution inhibits the reaction [SLC22A8 protein results in increased import of estrone sulfate]
SLC22A8 protein results in increased uptake of estrone sulfate; SLC22A8 results in increased uptake of estrone sulfate
3,4-dihydroxymandelic acid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; 3,4-Dihydroxyphenylacetic Acid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; 5-methoxyindoleacetic acid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Bumetanide inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; estrone sulfate inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]; Furosemide inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; hexadecafluoro-nonanoic acid inhibits the reaction [SLC22A8 protein results in increased import of estrone sulfate]; Homovanillic Acid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Indocyanine Green inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; methoxytryptophol inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Penicillin G inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; perfluoro-n-heptanoic acid inhibits the reaction [SLC22A8 protein results in increased import of estrone sulfate]; perfluorodecanoic acid inhibits the reaction [SLC22A8 protein results in increased import of estrone sulfate]; perfluorooctanoic acid inhibits the reaction [SLC22A8 protein results in increased import of estrone sulfate]; Piroxicam inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Probenecid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Sulfobromophthalein inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Vanilmandelic Acid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]
CTD PMID:10224140, PMID:11306713, PMID:15100168, PMID:15319347, PMID:15496291, PMID:16079298, PMID:16098483, PMID:16857889, PMID:17255469, PMID:19605544, PMID:19643159, PMID:19915082, PMID:21256917, PMID:27989701, PMID:28629854, PMID:28890383, PMID:32003934, PMID:32305507 NCBI chr 1:224,799,444...224,818,482
Ensembl chr 1:224,800,252...224,818,482
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 affects uptake
multiple interactions
increases uptake
increases transport
increases import
ISO SLCO1A4 protein affects the uptake of estrone sulfate
7-hydroxymethotrexate inhibits the reaction [SLCO1A2 mRNA results in increased import of estrone sulfate]; artemisinine inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; Chloroquine inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; Mefloquine inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; Methotrexate inhibits the reaction [SLCO1A2 mRNA results in increased import of estrone sulfate]; naringin inhibits the reaction [SLCO1A2 protein alternative form results in increased uptake of estrone sulfate]; naringin inhibits the reaction [SLCO1A2 protein results in increased transport of estrone sulfate]; perfluorodecanoic acid inhibits the reaction [SLCO1A2 protein results in increased import of estrone sulfate]; Pyrimethamine inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; Quinine inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]
SLCO1A2 protein alternative form results in increased uptake of estrone sulfate; SLCO1A2 protein results in increased uptake of estrone sulfate
SLCO1A2 mRNA results in increased import of estrone sulfate; SLCO1A2 protein results in increased import of estrone sulfate
CTD PMID:16702441, PMID:20639259, PMID:21561886, PMID:25466967, PMID:27504015 NCBI chr 4:175,969,549...176,026,227
Ensembl chr 4:175,969,549...176,026,163
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions ISO cyazofamid inhibits the reaction [SLCO1B3 protein results in increased uptake of estrone sulfate] CTD PMID:32003934 NCBI chr 4:175,814,118...175,881,775
Ensembl chr 4:175,814,118...175,881,768
JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 increases import
increases uptake
multiple interactions
ISO SLCO2B1 protein results in increased import of estrone sulfate; SLCO2B1 results in increased import of estrone sulfate
SLCO2B1 protein results in increased uptake of estrone sulfate
2,2',4,4',5,6'-hexabromodiphenyl ether inhibits the reaction [SLCO2B1 results in increased import of estrone sulfate]; 2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [SLCO2B1 results in increased import of estrone sulfate]; [icariin results in decreased activity of SLCO2B1 protein] which results in decreased uptake of estrone sulfate; daidzein inhibits the reaction [SLCO2B1 protein results in increased transport of estrone sulfate]; daidzein metabolite inhibits the reaction [SLCO2B1 protein results in increased transport of estrone sulfate]; estrone sulfate inhibits the reaction [SLCO2B1 protein results in increased transport of daidzein metabolite]; estrone sulfate inhibits the reaction [SLCO2B1 protein results in increased uptake of Quercetin]; Mefloquine affects the reaction [SLCO2B1 protein results in increased uptake of estrone sulfate]; pentabromodiphenyl ether inhibits the reaction [SLCO2B1 results in increased import of estrone sulfate]; Rutin promotes the reaction [SLCO2B1 protein results in increased uptake of estrone sulfate]; Sulfobromophthalein inhibits the reaction [SLCO2B1 protein results in increased import of estrone sulfate]; Tobacco Smoke Pollution inhibits the reaction [SLCO2B1 protein results in increased import of estrone sulfate]
CTD PMID:16714376, PMID:20176623, PMID:24265111, PMID:24285294, PMID:24947867, PMID:25319728, PMID:27450509, PMID:27504015 NCBI chr 1:164,623,313...164,671,612
Ensembl chr 1:164,623,599...164,671,577
JBrowse link
G Slco3a1 solute carrier organic anion transporter family, member 3a1 multiple interactions ISO estrone sulfate promotes the reaction [SLCO3A1 protein results in increased uptake of simvastatin acid] CTD PMID:28887287 NCBI chr 1:135,790,854...136,073,640
Ensembl chr 1:135,790,810...136,073,540
JBrowse link
G Sts steroid sulfatase affects metabolic processing
decreases sulfation
ISO STS protein affects the metabolism of estrone sulfate
STS protein results in decreased sulfation of estrone sulfate
CTD PMID:15597397, PMID:16054388 NCBI chr  X:45,420,418...45,428,748
Ensembl chr  X:45,420,596...45,428,750
JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 multiple interactions ISO [[Oxygen deficiency co-treated with Oxygen] results in increased expression of SULT1E1 protein] which results in increased abundance of estrone sulfate CTD PMID:25922074 NCBI chr14:22,070,861...22,089,264
Ensembl chr14:22,072,024...22,089,248
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        pharmaceutical 19275
          drug 19275
            antineoplastic agent 16985
              estrone 125
                15alpha-hydroxyestrone 0
                16alpha-hydroxyestrone + 0
                16beta-hydroxyestrone 0
                2-hydroxyestrone + 9
                2-methoxyestrone + 1
                2-methoxyestrone 3-sulfate 0
                4-hydroxyestrone + 6
                4-methoxyestrone + 0
                6alpha-hydroxyestrone 0
                6beta-hydroxyestrone 0
                estrone 3-O-(beta-D-glucuronide) 1
                estrone 3-sulfate 21
                estrone sodium sulfate 0
                estropipate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      ketone 16144
                                        oxo steroid 9276
                                          17-oxo steroid 257
                                            estrone 125
                                              15alpha-hydroxyestrone 0
                                              16alpha-hydroxyestrone + 0
                                              16beta-hydroxyestrone 0
                                              2-hydroxyestrone + 9
                                              2-methoxyestrone + 1
                                              2-methoxyestrone 3-sulfate 0
                                              4-hydroxyestrone + 6
                                              4-methoxyestrone + 0
                                              6alpha-hydroxyestrone 0
                                              6beta-hydroxyestrone 0
                                              estrone 3-O-(beta-D-glucuronide) 1
                                              estrone 3-sulfate 21
                                              estrone sodium sulfate 0
                                              estropipate 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.