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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:erdosteine
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Accession:CHEBI:135014 term browser browse the term
Synonyms:related_synonym: Formula=C8H11NO4S2;   InChI=1S/C8H11NO4S2/c10-6(3-14-4-7(11)12)9-5-1-2-15-8(5)13/h5H,1-4H2,(H,9,10)(H,11,12);   InChIKey=QGFORSXNKQLDNO-UHFFFAOYSA-N;   SMILES=N(C(CSCC(O)=O)=O)C1C(=O)SCC1;   dithiosteine
 xref: CAS:84611-23-4;   Drug_Central:1041
 xref_mesh: MESH:C048498


show annotations for term's descendants           Sort by:
erdosteine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADA adenosine deaminase multiple interactions ISO erdosteine inhibits the reaction [Doxorubicin results in increased activity of ADA protein] CTD PMID:12965118 NCBI chr20:44,619,522...44,651,699
Ensembl chr20:44,584,896...44,652,252 		JBrowse link
G AIFM1 apoptosis inducing factor mitochondria associated 1 multiple interactions ISO erdosteine inhibits the reaction [Cisplatin affects the localization of AIFM1 protein] CTD PMID:26193055 NCBI chr  X:130,129,362...130,165,841
Ensembl chr  X:130,124,666...130,165,879 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions ISO erdosteine inhibits the reaction [Cisplatin results in increased expression of BAX protein]
erdosteine inhibits the reaction [Isoproterenol results in increased expression of BAX protein]		 CTD PMID:26193055 PMID:33210414 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G BBC3 BCL2 binding component 3 multiple interactions ISO erdosteine inhibits the reaction [Cisplatin results in increased expression of BBC3 protein] CTD PMID:26193055 NCBI chr19:47,220,824...47,232,860
Ensembl chr19:47,220,822...47,232,766 		JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions ISO [erdosteine co-treated with Isoproterenol] affects the expression of BCL2 protein CTD PMID:33210414 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G BCL2L1 BCL2 like 1 multiple interactions ISO erdosteine inhibits the reaction [Cisplatin results in decreased expression of BCL2L1 mRNA]; erdosteine inhibits the reaction [Cisplatin results in decreased expression of BCL2L1 protein] CTD PMID:26193055 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989 		JBrowse link
G CASP3 caspase 3 multiple interactions ISO erdosteine inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]
[erdosteine co-treated with Isoproterenol] affects the expression of CASP3 protein		 CTD PMID:26193055 PMID:33210414 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CAT catalase increases activity
multiple interactions		 ISO erdosteine results in increased activity of CAT protein
erdosteine inhibits the reaction [Acetaminophen results in decreased expression of CAT protein]; erdosteine inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]		 CTD PMID:12518339 PMID:16532256 PMID:33210414 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060 		JBrowse link
G CYCS cytochrome c, somatic multiple interactions ISO erdosteine inhibits the reaction [Cisplatin affects the localization of CYCS protein] CTD PMID:26193055 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260 		JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit increases expression ISO erdosteine results in increased expression of GCLC protein CTD PMID:26193055 NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970 		JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit increases expression ISO erdosteine results in increased expression of GCLM protein CTD PMID:26193055 NCBI chr 1:93,885,199...93,909,430
Ensembl chr 1:93,885,199...93,909,456 		JBrowse link
G GSS glutathione synthetase increases expression ISO erdosteine results in increased expression of GSS protein CTD PMID:26193055 NCBI chr20:34,928,432...34,956,027
Ensembl chr20:34,928,432...34,956,027 		JBrowse link
G H2AX H2A.X variant histone multiple interactions ISO erdosteine inhibits the reaction [Cisplatin results in increased phosphorylation of H2AX protein] CTD PMID:26193055 NCBI chr11:119,093,874...119,095,465
Ensembl chr11:119,093,874...119,095,465 		JBrowse link
G HMOX1 heme oxygenase 1 increases expression
multiple interactions		 ISO erdosteine results in increased expression of HMOX1 protein
[erdosteine co-treated with Isoproterenol] results in increased expression of HMOX1 protein		 CTD PMID:26193055 PMID:33210414 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214 		JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO erdosteine inhibits the reaction [Cisplatin results in increased expression of IL1B mRNA]; erdosteine inhibits the reaction [Cisplatin results in increased expression of IL1B protein] CTD PMID:26193055 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL6 interleukin 6 multiple interactions ISO erdosteine inhibits the reaction [Cisplatin results in increased expression of IL6 mRNA]; erdosteine inhibits the reaction [Cisplatin results in increased expression of IL6 protein]
erdosteine inhibits the reaction [Isoproterenol results in increased expression of IL6 protein]		 CTD PMID:26193055 PMID:33210414 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions ISO erdosteine inhibits the reaction [Isoproterenol results in increased expression of and results in increased phosphorylation of MAPK1 protein] CTD PMID:33210414 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions ISO erdosteine inhibits the reaction [Isoproterenol results in increased expression of and results in increased phosphorylation of MAPK3 protein] CTD PMID:33210414 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MPO myeloperoxidase multiple interactions ISO erdosteine inhibits the reaction [Nicotine results in increased activity of MPO protein] CTD PMID:17216608 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions ISO erdosteine promotes the reaction [Cisplatin results in increased expression of NFE2L2 protein]
[erdosteine co-treated with Isoproterenol] results in increased expression of NFE2L2 protein		 CTD PMID:26193055 PMID:33210414 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions ISO erdosteine inhibits the reaction [Cisplatin results in increased cleavage of PARP1 protein]
erdosteine affects the reaction [Isoproterenol results in increased expression of PARP1 protein]		 CTD PMID:26193055 PMID:33210414 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154 		JBrowse link
G SOD1 superoxide dismutase 1 increases expression ISO erdosteine results in increased expression of SOD1 protein CTD PMID:26193055 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931 		JBrowse link
G TNF tumor necrosis factor multiple interactions ISO erdosteine inhibits the reaction [Cisplatin results in increased expression of TNF mRNA]; erdosteine inhibits the reaction [Cisplatin results in increased expression of TNF protein]
erdosteine inhibits the reaction [Isoproterenol results in increased expression of TNF protein]; erdosteine inhibits the reaction [Nicotine results in increased expression of TNF protein]		 CTD PMID:17216608 PMID:26193055 PMID:33210414 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TP53 tumor protein p53 multiple interactions ISO erdosteine inhibits the reaction [Cisplatin affects the localization of TRP53 protein modified form]; erdosteine inhibits the reaction [Cisplatin results in increased phosphorylation of TRP53 protein] CTD PMID:26193055 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538 		JBrowse link
G XDH xanthine dehydrogenase multiple interactions ISO erdosteine inhibits the reaction [Doxorubicin results in increased activity of XDH protein] CTD PMID:12965118 NCBI chr 2:31,334,321...31,414,742
Ensembl chr 2:31,334,321...31,414,742 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26041
    role 25957
      application 25179
        NMR chemical shift reference compound 20305
          ammonia 19960
            organic amino compound 19960
              amino acid 17175
                N-acyl-amino acid 10326
                  erdosteine 25
Path 2
Term Annotations click to browse term
  CHEBI ontology 26041
    subatomic particle 26016
      composite particle 26016
        hadron 26016
          baryon 26016
            nucleon 26016
              atomic nucleus 26016
                atom 26016
                  main group element atom 25841
                    p-block element atom 25841
                      carbon group element atom 25441
                        carbon atom 25399
                          organic molecular entity 25399
                            heteroorganic entity 24773
                              organochalcogen compound 24384
                                organooxygen compound 24061
                                  carbon oxoacid 22757
                                    carboxylic acid 22737
                                      carboacyl group 20074
                                        univalent carboacyl group 20074
                                          carbamoyl group 19588
                                            carboxamide 19588
                                              N-acyl-amino acid 10326
                                                erdosteine 25
paths to the root