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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Ophiopogonin D
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Accession:CHEBI:80883 term browser browse the term
Definition:A steroid saponin that has formula C44H70O16.
Synonyms:related_synonym: Formula=C44H70O16;   InChI=1S/C44H70O16/c1-18-9-12-44(54-16-18)19(2)30-28(60-44)15-26-24-8-7-22-13-23(45)14-29(43(22,6)25(24)10-11-42(26,30)5)57-41-38(59-40-36(52)34(50)31(47)20(3)55-40)37(32(48)21(4)56-41)58-39-35(51)33(49)27(46)17-53-39/h7,18-21,23-41,45-52H,8-17H2,1-6H3/t18-,19+,20+,21-,23-,24-,25+,26+,27-,28+,29-,30+,31+,32+,33+,34-,35-,36-,37+,38-,39+,40+,41+,42+,43+,44-/m1/s1;   InChIKey=FHKHGNFKBPFJCB-LYLKFOBISA-N;   SMILES=C[C@H]1[C@H]2[C@H](C[C@H]3[C@@H]4CC=C5C[C@@H](O)C[C@@H](O[C@@H]6O[C@H](C)[C@H](O)[C@H](O[C@@H]7OC[C@@H](O)[C@H](O)[C@H]7O)[C@H]6O[C@@H]6O[C@@H](C)[C@H](O)[C@@H](O)[C@H]6O)[C@]5(C)[C@H]4CC[C@]23C)O[C@]11CC[C@@H](C)CO1
 xref: KEGG:C17042
 xref_mesh: MESH:C046996



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Ophiopogonin D term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO ITGB1 protein inhibits the reaction [ophiopogonin D inhibits the reaction [TGFB1 protein results in increased phosphorylation of AKT1 protein]]; ophiopogonin D inhibits the reaction [TGFB1 protein results in increased phosphorylation of AKT1 protein] CTD PMID:32818624 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO ophiopogonin D results in increased expression of BAX protein
3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [ophiopogonin D results in increased expression of BAX protein]
CTD PMID:35905946 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO ophiopogonin D results in decreased expression of BCL2 protein
3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [ophiopogonin D results in decreased expression of BCL2 protein]
CTD PMID:35905946 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO ITGB1 protein inhibits the reaction [ophiopogonin D inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]]; ophiopogonin D inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein] CTD PMID:32818624 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdh2 cadherin 2 multiple interactions ISO ITGB1 protein inhibits the reaction [ophiopogonin D inhibits the reaction [TGFB1 protein results in increased expression of CDH2 protein]]; ophiopogonin D inhibits the reaction [TGFB1 protein results in increased expression of CDH2 protein] CTD PMID:32818624 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO ITGB1 protein inhibits the reaction [ophiopogonin D inhibits the reaction [TGFB1 protein results in increased expression of and affects the localization of CTNNB1 protein]]; ophiopogonin D inhibits the reaction [TGFB1 protein results in increased expression of and affects the localization of CTNNB1 protein] CTD PMID:32818624 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Hmox1 heme oxygenase 1 decreases expression ISO ophiopogonin D results in decreased expression of HMOX1 protein CTD PMID:35905946 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Itgb1 integrin subunit beta 1 multiple interactions ISO ITGB1 protein inhibits the reaction [ophiopogonin D inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]]; ITGB1 protein inhibits the reaction [ophiopogonin D inhibits the reaction [TGFB1 protein results in increased expression of and affects the localization of CTNNB1 protein]]; ITGB1 protein inhibits the reaction [ophiopogonin D inhibits the reaction [TGFB1 protein results in increased expression of CDH2 protein]]; ITGB1 protein inhibits the reaction [ophiopogonin D inhibits the reaction [TGFB1 protein results in increased expression of MMP9 protein]]; ITGB1 protein inhibits the reaction [ophiopogonin D inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]]; ITGB1 protein inhibits the reaction [ophiopogonin D inhibits the reaction [TGFB1 protein results in increased phosphorylation of AKT1 protein]]; ITGB1 protein inhibits the reaction [ophiopogonin D inhibits the reaction [TGFB1 protein results in increased phosphorylation of PTK2 protein]]; ITGB1 protein inhibits the reaction [ophiopogonin D inhibits the reaction [TGFB1 protein results in increased phosphorylation of SRC protein]]; ophiopogonin D inhibits the reaction [TGFB1 protein results in increased expression of ITGB1 protein] CTD PMID:32818624 NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases expression
multiple interactions
ISO ophiopogonin D results in increased expression of MAP1LC3B protein
3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [ophiopogonin D results in increased expression of MAP1LC3B protein]
CTD PMID:35905946 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO [ophiopogonin D co-treated with TGFB1 protein] results in decreased expression of and results in decreased activity of MMP9 protein; ITGB1 protein inhibits the reaction [ophiopogonin D inhibits the reaction [TGFB1 protein results in increased expression of MMP9 protein]]; ophiopogonin D inhibits the reaction [TGFB1 protein results in increased expression of MMP9 protein] CTD PMID:32818624 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 decreases expression
multiple interactions
ISO ophiopogonin D results in decreased expression of NFE2L2 protein
3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [ophiopogonin D results in decreased expression of NFE2L2 protein]
CTD PMID:35905946 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Pink1 PTEN induced kinase 1 multiple interactions
increases expression
ISO 3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [ophiopogonin D results in increased expression of PINK1 protein] CTD PMID:35905946 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635
JBrowse link
G Ptk2 protein tyrosine kinase 2 multiple interactions ISO ITGB1 protein inhibits the reaction [ophiopogonin D inhibits the reaction [TGFB1 protein results in increased phosphorylation of PTK2 protein]]; ophiopogonin D inhibits the reaction [TGFB1 protein results in increased phosphorylation of PTK2 protein] CTD PMID:32818624 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO ITGB1 protein inhibits the reaction [ophiopogonin D inhibits the reaction [TGFB1 protein results in increased phosphorylation of SRC protein]]; ophiopogonin D inhibits the reaction [TGFB1 protein results in increased phosphorylation of SRC protein] CTD PMID:32818624 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G Srl sarcalumenin decreases expression ISO ophiopogonin D results in decreased expression of SRL protein CTD PMID:35905946 NCBI chr10:11,033,976...11,078,103
Ensembl chr10:11,034,035...11,078,101
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO [ophiopogonin D co-treated with TGFB1 protein] results in decreased expression of and results in decreased activity of MMP9 protein; ITGB1 protein inhibits the reaction [ophiopogonin D inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]]; ITGB1 protein inhibits the reaction [ophiopogonin D inhibits the reaction [TGFB1 protein results in increased expression of and affects the localization of CTNNB1 protein]]; ITGB1 protein inhibits the reaction [ophiopogonin D inhibits the reaction [TGFB1 protein results in increased expression of CDH2 protein]]; ITGB1 protein inhibits the reaction [ophiopogonin D inhibits the reaction [TGFB1 protein results in increased expression of MMP9 protein]]; ITGB1 protein inhibits the reaction [ophiopogonin D inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]]; ITGB1 protein inhibits the reaction [ophiopogonin D inhibits the reaction [TGFB1 protein results in increased phosphorylation of AKT1 protein]]; ITGB1 protein inhibits the reaction [ophiopogonin D inhibits the reaction [TGFB1 protein results in increased phosphorylation of PTK2 protein]]; ITGB1 protein inhibits the reaction [ophiopogonin D inhibits the reaction [TGFB1 protein results in increased phosphorylation of SRC protein]]; ophiopogonin D inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]; ophiopogonin D inhibits the reaction [TGFB1 protein results in increased expression of and affects the localization of CTNNB1 protein]; ophiopogonin D inhibits the reaction [TGFB1 protein results in increased expression of CDH2 protein]; ophiopogonin D inhibits the reaction [TGFB1 protein results in increased expression of ITGB1 protein]; ophiopogonin D inhibits the reaction [TGFB1 protein results in increased expression of MMP9 protein]; ophiopogonin D inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]; ophiopogonin D inhibits the reaction [TGFB1 protein results in increased phosphorylation of AKT1 protein]; ophiopogonin D inhibits the reaction [TGFB1 protein results in increased phosphorylation of PTK2 protein]; ophiopogonin D inhibits the reaction [TGFB1 protein results in increased phosphorylation of SRC protein] CTD PMID:32818624 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Vim vimentin multiple interactions ISO ITGB1 protein inhibits the reaction [ophiopogonin D inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]]; ophiopogonin D inhibits the reaction [TGFB1 protein results in increased expression of VIM protein] CTD PMID:32818624 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      biological role 19782
        biochemical role 19496
          metabolite 19484
            saponin 486
              steroid saponin 358
                Ophiopogonin D 17
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            heteroorganic entity 19460
                              organochalcogen compound 19224
                                organooxygen compound 19141
                                  carbohydrates and carbohydrate derivatives 15270
                                    carbohydrate 15270
                                      carbohydrate derivative 14278
                                        glycosyl compound 13035
                                          glycoside 11818
                                            saponin 486
                                              steroid saponin 358
                                                Ophiopogonin D 17
paths to the root