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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:steroid saponin
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Accession:CHEBI:61655 term browser browse the term
Definition:Any saponin derived from a hydroxysteroid.
Synonyms:related_synonym: glycosteroid;   glycosteroids;   glycosyl steroid;   glycosyl steroids;   steroid glycoside;   steroid glycosides;   steroid saponins;   steroidal glycoside;   steroidal glycosides;   sterol glycoside;   sterol glycosides;   steryl glycoside;   steryl glycosides
 xref: PMID:18486659;   PMID:20346608;   PMID:20846658


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(20S)-ginsenoside Rg3 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
decreases expression		 ISO XMU-MP-1 inhibits the reaction [ginsenoside Rg3 results in decreased expression of ABCG2 mRNA] CTD PMID:31916386 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Acp5 acid phosphatase 5, tartrate resistant multiple interactions EXP ginsenoside Rg3 inhibits the reaction [Dexamethasone results in increased activity of ACP5 protein] CTD PMID:27387537 NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929 		JBrowse link
G Ar androgen receptor increases degradation
multiple interactions		 ISO ginsenoside Rg3 results in increased degradation of AR protein
ginsenoside Rg3 inhibits the reaction [Testosterone results in increased expression of AR protein]		 CTD PMID:22101440 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Areg amphiregulin decreases expression ISO ginsenoside Rg3 results in decreased expression of AREG mRNA CTD PMID:31916386 NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO ginsenoside Rg3 inhibits the reaction [cagA protein, Helicobacter pylori results in decreased expression of BAX protein] CTD PMID:26427350 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO ginsenoside Rg3 inhibits the reaction [cagA protein, Helicobacter pylori results in increased expression of BCL2 protein] CTD PMID:26427350 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions ISO [Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of BDNF protein]; [staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] inhibits the reaction [[Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of BDNF protein]] CTD PMID:24394491 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Becn1 beclin 1 multiple interactions ISO ginsenoside Rg3 inhibits the reaction [Cisplatin results in decreased expression of BECN1 protein]
3-methyladenine inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Cisplatin results in decreased expression of BECN1 protein]]; ginsenoside Rg3 inhibits the reaction [Cisplatin results in decreased expression of BECN1 protein]		 CTD PMID:34423507 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Bglap bone gamma-carboxyglutamate protein multiple interactions EXP ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of BGLAP protein] CTD PMID:27387537 NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO ginsenoside Rg3 results in decreased expression of BIRC5 mRNA; ginsenoside Rg3 results in decreased expression of BIRC5 protein CTD PMID:19778801 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Bmp2 bone morphogenetic protein 2 multiple interactions EXP ginsenoside Rg3 inhibits the reaction [Dexamethasone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of BMP2 protein]]; ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of BMP2 mRNA]; ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of BMP2 protein]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of BMP2 protein]]] CTD PMID:27387537 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397 		JBrowse link
G Bmpr1a bone morphogenetic protein receptor type 1A multiple interactions EXP ginsenoside Rg3 inhibits the reaction [Dexamethasone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of BMPR1A protein]]; ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of BMPR1A mRNA]; ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of BMPR1A protein]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of BMPR1A protein]]] CTD PMID:27387537 NCBI chr16:9,736,390...9,829,825
Ensembl chr16:9,736,630...9,780,616 		JBrowse link
G Casp1 caspase 1 multiple interactions ISO ginsenoside Rg3 inhibits the reaction [Cisplatin results in increased expression of CASP1 protein] CTD PMID:34423507 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions		 ISO ginsenoside Rg3 results in increased cleavage of CASP3 protein
[ginsenoside Rg3 co-treated with osimertinib] results in increased cleavage of CASP3 protein; ginsenoside Rg3 inhibits the reaction [cagA protein, Helicobacter pylori results in decreased cleavage of CASP3 protein]		 CTD PMID:22101440 PMID:26427350 PMID:31916386 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO ginsenoside Rg3 inhibits the reaction [cagA protein, Helicobacter pylori results in decreased cleavage of CASP8 protein] CTD PMID:26427350 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO ginsenoside Rg3 inhibits the reaction [cagA protein, Helicobacter pylori results in decreased cleavage of CASP9 protein] CTD PMID:26427350 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase multiple interactions EXP ginsenoside Rg3 inhibits the reaction [dimethoxon results in decreased activity of CAT protein] CTD PMID:26240163 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccn1 cellular communication network factor 1 decreases expression ISO ginsenoside Rg3 results in decreased expression of CCN1 mRNA CTD PMID:31916386 NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484 		JBrowse link
G Ccn2 cellular communication network factor 2 decreases expression ISO ginsenoside Rg3 results in decreased expression of CCN2 mRNA CTD PMID:31916386 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein] CTD PMID:24793912 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Dpp4 dipeptidylpeptidase 4 multiple interactions ISO [Xiao-Ke-An results in increased abundance of ginsenoside Rg3] which results in decreased activity of DPP4 protein CTD PMID:32535096 NCBI chr 3:46,962,233...47,043,870
Ensembl chr 3:46,962,243...47,043,901 		JBrowse link
G Egf epidermal growth factor multiple interactions ISO EGF protein promotes the reaction [ginsenoside Rg3 affects the phosphorylation of EGFR protein]; ginsenoside Rg3 inhibits the reaction [EGF protein promotes the reaction [EGFR protein binds to EGFR protein]] CTD PMID:25824408 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
affects phosphorylation		 ISO EGF protein promotes the reaction [ginsenoside Rg3 affects the phosphorylation of EGFR protein]; ginsenoside Rg3 inhibits the reaction [EGF protein promotes the reaction [EGFR protein binds to EGFR protein]]; ginsenoside Rg3 results in decreased expression of and affects the localization of EGFR protein CTD PMID:25824408 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Epcam epithelial cell adhesion molecule decreases expression ISO ginsenoside Rg3 results in decreased expression of EPCAM mRNA CTD PMID:31916386 NCBI chr 6:6,880,142...6,896,103
Ensembl chr 6:6,878,237...6,896,127 		JBrowse link
G Fut4 fucosyltransferase 4 multiple interactions
decreases expression		 ISO ginsenoside Rg3 inhibits the reaction [cagA protein, Helicobacter pylori results in increased expression of FUT4 protein]
ginsenoside Rg3 results in decreased expression of FUT4 protein		 CTD PMID:26427350 NCBI chr 8:11,586,721...11,590,682
Ensembl chr 8:11,586,721...11,590,682 		JBrowse link
G Hsf1 heat shock transcription factor 1 multiple interactions
decreases expression		 ISO ginsenoside Rg3 inhibits the reaction [cagA protein, Helicobacter pylori results in increased expression of HSF1 protein]
ginsenoside Rg3 results in decreased expression of HSF1 protein		 CTD PMID:26427350 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011 		JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions		 EXP
ISO		 ginsenoside Rg3 results in increased expression of IL1B protein
ginsenoside Rg3 inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; ginsenoside Rg3 inhibits the reaction [Cisplatin results in increased expression of IL1B protein]		 CTD PMID:14534150 PMID:33050067 PMID:34423507 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO ginsenoside Rg3 inhibits the reaction [Galactose results in increased secretion of IL6 protein] CTD PMID:29412148 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase decreases expression ISO ginsenoside Rg3 results in decreased expression of KIT mRNA CTD PMID:31916386 NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652 		JBrowse link
G Klf4 KLF transcription factor 4 decreases expression ISO ginsenoside Rg3 results in decreased expression of KLF4 mRNA CTD PMID:31916386 NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602 		JBrowse link
G Klk1c10 kallikrein 1-related peptidase C10 multiple interactions ISO ginsenoside Rg3 inhibits the reaction [Testosterone results in increased expression of KLK3 mRNA]; ginsenoside Rg3 inhibits the reaction [Testosterone results in increased expression of KLK3 protein] CTD PMID:22101440 NCBI chr 1:94,402,993...94,407,052
Ensembl chr 1:94,402,993...94,407,052 		JBrowse link
G Lats1 large tumor suppressor kinase 1 increases expression ISO ginsenoside Rg3 results in increased expression of LATS1 mRNA CTD PMID:31916386 NCBI chr 1:2,160,411...2,193,640
Ensembl chr 1:2,160,411...2,193,640 		JBrowse link
G Lats2 large tumor suppressor kinase 2 increases expression ISO ginsenoside Rg3 results in increased expression of LATS2 mRNA CTD PMID:31916386 NCBI chr15:31,825,068...31,877,193
Ensembl chr15:31,825,092...31,877,220 		JBrowse link
G Map2 microtubule-associated protein 2 increases expression ISO ginsenoside Rg3 results in increased expression of MAP2 mRNA CTD PMID:24599032 NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809 		JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions ISO [ginsenoside Rg3 co-treated with osimertinib] results in decreased expression of MKI67 protein CTD PMID:31916386 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased expression of and results in increased activity of MMP2 protein]; ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased expression of MMP2 mRNA] CTD PMID:24793912 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP ginsenoside Rg3 inhibits the reaction [dimethoxon results in increased activity of MPO protein] CTD PMID:26240163 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO ginsenoside Rg3 results in decreased expression of MYC mRNA CTD PMID:31916386 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Nanog Nanog homeobox decreases expression ISO ginsenoside Rg3 results in decreased expression of NANOG mRNA CTD PMID:31916386 NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
increases activity		 EXP [ginsenoside Rg3 results in increased phosphorylation of and results in increased degradation of NFKBIA protein] which results in increased activity of NFKB1 protein
ginsenoside Rg3 results in increased activity of NFKB1 protein		 CTD PMID:14534150 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP [ginsenoside Rg3 results in increased phosphorylation of and results in increased degradation of NFKBIA protein] which results in increased activity of NFKB1 protein; [ginsenoside Rg3 results in increased phosphorylation of and results in increased degradation of NFKBIA protein] which results in increased activity of RELA protein CTD PMID:14534150 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO ginsenoside Rg3 inhibits the reaction [Cisplatin results in increased expression of NLRP3 protein]
3-methyladenine inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Cisplatin results in increased expression of NLRP3 protein]]; ginsenoside Rg3 inhibits the reaction [Cisplatin results in increased expression of NLRP3 protein]		 CTD PMID:34423507 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Nog noggin multiple interactions EXP NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of BMP2 protein]]]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of BMPR1A protein]]]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of RUNX2 protein]]]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of TNFRSF11B mRNA]]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of TNFRSF11B protein]]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone results in increased expression of TNFSF11 mRNA]]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone results in increased expression of TNFSF11 protein]] CTD PMID:27387537 NCBI chr10:74,128,712...74,130,339
Ensembl chr10:74,128,712...74,130,339 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression		 EXP Staurosporine inhibits the reaction [ginsenoside Rg3 results in increased expression of NOS2 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [ginsenoside Rg3 results in increased expression of NOS2 protein]
ginsenoside Rg3 results in increased expression of NOS2 mRNA		 CTD PMID:14534150 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 multiple interactions ISO [staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] inhibits the reaction [[Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of BDNF protein]]; [staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] inhibits the reaction [[Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] results in decreased susceptibility to Chlorodiphenyl (54% Chlorine)]; [staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] results in decreased susceptibility to [Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3]
[Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of NTRK2 protein modified form]; [staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] inhibits the reaction [[Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] results in decreased susceptibility to Chlorodiphenyl (54% Chlorine)]; [staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] results in decreased susceptibility to [Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3]		 CTD PMID:24394491 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions		 ISO ginsenoside Rg3 results in increased cleavage of PARP1 protein
[ginsenoside Rg3 co-treated with osimertinib] results in increased cleavage of PARP1 protein; ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased cleavage of PARP1 protein]; ginsenoside Rg3 inhibits the reaction [cagA protein, Helicobacter pylori results in decreased cleavage of PARP1 protein]		 CTD PMID:22101440 PMID:24793912 PMID:26427350 PMID:31916386 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 increases expression EXP ginsenoside Rg3 results in increased expression of PCK1 mRNA CTD PMID:30144466 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191 		JBrowse link
G Pou5f1 POU class 5 homeobox 1 decreases expression ISO ginsenoside Rg3 results in decreased expression of POU5F1 mRNA CTD PMID:31916386 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression EXP ginsenoside Rg3 results in increased expression of PPARGC1A mRNA CTD PMID:30144466 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Prom1 prominin 1 decreases expression
multiple interactions		 ISO ginsenoside Rg3 results in decreased expression of PROM1 mRNA
XMU-MP-1 inhibits the reaction [ginsenoside Rg3 results in decreased expression of PROM1 mRNA]		 CTD PMID:31916386 NCBI chr14:66,989,545...67,094,534
Ensembl chr14:66,990,160...67,094,527 		JBrowse link
G Pycard PYD and CARD domain containing multiple interactions ISO ginsenoside Rg3 inhibits the reaction [Cisplatin results in increased expression of PYCARD protein]
3-methyladenine inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Cisplatin results in increased expression of PYCARD protein]]; ginsenoside Rg3 inhibits the reaction [Cisplatin results in increased expression of PYCARD protein]		 CTD PMID:34423507 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP
ISO		 [ginsenoside Rg3 results in increased phosphorylation of and results in increased degradation of NFKBIA protein] which results in increased activity of RELA protein; ginsenoside Rg3 affects the localization of and results in increased activity of RELA protein
ginsenoside Rg3 results in decreased expression of and results in decreased phosphorylation of RELA protein		 CTD PMID:14534150 PMID:33050067 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions EXP ginsenoside Rg3 inhibits the reaction [Dexamethasone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of RUNX2 protein]]; ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of RUNX2 mRNA]; ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of RUNX2 protein]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of RUNX2 protein]]] CTD PMID:27387537 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167 		JBrowse link
G Sall4 spalt-like transcription factor 4 decreases expression ISO ginsenoside Rg3 results in decreased expression of SALL4 mRNA CTD PMID:31916386 NCBI chr 3:157,474,067...157,491,055
Ensembl chr 3:157,474,642...157,490,822 		JBrowse link
G Sirt1 sirtuin 1 increases activity EXP ginsenoside Rg3 results in increased activity of SIRT1 protein CTD PMID:30144466 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Slc6a2 solute carrier family 6 member 2 multiple interactions ISO [Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of SLC6A2 protein] CTD PMID:24394491 NCBI chr19:14,010,292...14,055,317
Ensembl chr19:14,010,386...14,050,357 		JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions ISO [Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of SLC6A3 protein] CTD PMID:24394491 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413 		JBrowse link
G Smad2 SMAD family member 2 multiple interactions ISO ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein] CTD PMID:24793912 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323 		JBrowse link
G Snai1 snail family transcriptional repressor 1 multiple interactions ISO ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 mRNA]; ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 protein] CTD PMID:24793912 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969 		JBrowse link
G Sox2 SRY-box transcription factor 2 decreases expression ISO ginsenoside Rg3 results in decreased expression of SOX2 mRNA CTD PMID:31916386 NCBI chr 2:117,536,929...117,539,340
Ensembl chr 2:117,536,929...117,539,338 		JBrowse link
G Sp1 Sp1 transcription factor multiple interactions ISO ginsenoside Rg3 inhibits the reaction [cagA protein, Helicobacter pylori results in decreased expression of SP1 protein] CTD PMID:26427350 NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO ginsenoside Rg3 inhibits the reaction [Cisplatin results in increased expression of SQSTM1 protein]
3-methyladenine affects the reaction [ginsenoside Rg3 affects the reaction [Cisplatin affects the expression of SQSTM1 protein]]; ginsenoside Rg3 affects the reaction [Cisplatin affects the expression of SQSTM1 protein]		 CTD PMID:34423507 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Stk3 serine/threonine kinase 3 increases expression ISO ginsenoside Rg3 results in increased expression of STK3 mRNA CTD PMID:31916386 NCBI chr 7:66,053,209...66,323,292
Ensembl chr 7:66,052,345...66,323,233 		JBrowse link
G Stk4 serine/threonine kinase 4 increases expression ISO ginsenoside Rg3 results in increased expression of STK4 mRNA CTD PMID:31916386 NCBI chr 3:152,745,958...152,827,747
Ensembl chr 3:152,745,681...152,827,744 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]; ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased cleavage of PARP1 protein]; ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased expression of and results in increased activity of MMP2 protein]; ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased expression of MMP2 mRNA]; ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 mRNA]; ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 protein]; ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]; ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein] CTD PMID:24793912 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Thy1 Thy-1 cell surface antigen decreases expression ISO ginsenoside Rg3 results in decreased expression of THY1 mRNA CTD PMID:31916386 NCBI chr 8:44,389,495...44,394,688
Ensembl chr 8:44,389,513...44,394,659 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions		 EXP
ISO		 ginsenoside Rg3 results in increased expression of TNF protein
ginsenoside Rg3 inhibits the reaction [dimethoxon results in increased expression of TNF protein]
ginsenoside Rg3 inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of TNF protein]; ginsenoside Rg3 inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]		 CTD PMID:14534150 PMID:26240163 PMID:33050067 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B multiple interactions EXP ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of TNFRSF11B mRNA]; ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of TNFRSF11B protein]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of TNFRSF11B mRNA]]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of TNFRSF11B protein]] CTD PMID:27387537 NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538 		JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions EXP ginsenoside Rg3 inhibits the reaction [Dexamethasone results in increased expression of TNFSF11 mRNA]; ginsenoside Rg3 inhibits the reaction [Dexamethasone results in increased expression of TNFSF11 protein]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone results in increased expression of TNFSF11 mRNA]]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone results in increased expression of TNFSF11 protein]] CTD PMID:27387537 NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445 		JBrowse link
G Vim vimentin multiple interactions ISO ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased expression of VIM protein] CTD PMID:24793912 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
G Wwtr1 WW domain containing transcription regulator 1 decreases expression ISO ginsenoside Rg3 results in decreased expression of WWTR1 mRNA CTD PMID:31916386 NCBI chr 2:141,651,159...141,766,919
Ensembl chr 2:141,648,108...141,766,968 		JBrowse link
G Yap1 Yes1 associated transcriptional regulator decreases expression ISO ginsenoside Rg3 results in decreased expression of YAP1 mRNA CTD PMID:31916386 NCBI chr 8:5,095,705...5,166,808
Ensembl chr 8:5,095,722...5,167,010 		JBrowse link
(20S)-ginsenoside Rh1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO ginsenoside Rh1 results in increased expression of FOS mRNA CTD PMID:16204943 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:21875580 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO ginsenoside Rh1 inhibits the reaction [Oxazolone results in increased expression of IL1B mRNA]; ginsenoside Rh1 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL1B mRNA] CTD PMID:16557482 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il4 interleukin 4 decreases expression ISO ginsenoside Rh1 results in decreased expression of IL4 CTD PMID:22855946 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO ginsenoside Rh1 inhibits the reaction [Galactose results in increased secretion of IL6 protein] CTD PMID:29412148 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Itga4 integrin subunit alpha 4 multiple interactions ISO ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of [ITGA4 protein binds to ITGB1 protein]] CTD PMID:21875580 NCBI chr 3:64,162,764...64,235,010
Ensembl chr 3:64,163,085...64,233,715 		JBrowse link
G Itgal integrin subunit alpha L multiple interactions ISO ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of [ITGAL protein binds to ITGB2 protein]] CTD PMID:21875580 NCBI chr 1:181,918,183...181,955,735
Ensembl chr 1:181,918,183...181,955,732 		JBrowse link
G Itgb1 integrin subunit beta 1 multiple interactions ISO ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of [ITGA4 protein binds to ITGB1 protein]] CTD PMID:21875580 NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195 		JBrowse link
G Itgb2 integrin subunit beta 2 multiple interactions ISO ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of [ITGAL protein binds to ITGB2 protein]] CTD PMID:21875580 NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases activity ISO ginsenoside Rh1 results in decreased activity of JUN protein CTD PMID:22855946 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Lpl lipoprotein lipase increases secretion ISO ginsenoside Rh1 results in increased secretion of LPL protein CTD PMID:8988629 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249 		JBrowse link
G Pgr progesterone receptor increases expression ISO ginsenoside Rh1 results in increased expression of PGR protein CTD PMID:16204943 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO ginsenoside Rh1 inhibits the reaction [bisphenol A results in increased expression of PPARG mRNA]; ginsenoside Rh1 inhibits the reaction [bisphenol A results in increased expression of PPARG protein] CTD PMID:32623698 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO ginsenoside Rh1 inhibits the reaction [Oxazolone results in increased expression of PTGS2 mRNA]; ginsenoside Rh1 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 mRNA] CTD PMID:16557482 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Sele selectin E multiple interactions ISO ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of SELE protein] CTD PMID:21875580 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741 		JBrowse link
G Tff1 trefoil factor 1 increases expression ISO ginsenoside Rh1 results in increased expression of TFF1 mRNA CTD PMID:16204943 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
decreases response to substance		 ISO ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of [ITGA4 protein binds to ITGB1 protein]]; ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of [ITGAL protein binds to ITGB2 protein]]; ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of SELE protein]; ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
ginsenoside Rh1 inhibits the reaction [Oxazolone results in increased expression of TNF mRNA]; ginsenoside Rh1 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNF mRNA]
ginsenoside Rh1 results in decreased expression of TNF
ginsenoside Rh1 results in decreased susceptibility to TNF protein		 CTD PMID:16557482 PMID:21875580 PMID:22855946 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] CTD PMID:21875580 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
(20S)-ginsenoside Rh2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO ginsenoside Rh2 results in decreased phosphorylation of AKT1 protein CTD PMID:32762018 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO ginsenoside Rh2 results in increased expression of BAX protein CTD PMID:26482938 PMID:32762018 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO ginsenoside Rh2 results in decreased expression of BCL2 protein CTD PMID:26482938 PMID:32762018 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 increases cleavage
decreases expression		 ISO ginsenoside Rh2 results in increased cleavage of CASP3 protein
ginsenoside Rh2 results in decreased expression of CASP3 protein		 CTD PMID:26482938 PMID:32762018 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 decreases expression ISO ginsenoside Rh2 results in decreased expression of CASP9 protein CTD PMID:32762018 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO ginsenoside Rh2 results in decreased expression of CCND1 protein CTD PMID:26482938 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Hdac1 histone deacetylase 1 decreases expression ISO ginsenoside Rh2 results in decreased expression of HDAC1 protein CTD PMID:26482938 NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111 		JBrowse link
G Hdac2 histone deacetylase 2 decreases expression ISO ginsenoside Rh2 results in decreased expression of HDAC2 protein CTD PMID:26482938 NCBI chr20:40,548,244...40,571,609
Ensembl chr20:40,548,250...40,571,609 		JBrowse link
G Hdac6 histone deacetylase 6 decreases expression ISO ginsenoside Rh2 results in decreased expression of HDAC6 protein CTD PMID:26482938 NCBI chr  X:14,550,645...14,572,445
Ensembl chr  X:14,551,044...14,572,441 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO ginsenoside Rh2 inhibits the reaction [Galactose results in increased secretion of IL6 protein] CTD PMID:29412148 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation
increases phosphorylation		 ISO ginsenoside Rh2 results in decreased phosphorylation of MAPK1 protein
ginsenoside Rh2 results in increased phosphorylation of MAPK1 protein		 CTD PMID:26482938 PMID:32762018 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation
increases phosphorylation		 ISO ginsenoside Rh2 results in decreased phosphorylation of MAPK3 protein
ginsenoside Rh2 results in increased phosphorylation of MAPK3 protein		 CTD PMID:26482938 PMID:32762018 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation ISO ginsenoside Rh2 results in decreased phosphorylation of MTOR protein CTD PMID:32762018 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression ISO ginsenoside Rh2 results in increased expression of NFKBIA protein CTD PMID:32762018 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO ginsenoside Rh2 results in increased expression of and results in decreased phosphorylation of RELA protein CTD PMID:32762018 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
16alpha,17beta-Estriol 17-(beta-D-glucuronide) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions EXP estriol 17-glucuronide inhibits the reaction [ABCB1 results in increased transport of estradiol-17 beta-glucuronide] CTD PMID:9794924 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
alpha-Chaconine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1b interleukin 1 beta multiple interactions ISO alpha-chaconine inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; alpha-chaconine inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:25913072 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO alpha-chaconine inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; alpha-chaconine inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] CTD PMID:25913072 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO alpha-chaconine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of and affects the localization of JUN protein]; alpha-chaconine inhibits the reaction [Lipopolysaccharides results in increased expression of JUN protein modified form] CTD PMID:25913072 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Map2k7 mitogen activated protein kinase kinase 7 multiple interactions ISO alpha-chaconine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAP2K7 protein] CTD PMID:25913072 NCBI chr12:2,591,312...2,600,534
Ensembl chr12:2,591,219...2,604,222 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 multiple interactions ISO alpha-chaconine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAP3K7 protein] CTD PMID:25913072 NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO alpha-chaconine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK8 protein] CTD PMID:25913072 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO alpha-chaconine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK9 protein] CTD PMID:25913072 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO alpha-chaconine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]; alpha-chaconine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein] CTD PMID:25913072 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO alpha-chaconine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]; alpha-chaconine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein] CTD PMID:25913072 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO alpha-chaconine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; alpha-chaconine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:25913072 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
alpha-Solamarine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bad BCL2-associated agonist of cell death multiple interactions ISO alpha-solamargine inhibits the reaction [Sevoflurane results in increased expression of BAD mRNA]; alpha-solamargine inhibits the reaction [Sevoflurane results in increased expression of BAD protein] CTD PMID:35350913 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of BCL2L1 mRNA]; alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of BCL2L1 protein] CTD PMID:35350913 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions ISO alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of BDNF protein] CTD PMID:35350913 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO alpha-solamargine inhibits the reaction [Sevoflurane results in increased cleavage of CASP3 protein]; alpha-solamargine inhibits the reaction [Sevoflurane results in increased expression of CASP3 mRNA] CTD PMID:35350913 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of CREB1 protein] CTD PMID:35350913 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 multiple interactions ISO alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of DLG4 protein] CTD PMID:35350913 NCBI chr10:54,740,700...54,769,097
Ensembl chr10:54,739,470...54,767,153 		JBrowse link
G Foxo3 forkhead box O3 multiple interactions ISO alpha-solamargine inhibits the reaction [Sevoflurane results in decreased phosphorylation of and affects the localization of FOXO3 protein]; alpha-solamargine inhibits the reaction [Sevoflurane results in decreased phosphorylation of FOXO3 protein] CTD PMID:35350913 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of GCLC protein] CTD PMID:35350913 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions ISO alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of GCLM mRNA] CTD PMID:35350913 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions ISO alpha-solamargine inhibits the reaction [Sevoflurane results in increased expression of HMGB1 mRNA] CTD PMID:35350913 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of HMOX1 mRNA]; alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of HMOX1 protein] CTD PMID:35350913 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO alpha-solamargine inhibits the reaction [Sevoflurane results in increased expression of IL1B mRNA] CTD PMID:35350913 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of NQO1 mRNA]; alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of NQO1 protein] CTD PMID:35350913 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 multiple interactions ISO alpha-solamargine inhibits the reaction [Sevoflurane results in decreased phosphorylation of NTRK2 protein] CTD PMID:35350913 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136 		JBrowse link
G Prrx1 paired related homeobox 1 multiple interactions ISO alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of PRRX1 protein] CTD PMID:35350913 NCBI chr13:75,600,777...75,671,896
Ensembl chr13:75,601,706...75,670,866 		JBrowse link
G Sypl1 synaptophysin-like 1 multiple interactions ISO alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of SYPL1 protein] CTD PMID:35350913 NCBI chr 6:49,565,111...49,585,205
Ensembl chr 6:49,565,154...49,585,330 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO alpha-solamargine inhibits the reaction [Sevoflurane results in increased expression of TNF mRNA] CTD PMID:35350913 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Beta-Solamarine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions		 ISO beta-solamarine results in increased expression of BAX protein
beta-solamarine promotes the reaction [Cisplatin results in increased expression of BAX protein]		 CTD PMID:17619073 PMID:20647040 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO beta-solamarine results in decreased expression of BCL2 protein CTD PMID:17619073 PMID:20647040 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO beta-solamarine results in decreased expression of BCL2L1 protein CTD PMID:17619073 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Casp3 caspase 3 increases activity
increases cleavage
multiple interactions		 ISO beta-solamarine results in increased activity of CASP3 protein
beta-solamarine results in increased cleavage of CASP3 protein
beta-solamarine promotes the reaction [Cisplatin results in increased activity of CASP3 protein]		 CTD PMID:17619073 PMID:20647040 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 multiple interactions
increases activity		 ISO beta-solamarine promotes the reaction [Cisplatin results in increased activity of CASP8 protein]
beta-solamarine results in increased activity of CASP8 protein		 CTD PMID:17619073 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity
increases cleavage		 ISO beta-solamarine promotes the reaction [Cisplatin results in increased activity of CASP9 protein]
beta-solamarine results in increased activity of CASP9 protein
beta-solamarine results in increased cleavage of CASP9 protein		 CTD PMID:17619073 PMID:20647040 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ctsb cathepsin B affects localization ISO beta-solamarine affects the localization of CTSB protein CTD PMID:20647040 NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500 		JBrowse link
G Fadd Fas associated via death domain increases expression ISO beta-solamarine results in increased expression of FADD protein CTD PMID:17619073 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653 		JBrowse link
G Fas Fas cell surface death receptor increases expression ISO beta-solamarine results in increased expression of FAS protein CTD PMID:17619073 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A increases expression ISO beta-solamarine results in increased expression of TNFRSF1A protein CTD PMID:17619073 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591 		JBrowse link
G Tradd TNFRSF1A-associated via death domain increases expression ISO beta-solamarine results in increased expression of TRADD protein CTD PMID:17619073 NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638 		JBrowse link
digitonin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccnb1 cyclin B1 increases expression ISO Digitonin results in increased expression of CCNB1 protein CTD PMID:36030841 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccnd1 cyclin D1 increases expression ISO Digitonin results in increased expression of CCND1 protein CTD PMID:36030841 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cdh5 cadherin 5 multiple interactions ISO Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in decreased expression of CDH5 protein] CTD PMID:31404653 NCBI chr19:815,415...854,478
Ensembl chr19:815,411...854,368 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression ISO Digitonin results in decreased expression of CDKN1A protein CTD PMID:36030841 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases expression ISO Digitonin results in decreased expression of CDKN1B protein CTD PMID:36030841 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO Digitonin results in increased expression of CYP2B10 protein CTD PMID:36030841 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Etv2 ETS variant transcription factor 2 multiple interactions ISO Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in decreased expression of CDH5 protein]; Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in increased expression of SPN protein] CTD PMID:31404653 NCBI chr 1:85,890,562...85,894,025
Ensembl chr 1:85,890,559...85,893,431 		JBrowse link
G Gata2 GATA binding protein 2 multiple interactions ISO Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in decreased expression of CDH5 protein]; Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in increased expression of SPN protein] CTD PMID:31404653 NCBI chr 4:120,654,205...120,667,763
Ensembl chr 4:120,658,986...120,667,761 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha decreases expression ISO Digitonin results in decreased expression of HIF1A protein CTD PMID:34717917 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Nek2 NIMA-related kinase 2 increases expression ISO Digitonin results in increased expression of NEK2 protein CTD PMID:36030841 NCBI chr13:103,405,818...103,419,063
Ensembl chr13:103,405,819...103,419,051 		JBrowse link
G Rbl2 RB transcriptional corepressor like 2 decreases expression ISO Digitonin results in decreased expression of RBL2 protein CTD PMID:36030841 NCBI chr19:15,876,852...15,923,632
Ensembl chr19:15,876,853...15,923,572 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Digitonin inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 increases expression ISO Digitonin results in increased expression of SLCO1A4 protein CTD PMID:36030841 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573 		JBrowse link
G Spn sialophorin multiple interactions ISO Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in increased expression of SPN protein] CTD PMID:31404653 NCBI chr 1:181,746,937...181,759,564
Ensembl chr 1:181,746,429...181,759,628 		JBrowse link
digoxin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca8 ATP binding cassette subfamily A member 8 multiple interactions ISO Digoxin inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide] CTD PMID:12379217 NCBI chr10:94,917,520...94,991,199
Ensembl chr10:94,917,520...94,990,988 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A affects abundance
affects uptake
increases uptake
multiple interactions
increases export
increases transport
affects secretion
increases expression
affects binding
decreases uptake
affects transport		 ISO
EXP		 ABCB1 gene SNP affects the abundance of Digoxin
ABCB1A protein affects the uptake of Digoxin
ABCB1 protein results in increased uptake of Digoxin
18alpha-glycyrrhetinic acid inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Digoxin results in increased expression of ABCB1 protein]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Digoxin results in increased expression of ABCB1 mRNA]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Digoxin results in increased expression of ABCB1 protein]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; [citronellal results in decreased activity of ABCB1 protein] which results in decreased export of Digoxin; [citronellol results in decreased activity of ABCB1 protein] which results in decreased export of Digoxin; [Cyclosporine binds to and results in decreased activity of ABCB1 protein] which results in decreased export of Digoxin; [Digoxin results in increased expression of ABCB1] which results in decreased susceptibility to Doxorubicin; [Elacridar binds to and results in decreased activity of ABCB1 protein] which results in decreased export of Digoxin; [Elacridar results in decreased activity of ABCB1 protein] which results in increased uptake of Digoxin; [isopropyl 5,12-hydroxypentadeca-8,10-dien-6,14-diynoate results in decreased activity of ABCB1 protein] which results in increased uptake of Digoxin; [Ketoconazole binds to and results in decreased activity of ABCB1 protein] which results in decreased export of Digoxin; [Ketoconazole results in decreased activity of ABCB1 protein] which results in increased uptake of Digoxin; [Plant Extracts results in decreased activity of ABCB1 protein] which results in decreased export of Digoxin; [valspodar results in decreased activity of ABCB1 protein] which results in decreased transport of Digoxin; [Verapamil binds to and results in decreased activity of ABCB1 protein] which results in decreased export of Digoxin; [Verapamil results in decreased activity of ABCB1 protein] which results in decreased transport of Digoxin; ABCB1 protein binds to and affects the metabolism of Digoxin; abietic acid inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]; Amiodarone inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; azelastine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; benidipine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Bepridil inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; beta-pinene inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]; Bisoprolol inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Capsaicin affects the reaction [ABCB1 protein results in increased export of Digoxin]; Carvedilol inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; citronellal inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]; citronellol inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]; cucurbitacin I inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]; Curcumin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; cyazofamid affects the reaction [ABCB1 protein results in increased uptake of Digoxin]; dehydroandrographolide inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; desethylamiodarone inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; desmethylazelastine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Diazinon affects the reaction [ABCB1 protein results in increased transport of Digoxin]; Digoxin inhibits the reaction [ABCB1 protein results in increased transport of quinidinium]; Diltiazem inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Doxazosin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; efonidipine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Emodin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Fusidic Acid inhibits the reaction [ABCB1 protein results in increased export of Digoxin]; gamma-terpinene inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]; gingerol inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; ginsenoside F2 analog inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Glycyrrhetinic Acid inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]; Itraconazole inhibits the reaction [ABCB1 protein affects the transport of Digoxin]; Ketoconazole inhibits the reaction [ABCB1 protein affects the transport of Digoxin]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; KN 93 inhibits the reaction [Digoxin results in increased expression of ABCB1 protein]; manidipine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; mepirodipine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Nicardipine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; nilvadipine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Nisoldipine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; nobiletin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; ophiobolin A inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]; Propranolol inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; rhodioloside affects the reaction [ABCB1 protein results in increased transport of Digoxin]; Rifampin promotes the reaction [ABCB1 protein results in increased transport of Digoxin]; sciadopitysin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; sinensetin analog inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; sinensetin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; spinosad inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; tangeretin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; terpinolene inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]; valspodar inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Verapamil inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Verapamil inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]
[P-glycoprotein inducer and activator TX5 results in increased activity of ABCB1 protein] which results in increased export of Digoxin; Acetaminophen promotes the reaction [ABCB1 protein results in increased transport of Digoxin]
ABCB1A protein results in increased uptake of Digoxin
ABCB1 protein affects the secretion of Digoxin
Digoxin results in increased expression of ABCB1 mRNA; Digoxin results in increased expression of ABCB1 protein
Digoxin binds to ABCB1 protein
ABCB1 protein results in decreased uptake of Digoxin
ABCB1 gene SNP affects the transport of Digoxin; ABCB1 protein affects the transport of Digoxin		 CTD PMID:10527640 PMID:10562306 PMID:10617675 PMID:10997946 PMID:11231118 More... NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B affects uptake ISO ABCB1B protein affects the uptake of Digoxin CTD PMID:10562306 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 decreases activity ISO Digoxin results in decreased activity of ABCG2 protein CTD PMID:15365089 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions ISO Digoxin inhibits the reaction [Ethinyl Estradiol results in increased secretion of ALPL protein] CTD PMID:36329302 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446 		JBrowse link
G Atp1a2 ATPase Na+/K+ transporting subunit alpha 2 decreases expression
multiple interactions		 EXP Digoxin results in decreased expression of ATP1A2 mRNA
N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Digoxin results in decreased expression of ATP1A2 mRNA]		 CTD PMID:19687166 NCBI chr13:84,729,597...84,754,544
Ensembl chr13:84,729,601...84,754,544 		JBrowse link
G Atp1a3 ATPase Na+/K+ transporting subunit alpha 3 decreases expression
multiple interactions		 EXP Digoxin results in decreased expression of ATP1A3 mRNA
N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Digoxin results in decreased expression of ATP1A3 mRNA]		 CTD PMID:19687166 NCBI chr 1:80,572,790...80,601,936
Ensembl chr 1:80,572,796...80,601,918 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Digoxin results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression ISO Digoxin results in decreased expression of CCL4 protein CTD PMID:20116850 NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression ISO Digoxin results in decreased expression of CCL5 protein CTD PMID:20116850 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO Digoxin inhibits the reaction [Ethinyl Estradiol results in increased expression of CXCL10 mRNA]; Digoxin inhibits the reaction [Ethinyl Estradiol results in increased expression of CXCL10 protein] CTD PMID:36329302 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 multiple interactions ISO Digoxin inhibits the reaction [Ethinyl Estradiol results in increased expression of CXCL9 mRNA]; Digoxin inhibits the reaction [Ethinyl Estradiol results in increased expression of CXCL9 protein] CTD PMID:36329302 NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435 		JBrowse link
G Cxcr3 C-X-C motif chemokine receptor 3 multiple interactions ISO Digoxin inhibits the reaction [Ethinyl Estradiol results in increased expression of CXCR3 mRNA]; Digoxin inhibits the reaction [Ethinyl Estradiol results in increased expression of CXCR3 protein] CTD PMID:36329302 NCBI chr  X:66,844,318...66,846,969
Ensembl chr  X:66,844,318...66,846,969 		JBrowse link
G Egr1 early growth response 1 multiple interactions ISO Digoxin inhibits the reaction [Ethinyl Estradiol results in increased expression of EGR1 mRNA]; Digoxin inhibits the reaction [Ethinyl Estradiol results in increased expression of EGR1 protein] CTD PMID:36329302 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Fancd2 FA complementation group D2 multiple interactions ISO Digoxin inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein] CTD PMID:24124520 NCBI chr 4:146,679,014...146,743,422
Ensembl chr 4:146,679,179...146,743,412 		JBrowse link
G Fanci FA complementation group I multiple interactions ISO Digoxin inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCI protein] CTD PMID:24124520 NCBI chr 1:133,327,264...133,383,661
Ensembl chr 1:133,327,297...133,383,640 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase decreases activity EXP Digoxin results in decreased activity of G6PD protein CTD PMID:26820767 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G Gfap glial fibrillary acidic protein increases expression EXP Digoxin results in increased expression of GFAP mRNA CTD PMID:22954530 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 multiple interactions ISO Digoxin inhibits the reaction [Ethinyl Estradiol results in increased secretion of GOT1 protein] CTD PMID:36329302 NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO Digoxin inhibits the reaction [Ethinyl Estradiol results in increased secretion of GPT protein] CTD PMID:36329302 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gsr glutathione-disulfide reductase decreases activity EXP Digoxin results in decreased activity of GSR protein CTD PMID:26820767 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
increases activity
affects localization		 ISO 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Digoxin affects the localization of HIF1A protein]; 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Digoxin results in increased phosphorylation of HIF1A protein]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Digoxin affects the localization of HIF1A protein]; Digoxin results in increased phosphorylation of and results in increased expression of HIF1A protein; KN 93 inhibits the reaction [Digoxin affects the localization of HIF1A protein]; KN 93 inhibits the reaction [Digoxin results in increased phosphorylation of HIF1A protein]
Digoxin results in increased activity of HIF1A protein		 CTD PMID:19647009 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Digoxin inhibits the reaction [Ethinyl Estradiol results in increased expression of ICAM1 mRNA] CTD PMID:36329302 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Ifng interferon gamma multiple interactions ISO [Digoxin co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG mRNA CTD PMID:29594315 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il2 interleukin 2 multiple interactions ISO [Digoxin co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA CTD PMID:29594315 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il6r interleukin 6 receptor decreases expression ISO Digoxin results in decreased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536 		JBrowse link
G Ins2 insulin 2 decreases response to substance ISO
EXP		 INS protein results in decreased susceptibility to Digoxin CTD PMID:22562035 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
affects response to substance
decreases expression
decreases activity		 ISO Astemizole inhibits the reaction [Digoxin results in decreased activity of KCNH2 protein]; Astemizole inhibits the reaction [Digoxin results in decreased metabolism of KCNH2 protein modified form]; Sodium deficiency inhibits the reaction [Digoxin results in decreased expression of KCNH2 protein]
KCNH2 gene affects the susceptibility to Digoxin
Digoxin results in decreased expression of KCNH2 protein modified form		 CTD PMID:19139152 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 EXP N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Digoxin results in increased phosphorylation of MAPK1 protein] CTD PMID:19687166 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions		 EXP Digoxin results in increased phosphorylation of MAPK3 protein
N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Digoxin results in increased phosphorylation of MAPK3 protein]		 CTD PMID:19687166 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Nos3 nitric oxide synthase 3 decreases response to substance ISO NOS3 protein results in decreased susceptibility to Digoxin CTD PMID:11761419 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nppa natriuretic peptide A multiple interactions
increases expression		 EXP N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Digoxin results in increased expression of NPPA mRNA] CTD PMID:19687166 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Nppb natriuretic peptide B increases expression ISO Digoxin results in increased expression of NPPB protein CTD PMID:16032632 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO Digoxin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Pgd phosphogluconate dehydrogenase decreases activity EXP Digoxin results in decreased activity of PGD protein CTD PMID:26820767 NCBI chr 5:159,582,746...159,598,945
Ensembl chr 5:159,561,271...159,742,778 		JBrowse link
G Rorc RAR-related orphan receptor C decreases activity
multiple interactions		 ISO Digoxin results in decreased activity of RORC protein
Digoxin inhibits the reaction [Ethinyl Estradiol results in increased expression of RORC mRNA]; Digoxin inhibits the reaction [Ethinyl Estradiol results in increased expression of RORC protein]		 CTD PMID:21441909 PMID:36329302 NCBI chr 2:182,009,707...182,034,910
Ensembl chr 2:182,009,286...182,034,907 		JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO Digoxin inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678 		JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions ISO Digoxin inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612 		JBrowse link
G Slc9a1 solute carrier family 9 member A1 increases expression
multiple interactions		 EXP Digoxin results in increased expression of SLC9A1 mRNA
N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Digoxin results in increased expression of SLC9A1 mRNA]		 CTD PMID:19687166 NCBI chr 5:145,576,341...145,629,630
Ensembl chr 5:145,576,334...145,629,624 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 multiple interactions
increases uptake
decreases activity
affects transport		 ISO
EXP		 Digoxin inhibits the reaction [SLCO1A4 protein results in increased uptake of epyrifenacil metabolite]; Elacridar affects the reaction [SLCO1A4 protein affects the transport of Digoxin]
SLCO1A4 protein results in increased uptake of Digoxin
Digoxin inhibits the reaction [SLCO1A4 protein results in increased uptake of Digoxin]; Quinine inhibits the reaction [SLCO1A4 protein results in increased uptake of Digoxin]; Rifampin inhibits the reaction [SLCO1A4 protein results in increased uptake of Digoxin]
Digoxin results in decreased activity of SLCO1A4 protein		 CTD PMID:11883641 PMID:19833843 PMID:34619012 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions ISO Digoxin inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLCO1B2 mRNA] CTD PMID:36329302 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981 		JBrowse link
G Tardbp TAR DNA binding protein multiple interactions ISO Digoxin inhibits the reaction [TARDBP protein binds to TARDBP protein] CTD PMID:23891805 NCBI chr 5:159,050,518...159,062,218
Ensembl chr 5:159,051,799...159,062,055 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Digoxin results in decreased expression of VEGFA protein CTD PMID:20116850 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
dioscin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions EXP dioscin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCB11 mRNA]; dioscin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCB11 protein] CTD PMID:27317372 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A decreases expression ISO
EXP		 dioscin results in decreased expression of ABCB1 mRNA; dioscin results in decreased expression of ABCB1 protein CTD PMID:24680847 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions EXP dioscin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCC2 mRNA]; dioscin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCC2 protein] CTD PMID:27317372 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain multiple interactions EXP
ISO		 dioscin inhibits the reaction [Ethanol results in decreased expression of ACADM protein] CTD PMID:24146112 NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147 		JBrowse link
G Acads acyl-CoA dehydrogenase short chain multiple interactions ISO
EXP		 dioscin inhibits the reaction [Ethanol results in decreased expression of ACADS protein] CTD PMID:24146112 NCBI chr12:41,493,650...41,502,897
Ensembl chr12:41,493,626...41,502,898 		JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions EXP
ISO		 dioscin inhibits the reaction [Ethanol results in decreased expression of ACOX1 mRNA] CTD PMID:24146112 NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232 		JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 multiple interactions ISO
EXP		 dioscin inhibits the reaction [Ethanol results in decreased expression of ACSL1 protein] CTD PMID:24146112 NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541 		JBrowse link
G Acsl5 acyl-CoA synthetase long-chain family member 5 multiple interactions ISO
EXP		 dioscin inhibits the reaction [Ethanol results in decreased expression of ACSL5 protein] CTD PMID:24146112 NCBI chr 1:254,289,513...254,336,608
Ensembl chr 1:254,292,521...254,336,607 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of ACTA2 protein] CTD PMID:35481609 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases expression		 ISO dioscin inhibits the reaction [TGFB1 protein results in increased phosphorylation of AKT1 protein]; dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of AKT1 protein]
dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased phosphorylation of AKT1 protein]
dioscin results in decreased expression of AKT1 mRNA		 CTD PMID:25111127 PMID:29990575 PMID:35481609 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Aldh7a1 aldehyde dehydrogenase 7 family, member A1 multiple interactions ISO
EXP		 dioscin inhibits the reaction [Ethanol results in decreased expression of ALDH7A1 protein] CTD PMID:24146112 NCBI chr18:50,003,242...50,042,193
Ensembl chr18:50,009,934...50,042,193 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 decreases expression ISO dioscin results in decreased expression of APAF1 mRNA CTD PMID:33359023 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540 		JBrowse link
G Atf6 activating transcription factor 6 multiple interactions EXP
ISO		 dioscin inhibits the reaction [Ethanol results in increased expression of ATF6 protein] CTD PMID:24146112 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177 		JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO dioscin results in increased expression of BAD mRNA CTD PMID:33359023 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions
increases expression		 ISO dioscin inhibits the reaction [Acetaminophen results in increased expression of BAK1 protein]
dioscin results in increased expression of BAK1 mRNA; dioscin results in increased expression of BAK1 protein		 CTD PMID:22334414 PMID:22939915 PMID:29990575 PMID:33359023 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression		 ISO dioscin inhibits the reaction [Acetaminophen results in increased expression of BAX protein]
dioscin results in increased expression of BAX mRNA; dioscin results in increased expression of BAX protein		 CTD PMID:22334414 PMID:22939915 PMID:33359023 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression ISO dioscin results in increased expression of BBC3 mRNA; dioscin results in increased expression of BBC3 protein CTD PMID:29990575 PMID:33359023 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression
decreases expression		 ISO dioscin inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein]
dioscin results in increased expression of BCL2 protein
dioscin results in decreased expression of BCL2 mRNA; dioscin results in decreased expression of BCL2 protein		 CTD PMID:22334414 PMID:22939915 PMID:24742230 PMID:29990575 PMID:33359023 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO dioscin results in decreased expression of BCL2L1 mRNA; dioscin results in decreased expression of BCL2L1 protein CTD PMID:22334414 PMID:29990575 PMID:33359023 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions
decreases expression		 ISO [Acetaminophen co-treated with dioscin] results in increased expression of BID protein
dioscin results in decreased expression of BID mRNA; dioscin results in decreased expression of BID protein		 CTD PMID:22334414 PMID:22939915 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 increases expression ISO dioscin results in increased expression of BIRC5 mRNA CTD PMID:29990575 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Casp3 caspase 3 multiple interactions
decreases expression
increases expression
increases activity		 EXP
ISO		 dioscin inhibits the reaction [Ethanol results in increased expression of CASP3 protein]
dioscin results in decreased expression of CASP3 mRNA; dioscin results in decreased expression of CASP3 protein
dioscin results in increased expression of CASP3 mRNA; dioscin results in increased expression of CASP3 protein
benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [dioscin results in increased expression of CASP3 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [dioscin results in increased expression of CASP3 protein]
dioscin results in increased activity of CASP3 protein		 CTD PMID:22334414 PMID:24146112 PMID:29990575 PMID:33359023 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 increases expression ISO dioscin results in increased expression of CASP7 mRNA CTD PMID:29990575 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp8 caspase 8 increases activity
multiple interactions
decreases expression
increases expression		 ISO dioscin results in increased activity of CASP8 protein
dioscin results in decreased expression of and results in increased cleavage of CASP8 protein
dioscin results in decreased expression of CASP8 mRNA
dioscin results in increased expression of CASP8 mRNA; dioscin results in increased expression of CASP8 protein		 CTD PMID:22334414 PMID:29990575 PMID:33359023 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions
decreases expression
increases expression		 EXP
ISO		 dioscin inhibits the reaction [Ethanol results in increased expression of CASP9 protein]
dioscin results in decreased expression of CASP9 mRNA; dioscin results in decreased expression of CASP9 protein
dioscin results in increased expression of CASP9 mRNA; dioscin results in increased expression of CASP9 protein		 CTD PMID:24146112 PMID:29990575 PMID:33359023 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccna2 cyclin A2 decreases expression ISO dioscin results in decreased expression of CCNA2 mRNA; dioscin results in decreased expression of CCNA2 protein CTD PMID:33359023 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO dioscin results in decreased expression of CCNB1 mRNA; dioscin results in decreased expression of CCNB1 protein CTD PMID:29990575 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccnd1 cyclin D1 increases expression
decreases expression		 ISO dioscin results in increased expression of CCND1 mRNA
dioscin results in decreased expression of CCND1 mRNA; dioscin results in decreased expression of CCND1 protein		 CTD PMID:29990575 PMID:33359023 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccne1 cyclin E1 decreases expression ISO dioscin results in decreased expression of CCNE1 mRNA; dioscin results in decreased expression of CCNE1 protein CTD PMID:33359023 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression ISO dioscin results in decreased expression of CDK1 mRNA; dioscin results in decreased expression of CDK1 protein CTD PMID:29990575 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO dioscin results in decreased expression of CDK2 mRNA; dioscin results in decreased expression of CDK2 protein CTD PMID:33359023 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO dioscin results in decreased expression of CDK4 mRNA CTD PMID:33359023 NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 decreases expression ISO dioscin results in decreased expression of CDK6 mRNA; dioscin results in decreased expression of CDK6 protein CTD PMID:33359023 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO dioscin results in increased expression of CDKN1A mRNA; dioscin results in increased expression of CDKN1A protein CTD PMID:29990575 PMID:33359023 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO dioscin results in increased expression of CDKN1B mRNA; dioscin results in increased expression of CDKN1B protein CTD PMID:33359023 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A increases expression ISO dioscin results in increased expression of CDKN2A mRNA; dioscin results in increased expression of CDKN2A protein CTD PMID:33359023 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Chek1 checkpoint kinase 1 decreases expression ISO dioscin results in decreased expression of CHEK1 mRNA; dioscin results in decreased expression of CHEK1 protein CTD PMID:33359023 NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009 		JBrowse link
G Chek2 checkpoint kinase 2 decreases expression ISO dioscin results in decreased expression of CHEK2 mRNA; dioscin results in decreased expression of CHEK2 protein CTD PMID:29990575 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions ISO
EXP		 dioscin inhibits the reaction [Ethanol results in decreased expression of CPT1A mRNA] CTD PMID:24146112 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Ctnnb1 catenin beta 1 increases expression
multiple interactions		 ISO dioscin results in increased expression of CTNNB1 mRNA; dioscin results in increased expression of CTNNB1 protein
fulvestrant inhibits the reaction [dioscin results in increased expression of CTNNB1 mRNA]		 CTD PMID:24742230 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cycs cytochrome c, somatic increases expression ISO dioscin results in increased expression of CYCS mRNA CTD PMID:33359023 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO
EXP		 dioscin inhibits the reaction [Acetaminophen results in increased expression of and results in increased activity of CYP2E1 protein]; dioscin inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CYP2E1 protein] CTD PMID:22939915 PMID:24146112 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Dgat1 diacylglycerol O-acyltransferase 1 multiple interactions ISO
EXP		 dioscin inhibits the reaction [Ethanol results in increased expression of DGAT1 mRNA] CTD PMID:24146112 NCBI chr 7:108,223,860...108,235,413
Ensembl chr 7:108,218,524...108,234,299 		JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 multiple interactions ISO
EXP		 dioscin inhibits the reaction [Ethanol results in increased expression of DGAT2 mRNA] CTD PMID:24146112 NCBI chr 1:153,454,078...153,484,432
Ensembl chr 1:153,454,080...153,484,428 		JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein increases expression ISO dioscin results in increased expression of DIABLO mRNA CTD PMID:29990575 NCBI chr12:33,055,784...33,070,401
Ensembl chr12:33,055,263...33,070,387 		JBrowse link
G Esr1 estrogen receptor 1 increases expression
multiple interactions		 ISO dioscin results in increased expression of ESR1 protein
fulvestrant inhibits the reaction [dioscin results in increased expression of ESR1 protein]		 CTD PMID:24742230 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
increases expression		 ISO fulvestrant inhibits the reaction [dioscin results in increased expression of ESR2 protein] CTD PMID:24742230 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Fadd Fas associated via death domain increases expression ISO dioscin results in increased expression of FADD mRNA; dioscin results in increased expression of FADD protein CTD PMID:22334414 PMID:29990575 PMID:33359023 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653 		JBrowse link
G Fas Fas cell surface death receptor increases expression ISO dioscin results in increased expression of FAS mRNA; dioscin results in increased expression of FAS protein CTD PMID:22334414 PMID:33359023 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Faslg Fas ligand increases expression ISO dioscin results in increased expression of FASLG mRNA; dioscin results in increased expression of FASLG protein CTD PMID:22334414 PMID:29990575 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Foxo1 forkhead box O1 increases expression ISO dioscin results in increased expression of FOXO1 mRNA CTD PMID:33359023 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP dioscin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of GPT protein] CTD PMID:27317372 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP
ISO		 dioscin inhibits the reaction [Ethanol results in decreased expression of GSR protein] CTD PMID:24146112 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions EXP dioscin inhibits the reaction [Doxorubicin results in increased expression of HMGB1 protein]
dioscin inhibited the reaction [thioacetamide increased expression of Hmgb1 protein in liver]		 CTD
RGD		 PMID:28082111 PMID:29091898 RGD:15090820 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP dioscin inhibits the reaction [Doxorubicin results in decreased expression of HMOX1 protein]
dioscin inhibited the reaction [thioacetamide decreased expression of Hmox1 protein in liver]		 CTD
RGD		 PMID:28082111 PMID:29091898 RGD:15090820 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP
ISO		 dioscin inhibits the reaction [Ethanol results in increased expression of HSPA5 protein] CTD PMID:24146112 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions EXP dioscin inhibited the reaction [thioacetamide increased expression of Icam1 protein in liver] RGD PMID:29091898 RGD:15090820 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Il13 interleukin 13 multiple interactions ISO dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of IL13 protein] CTD PMID:35481609 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP dioscin inhibits the reaction [Doxorubicin results in increased expression of IL1B mRNA]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of IL1B mRNA]]
dioscin inhibited the reaction [thioacetamide increased expression of IL-1b mRNA in liver]		 CTD
RGD		 PMID:28082111 PMID:29091898 RGD:15090820 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il4 interleukin 4 multiple interactions ISO dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of IL4 protein] CTD PMID:35481609 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il5 interleukin 5 multiple interactions ISO dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of IL5 protein] CTD PMID:35481609 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP		 dioscin inhibits the reaction [Ethanol results in increased expression of IL6 mRNA]
dioscin inhibited the reaction [thioacetamide increased expression of IL-6 mRNA in liver]
dioscin inhibits the reaction [Doxorubicin results in increased expression of IL6 mRNA]; dioscin inhibits the reaction [Ethanol results in increased expression of IL6 mRNA]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of IL6 mRNA]]		 CTD
RGD		 PMID:24146112 PMID:28082111 PMID:29091898 RGD:15090820 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Kdr kinase insert domain receptor multiple interactions ISO dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of KDR protein] CTD PMID:25111127 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions EXP dioscin inhibits the reaction [Doxorubicin results in increased expression of KEAP1 protein] CTD PMID:28082111 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862 		JBrowse link
G Krt18 keratin 18 multiple interactions ISO
EXP		 dioscin inhibits the reaction [Acetaminophen results in increased expression of KRT18 protein]; dioscin inhibits the reaction [Ethanol results in increased expression of KRT18 protein] CTD PMID:22939915 PMID:24146112 NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166 		JBrowse link
G Lrp5 LDL receptor related protein 5 multiple interactions
increases expression		 ISO fulvestrant inhibits the reaction [dioscin results in increased expression of LRP5 mRNA]; LRP5 protein affects the reaction [dioscin results in increased expression of TNFRSF11B mRNA]; LRP5 protein affects the reaction [dioscin results in increased expression of TNFSF11 mRNA] CTD PMID:24742230 NCBI chr 1:200,814,247...200,917,581
Ensembl chr 1:200,814,250...200,917,581 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP
ISO		 dioscin inhibits the reaction [Ethanol results in increased phosphorylation of MAPK1 protein]
dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK1 protein]		 CTD PMID:24146112 PMID:25111127 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP
ISO		 dioscin inhibits the reaction [Ethanol results in increased phosphorylation of MAPK3 protein]
dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK3 protein]		 CTD PMID:24146112 PMID:25111127 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases expression ISO dioscin results in increased expression of MAPK8 mRNA CTD PMID:29990575 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases expression ISO dioscin results in increased expression of MAPK9 mRNA CTD PMID:29990575 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mdh1 malate dehydrogenase 1 multiple interactions ISO dioscin inhibits the reaction [Acetaminophen results in decreased expression of MDH1 protein] CTD PMID:22939915 NCBI chr14:95,630,625...95,645,920
Ensembl chr14:95,630,306...95,645,925 		JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases expression ISO dioscin results in decreased expression of MTOR mRNA CTD PMID:29990575 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming multiple interactions ISO dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of MUC5AC mRNA] CTD PMID:35481609 NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP dioscin inhibits the reaction [Doxorubicin results in decreased expression of and affects the localization of NFE2L2 protein]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in decreased expression of NFE2L2 protein]]
dioscin inhibited the reaction [thioacetamide decreased expression of Nfe2L2 protein in liver]		 CTD
RGD		 PMID:28082111 PMID:29091898 RGD:15090820 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP dioscin inhibited the reaction [thioacetamide increased expression of Nfkb1 protein in liver] RGD PMID:29091898 RGD:15090820 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha decreases degradation ISO dioscin results in decreased degradation of NFKBIA protein CTD PMID:24680847 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP dioscin inhibited the reaction [thioacetamide decreased expression of Nqo1 protein in liver] RGD PMID:29091898 RGD:15090820 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 multiple interactions
increases expression		 EXP dioscin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of NR0B2 mRNA]
dioscin results in increased expression of NR0B2 mRNA		 CTD PMID:27317372 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions EXP dioscin inhibits the reaction [Doxorubicin results in decreased expression of NR1H4 protein]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in decreased expression of NFE2L2 protein]]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of IL1B mRNA]]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of IL6 mRNA]]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of RELA protein]]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of TNF mRNA]]
dioscin inhibited the reaction [thioacetamide decreased expression of Nr1h4 protein in liver]		 CTD
RGD		 PMID:28082111 PMID:29091898 RGD:15090820 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
decreases expression
increases expression		 ISO
EXP		 dioscin inhibits the reaction [Ethanol results in increased expression of PARP1 protein]
dioscin results in decreased expression of PARP1 mRNA; dioscin results in decreased expression of PARP1 protein
dioscin results in increased expression of PARP1 mRNA		 CTD PMID:24146112 PMID:29990575 PMID:33359023 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta decreases expression ISO dioscin results in decreased expression of PIK3CB mRNA CTD PMID:29990575 NCBI chr 8:99,594,600...99,699,772
Ensembl chr 8:99,594,644...99,699,663 		JBrowse link
G Pnp purine nucleoside phosphorylase multiple interactions ISO dioscin inhibits the reaction [Acetaminophen results in decreased expression of PNP protein] CTD PMID:22939915 NCBI chr15:24,170,607...24,178,269
Ensembl chr15:24,170,602...24,203,986 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP
ISO		 dioscin inhibits the reaction [Ethanol results in decreased expression of PPARA protein] CTD PMID:24146112 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Prdx1 peroxiredoxin 1 multiple interactions ISO dioscin inhibits the reaction [Acetaminophen results in decreased expression of PRDX1 protein] CTD PMID:22939915 NCBI chr 5:130,147,258...130,162,856
Ensembl chr 5:130,147,204...130,162,856 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions EXP dioscin inhibited the reaction [thioacetamide decreased expression of Prkaa1 protein in liver] RGD PMID:29091898 RGD:15090820 NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978 		JBrowse link
G Prkab1 protein kinase AMP-activated non-catalytic subunit beta 1 increases expression ISO dioscin results in increased expression of PRKAB1 mRNA CTD PMID:29990575 NCBI chr12:40,588,140...40,598,673
Ensembl chr12:40,588,211...40,598,661 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP dioscin inhibited the reaction [thioacetamide increased expression of Ptgs2 protein in liver] RGD PMID:29091898 RGD:15090820 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ptk2 protein tyrosine kinase 2 multiple interactions ISO dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of PTK2 protein] CTD PMID:25111127 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP dioscin inhibits the reaction [Doxorubicin results in increased expression of RELA protein]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of RELA protein]] CTD PMID:28082111 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rgn regucalcin multiple interactions ISO dioscin inhibits the reaction [Acetaminophen results in decreased expression of RGN protein] CTD PMID:22939915 NCBI chr  X:1,619,030...1,634,456
Ensembl chr  X:1,619,032...1,634,450 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases expression ISO dioscin results in decreased expression of RPS6KB1 mRNA CTD PMID:29990575 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Slc10a1 solute carrier family 10 member 1 multiple interactions EXP dioscin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLC10A1 mRNA] CTD PMID:27317372 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 increases expression EXP dioscin results in increased expression of SLCO1A2 mRNA CTD PMID:27317372 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions
increases expression		 EXP dioscin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLCO1B2 mRNA]; dioscin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLCO1B2 protein]
dioscin results in increased expression of SLCO1B2 mRNA		 CTD PMID:27317372 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of SRC protein] CTD PMID:25111127 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Suox sulfite oxidase multiple interactions ISO dioscin inhibits the reaction [Acetaminophen results in decreased expression of SUOX protein] CTD PMID:22939915 NCBI chr 7:1,103,149...1,107,156
Ensembl chr 7:1,103,151...1,107,038 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of TGFB1 protein]
dioscin inhibits the reaction [TGFB1 protein results in increased phosphorylation of AKT1 protein]		 CTD PMID:35481609 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression		 ISO
EXP		 dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of TNF protein]; dioscin inhibits the reaction [Ethanol results in increased expression of TNF mRNA]
dioscin inhibited the reaction [thioacetamide increased expression of Tnfa mRNA in liver]
dioscin results in increased expression of TNF mRNA; dioscin results in increased expression of TNF protein
dioscin inhibits the reaction [Doxorubicin results in increased expression of TNF mRNA]; dioscin inhibits the reaction [Ethanol results in increased expression of TNF mRNA]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of TNF mRNA]]		 CTD
RGD		 PMID:22334414 PMID:24146112 PMID:28082111 PMID:29990575 PMID:33359023 More... RGD:15090820 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B increases expression
multiple interactions		 ISO dioscin results in increased expression of TNFRSF11B mRNA
fulvestrant inhibits the reaction [dioscin results in increased expression of TNFRSF11B mRNA]; LRP5 protein affects the reaction [dioscin results in increased expression of TNFRSF11B mRNA]		 CTD PMID:24742230 NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A increases expression ISO dioscin results in increased expression of TNFRSF1A mRNA; dioscin results in increased expression of TNFRSF1A protein CTD PMID:22334414 PMID:29990575 PMID:33359023 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591 		JBrowse link
G Tnfrsf25 TNF receptor superfamily member 25 increases expression ISO dioscin results in increased expression of TNFRSF25 mRNA CTD PMID:29990575 PMID:33359023 NCBI chr 5:162,621,669...162,626,341
Ensembl chr 5:162,622,075...162,626,341 		JBrowse link
G Tnfsf11 TNF superfamily member 11 decreases expression
multiple interactions		 ISO dioscin results in decreased expression of TNFSF11 mRNA
fulvestrant inhibits the reaction [dioscin results in increased expression of TNFSF11 mRNA]; LRP5 protein affects the reaction [dioscin results in increased expression of TNFSF11 mRNA]		 CTD PMID:24742230 NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression		 ISO
EXP		 dioscin inhibits the reaction [Acetaminophen results in increased expression of TRP53 protein]; dioscin inhibits the reaction [Ethanol results in increased expression of TRP53 protein]
dioscin results in increased expression of TP53 mRNA; dioscin results in increased expression of TP53 protein		 CTD PMID:22334414 PMID:22939915 PMID:24146112 PMID:29990575 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tradd TNFRSF1A-associated via death domain increases expression ISO dioscin results in increased expression of TRADD mRNA CTD PMID:29990575 PMID:33359023 NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638 		JBrowse link
G Traf1 TNF receptor-associated factor 1 increases expression ISO dioscin results in increased expression of TRAF1 protein CTD PMID:22334414 NCBI chr 3:18,222,024...18,242,163
Ensembl chr 3:18,222,054...18,241,807 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of AKT1 protein]; dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of KDR protein]; dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK1 protein]; dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK3 protein]; dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of PTK2 protein]; dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of SRC protein] CTD PMID:25111127 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Wee1 WEE1 G2 checkpoint kinase increases expression ISO dioscin results in increased expression of WEE1 mRNA CTD PMID:29990575 NCBI chr 1:164,173,681...164,197,688
Ensembl chr 1:164,174,779...164,197,688 		JBrowse link
ginsenoside C-K term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cxcr1 C-X-C motif chemokine receptor 1 multiple interactions ISO ginsenoside M1 inhibits the reaction [TNF protein results in increased expression of CXCR1 protein] CTD PMID:21875580 NCBI chr 9:75,766,894...75,771,079
Ensembl chr 9:75,766,770...75,771,084 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO ginsenoside M1 inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:21875580 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Ifng interferon gamma decreases expression ISO ginsenoside M1 results in decreased expression of IFNG mRNA CTD PMID:15914323 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il1b interleukin 1 beta decreases expression ISO ginsenoside M1 results in decreased expression of IL1B mRNA CTD PMID:15914323 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il4 interleukin 4 decreases expression ISO ginsenoside M1 results in decreased expression of IL4 mRNA CTD PMID:15914323 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO ginsenoside M1 inhibits the reaction [Galactose results in increased secretion of IL6 protein] CTD PMID:29412148 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Itga4 integrin subunit alpha 4 multiple interactions ISO ginsenoside M1 inhibits the reaction [TNF protein results in increased expression of [ITGA4 protein binds to ITGB1 protein]] CTD PMID:21875580 NCBI chr 3:64,162,764...64,235,010
Ensembl chr 3:64,163,085...64,233,715 		JBrowse link
G Itgal integrin subunit alpha L multiple interactions ISO ginsenoside M1 inhibits the reaction [TNF protein results in increased expression of [ITGAL protein binds to ITGB2 protein]] CTD PMID:21875580 NCBI chr 1:181,918,183...181,955,735
Ensembl chr 1:181,918,183...181,955,732 		JBrowse link
G Itgb1 integrin subunit beta 1 multiple interactions ISO ginsenoside M1 inhibits the reaction [TNF protein results in increased expression of [ITGA4 protein binds to ITGB1 protein]] CTD PMID:21875580 NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195 		JBrowse link
G Itgb2 integrin subunit beta 2 multiple interactions ISO ginsenoside M1 inhibits the reaction [TNF protein results in increased expression of [ITGAL protein binds to ITGB2 protein]] CTD PMID:21875580 NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases secretion ISO ginsenoside M1 results in decreased secretion of MMP9 protein CTD PMID:21875580 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP ginsenoside M1 results in decreased activity of [NFKB1 protein binds to RELA protein] CTD PMID:15802804 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP ginsenoside M1 results in decreased expression of and results in decreased activity of NOS2 protein CTD PMID:15802804 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G P2rx4 purinergic receptor P2X 4 multiple interactions ISO [ginsenoside M1 co-treated with Adenosine Triphosphate] results in increased activity of P2RX4 protein; ginsenoside M1 promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein] CTD PMID:30545933 NCBI chr12:33,844,609...33,862,265
Ensembl chr12:33,844,396...33,862,253 		JBrowse link
G P2rx7 purinergic receptor P2X 7 decreases response to substance ISO P2RX7 gene mutant form results in decreased susceptibility to ginsenoside M1 CTD PMID:30545933 NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO
EXP		 ginsenoside M1 results in decreased expression of PTGS2 mRNA
ginsenoside M1 results in decreased expression of PTGS2 protein		 CTD PMID:15802804 PMID:15914323 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP ginsenoside M1 results in decreased activity of [NFKB1 protein binds to RELA protein] CTD PMID:15802804 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Sele selectin E multiple interactions ISO ginsenoside M1 inhibits the reaction [TNF protein results in increased expression of SELE protein] CTD PMID:21875580 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
decreases response to substance		 ISO ginsenoside M1 inhibits the reaction [TNF protein results in increased expression of [ITGA4 protein binds to ITGB1 protein]]; ginsenoside M1 inhibits the reaction [TNF protein results in increased expression of [ITGAL protein binds to ITGB2 protein]]; ginsenoside M1 inhibits the reaction [TNF protein results in increased expression of CXCR1 protein]; ginsenoside M1 inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; ginsenoside M1 inhibits the reaction [TNF protein results in increased expression of SELE protein]; ginsenoside M1 inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; ginsenoside M1 inhibits the reaction [TNF protein results in increased secretion of CXCL8 protein]
ginsenoside M1 results in decreased expression of TNF mRNA
ginsenoside M1 results in decreased susceptibility to TNF protein		 CTD PMID:15914323 PMID:21875580 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO ginsenoside M1 inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] CTD PMID:21875580 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
ginsenoside F1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il6 interleukin 6 multiple interactions ISO ginsenoside F1 inhibits the reaction [Galactose results in increased secretion of IL6 protein] CTD PMID:29412148 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO ginsenoside F1 inhibits the reaction [Galactose affects the localization of RELA protein] CTD PMID:29412148 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
ginsenoside F2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO ginsenoside F2 analog inhibits the reaction [ABCB1 protein results in increased transport of Digoxin] CTD PMID:24380838 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
ginsenoside Rb1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rb1 results in increased phosphorylation of AKT1 protein]; Fulvestrant inhibits the reaction [ginsenoside Rb1 results in increased phosphorylation of AKT1 protein]; Pertussis Toxin inhibits the reaction [ginsenoside Rb1 results in increased phosphorylation of AKT1 protein] CTD PMID:19781563 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Atp6v1a ATPase H+ transporting V1 subunit A multiple interactions ISO ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of ATP6V1A mRNA] CTD PMID:34812491 NCBI chr11:56,561,444...56,614,694
Ensembl chr11:56,560,974...56,614,694 		JBrowse link
G Atp6v1b2 ATPase H+ transporting V1 subunit B2 multiple interactions ISO ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of ATP6V1B2 mRNA] CTD PMID:34812491 NCBI chr16:20,617,515...20,641,651
Ensembl chr16:20,617,518...20,641,745 		JBrowse link
G Bmp2 bone morphogenetic protein 2 multiple interactions
increases expression		 EXP ginsenoside Rb1 inhibits the reaction [aluminum chloride results in decreased expression of BMP2 mRNA]
ginsenoside Rb1 results in increased expression of BMP2 mRNA		 CTD PMID:27470910 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO ginsenoside Rb1 inhibits the reaction [Oxidopamine results in increased activity of CASP3 protein] CTD PMID:19781563 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Clcn7 chloride voltage-gated channel 7 multiple interactions ISO ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of CLCN7 mRNA] CTD PMID:34812491 NCBI chr10:14,151,758...14,177,130
Ensembl chr10:14,151,758...14,177,130 		JBrowse link
G Ctsb cathepsin B multiple interactions ISO ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of CTSB mRNA] CTD PMID:34812491 NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500 		JBrowse link
G Ctsd cathepsin D multiple interactions ISO ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of CTSD mRNA] CTD PMID:34812491 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO ginsenoside Rb1 inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA] CTD PMID:22386813 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 protein]; Cycloheximide inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 mRNA]; Cycloheximide inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 protein]; Dactinomycin inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 protein]; fulvestrant inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 mRNA]; fulvestrant inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 protein]; ginsenoside Rb1 results in increased expression of and results in increased activity of HMOX1 protein; Pertussis Toxin inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 mRNA]; Pertussis Toxin inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 protein]
[astragaloside A co-treated with ginsenoside Rg1 co-treated with ginsenoside Rb1 co-treated with notoginsenoside R1] results in increased expression of HMOX1 mRNA; [astragaloside A co-treated with ginsenoside Rg1 co-treated with ginsenoside Rb1 co-treated with notoginsenoside R1] results in increased expression of HMOX1 protein		 CTD PMID:19781563 PMID:25422538 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions
increases expression		 EXP ginsenoside Rb1 inhibits the reaction [aluminum chloride results in decreased expression of IGF1 mRNA]
ginsenoside Rb1 results in increased expression of IGF1 mRNA		 CTD PMID:27470910 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP ginsenoside Rb1 inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:17655881 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Itgam integrin subunit alpha M multiple interactions EXP ginsenoside Rb1 inhibits the reaction [Lipopolysaccharides results in increased expression of ITGAM protein] CTD PMID:17655881 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Itgb2 integrin subunit beta 2 multiple interactions EXP ginsenoside Rb1 inhibits the reaction [Lipopolysaccharides results in increased expression of ITGB2 protein] CTD PMID:17655881 NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600 		JBrowse link
G Kcne1 potassium voltage-gated channel subfamily E regulatory subunit 1 increases expression ISO ginsenoside Rb1 results in increased expression of KCNE1 CTD PMID:24615935 NCBI chr11:31,580,951...31,594,116
Ensembl chr11:31,580,742...31,593,901 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 affects activity ISO ginsenoside Rb1 affects the activity of KCNH2 protein CTD PMID:15842772 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Lamp1 lysosomal-associated membrane protein 1 multiple interactions ISO ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of LAMP1 mRNA] CTD PMID:34812491 NCBI chr16:76,355,982...76,380,700
Ensembl chr16:76,355,984...76,381,883 		JBrowse link
G Map2 microtubule-associated protein 2 increases expression ISO ginsenoside Rb1 results in increased expression of MAP2 mRNA CTD PMID:24599032 NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809 		JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 multiple interactions ISO ginsenoside Rb1 inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA] CTD PMID:22386813 NCBI chr18:74,046,422...74,156,041
Ensembl chr18:74,046,904...74,156,028 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
affects localization
increases expression		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rb1 results in increased localization of NFE2L2 protein]; [ginsenoside Rb1 co-treated with ginsenoside 20S-protopanaxatriol] results in increased expression of NFE2L2 protein; fulvestrant inhibits the reaction [ginsenoside Rb1 results in increased localization of NFE2L2 protein]; ginsenoside Rb1 results in increased activity of and results in increased localization of NFE2L2 protein; Pertussis Toxin inhibits the reaction [ginsenoside Rb1 results in increased localization of NFE2L2 protein]
ginsenoside Rb1 affects the localization of NFE2L2 protein
[astragaloside A co-treated with ginsenoside Rg1 co-treated with ginsenoside Rb1 co-treated with notoginsenoside R1] affects the localization of NFE2L2 protein
ginsenoside Rb1 results in increased expression of NFE2L2 mRNA		 CTD PMID:19781563 PMID:22780686 PMID:25422538 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G P2rx4 purinergic receptor P2X 4 multiple interactions ISO ginsenoside Rb1 promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein] CTD PMID:30545933 NCBI chr12:33,844,609...33,862,265
Ensembl chr12:33,844,396...33,862,253 		JBrowse link
G Pgr progesterone receptor increases expression ISO ginsenoside Rb1 results in increased expression of PGR protein CTD PMID:16204943 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO ginsenoside Rb1 inhibits the reaction [TNFSF11 protein affects the localization of RELA protein] CTD PMID:22386813 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Runx2 RUNX family transcription factor 2 increases expression
multiple interactions		 EXP ginsenoside Rb1 results in increased expression of RUNX2 mRNA
ginsenoside Rb1 inhibits the reaction [aluminum chloride results in decreased expression of RUNX2 mRNA]		 CTD PMID:27470910 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions ISO ginsenoside Rb1 binds to and results in decreased activity of SLCO1B3 protein CTD PMID:25297453 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
decreases expression		 ISO ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased expression of SQSTM1 protein]
ginsenoside Rb1 results in decreased expression of SQSTM1 protein		 CTD PMID:34812491 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Tfeb transcription factor EB multiple interactions ISO [ginsenoside Rb1 co-treated with alpha-Chlorohydrin] affects the localization of TFEB protein; ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of TFEB mRNA] CTD PMID:34812491 NCBI chr 9:13,198,890...13,254,726
Ensembl chr 9:13,198,891...13,254,714 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
increases expression		 EXP ginsenoside Rb1 inhibits the reaction [aluminum chloride results in decreased expression of TGFB1 mRNA]
ginsenoside Rb1 results in increased expression of TGFB1 mRNA		 CTD PMID:27470910 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO ginsenoside Rb1 inhibits the reaction [TNFSF11 protein results in increased expression of TNF mRNA] CTD PMID:22386813 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions
decreases response to substance		 ISO ginsenoside Rb1 inhibits the reaction [TNFSF11 protein affects the localization of RELA protein]; ginsenoside Rb1 inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]; ginsenoside Rb1 inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]; ginsenoside Rb1 inhibits the reaction [TNFSF11 protein results in increased expression of TNF mRNA]
ginsenoside Rb1 results in decreased susceptibility to TNFSF11 protein		 CTD PMID:22386813 NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445 		JBrowse link
ginsenoside Rb2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 increases expression EXP ginsenoside Rb2 results in increased expression of ABCC2 mRNA CTD PMID:23835644 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Lpl lipoprotein lipase increases secretion
decreases secretion		 ISO ginsenoside Rb2 results in increased secretion of LPL protein
ginsenoside Rb2 results in decreased secretion of LPL protein		 CTD PMID:8988629 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249 		JBrowse link
ginsenoside Rc term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions ISO ginsenoside Rc binds to and results in decreased activity of SLCO1B3 protein CTD PMID:25297453 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981 		JBrowse link
ginsenoside Rd term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO ginsenoside Rd results in increased phosphorylation of and results in increased activity of AKT1 protein CTD PMID:24599032 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G App amyloid beta precursor protein multiple interactions EXP ginsenoside Rd inhibits the reaction [APP protein modified form results in decreased expression of BCL2 mRNA]; ginsenoside Rd inhibits the reaction [APP protein modified form results in increased expression of BAX mRNA]; ginsenoside Rd inhibits the reaction [APP protein modified form results in increased expression of CASP3 protein modified form]; ginsenoside Rd inhibits the reaction [APP protein modified form results in increased expression of CYCS mRNA] CTD PMID:26111763 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP ginsenoside Rd inhibits the reaction [APP protein modified form results in increased expression of BAX mRNA] CTD PMID:26111763 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP ginsenoside Rd inhibits the reaction [APP protein modified form results in decreased expression of BCL2 mRNA] CTD PMID:26111763 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP ginsenoside Rd inhibits the reaction [APP protein modified form results in increased expression of CASP3 protein modified form] CTD PMID:26111763 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase increases expression EXP ginsenoside Rd results in increased expression of CAT protein CTD PMID:9933756 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions		 ISO ginsenoside Rd results in increased expression of CDKN1A mRNA
staurosporine aglycone inhibits the reaction [ginsenoside Rd results in increased expression of CDKN1A mRNA]		 CTD PMID:24599032 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Chat choline O-acetyltransferase increases expression
multiple interactions		 ISO ginsenoside Rd results in increased expression of CHAT mRNA; ginsenoside Rd results in increased expression of CHAT protein
staurosporine aglycone inhibits the reaction [ginsenoside Rd results in increased expression of CHAT mRNA]; staurosporine aglycone inhibits the reaction [ginsenoside Rd results in increased expression of CHAT protein]		 CTD PMID:24599032 NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP ginsenoside Rd inhibits the reaction [APP protein modified form results in increased expression of CYCS mRNA] CTD PMID:26111763 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Lpl lipoprotein lipase decreases secretion ISO ginsenoside Rd results in decreased secretion of LPL protein CTD PMID:8988629 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249 		JBrowse link
G Map2 microtubule-associated protein 2 increases expression ISO ginsenoside Rd results in increased expression of MAP2 mRNA; ginsenoside Rd results in increased expression of MAP2 protein CTD PMID:24599032 NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO ginsenoside Rd results in increased phosphorylation of and results in increased activity of MAPK1 protein CTD PMID:24599032 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO ginsenoside Rd results in increased phosphorylation of and results in increased activity of MAPK3 protein CTD PMID:24599032 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Ngf nerve growth factor increases expression ISO ginsenoside Rd results in increased expression of NGF mRNA CTD PMID:24599032 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Ngfr nerve growth factor receptor increases expression ISO ginsenoside Rd results in increased expression of NGFR mRNA; ginsenoside Rd results in increased expression of NGFR protein CTD PMID:24599032 NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518 		JBrowse link
G P2rx4 purinergic receptor P2X 4 multiple interactions ISO ginsenoside Rd promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein] CTD PMID:30545933 NCBI chr12:33,844,609...33,862,265
Ensembl chr12:33,844,396...33,862,253 		JBrowse link
G P2rx7 purinergic receptor P2X 7 decreases response to substance ISO P2RX7 gene mutant form results in decreased susceptibility to ginsenoside Rd CTD PMID:30545933 NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619 		JBrowse link
G Slc18a3 solute carrier family 18 member A3 increases expression ISO ginsenoside Rd results in increased expression of SLC18A3 mRNA CTD PMID:24599032 NCBI chr16:7,713,630...7,716,491 JBrowse link
G Slc5a7 solute carrier family 5 member 7 increases expression ISO ginsenoside Rd results in increased expression of SLC5A7 mRNA CTD PMID:24599032 NCBI chr 9:7,595,440...7,626,258
Ensembl chr 9:7,595,444...7,626,258 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions ISO ginsenoside Rd binds to and results in decreased activity of SLCO1B3 protein CTD PMID:25297453 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981 		JBrowse link
ginsenoside Re term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 increases transport EXP
ISO		 ABCB11 protein results in increased transport of ginsenoside Re CTD PMID:25297453 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases transport ISO ABCC1 protein results in increased transport of ginsenoside Re CTD PMID:25297453 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases transport EXP
ISO		 ABCC2 protein results in increased transport of ginsenoside Re CTD PMID:25297453 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 increases transport EXP
ISO		 ABCG2 protein results in increased transport of ginsenoside Re CTD PMID:25297453 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression
multiple interactions		 ISO ginsenoside Re results in increased expression of ADIPOQ mRNA
ginsenoside Re results in increased expression of and results in increased secretion of ADIPOQ protein		 CTD PMID:23545455 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Aif1 allograft inflammatory factor 1 multiple interactions
decreases expression		 ISO 3-((3,5-bis(trifluoromethyl)phenyl)methyloxy)-2-phenylpiperidine inhibits the reaction [norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased expression of AIF1 protein]]]]; ginsenoside Re affects the reaction [GPX1 protein affects the expression of AIF1 protein]; ginsenoside Re inhibits the reaction [Methamphetamine results in increased expression of AIF1 protein]; ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased expression of AIF1 protein]]; norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased expression of AIF1 protein]]]
ginsenoside Re results in decreased expression of AIF1 protein		 CTD PMID:29467000 PMID:36682417 NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation		 ISO
EXP		 ginsenoside Re results in increased phosphorylation of and results in increased activity of AKT1 protein
ginsenoside Re results in increased phosphorylation of AKT1 protein		 CTD PMID:17878692 PMID:17885204 PMID:24599032 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Ar androgen receptor multiple interactions ISO ginsenoside Re binds to and affects the activity of AR protein CTD PMID:16985185 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression
multiple interactions		 ISO
EXP		 ginsenoside Re results in decreased expression of BAX mRNA; ginsenoside Re results in decreased expression of BAX protein
3-((3,5-bis(trifluoromethyl)phenyl)methyloxy)-2-phenylpiperidine inhibits the reaction [norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased expression of BAX protein]]]]; Acetylcysteine inhibits the reaction [ginsenoside Re inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of BAX protein]]; Cyclosporine inhibits the reaction [ginsenoside Re inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of BAX protein]]; ginsenoside Re inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of BAX protein]; ginsenoside Re inhibits the reaction [Methamphetamine results in increased expression of BAX protein]; ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased expression of BAX protein]]; norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased expression of BAX protein]]]		 CTD PMID:12674765 PMID:15621629 PMID:29467000 PMID:37308051 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
multiple interactions		 ISO ginsenoside Re results in increased expression of BCL2 mRNA; ginsenoside Re results in increased expression of BCL2 protein
3-((3,5-bis(trifluoromethyl)phenyl)methyloxy)-2-phenylpiperidine inhibits the reaction [norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in decreased expression of BCL2 protein]]]]; 3-nitropropionic acid inhibits the reaction [ginsenoside Re inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in decreased expression of BCL2 protein]]; ginsenoside Re inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in decreased expression of BCL2 protein]; ginsenoside Re inhibits the reaction [Methamphetamine results in decreased expression of BCL2 protein]; ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in decreased expression of BCL2 protein]]; norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in decreased expression of BCL2 protein]]]		 CTD PMID:15621629 PMID:29467000 PMID:37308051 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO 3-nitropropionic acid inhibits the reaction [ginsenoside Re inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in decreased expression of BCL2L1 protein]]; ginsenoside Re inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in decreased expression of BCL2L1 protein] CTD PMID:37308051 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO 3-((3,5-bis(trifluoromethyl)phenyl)methyloxy)-2-phenylpiperidine inhibits the reaction [norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased cleavage of CASP3 protein]]]]; 3-nitropropionic acid inhibits the reaction [ginsenoside Re inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased cleavage of CASP3 protein]]; ginsenoside Re inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased cleavage of CASP3 protein]; ginsenoside Re inhibits the reaction [Lipopolysaccharides results in increased activity of CASP3 protein]; ginsenoside Re inhibits the reaction [Methamphetamine results in increased cleavage of CASP3 protein]; ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased cleavage of CASP3 protein]]; ginsenoside Re results in decreased cleavage of and results in decreased activity of CASP3 protein; norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased cleavage of CASP3 protein]]] CTD PMID:15621629 PMID:23102375 PMID:25523949 PMID:29467000 PMID:37308051 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase multiple interactions ISO ginsenoside Re inhibits the reaction [Methamphetamine results in increased activity of CAT protein]; PRKCD affects the reaction [ginsenoside Re inhibits the reaction [Methamphetamine results in increased activity of CAT protein]] CTD PMID:24430743 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO ginsenoside Re results in increased expression of CDKN1A mRNA CTD PMID:24599032 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Chat choline O-acetyltransferase increases expression
multiple interactions		 ISO ginsenoside Re results in increased expression of CHAT mRNA; ginsenoside Re results in increased expression of CHAT protein
staurosporine aglycone inhibits the reaction [ginsenoside Re results in increased expression of CHAT mRNA]; staurosporine aglycone inhibits the reaction [ginsenoside Re results in increased expression of CHAT protein]		 CTD PMID:24599032 NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO ginsenoside Re inhibits the reaction [TNF protein results in increased phosphorylation of CHUK protein] CTD PMID:17885204 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065 		JBrowse link
G Cldn1 claudin 1 multiple interactions ISO ginsenoside Re inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of CLDN1 protein] CTD PMID:22849695 NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724 		JBrowse link
G Crp C-reactive protein increases expression EXP ginsenoside Re results in increased expression of CRP protein CTD PMID:16797897 NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions ISO ginsenoside Re inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity of CYBA protein]]; ginsenoside Re inhibits the reaction [Phencyclidine results in increased activity of CYBA protein] CTD PMID:29037473 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721 		JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 increases expression EXP ginsenoside Re results in increased expression of CYP8B1 mRNA CTD PMID:23835644 NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO ginsenoside Re binds to and affects the activity of ESR1 protein CTD PMID:16985185 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Fabp4 fatty acid binding protein 4 increases expression ISO ginsenoside Re results in increased expression of FABP4 mRNA CTD PMID:23545455 NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578 		JBrowse link
G Fas Fas cell surface death receptor decreases expression
multiple interactions		 ISO ginsenoside Re results in decreased expression of FAS mRNA
ginsenoside Re inhibits the reaction [Dietary Fats results in increased expression of FAS mRNA]		 CTD PMID:21971952 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO ginsenoside Re results in increased expression of FOS mRNA CTD PMID:16204943 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 decreases expression ISO ginsenoside Re results in decreased expression of G6PC1 mRNA CTD PMID:21971952 NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804 		JBrowse link
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial multiple interactions ISO ginsenoside Re inhibits the reaction [Dietary Fats results in increased expression of GPAM mRNA] CTD PMID:21971952 NCBI chr 1:254,106,323...254,170,755
Ensembl chr 1:254,106,331...254,142,639 		JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO ginsenoside Re affects the reaction [GPX1 protein affects the expression of AIF1 protein]; ginsenoside Re affects the reaction [GPX1 protein affects the expression of and affects the localization of RELA protein]; ginsenoside Re affects the reaction [GPX1 protein affects the expression of PTAFR protein]; ginsenoside Re affects the reaction [GPX1 protein affects the phosphorylation of MAPK1 protein]; ginsenoside Re affects the reaction [GPX1 protein affects the phosphorylation of MAPK3 protein]; ginsenoside Re inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine affects the localization of NCF1 protein]]; ginsenoside Re inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in decreased activity of SOD2 protein]]; ginsenoside Re inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity of CYBA protein]]; ginsenoside Re inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity of SOD1 protein]] CTD PMID:29037473 PMID:36682417 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation ISO ginsenoside Re results in increased phosphorylation of GSK3B protein CTD PMID:17885204 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 increases expression ISO ginsenoside Re results in increased expression of HSPD1 protein CTD PMID:23144451 NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662 		JBrowse link
G Ifng interferon gamma decreases expression ISO ginsenoside Re results in decreased expression of IFNG protein CTD PMID:20230918 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO ginsenoside Re inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IKBKB protein] CTD PMID:22849695 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO ginsenoside Re inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; ginsenoside Re inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; ginsenoside Re metabolite inhibits the reaction [Oxazolone results in increased expression of IL1B mRNA]; ginsenoside Re metabolite inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL1B mRNA] CTD PMID:16557482 PMID:22494059 PMID:22849695 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO ginsenoside Re inhibits the reaction [TNF protein results in increased expression of IL6 mRNA] CTD PMID:17885204 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ins1 insulin 1 multiple interactions EXP ginsenoside Re inhibits the reaction [Dietary Fats inhibits the reaction [INS1 protein results in increased localization of SLC2A4 protein]] CTD PMID:22571876 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 multiple interactions ISO ginsenoside Re inhibits the reaction [Lipopolysaccharides results in increased degradation of IRAK1 protein]; ginsenoside Re inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IRAK1 protein] CTD PMID:22849695 NCBI chr  X:151,768,621...151,778,521
Ensembl chr  X:151,768,777...151,778,521 		JBrowse link
G Irak4 interleukin-1 receptor-associated kinase 4 multiple interactions ISO ginsenoside Re inhibits the reaction [Lipopolysaccharides results in increased degradation of IRAK4 protein] CTD PMID:22849695 NCBI chr 7:125,682,502...125,708,294
Ensembl chr 7:125,682,488...125,717,837 		JBrowse link
G Irgm immunity-related GTPase M decreases expression ISO ginsenoside Re results in decreased expression of IRGM protein CTD PMID:20230918 NCBI chr10:33,233,513...33,241,594
Ensembl chr10:33,233,455...33,241,578 		JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions
increases expression
increases phosphorylation		 ISO ginsenoside Re inhibits the reaction [TNF protein results in increased phosphorylation of IRS1 protein]
ginsenoside Re results in increased expression of IRS1 mRNA
ginsenoside Re results in increased phosphorylation of IRS1 protein		 CTD PMID:17885204 PMID:23545455 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122 		JBrowse link
G Kcne1 potassium voltage-gated channel subfamily E regulatory subunit 1 increases expression ISO ginsenoside Re results in increased expression of KCNE1 CTD PMID:24615935 NCBI chr11:31,580,951...31,594,116
Ensembl chr11:31,580,742...31,593,901 		JBrowse link
G Lpl lipoprotein lipase increases secretion ISO ginsenoside Re results in increased secretion of LPL protein CTD PMID:8988629 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249 		JBrowse link
G Lrpprc leucine-rich pentatricopeptide repeat containing increases expression ISO ginsenoside Re results in increased expression of LRPPRC protein CTD PMID:23144451 NCBI chr 6:9,859,816...9,942,294
Ensembl chr 6:9,859,867...9,942,293 		JBrowse link
G Map2 microtubule-associated protein 2 increases expression ISO ginsenoside Re results in increased expression of MAP2 mRNA; ginsenoside Re results in increased expression of MAP2 protein CTD PMID:24599032 NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 ISO ginsenoside Re affects the reaction [GPX1 protein affects the phosphorylation of MAPK1 protein]; ginsenoside Re results in increased phosphorylation of and results in increased activity of MAPK1 protein
ginsenoside Re results in increased phosphorylation of MAPK1 protein		 CTD PMID:24599032 PMID:36682417 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO ginsenoside Re affects the reaction [GPX1 protein affects the phosphorylation of MAPK3 protein]; ginsenoside Re results in increased phosphorylation of and results in increased activity of MAPK3 protein
ginsenoside Re results in increased phosphorylation of MAPK3 protein		 CTD PMID:24599032 PMID:36682417 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO ginsenoside Re inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein] CTD PMID:22849695 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Myl9 myosin light chain 9 affects phosphorylation EXP ginsenoside Re affects the phosphorylation of MYL9 protein CTD PMID:24658813 NCBI chr 3:145,281,943...145,288,333
Ensembl chr 3:145,281,937...145,288,333 		JBrowse link
G Mylk myosin light chain kinase affects expression EXP ginsenoside Re affects the expression of MYLK mRNA; ginsenoside Re affects the expression of MYLK protein CTD PMID:24658813 NCBI chr11:65,783,008...66,030,239
Ensembl chr11:65,783,008...66,030,261 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions ISO ginsenoside Re inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine affects the localization of NCF1 protein]]; ginsenoside Re inhibits the reaction [Phencyclidine affects the localization of NCF1 protein] CTD PMID:29037473 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO
EXP		 ginsenoside Re inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein] CTD PMID:17885204 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Ngf nerve growth factor increases expression ISO ginsenoside Re results in increased expression of NGF mRNA CTD PMID:24599032 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Ngfr nerve growth factor receptor increases expression ISO ginsenoside Re results in increased expression of NGFR mRNA; ginsenoside Re results in increased expression of NGFR protein CTD PMID:24599032 NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases expression		 ISO ginsenoside Re inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
ginsenoside Re results in decreased expression of NOS2 protein		 CTD PMID:15621629 PMID:23102375 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
increases phosphorylation		 ISO 2-aminoethoxydiphenyl borate inhibits the reaction [ginsenoside Re results in increased phosphorylation of NOS3 protein]; Calcium deficiency inhibits the reaction [ginsenoside Re results in increased phosphorylation of NOS3 protein]; Mifepristone inhibits the reaction [ginsenoside Re results in increased phosphorylation of NOS3 protein] CTD PMID:17490654 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression ISO ginsenoside Re results in increased expression of NR0B2 mRNA CTD PMID:21971952 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions
increases activity		 ISO [ginsenoside Re results in increased activity of NR3C1 protein] which results in increased abundance of Nitric Oxide CTD PMID:17490654 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Ocln occludin multiple interactions ISO ginsenoside Re inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of OCLN protein] CTD PMID:22849695 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO ginsenoside Re inhibits the reaction [Methamphetamine results in increased cleavage of PARP1 protein] CTD PMID:25523949 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 multiple interactions
decreases expression		 ISO ginsenoside Re inhibits the reaction [Dietary Fats results in increased expression of PCK1 mRNA]
ginsenoside Re results in decreased expression of PCK1 mRNA		 CTD PMID:21971952 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191 		JBrowse link
G Pdyn prodynorphin multiple interactions ISO 3-((3,5-bis(trifluoromethyl)phenyl)methyloxy)-2-phenylpiperidine inhibits the reaction [norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in decreased expression of BCL2 protein]]]]; 3-((3,5-bis(trifluoromethyl)phenyl)methyloxy)-2-phenylpiperidine inhibits the reaction [norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in decreased expression of TH protein]]]]; 3-((3,5-bis(trifluoromethyl)phenyl)methyloxy)-2-phenylpiperidine inhibits the reaction [norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased cleavage of CASP3 protein]]]]; 3-((3,5-bis(trifluoromethyl)phenyl)methyloxy)-2-phenylpiperidine inhibits the reaction [norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased expression of AIF1 protein]]]]; 3-((3,5-bis(trifluoromethyl)phenyl)methyloxy)-2-phenylpiperidine inhibits the reaction [norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased expression of BAX protein]]]]; ginsenoside Re inhibits the reaction [Methamphetamine results in decreased expression of PDYN mRNA]; ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in decreased expression of BCL2 protein]]; ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in decreased expression of TH protein]]; ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased cleavage of CASP3 protein]]; ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased expression of AIF1 protein]]; ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased expression of BAX protein]]; norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in decreased expression of BCL2 protein]]]; norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in decreased expression of TH protein]]]; norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased cleavage of CASP3 protein]]]; norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased expression of AIF1 protein]]]; norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased expression of BAX protein]]] CTD PMID:29467000 NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334 		JBrowse link
G Pgr progesterone receptor multiple interactions
increases expression		 ISO ginsenoside Re binds to and affects the activity of PGR protein
ginsenoside Re results in increased expression of PGR protein		 CTD PMID:16204943 PMID:16985185 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression ISO ginsenoside Re results in increased expression of PPARG mRNA CTD PMID:23545455 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 increases phosphorylation
multiple interactions		 ISO ginsenoside Re results in increased phosphorylation of PRKAA1 protein
ginsenoside Re inhibits the reaction [Dietary Fats results in decreased phosphorylation of PRKAA1 protein]		 CTD PMID:21971952 NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978 		JBrowse link
G Prkcd protein kinase C, delta multiple interactions
increases response to substance		 ISO 3-nitropropionic acid inhibits the reaction [ginsenoside Re inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased cleavage of and results in increased phosphorylation of PRKCD protein]]; ginsenoside Re inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased cleavage of and results in increased phosphorylation of PRKCD protein]; ginsenoside Re inhibits the reaction [Methamphetamine affects the localization of PRKCD protein]; PRKCD affects the reaction [ginsenoside Re inhibits the reaction [Methamphetamine results in increased activity of CAT protein]]; PRKCD affects the reaction [ginsenoside Re inhibits the reaction [Methamphetamine results in increased activity of SOD1 protein]]
ginsenoside Re inhibits the reaction [Methamphetamine affects the localization of PRKCD protein]; ginsenoside Re inhibits the reaction [Methamphetamine results in increased expression of and results in increased cleavage of PRKCD protein]
PRKCD results in increased susceptibility to ginsenoside Re		 CTD PMID:24430743 PMID:25523949 PMID:37308051 NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352 		JBrowse link
G Ptafr platelet-activating factor receptor multiple interactions
decreases expression		 ISO ginsenoside Re affects the reaction [GPX1 protein affects the expression of PTAFR protein]
ginsenoside Re results in decreased expression of PTAFR protein		 CTD PMID:36682417 NCBI chr 5:144,765,770...144,795,057
Ensembl chr 5:144,765,976...144,795,251 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO ginsenoside Re inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; ginsenoside Re metabolite inhibits the reaction [Oxazolone results in increased expression of PTGS2 mRNA]; ginsenoside Re metabolite inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 mRNA] CTD PMID:16557482 PMID:23102375 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO ginsenoside Re affects the reaction [GPX1 protein affects the expression of and affects the localization of RELA protein]; ginsenoside Re results in decreased expression of and affects the localization of RELA protein CTD PMID:36682417 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 increases phosphorylation ISO ginsenoside Re results in increased phosphorylation of RPS6KB1 protein CTD PMID:17885204 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Scd stearoyl-CoA desaturase decreases expression
multiple interactions		 ISO ginsenoside Re results in decreased expression of SCD mRNA
ginsenoside Re inhibits the reaction [Dietary Fats results in increased expression of SCD1 mRNA]		 CTD PMID:21971952 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562 		JBrowse link
G Slc18a3 solute carrier family 18 member A3 increases expression ISO ginsenoside Re results in increased expression of SLC18A3 mRNA CTD PMID:24599032 NCBI chr16:7,713,630...7,716,491 JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions
increases localization		 EXP
ISO		 ginsenoside Re inhibits the reaction [Dietary Fats inhibits the reaction [INS1 protein results in increased localization of SLC2A4 protein]]
ginsenoside Re results in increased localization of SLC2A4 protein		 CTD PMID:17885204 PMID:22571876 PMID:23545455 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565 		JBrowse link
G Slc5a7 solute carrier family 5 member 7 increases expression ISO ginsenoside Re results in increased expression of SLC5A7 mRNA CTD PMID:24599032 NCBI chr 9:7,595,440...7,626,258
Ensembl chr 9:7,595,444...7,626,258 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions EXP
ISO		 SLCO1B2 protein binds to and results in increased transport of ginsenoside Re
SLCO1B3 protein binds to and results in increased transport of ginsenoside Re		 CTD PMID:25297453 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 multiple interactions ISO ginsenoside Re inhibits the reaction [TNF protein results in increased expression of SOCS3 mRNA] CTD PMID:17885204 NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
decreases activity		 ISO ginsenoside Re inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity of SOD1 protein]]; ginsenoside Re inhibits the reaction [Methamphetamine results in increased activity of SOD1 protein]; PRKCD affects the reaction [ginsenoside Re inhibits the reaction [Methamphetamine results in increased activity of SOD1 protein]]
ginsenoside Re results in decreased activity of SOD1 protein		 CTD PMID:24430743 PMID:29037473 PMID:36682417 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO ginsenoside Re inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in decreased activity of SOD2 protein]; ginsenoside Re inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in decreased activity of SOD2 protein]] CTD PMID:29037473 PMID:37308051 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions
decreases expression		 ISO ginsenoside Re inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]
ginsenoside Re results in decreased expression of SREBF1 mRNA		 CTD PMID:21971952 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Stk11 serine/threonine kinase 11 increases phosphorylation ISO ginsenoside Re results in increased phosphorylation of STK11 protein CTD PMID:21971952 NCBI chr 7:9,574,553...9,591,315
Ensembl chr 7:9,575,269...9,591,315 		JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions ISO ginsenoside Re inhibits the reaction [Methamphetamine results in increased expression of TAC1 mRNA]; ginsenoside Re inhibits the reaction [Methamphetamine results in increased expression of TAC1 protein modified form]; norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [Methamphetamine results in increased expression of TAC1 mRNA]]; norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [Methamphetamine results in increased expression of TAC1 protein modified form]] CTD PMID:29467000 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178 		JBrowse link
G Tbc1d4 TBC1 domain family, member 4 increases phosphorylation ISO ginsenoside Re results in increased phosphorylation of TBC1D4 protein CTD PMID:17885204 NCBI chr15:78,256,030...78,434,168
Ensembl chr15:78,257,121...78,434,265 		JBrowse link
G Tff1 trefoil factor 1 increases expression ISO ginsenoside Re results in increased expression of TFF1 mRNA CTD PMID:16204943 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597 		JBrowse link
G Th tyrosine hydroxylase multiple interactions ISO ginsenoside Re inhibits the reaction [Methamphetamine results in decreased expression of and results in decreased activity of TH protein]
3-((3,5-bis(trifluoromethyl)phenyl)methyloxy)-2-phenylpiperidine inhibits the reaction [norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in decreased expression of TH protein]]]]; ginsenoside Re inhibits the reaction [Methamphetamine results in decreased expression of TH protein]; ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in decreased expression of TH protein]]; norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in decreased expression of TH protein]]]		 CTD PMID:25523949 PMID:29467000 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO ginsenoside Re inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of TJP1 protein] CTD PMID:22849695 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO ginsenoside Re inhibits the reaction [Lipopolysaccharides binds to TLR4 protein] CTD PMID:22849695 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP		 ginsenoside Re inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; ginsenoside Re inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; ginsenoside Re inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; ginsenoside Re inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]; ginsenoside Re inhibits the reaction [TNF protein results in increased expression of SOCS3 mRNA]; ginsenoside Re inhibits the reaction [TNF protein results in increased phosphorylation of CHUK protein]; ginsenoside Re inhibits the reaction [TNF protein results in increased phosphorylation of IRS1 protein]; ginsenoside Re metabolite inhibits the reaction [Oxazolone results in increased expression of TNF mRNA]; ginsenoside Re metabolite inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNF mRNA]; ginsenoside Re results in decreased expression of and results in decreased secretion of TNF protein CTD PMID:16557482 PMID:17885204 PMID:22494059 PMID:22849695 PMID:23545455 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
ginsenoside Rf term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoa1 apolipoprotein A1 multiple interactions
decreases expression		 ISO ginsenoside Rf inhibits the reaction [pirinixic acid results in decreased expression of APOA1 mRNA]; ginsenoside Rf inhibits the reaction [pirinixic acid results in decreased expression of APOA1 protein]; PPARA protein affects the reaction [ginsenoside Rf inhibits the reaction [pirinixic acid results in decreased expression of APOA1 mRNA]]
ginsenoside Rf results in decreased expression of APOA1 protein		 CTD PMID:16297877 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035 		JBrowse link
G Apoc3 apolipoprotein C3 multiple interactions
decreases expression
increases expression		 ISO ginsenoside Rf inhibits the reaction [pirinixic acid results in decreased expression of APOC3 mRNA]; ginsenoside Rf inhibits the reaction [pirinixic acid results in decreased expression of APOC3 protein]; PPARA protein affects the reaction [ginsenoside Rf inhibits the reaction [pirinixic acid results in decreased expression of APOC3 mRNA]]; PPARA protein affects the reaction [ginsenoside Rf results in increased expression of APOC3 mRNA]
ginsenoside Rf results in decreased expression of APOC3 protein		 CTD PMID:16297877 NCBI chr 8:46,531,478...46,533,658
Ensembl chr 8:46,531,478...46,533,583 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 affects activity ISO ginsenoside Rf affects the activity of KCNH2 protein CTD PMID:15842772 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
decreases expression		 ISO ginsenoside Rf binds to and results in decreased activity of PPARA protein; ginsenoside Rf inhibits the reaction [pirinixic acid results in increased activity of PPARA protein]; ginsenoside Rf inhibits the reaction [pirinixic acid results in increased expression of PPARA mRNA]; PPARA protein affects the reaction [ginsenoside Rf inhibits the reaction [pirinixic acid results in decreased expression of APOA1 mRNA]]; PPARA protein affects the reaction [ginsenoside Rf inhibits the reaction [pirinixic acid results in decreased expression of APOC3 mRNA]]; PPARA protein affects the reaction [ginsenoside Rf results in increased expression of APOC3 mRNA]
ginsenoside Rf results in decreased expression of PPARA mRNA		 CTD PMID:16297877 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
ginsenoside Rg1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 increases transport
multiple interactions		 EXP
ISO		 ABCB11 protein results in increased transport of ginsenoside Rg1
ginsenoside Rg1 inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of ABCB11 mRNA]; ginsenoside Rg1 inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of ABCB11 protein]
ginsenoside Rg1 promotes the reaction [Carbon Tetrachloride results in increased expression of ABCB11 protein]		 CTD PMID:25297453 PMID:29964319 PMID:32198087 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases transport ISO ABCC1 protein results in increased transport of ginsenoside Rg1 CTD PMID:25297453 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases transport
multiple interactions
increases expression		 EXP
ISO		 ABCC2 protein results in increased transport of ginsenoside Rg1
ginsenoside Rg1 inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of ABCC2 mRNA]; ginsenoside Rg1 inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of ABCC2 protein]
ginsenoside Rg1 promotes the reaction [Carbon Tetrachloride results in increased expression of ABCC2 protein]; Tretinoin inhibits the reaction [ginsenoside Rg1 promotes the reaction [Carbon Tetrachloride results in increased expression of ABCC2 protein]]
ginsenoside Rg1 results in increased expression of ABCC2 protein		 CTD PMID:25297453 PMID:29964319 PMID:32198087 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression
multiple interactions		 ISO ginsenoside Rg1 results in increased expression of ABCC3 protein
ginsenoside Rg1 promotes the reaction [Carbon Tetrachloride results in increased expression of ABCC3 protein]; Tretinoin inhibits the reaction [ginsenoside Rg1 promotes the reaction [Carbon Tetrachloride results in increased expression of ABCC3 protein]]		 CTD PMID:29964319 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 increases expression
multiple interactions		 ISO ginsenoside Rg1 results in increased expression of ABCC4 protein
ginsenoside Rg1 promotes the reaction [Carbon Tetrachloride results in increased expression of ABCC4 protein]		 CTD PMID:29964319 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 increases transport EXP
ISO		 ABCG2 protein results in increased transport of ginsenoside Rg1 CTD PMID:25297453 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Ache acetylcholinesterase decreases activity ISO ginsenoside Rg1 results in decreased activity of ACHE protein CTD PMID:20564503 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Adam10 ADAM metallopeptidase domain 10 multiple interactions EXP ginsenoside Rg1 inhibits the reaction [[APP protein alternative form co-treated with Dexamethasone] results in decreased expression of ADAM10 mRNA] CTD PMID:22484447 NCBI chr 8:71,346,008...71,477,889
Ensembl chr 8:71,345,837...71,477,889 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO
EXP		 ginsenoside Rg1 inhibits the reaction [Chlorpyrifos results in decreased phosphorylation of AKT1 protein]; ginsenoside Rg1 inhibits the reaction [Dibutyl Phthalate results in decreased expression of AKT1 mRNA]; ginsenoside Rg1 inhibits the reaction [Dibutyl Phthalate results in decreased phosphorylation of AKT1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in decreased phosphorylation of AKT1 protein]]; ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in decreased phosphorylation of AKT1 protein]
ginsenoside Rg1 inhibits the reaction [Doxorubicin results in increased expression of AKT1 mRNA]		 CTD PMID:33331133 PMID:34783124 PMID:34859534 PMID:36811218 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 multiple interactions ISO ginsenoside Rg1 promotes the reaction [Doxorubicin results in increased expression of APAF1 mRNA] CTD PMID:34783124 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540 		JBrowse link
G App amyloid beta precursor protein multiple interactions EXP ginsenoside Rg1 inhibits the reaction [[APP protein alternative form co-treated with Dexamethasone] results in decreased expression of ADAM10 mRNA]; ginsenoside Rg1 inhibits the reaction [[APP protein alternative form co-treated with Dexamethasone] results in increased expression of APP mRNA]; ginsenoside Rg1 inhibits the reaction [[APP protein alternative form co-treated with Dexamethasone] results in increased expression of APP protein alternative form]; ginsenoside Rg1 inhibits the reaction [[APP protein alternative form co-treated with Dexamethasone] results in increased expression of APP protein]; ginsenoside Rg1 inhibits the reaction [[APP protein alternative form co-treated with Dexamethasone] results in increased expression of BACE1 mRNA]; ginsenoside Rg1 results in decreased susceptibility to [APP protein alternative form co-treated with Dexamethasone] CTD PMID:22484447 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Atf6 activating transcription factor 6 multiple interactions ISO ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased expression of ATF6 protein] CTD PMID:30918470 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177 		JBrowse link
G Atm ATM serine/threonine kinase multiple interactions ISO ginsenoside Rg1 promotes the reaction [Doxorubicin results in increased expression of ATM mRNA] CTD PMID:34783124 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Bace1 beta-secretase 1 multiple interactions EXP ginsenoside Rg1 inhibits the reaction [[APP protein alternative form co-treated with Dexamethasone] results in increased expression of BACE1 mRNA] CTD PMID:22484447 NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876 		JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rg1 inhibits the reaction [Rotenone results in increased phosphorylation of BAD protein]]; ginsenoside Rg1 inhibits the reaction [Rotenone results in increased phosphorylation of BAD protein]; Mifepristone inhibits the reaction [ginsenoside Rg1 inhibits the reaction [Rotenone results in increased phosphorylation of BAD protein]]; SH-6 compound inhibits the reaction [ginsenoside Rg1 inhibits the reaction [Rotenone results in increased phosphorylation of BAD protein]] CTD PMID:17123556 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions		 ISO
EXP		 ginsenoside Rg1 results in increased expression of BAX protein
ginsenoside Rg1 inhibits the reaction [Chlorpyrifos results in increased expression of BAX protein]
ginsenoside Rg1 promotes the reaction [Doxorubicin results in increased expression of BAX mRNA]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]]; ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]		 CTD PMID:28371286 PMID:34783124 PMID:34859534 PMID:36811218 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 ISO
EXP		 ginsenoside Rg1 results in decreased expression of BCL2 protein
ginsenoside Rg1 inhibits the reaction [Chlorpyrifos results in decreased expression of BCL2 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]]; ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]; ginsenoside Rg1 inhibits the reaction [Oxygen deficiency results in decreased expression of BCL2 protein]		 CTD PMID:26593335 PMID:28371286 PMID:34859534 PMID:36811218 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 ISO
EXP		 ginsenoside Rg1 inhibits the reaction [cobaltous chloride results in increased activity of CASP3 protein]; ginsenoside Rg1 promotes the reaction [Doxorubicin results in increased expression of CASP3 mRNA]
ginsenoside Rg1 inhibits the reaction [Chlorpyrifos results in increased cleavage of CASP3 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP3 protein]]; ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP3 protein]
ginsenoside Rg1 results in increased activity of CASP3 protein		 CTD PMID:24386346 PMID:28371286 PMID:34783124 PMID:34859534 PMID:36811218 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions		 ISO
EXP		 ginsenoside Rg1 results in increased activity of CASP9 protein
ginsenoside Rg1 inhibits the reaction [Chlorpyrifos results in increased cleavage of CASP9 protein]
ginsenoside Rg1 promotes the reaction [Doxorubicin results in increased expression of CASP9 mRNA]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP9 protein]]; ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP9 protein]		 CTD PMID:28371286 PMID:34783124 PMID:34859534 PMID:36811218 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase multiple interactions ISO
EXP		 ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]
ginsenoside Rg1 inhibits the reaction [Oxygen deficiency results in decreased expression of CAT protein]		 CTD PMID:29964319 PMID:37923178 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccne1 cyclin E1 multiple interactions ISO ginsenoside Rg1 affects the reaction [tert-Butylhydroperoxide affects the expression of CCNE1 protein] CTD PMID:15606011 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO ginsenoside Rg1 inhibits the reaction [Dibutyl Phthalate results in decreased expression of CDH1 mRNA]; ginsenoside Rg1 inhibits the reaction [Dibutyl Phthalate results in decreased expression of CDH1 protein] CTD PMID:33331133 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions ISO ginsenoside Rg1 affects the reaction [tert-Butylhydroperoxide affects the expression of CDK2 protein] CTD PMID:15606011 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO ginsenoside Rg1 affects the reaction [tert-Butylhydroperoxide affects the expression of CDKN1A protein]; ginsenoside Rg1 promotes the reaction [Doxorubicin results in increased expression of CDKN1A mRNA] CTD PMID:15606011 PMID:34783124 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO ginsenoside Rg1 inhibits the reaction [Dibutyl Phthalate results in decreased expression of CREB1 protein] CTD PMID:33331133 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions EXP ginsenoside Rg1 inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of CYP2B10 mRNA]; ginsenoside Rg1 inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of CYP2B10 protein] CTD PMID:32198087 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in increased expression of CYP2E1 mRNA] CTD PMID:29964319 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions EXP ginsenoside Rg1 inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of CYP3A4 mRNA]; ginsenoside Rg1 inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of CYP3A4 protein] CTD PMID:32198087 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased expression of DDIT3 protein] CTD PMID:30918470 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions ISO ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased expression of ERN1 protein] CTD PMID:30918470 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO ginsenoside Rg1 results in increased expression of FOS mRNA CTD PMID:16204943 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions ISO ginsenoside Rg1 inhibits the reaction [Dibutyl Phthalate results in increased expression of FSHB protein] CTD PMID:33331133 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370 		JBrowse link
G Fshr follicle stimulating hormone receptor multiple interactions ISO ginsenoside Rg1 inhibits the reaction [Dibutyl Phthalate results in decreased expression of FSHR protein] CTD PMID:33331133 NCBI chr 6:5,198,825...5,406,785
Ensembl chr 6:5,198,825...5,406,785 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions		 ISO ginsenoside Rg1 results in increased expression of GCLC mRNA
ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC mRNA]; NFE2L2 protein affects the reaction [ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC mRNA]]		 CTD PMID:29964319 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression
multiple interactions		 ISO ginsenoside Rg1 results in increased expression of GCLM protein
ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLM protein]		 CTD PMID:29964319 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions ISO ginsenoside Rg1 inhibits the reaction [Dibutyl Phthalate results in decreased expression of GJA1 mRNA]; ginsenoside Rg1 inhibits the reaction [Dibutyl Phthalate results in decreased expression of GJA1 protein] CTD PMID:33331133 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582 		JBrowse link
G Glud1 glutamate dehydrogenase 1 multiple interactions EXP ginsenoside Rg1 inhibits the reaction [Oxygen deficiency results in increased expression of GLUD1 protein] CTD PMID:26593335 NCBI chr16:9,640,312...9,673,961
Ensembl chr16:9,640,312...9,673,957 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein] CTD PMID:29964319 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in decreased phosphorylation of GSK3B protein]]; ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in decreased phosphorylation of GSK3B protein] CTD PMID:34859534 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO ginsenoside Rg1 promotes the reaction [Doxorubicin results in increased expression of H2AX mRNA] CTD PMID:34783124 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression		 ISO [astragaloside A co-treated with ginsenoside Rg1 co-treated with ginsenoside Rb1 co-treated with notoginsenoside R1] results in increased expression of HMOX1 mRNA; [astragaloside A co-treated with ginsenoside Rg1 co-treated with ginsenoside Rb1 co-treated with notoginsenoside R1] results in increased expression of HMOX1 protein; ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in decreased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in decreased expression of HMOX1 mRNA]]; Tretinoin inhibits the reaction [ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in decreased expression of HMOX1 mRNA]]
ginsenoside Rg1 results in increased expression of HMOX1 mRNA; ginsenoside Rg1 results in increased expression of HMOX1 protein		 CTD PMID:25422538 PMID:29964319 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased expression of HSPA5 protein] CTD PMID:30918470 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Ifng interferon gamma multiple interactions EXP ginsenoside Rg1 inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IFNG protein] CTD PMID:32198087 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP		 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B]]; ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B protein]; ginsenoside Rg1 inhibits the reaction [Chlorpyrifos results in increased expression of IL1B protein]; ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B]
ginsenoside Rg1 inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL1B protein]		 CTD PMID:22214447 PMID:29964319 PMID:32198087 PMID:36811218 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP
ISO		 ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; ginsenoside Rg1 inhibits the reaction [Oxygen deficiency results in increased expression of IL6 protein]
ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 protein]; ginsenoside Rg1 inhibits the reaction [Chlorpyrifos results in increased expression of IL6 protein]; ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]		 CTD PMID:17655881 PMID:29964319 PMID:30918470 PMID:36811218 PMID:37923178 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Inha inhibin subunit alpha multiple interactions ISO ginsenoside Rg1 inhibits the reaction [Dibutyl Phthalate results in decreased expression of INHA protein] CTD PMID:33331133 NCBI chr 9:76,994,465...76,997,366
Ensembl chr 9:76,993,589...76,997,248 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 affects activity ISO ginsenoside Rg1 affects the activity of KCNH2 protein CTD PMID:15842772 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions ISO ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in increased expression of KEAP1 protein] CTD PMID:29964319 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862 		JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions ISO ginsenoside Rg1 inhibits the reaction [Dibutyl Phthalate results in decreased expression of LHB protein] CTD PMID:33331133 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Lpl lipoprotein lipase increases secretion ISO ginsenoside Rg1 results in increased secretion of LPL protein CTD PMID:8988629 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249 		JBrowse link
G Map2 microtubule-associated protein 2 increases expression ISO ginsenoside Rg1 results in increased expression of MAP2 mRNA CTD PMID:24599032 NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
affects phosphorylation		 ISO PLCG1 affects the reaction [ginsenoside Rg1 affects the phosphorylation of MAPK1 protein] CTD PMID:22214447 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 affects phosphorylation
multiple interactions		 ISO ginsenoside Rg1 affects the phosphorylation of MAPK3 protein
PLCG1 affects the reaction [ginsenoside Rg1 affects the phosphorylation of MAPK3 protein]		 CTD PMID:22214447 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO ginsenoside Rg1 inhibits the reaction [cobaltous chloride results in increased phosphorylation of MAPK8 protein] CTD PMID:24386346 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO ginsenoside Rg1 inhibits the reaction [cobaltous chloride results in increased phosphorylation of MAPK9 protein] CTD PMID:24386346 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase multiple interactions
increases expression		 ISO Mifepristone inhibits the reaction [ginsenoside Rg1 results in increased expression of MET protein]; MIR23A mRNA inhibits the reaction [ginsenoside Rg1 results in increased expression of MET protein] CTD PMID:26115870 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876 		JBrowse link
G Mfn2 mitofusin 2 multiple interactions EXP ginsenoside Rg1 inhibits the reaction [Oxygen deficiency results in decreased expression of MFN2 mRNA]; ginsenoside Rg1 inhibits the reaction [Oxygen deficiency results in decreased expression of MFN2 protein] CTD PMID:26593335 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342 		JBrowse link
G Mir23a microRNA 23a decreases expression
multiple interactions		 ISO ginsenoside Rg1 results in decreased expression of MIR23A mRNA
Mifepristone inhibits the reaction [ginsenoside Rg1 results in decreased expression of MIR23A mRNA]; MIR23A mRNA inhibits the reaction [ginsenoside Rg1 results in increased expression of MET protein]		 CTD PMID:26115870 NCBI chr19:23,954,997...23,955,071
Ensembl chr19:23,954,997...23,955,071 		JBrowse link
G Mmp2 matrix metallopeptidase 2 increases expression EXP ginsenoside Rg1 results in increased expression of MMP2 protein CTD PMID:23738715 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression EXP ginsenoside Rg1 results in increased expression of MMP9 protein CTD PMID:23738715 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO ginsenoside Rg1 inhibits the reaction [cobaltous chloride results in decreased activity of [MTOR protein binds to RAPTOR protein]]; ginsenoside Rg1 results in increased activity of [MTOR protein binds to RAPTOR protein]
ginsenoside Rg1 inhibits the reaction [Dibutyl Phthalate results in decreased expression of MTOR protein]		 CTD PMID:24386346 PMID:33331133 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
affects localization
increases expression		 ISO [ginsenoside Rg1 co-treated with ginsenoside 20S-protopanaxatriol] results in increased expression of NFE2L2 protein
ginsenoside Rg1 affects the localization of NFE2L2 protein
[astragaloside A co-treated with ginsenoside Rg1 co-treated with ginsenoside Rb1 co-treated with notoginsenoside R1] affects the localization of NFE2L2 protein; ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in decreased expression of NFE2L2 protein]; NFE2L2 protein affects the reaction [ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC mRNA]]; NFE2L2 protein affects the reaction [ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in decreased expression of HMOX1 mRNA]]; NFE2L2 protein affects the reaction [ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in decreased expression of NQO1 mRNA]]; Tretinoin inhibits the reaction [ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in decreased expression of NFE2L2 protein]]
ginsenoside Rg1 results in increased expression of NFE2L2 mRNA		 CTD PMID:22780686 PMID:25422538 PMID:29964319 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkbia NFKB inhibitor alpha affects phosphorylation
multiple interactions		 ISO ginsenoside Rg1 affects the phosphorylation of NFKBIA protein
PLCG1 affects the reaction [ginsenoside Rg1 affects the phosphorylation of NFKBIA protein]		 CTD PMID:22214447 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2]]; ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]; ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2] CTD PMID:22214447 PMID:29964319 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in decreased expression of NQO1 mRNA]; ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in decreased expression of NQO1 protein]; NFE2L2 protein affects the reaction [ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in decreased expression of NQO1 mRNA]]; Tretinoin inhibits the reaction [ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in decreased expression of NQO1 mRNA]] CTD PMID:29964319 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions EXP ginsenoside Rg1 inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of NR1H4 mRNA]; ginsenoside Rg1 inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of NR1H4 protein] CTD PMID:32198087 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Pgr progesterone receptor increases expression ISO ginsenoside Rg1 results in increased expression of PGR protein CTD PMID:16204943 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha multiple interactions ISO ginsenoside Rg1 inhibits the reaction [Dibutyl Phthalate results in decreased expression of PIK3CA mRNA] CTD PMID:33331133 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032 		JBrowse link
G Plcg1 phospholipase C, gamma 1 multiple interactions ISO PLCG1 affects the reaction [ginsenoside Rg1 affects the phosphorylation of MAPK1 protein]; PLCG1 affects the reaction [ginsenoside Rg1 affects the phosphorylation of MAPK3 protein]; PLCG1 affects the reaction [ginsenoside Rg1 affects the phosphorylation of NFKBIA protein] CTD PMID:22214447 NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions ISO ginsenoside Rg1 inhibits the reaction [cobaltous chloride results in increased phosphorylation of PRKAA1 protein] CTD PMID:24386346 NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978 		JBrowse link
G Pten phosphatase and tensin homolog multiple interactions ISO ginsenoside Rg1 inhibits the reaction [Dibutyl Phthalate results in increased expression of PTEN protein] CTD PMID:33331133 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2]]; ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein]; ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2] CTD PMID:22214447 PMID:29964319 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rad51 RAD51 recombinase multiple interactions ISO ginsenoside Rg1 promotes the reaction [Doxorubicin results in increased expression of RAD51 mRNA] CTD PMID:34783124 NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035 		JBrowse link
G Rps6 ribosomal protein S6 increases phosphorylation ISO ginsenoside Rg1 results in increased phosphorylation of RPS6 protein CTD PMID:24386346 NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602 		JBrowse link
G Rptor regulatory associated protein of MTOR, complex 1 multiple interactions ISO ginsenoside Rg1 inhibits the reaction [cobaltous chloride results in decreased activity of [MTOR protein binds to RAPTOR protein]]; ginsenoside Rg1 results in increased activity of [MTOR protein binds to RAPTOR protein] CTD PMID:24386346 NCBI chr10:104,878,487...105,176,986
Ensembl chr10:104,878,487...105,176,983 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased expression of SIRT1 protein] CTD PMID:30918470 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Slc10a1 solute carrier family 10 member 1 multiple interactions EXP ginsenoside Rg1 inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLC10A1 mRNA]; ginsenoside Rg1 inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLC10A1 protein] CTD PMID:32198087 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions EXP
ISO		 SLCO1B2 protein binds to and results in increased transport of ginsenoside Rg1
SLCO1B3 protein binds to and results in increased transport of ginsenoside Rg1		 CTD PMID:25297453 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP ginsenoside Rg1 inhibits the reaction [Oxygen deficiency results in decreased expression of SOD1 protein] CTD PMID:37923178 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 multiple interactions EXP ginsenoside Rg1 inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SULT2A1 mRNA]; ginsenoside Rg1 inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SULT2A1 protein] CTD PMID:32198087 NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134 		JBrowse link
G Tff1 trefoil factor 1 increases expression ISO ginsenoside Rg1 results in increased expression of TFF1 mRNA CTD PMID:16204943 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP		 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased expression of TNF]]; ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; ginsenoside Rg1 inhibits the reaction [Chlorpyrifos results in increased expression of TNF protein]; ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased expression of TNF]; ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
ginsenoside Rg1 inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of TNF protein]; ginsenoside Rg1 inhibits the reaction [Oxygen deficiency results in increased expression of TNF protein]		 CTD PMID:22214447 PMID:29964319 PMID:30918470 PMID:32198087 PMID:36811218 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO ginsenoside Rg1 promotes the reaction [Doxorubicin results in increased expression of TP53 mRNA] CTD PMID:34783124 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions EXP ginsenoside Rg1 inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of UGT1A1 mRNA]; ginsenoside Rg1 inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of UGT1A1 protein] CTD PMID:32198087 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Xrcc1 X-ray repair cross complementing 1 multiple interactions ISO ginsenoside Rg1 promotes the reaction [Doxorubicin results in increased expression of XRCC1 mRNA] CTD PMID:34783124 NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701 		JBrowse link
ginsenoside Rg2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 increases expression EXP ginsenoside Rg2 results in increased expression of ABCC2 mRNA CTD PMID:23835644 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rg2 inhibits the reaction [APP protein modified form results in decreased phosphorylation of AKT1 protein]]; ginsenoside Rg2 inhibits the reaction [APP protein modified form results in decreased phosphorylation of AKT1 protein] CTD PMID:28756148 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G App amyloid beta precursor protein multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rg2 inhibits the reaction [APP protein modified form results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rg2 inhibits the reaction [APP protein modified form results in increased activity of CASP3 protein]]; ginsenoside Rg2 inhibits the reaction [APP protein modified form results in decreased expression of BCL2 protein]; ginsenoside Rg2 inhibits the reaction [APP protein modified form results in decreased phosphorylation of AKT1 protein]; ginsenoside Rg2 inhibits the reaction [APP protein modified form results in increased activity of and results in increased cleavage of CASP3 protein]; ginsenoside Rg2 inhibits the reaction [APP protein modified form results in increased expression of BAX protein] CTD PMID:28756148 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP ginsenoside Rg2 inhibits the reaction [APP protein modified form results in increased expression of BAX protein] CTD PMID:28756148 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP ginsenoside Rg2 inhibits the reaction [APP protein modified form results in decreased expression of BCL2 protein] CTD PMID:28756148 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Becn2 beclin 2 multiple interactions ISO ginsenoside Rg2 inhibits the reaction [BECN2 protein binds to GPRASP1 protein] CTD PMID:27305347 NCBI chr13:87,842,980...87,892,410
Ensembl chr13:87,844,531...87,845,787 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rg2 inhibits the reaction [APP protein modified form results in increased activity of CASP3 protein]]; ginsenoside Rg2 inhibits the reaction [APP protein modified form results in increased activity of and results in increased cleavage of CASP3 protein] CTD PMID:28756148 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Crtc2 CREB regulated transcription coactivator 2 multiple interactions ISO [ginsenoside Rg2 results in increased activity of NR0B2 protein] which results in decreased activity of CRTC2 protein CTD PMID:22062806 NCBI chr 2:175,709,603...175,719,768
Ensembl chr 2:175,709,644...175,719,763 		JBrowse link
G G6pc3 glucose 6 phosphatase catalytic subunit 3 decreases expression
multiple interactions		 ISO ginsenoside Rg2 results in decreased expression of G6PC3 mRNA
dorsomorphin inhibits the reaction [ginsenoside Rg2 results in decreased expression of G6PC3 mRNA]		 CTD PMID:22062806 NCBI chr10:87,146,987...87,151,223
Ensembl chr10:87,146,901...87,151,221 		JBrowse link
G Gprasp1 G protein-coupled receptor associated sorting protein 1 multiple interactions ISO ginsenoside Rg2 inhibits the reaction [BECN2 protein binds to GPRASP1 protein] CTD PMID:27305347 NCBI chr  X:98,764,853...98,772,685
Ensembl chr  X:98,709,841...98,772,851 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation
multiple interactions		 ISO ginsenoside Rg2 results in increased phosphorylation of GSK3B protein
[[ginsenoside Rg2 results in increased phosphorylation of GSK3B protein] co-treated with [ginsenoside Rg2 results in increased expression of NR0B2 mRNA]] results in decreased chemical synthesis of Glucose; dorsomorphin inhibits the reaction [ginsenoside Rg2 results in increased phosphorylation of GSK3B protein]		 CTD PMID:22062806 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases expression		 ISO bafilomycin A1 promotes the reaction [ginsenoside Rg2 results in increased expression of MAP1LC3B protein modified form] CTD PMID:27305347 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 multiple interactions
increases expression
increases activity		 ISO [[ginsenoside Rg2 results in increased phosphorylation of GSK3B protein] co-treated with [ginsenoside Rg2 results in increased expression of NR0B2 mRNA]] results in decreased chemical synthesis of Glucose; [ginsenoside Rg2 results in increased activity of NR0B2 protein] which results in decreased activity of CRTC2 protein CTD PMID:22062806 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 multiple interactions
decreases expression		 ISO dorsomorphin inhibits the reaction [ginsenoside Rg2 results in decreased expression of PCK1 mRNA] CTD PMID:22062806 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions
decreases expression		 ISO dorsomorphin inhibits the reaction [ginsenoside Rg2 results in decreased expression of PPARGC1A mRNA] CTD PMID:22062806 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
decreases expression		 ISO bafilomycin A1 promotes the reaction [ginsenoside Rg2 results in decreased expression of SQSTM1 protein] CTD PMID:27305347 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Stk11 serine/threonine kinase 11 increases phosphorylation
multiple interactions		 ISO ginsenoside Rg2 results in increased phosphorylation of STK11 protein
dorsomorphin inhibits the reaction [ginsenoside Rg2 results in increased phosphorylation of STK11 protein]		 CTD PMID:22062806 NCBI chr 7:9,574,553...9,591,315
Ensembl chr 7:9,575,269...9,591,315 		JBrowse link
gypenoside LXXV term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions		 ISO gypenoside LXXV results in increased phosphorylation of AKT1 protein
2-chloro-5-nitrobenzanilide inhibits the reaction [gypenoside LXXV results in increased phosphorylation of AKT1 protein]		 CTD PMID:35192202 PMID:36325883 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO gypenoside LXXV inhibits the reaction [LEPR gene mutant form results in increased expression of CCL2 protein] CTD PMID:35192202 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions
increases expression		 ISO gypenoside LXXV results in increased expression of and results in increased secretion of CTGF protein
gypenoside LXXV results in increased expression of CTGF mRNA		 CTD PMID:31018484 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO gypenoside LXXV inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; gypenoside LXXV inhibits the reaction [LEPR gene mutant form results in increased expression of IL1B protein] CTD PMID:33050067 PMID:35192202 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO gypenoside LXXV inhibits the reaction [LEPR gene mutant form results in increased expression of IL6 protein] CTD PMID:35192202 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Irs1 insulin receptor substrate 1 decreases phosphorylation
multiple interactions		 ISO gypenoside LXXV results in decreased phosphorylation of IRS1 protein
2-chloro-5-nitrobenzanilide inhibits the reaction [gypenoside LXXV results in decreased expression of and results in decreased phosphorylation of IRS1 protein]; gypenoside LXXV results in decreased expression of and results in decreased phosphorylation of IRS1 protein		 CTD PMID:35192202 PMID:36325883 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122 		JBrowse link
G Lepr leptin receptor multiple interactions ISO gypenoside LXXV inhibits the reaction [LEPR gene mutant form results in increased expression of CCL2 protein]; gypenoside LXXV inhibits the reaction [LEPR gene mutant form results in increased expression of IL1B protein]; gypenoside LXXV inhibits the reaction [LEPR gene mutant form results in increased expression of IL6 protein]; gypenoside LXXV inhibits the reaction [LEPR gene mutant form results in increased expression of TNF protein] CTD PMID:35192202 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908 		JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 multiple interactions ISO gypenoside LXXV binds to and affects the localization of NR3C2 protein CTD PMID:31018484 NCBI chr19:30,715,634...31,059,885
Ensembl chr19:30,715,648...31,059,885 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression
multiple interactions		 ISO
EXP		 gypenoside LXXV results in increased expression of PPARG protein
2-chloro-5-nitrobenzanilide inhibits the reaction [gypenoside LXXV results in increased expression of PPARG protein]
2-chloro-5-nitrobenzanilide inhibits the reaction [gypenoside LXXV binds to and results in increased activity of PPARG protein]; gypenoside LXXV binds to and results in increased activity of PPARG protein		 CTD PMID:35192202 PMID:36325883 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO gypenoside LXXV results in decreased expression of and results in decreased phosphorylation of RELA protein CTD PMID:33050067 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 affects localization
increases expression
multiple interactions		 ISO gypenoside LXXV affects the localization of SLC2A4 protein
gypenoside LXXV results in increased expression of SLC2A4 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [gypenoside LXXV affects the localization of SLC2A4 protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [gypenoside LXXV affects the localization of SLC2A4 protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [gypenoside LXXV results in increased expression of SLC2A4 protein]		 CTD PMID:35192202 PMID:36325883 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression ISO gypenoside LXXV results in decreased expression of TGFB1 protein CTD PMID:33050067 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO gypenoside LXXV inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of TNF protein]; gypenoside LXXV inhibits the reaction [LEPR gene mutant form results in increased expression of TNF protein]; gypenoside LXXV inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA] CTD PMID:33050067 PMID:35192202 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
notoginsenoside R1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 increases transport EXP
ISO		 ABCB11 protein results in increased transport of notoginsenoside R1 CTD PMID:25297453 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A increases expression
multiple interactions		 ISO notoginsenoside R1 results in increased expression of ABCB1 mRNA
notoginsenoside R1 results in increased expression of ABCB1A mRNA
NR1I2 protein promotes the reaction [notoginsenoside R1 results in increased expression of ABCB1 mRNA]		 CTD PMID:25472953 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases transport ISO ABCC1 protein results in increased transport of notoginsenoside R1 CTD PMID:25297453 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases transport EXP
ISO		 ABCC2 protein results in increased transport of notoginsenoside R1 CTD PMID:25297453 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 increases transport EXP
ISO		 ABCG2 protein results in increased transport of notoginsenoside R1 CTD PMID:25297453 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions		 ISO notoginsenoside R1 results in increased phosphorylation of AKT1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [notoginsenoside R1 inhibits the reaction [triethylene glycol dimethacrylate results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [notoginsenoside R1 results in increased phosphorylation of AKT1 protein]; notoginsenoside R1 inhibits the reaction [triethylene glycol dimethacrylate results in decreased phosphorylation of AKT1 protein]		 CTD PMID:33689844 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Apoe apolipoprotein E multiple interactions ISO notoginsenoside R1 inhibits the reaction [APOE gene mutant form results in decreased abundance of Glutathione]; notoginsenoside R1 inhibits the reaction [APOE gene mutant form results in decreased expression of MIR20A mRNA]; notoginsenoside R1 inhibits the reaction [APOE gene mutant form results in increased abundance of Cholesterol]; notoginsenoside R1 inhibits the reaction [APOE gene mutant form results in increased abundance of Triglycerides]; notoginsenoside R1 inhibits the reaction [APOE gene mutant form results in increased expression of IFNG protein]; notoginsenoside R1 inhibits the reaction [APOE gene mutant form results in increased expression of IL2 protein]; notoginsenoside R1 inhibits the reaction [APOE gene mutant form results in increased expression of IL6 protein]; notoginsenoside R1 inhibits the reaction [APOE gene mutant form results in increased expression of MIR126A mRNA]; notoginsenoside R1 inhibits the reaction [APOE gene mutant form results in increased expression of MIR21A mRNA]; notoginsenoside R1 inhibits the reaction [APOE gene mutant form results in increased expression of TNF protein] CTD PMID:24933211 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G App amyloid beta precursor protein multiple interactions ISO
EXP		 notoginsenoside R1 inhibits the reaction [[APP gene mutant form co-treated with PSEN1 gene mutant form] results in increased expression of APP protein modified form]
notoginsenoside R1 inhibits the reaction [APP protein modified form results in decreased expression of BCL2 protein]; notoginsenoside R1 inhibits the reaction [APP protein modified form results in increased cleavage of CASP3 protein]; notoginsenoside R1 inhibits the reaction [APP protein modified form results in increased expression of BAX protein]; notoginsenoside R1 inhibits the reaction [APP protein modified form results in increased phosphorylation of MAPK1 protein]; notoginsenoside R1 inhibits the reaction [APP protein modified form results in increased phosphorylation of MAPK3 protein]; notoginsenoside R1 inhibits the reaction [APP protein modified form results in increased phosphorylation of MAPK8 protein]; notoginsenoside R1 inhibits the reaction [APP protein modified form results in increased phosphorylation of MAPK9 protein]		 CTD PMID:24975829 PMID:25714973 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Atp5f1d ATP synthase F1 subunit delta multiple interactions EXP 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid inhibits the reaction [notoginsenoside R1 inhibits the reaction [[Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in decreased expression of ATP5F1D protein]]; notoginsenoside R1 inhibits the reaction [[Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in decreased expression of ATP5F1D protein] CTD PMID:25305180 NCBI chr 7:9,560,604...9,565,919
Ensembl chr 7:9,560,608...9,565,929 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO
EXP		 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [notoginsenoside R1 inhibits the reaction [triethylene glycol dimethacrylate results in increased expression of BAX protein]]; 3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [notoginsenoside R1 inhibits the reaction [triethylene glycol dimethacrylate results in increased expression of BAX protein]]; Cyclosporine inhibits the reaction [notoginsenoside R1 inhibits the reaction [triethylene glycol dimethacrylate results in increased expression of BAX protein]]; notoginsenoside R1 inhibits the reaction [Excitatory Amino Acid Agonists results in increased expression of BAX protein]; notoginsenoside R1 inhibits the reaction [triethylene glycol dimethacrylate results in increased expression of BAX protein]
notoginsenoside R1 inhibits the reaction [[Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in increased expression of BAX protein]; notoginsenoside R1 inhibits the reaction [APP protein modified form results in increased expression of BAX protein]		 CTD PMID:19224577 PMID:24975829 PMID:25305180 PMID:33689844 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression		 ISO
EXP		 notoginsenoside R1 inhibits the reaction [Excitatory Amino Acid Agonists results in decreased expression of BCL2 protein]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]
notoginsenoside R1 results in increased expression of BCL2
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid inhibits the reaction [notoginsenoside R1 inhibits the reaction [[Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in decreased expression of BCL2 protein]]; notoginsenoside R1 inhibits the reaction [[Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in decreased expression of BCL2 protein]; notoginsenoside R1 inhibits the reaction [APP protein modified form results in decreased expression of BCL2 protein]		 CTD PMID:19224577 PMID:20023602 PMID:23170834 PMID:24975829 PMID:25305180 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bglap bone gamma-carboxyglutamate protein multiple interactions
increases expression		 ISO fulvestrant inhibits the reaction [notoginsenoside R1 results in increased expression of BGLAP mRNA] CTD PMID:26362186 NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495 		JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of BID protein modified form] CTD PMID:23170834 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP		 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [notoginsenoside R1 inhibits the reaction [triethylene glycol dimethacrylate results in increased cleavage of CASP3 protein]]; 3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [notoginsenoside R1 inhibits the reaction [triethylene glycol dimethacrylate results in increased cleavage of CASP3 protein]]; Cyclosporine inhibits the reaction [notoginsenoside R1 inhibits the reaction [triethylene glycol dimethacrylate results in increased cleavage of CASP3 protein]]; MCL1 protein promotes the reaction [notoginsenoside R1 inhibits the reaction [Bupivacaine results in increased cleavage of CASP3 protein]]; notoginsenoside R1 inhibits the reaction [Bupivacaine results in increased cleavage of CASP3 protein]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased activity of CASP3 protein]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of CASP3 protein modified form]; notoginsenoside R1 inhibits the reaction [triethylene glycol dimethacrylate results in increased cleavage of CASP3 protein]
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid inhibits the reaction [notoginsenoside R1 inhibits the reaction [[Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in increased cleavage of CASP3 protein]]; notoginsenoside R1 inhibits the reaction [[Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in increased activity of CASP3 protein]; notoginsenoside R1 inhibits the reaction [[Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in increased cleavage of CASP3 protein]; notoginsenoside R1 inhibits the reaction [APP protein modified form results in increased cleavage of CASP3 protein]; notoginsenoside R1 inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased activity of CASP3 protein]		 CTD PMID:23170834 PMID:24437944 PMID:24720662 PMID:24975829 PMID:25305180 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased activity of CASP8 protein] CTD PMID:23170834 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO MCL1 protein promotes the reaction [notoginsenoside R1 inhibits the reaction [Bupivacaine results in increased cleavage of CASP9 protein]]; notoginsenoside R1 inhibits the reaction [Bupivacaine results in increased cleavage of CASP9 protein]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased activity of CASP9 protein] CTD PMID:23170834 PMID:38316350 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase multiple interactions EXP notoginsenoside R1 inhibits the reaction [Streptozocin results in decreased activity of CAT protein] CTD PMID:25503068 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein] CTD PMID:23170834 PMID:25472953 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Chat choline O-acetyltransferase increases expression ISO notoginsenoside R1 results in increased expression of CHAT CTD PMID:25714973 NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO notoginsenoside R1 inhibits the reaction [Dextran Sulfate results in increased expression of CHUK protein modified form] CTD PMID:25472953 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity EXP notoginsenoside R1 results in decreased activity of CYP1A2 protein CTD PMID:25834921 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression ISO notoginsenoside R1 results in increased expression of CYP3A4 mRNA CTD PMID:25472953 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
increases expression		 ISO
EXP		 notoginsenoside R1 results in increased phosphorylation of and results in increased activity of ESR1 protein
notoginsenoside R1 results in increased expression of ESR1; notoginsenoside R1 results in increased expression of ESR1 mRNA; notoginsenoside R1 results in increased expression of ESR1 protein
[1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole results in decreased activity of ESR1 protein] which results in decreased susceptibility to notoginsenoside R1; [notoginsenoside R1 co-treated with Lipopolysaccharides] results in increased expression of ESR1 protein; fulvestrant inhibits the reaction [[notoginsenoside R1 co-treated with Lipopolysaccharides] results in increased expression of ESR1 protein]		 CTD PMID:23170834 PMID:24720662 PMID:25738436 PMID:26362186 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 increases expression EXP notoginsenoside R1 results in increased expression of ESR2 CTD PMID:24720662 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions ISO notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of F3 mRNA]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of F3 protein] CTD PMID:9102164 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of FAS mRNA] CTD PMID:23170834 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO notoginsenoside R1 inhibits the reaction [Hydrogen Peroxide results in increased expression of and results in increased secretion of FN1 protein]; notoginsenoside R1 inhibits the reaction [Hydrogen Peroxide results in increased expression of FN1 mRNA]; notoginsenoside R1 inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of FN1 protein]; notoginsenoside R1 inhibits the reaction [TNF protein results in increased expression of FN1 mRNA] CTD PMID:16632126 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
increases expression		 EXP Cycloheximide inhibits the reaction [notoginsenoside R1 results in increased expression of GCLC protein]; Dactinomycin inhibits the reaction [notoginsenoside R1 results in increased expression of GCLC protein]; fulvestrant inhibits the reaction [notoginsenoside R1 results in increased expression of GCLC protein]; NFE2L2 promotes the reaction [notoginsenoside R1 results in increased expression of GCLC protein]; notoginsenoside R1 promotes the reaction [Hydrogen Peroxide results in increased expression of GCLC protein] CTD PMID:24437944 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 multiple interactions ISO [GRIN1 protein co-treated with GRIN2B protein] results in increased susceptibility to notoginsenoside R1 CTD PMID:19224577 NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B multiple interactions ISO [GRIN1 protein co-treated with GRIN2B protein] results in increased susceptibility to notoginsenoside R1 CTD PMID:19224577 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions
increases expression		 ISO
EXP		 fulvestrant inhibits the reaction [notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in decreased expression of GSK3B protein modified form]]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in decreased expression of GSK3B protein modified form]; wortmannin inhibits the reaction [notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in decreased expression of GSK3B protein modified form]]
notoginsenoside R1 results in increased expression of GSK3B protein modified form		 CTD PMID:23170834 PMID:24720662 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression		 ISO
EXP		 [astragaloside A co-treated with ginsenoside Rg1 co-treated with ginsenoside Rb1 co-treated with notoginsenoside R1] results in increased expression of HMOX1 mRNA; [astragaloside A co-treated with ginsenoside Rg1 co-treated with ginsenoside Rb1 co-treated with notoginsenoside R1] results in increased expression of HMOX1 protein
notoginsenoside R1 results in increased expression of HMOX1; notoginsenoside R1 results in increased expression of HMOX1 protein
Cycloheximide inhibits the reaction [notoginsenoside R1 results in increased expression of HMOX1 protein]; Dactinomycin inhibits the reaction [notoginsenoside R1 results in increased expression of HMOX1 protein]; fulvestrant inhibits the reaction [notoginsenoside R1 results in increased expression of HMOX1 protein]; NFE2L2 promotes the reaction [notoginsenoside R1 results in increased expression of HMOX1 protein]; notoginsenoside R1 promotes the reaction [Hydrogen Peroxide results in increased expression of HMOX1 protein]