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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:bromodichloromethane
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Accession:CHEBI:34591 term browser browse the term
Definition:A halomethane that is dichloromethane in which oneof the hydrogens has been replaced by a bromine atom. It occurs as a contaminant in drinking water.
Synonyms:exact_synonym: bromo(dichloro)methane
 related_synonym: CHBrCl2;   Formula=CHBrCl2;   InChI=1S/CHBrCl2/c2-1(3)4/h1H;   InChIKey=FMWLUWPQPKEARP-UHFFFAOYSA-N;   SMILES=[H]C(Cl)(Cl)Br;   dichlorobromomethane;   dichloromonobromomethane;   monobromodichloromethane
 xref: Beilstein:1697005;   CAS:75-27-4;   Gmelin:25941;   KEGG:C14708
 xref_mesh: MESH:C025191
 xref: PMID:23446885;   PMID:24001804;   PMID:24647036;   Reaxys:1697005;   Wikipedia:Bromodichloromethane


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bromodichloromethane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B3gat1 beta-1,3-glucuronyltransferase 1 multiple interactions ISO [bromodichloromethane co-treated with Dietary Fats] results in increased expression of B3GAT1 protein CTD PMID:24211274 NCBI chr 8:25,087,123...25,114,692
Ensembl chr 8:25,087,547...25,113,395 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO [bromodichloromethane co-treated with Dietary Fats] results in increased expression of CASP3 protein modified form; [PRF1 protein co-treated with RAG2 protein] affects the reaction [[bromodichloromethane co-treated with Dietary Fats] results in increased expression of CASP3 protein modified form]; LEP protein affects the reaction [[bromodichloromethane co-treated with Dietary Fats] results in increased expression of CASP3 protein modified form] CTD PMID:24211274 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO bromodichloromethane promotes the reaction [Dietary Fats results in increased expression of CCL2 protein] CTD PMID:23438451 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccnd1 cyclin D1 increases expression EXP bromodichloromethane results in increased expression of CCND1 mRNA CTD PMID:24001804 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cd68 Cd68 molecule multiple interactions ISO [Dietary Fats co-treated with bromodichloromethane] results in increased expression of CD68 mRNA; gadolinium chloride inhibits the reaction [[Dietary Fats co-treated with bromodichloromethane] results in increased expression of CD68 mRNA] CTD PMID:23438451 NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697 		JBrowse link
G Cdh1 cadherin 1 decreases expression
increases methylation		 EXP bromodichloromethane results in decreased expression of CDH1 mRNA; bromodichloromethane results in decreased expression of CDH1 protein
bromodichloromethane results in increased methylation of CDH1 gene		 CTD PMID:24001804 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases metabolic processing
decreases expression
increases expression
affects metabolic processing
multiple interactions		 ISO
EXP		 CYP1A2 protein results in increased metabolism of bromodichloromethane
bromodichloromethane results in decreased expression of CYP1A2 protein
bromodichloromethane results in increased expression of CYP1A2 protein
CYP1A2 protein affects the metabolism of bromodichloromethane
isosafrole inhibits the reaction [CYP1A2 protein affects the metabolism of bromodichloromethane]; Tetrachlorodibenzodioxin promotes the reaction [CYP1A2 protein affects the metabolism of bromodichloromethane]		 CTD PMID:11295256 PMID:12062927 PMID:12076521 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression
increases metabolic processing
decreases expression		 EXP bromodichloromethane results in increased expression of CYP2B1 protein
CYP2B1 protein results in increased metabolism of bromodichloromethane
bromodichloromethane results in decreased expression of CYP2B1 protein		 CTD PMID:11295256 PMID:12076521 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases metabolic processing EXP CYP2B2 protein results in increased metabolism of bromodichloromethane CTD PMID:12076521 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
decreases response to substance
increases metabolic processing
increases expression		 EXP
ISO		 CYP2E1 protein results in increased metabolism of and results in increased activity of bromodichloromethane
[Dietary Fats co-treated with bromodichloromethane] results in increased expression of CYP2E1 protein; CYP2E1 protein affects the reaction [[bromodichloromethane co-treated with Dietary Fats] results in increased expression of IFNG mRNA]; CYP2E1 protein affects the reaction [[bromodichloromethane co-treated with Dietary Fats] results in increased expression of IL1B mRNA]; CYP2E1 protein affects the reaction [[bromodichloromethane co-treated with Dietary Fats] results in increased expression of IL2 mRNA]; CYP2E1 protein affects the susceptibility to [bromodichloromethane co-treated with Dietary Fats]
CYP2E1 gene mutant form results in decreased susceptibility to bromodichloromethane
CYP2E1 protein results in increased metabolism of bromodichloromethane
bromodichloromethane results in increased expression of CYP2E1 protein		 CTD PMID:9458004 PMID:11295256 PMID:12076521 PMID:12076522 PMID:18350910 More... NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases metabolic processing ISO CYP3A4 protein results in increased metabolism of bromodichloromethane CTD PMID:12076521 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Gpt glutamic--pyruvic transaminase increases expression ISO bromodichloromethane results in increased expression of GPT CTD PMID:25640707 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gstt1 glutathione S-transferase theta 1 increases metabolic processing
multiple interactions		 ISO
EXP		 GSTT1 protein results in increased metabolism of bromodichloromethane
GSTT1 protein affects the metabolism of [bromodichloromethane co-treated with Glutathione]		 CTD PMID:12588193 PMID:14998683 NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585 		JBrowse link
G Ifng interferon gamma multiple interactions ISO [bromodichloromethane co-treated with Dietary Fats] results in increased expression of IFNG mRNA; CYP2E1 protein affects the reaction [[bromodichloromethane co-treated with Dietary Fats] results in increased expression of IFNG mRNA] CTD PMID:24211274 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [bromodichloromethane co-treated with Dietary Fats] results in increased expression of IL1B mRNA; CYP2E1 protein affects the reaction [[bromodichloromethane co-treated with Dietary Fats] results in increased expression of IL1B mRNA] CTD PMID:24211274 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il2 interleukin 2 multiple interactions ISO [bromodichloromethane co-treated with Dietary Fats] results in increased expression of IL2 mRNA; [PRF1 protein co-treated with RAG2 protein] affects the reaction [[bromodichloromethane co-treated with Dietary Fats] results in increased expression of IL2 mRNA]; CYP2E1 protein affects the reaction [[bromodichloromethane co-treated with Dietary Fats] results in increased expression of IL2 mRNA] CTD PMID:24211274 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases expression EXP bromodichloromethane results in decreased expression of JUN mRNA CTD PMID:24001804 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Lep leptin increases expression
multiple interactions
decreases response to substance		 ISO bromodichloromethane results in increased expression of LEP mRNA
bromodichloromethane promotes the reaction [Dietary Fats results in increased expression of LEP mRNA]; LEP protein affects the reaction [[bromodichloromethane co-treated with Dietary Fats] results in increased expression of CASP3 protein modified form]; LEP protein affects the reaction [[Dietary Fats co-treated with bromodichloromethane] affects the localization of NCF2 protein]; LEP protein results in decreased susceptibility to [Dietary Fats co-treated with bromodichloromethane]
LEP gene mutant form results in decreased susceptibility to bromodichloromethane		 CTD PMID:23438451 PMID:23640861 PMID:24211274 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Lepr leptin receptor multiple interactions ISO LEPR protein affects the reaction [[Dietary Fats co-treated with bromodichloromethane] affects the localization of NCF2 protein]; LEPR protein results in decreased susceptibility to [Dietary Fats co-treated with bromodichloromethane] CTD PMID:23438451 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908 		JBrowse link
G Lhb luteinizing hormone subunit beta decreases secretion EXP bromodichloromethane results in decreased secretion of LHB protein CTD PMID:14657523 PMID:17344021 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases methylation
increases expression
decreases expression		 ISO
EXP		 bromodichloromethane results in decreased methylation of MYC promoter
bromodichloromethane results in increased expression of MYC mRNA
bromodichloromethane results in decreased expression of MYC mRNA		 CTD PMID:11099637 PMID:24001804 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Ncf2 neutrophil cytosolic factor 2 multiple interactions ISO [Dietary Fats co-treated with bromodichloromethane] affects the localization of NCF2 protein; LEP protein affects the reaction [[Dietary Fats co-treated with bromodichloromethane] affects the localization of NCF2 protein]; LEPR protein affects the reaction [[Dietary Fats co-treated with bromodichloromethane] affects the localization of NCF2 protein] CTD PMID:23438451 NCBI chr13:64,955,622...64,986,144
Ensembl chr13:64,955,503...64,986,277 		JBrowse link
G Pcna proliferating cell nuclear antigen increases expression ISO
EXP		 bromodichloromethane results in increased expression of PCNA protein CTD PMID:8717228 PMID:11099637 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Prf1 perforin 1 multiple interactions ISO [PRF1 protein co-treated with RAG2 protein] affects the reaction [[bromodichloromethane co-treated with Dietary Fats] results in increased expression of CASP3 protein modified form]; [PRF1 protein co-treated with RAG2 protein] affects the reaction [[bromodichloromethane co-treated with Dietary Fats] results in increased expression of IL2 mRNA]; [PRF1 protein co-treated with RAG2 protein] affects the susceptibility to [bromodichloromethane co-treated with Dietary Fats] CTD PMID:24211274 NCBI chr20:29,246,202...29,251,712
Ensembl chr20:29,246,202...29,251,701 		JBrowse link
G Rag2 recombination activating 2 multiple interactions ISO [PRF1 protein co-treated with RAG2 protein] affects the reaction [[bromodichloromethane co-treated with Dietary Fats] results in increased expression of CASP3 protein modified form]; [PRF1 protein co-treated with RAG2 protein] affects the reaction [[bromodichloromethane co-treated with Dietary Fats] results in increased expression of IL2 mRNA]; [PRF1 protein co-treated with RAG2 protein] affects the susceptibility to [bromodichloromethane co-treated with Dietary Fats] CTD PMID:24211274 NCBI chr 3:87,902,373...87,910,227
Ensembl chr 3:87,902,238...87,911,066 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Dietary Fats co-treated with bromodichloromethane] results in increased expression of TNF protein CTD PMID:23438451 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
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  CHEBI ontology 19841
    role 19817
      application 19661
        reagent 18015
          bromodichloromethane 26
Path 2
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  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19789
                    main group molecular entity 19789
                      s-block molecular entity 19626
                        hydrogen molecular entity 19613
                          hydrides 19120
                            organic hydride 18689
                              organic fundamental parent 18689
                                hydrocarbon 18435
                                  halohydrocarbon 15712
                                    haloalkane 12881
                                      halomethane 10354
                                        bromodichloromethane 26
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