|
Symbol |
Object Name |
Qualifiers
|
Evidence |
Notes |
Source |
PubMed Reference(s) |
RGD Reference(s) |
Position |
|
G
|
Akt1
|
AKT serine/threonine kinase 1
|
multiple interactions decreases phosphorylation
|
ISO
|
fraxetin inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein] fraxetin results in decreased phosphorylation of AKT1 protein
|
CTD |
PMID:34553399 PMID:37867445 |
|
NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921
|
|
G
|
Bax
|
BCL2 associated X, apoptosis regulator
|
decreases expression increases expression
|
ISO
|
fraxetin results in decreased expression of BAX protein Fraxetin increases expression of BAX protein in colorectum fraxetin results in increased expression of BAX mRNA; fraxetin results in increased expression of BAX protein
|
CTD RGD |
PMID:15996779 PMID:37867445 PMID:32504672 |
RGD:125097526 |
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
|
|
G
|
Bcl2
|
BCL2, apoptosis regulator
|
decreases expression
|
ISO
|
Fraxetin decreases expression of BCL2 protein in colorectum fraxetin results in decreased expression of BCL2 mRNA; fraxetin results in decreased expression of BCL2 protein
|
CTD RGD |
PMID:37867445 PMID:32504672 |
RGD:125097526 |
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
|
|
G
|
Casp3
|
caspase 3
|
decreases activity increases cleavage
|
ISO
|
fraxetin results in decreased activity of CASP3 protein fraxetin results in increased cleavage of CASP3 protein
|
CTD |
PMID:15996779 PMID:37867445 |
|
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
|
|
G
|
Casp9
|
caspase 9
|
decreases activity
|
ISO
|
fraxetin results in decreased activity of CASP9 protein
|
CTD |
PMID:15996779 |
|
Ensembl chr 5:154,109,046...154,126,626
|
|
G
|
Cat
|
catalase
|
multiple interactions
|
ISO
|
fraxetin inhibits the reaction [Rotenone results in increased expression of and results in increased activity of CAT protein]
|
CTD |
PMID:15904944 |
|
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
|
|
G
|
Ccna2
|
cyclin A2
|
decreases expression
|
ISO
|
Fraxetin decreases expression of CCNA2 protein in colorectum
|
RGD |
PMID:32504672 |
RGD:125097526 |
NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:119,426,089...119,433,577
|
|
G
|
Ccne1
|
cyclin E1
|
decreases expression
|
ISO
|
Fraxetin decreases expression of CCNE1 protein in colorectum
|
RGD |
PMID:32504672 |
RGD:125097526 |
NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:90,781,949...90,791,101
|
|
G
|
Cdk2
|
cyclin dependent kinase 2
|
decreases expression
|
ISO
|
Fraxetin decreases expression of CDK2 protein in colorectum
|
RGD |
PMID:32504672 |
RGD:125097526 |
NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,129,811...1,137,403
|
|
G
|
Cycs
|
cytochrome c, somatic
|
affects localization
|
ISO
|
fraxetin affects the localization of CYCS protein
|
CTD |
PMID:15996779 |
|
NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
|
|
G
|
Il6
|
interleukin 6
|
multiple interactions
|
ISO
|
fraxetin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL6 mRNA]
|
CTD |
PMID:30496664 |
|
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
|
|
G
|
Jak2
|
Janus kinase 2
|
decreases phosphorylation
|
ISO
|
Fraxetin decreases phosphorylation of JAK2 protein in colorectum
|
RGD |
PMID:32504672 |
RGD:125097526 |
NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:226,995,334...227,054,189
|
|
G
|
Mapk8
|
mitogen-activated protein kinase 8
|
decreases phosphorylation
|
ISO
|
fraxetin results in decreased phosphorylation of MAPK8 protein
|
CTD |
PMID:37867445 |
|
NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981
|
|
G
|
Mki67
|
marker of proliferation Ki-67
|
decreases expression
|
ISO
|
fraxetin results in decreased expression of MKI67 protein
|
CTD |
PMID:37867445 |
|
NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:190,496,319...190,522,762
|
|
G
|
Parp1
|
poly (ADP-ribose) polymerase 1
|
increases cleavage
|
ISO
|
fraxetin results in increased cleavage of PARP1 protein
|
CTD |
PMID:37867445 |
|
NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404
|
|
G
|
Skp2
|
S-phase kinase associated protein 2
|
decreases expression
|
ISO
|
Fraxetin decreases expression of SKP2 mRNA and protein in colorectum
|
RGD |
PMID:32504672 |
RGD:125097526 |
NCBI chr 2:58,161,226...58,189,293
Ensembl chr 2:58,161,229...58,189,338
|
|
G
|
Sod2
|
superoxide dismutase 2
|
multiple interactions
|
ISO
|
fraxetin inhibits the reaction [Rotenone results in increased expression of and results in increased activity of SOD2 protein]
|
CTD |
PMID:15904944 |
|
NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189
|
|
G
|
Stat3
|
signal transducer and activator of transcription 3
|
decreases phosphorylation
|
ISO
|
Fraxetin decreases phosphorylation of STAT3 protein in colorectum
|
RGD |
PMID:32504672 |
RGD:125097526 |
NCBI chr10:86,311,528...86,363,513
Ensembl chr10:85,811,218...85,863,057
|
|
G
|
Tnf
|
tumor necrosis factor
|
multiple interactions
|
ISO
|
fraxetin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of TNF mRNA]
|
CTD |
PMID:30496664 |
|
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
|
|