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G |
Samhd1 |
SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 |
decreases abundance |
ISO |
SAMHD1 protein results in decreased abundance of deoxyguanosine triphosphate |
CTD |
PMID:26342080 |
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NCBI chr 3:166,179,742...166,214,448
Ensembl chr 3:145,761,558...145,794,386
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G |
Akt1 |
AKT serine/threonine kinase 1 |
decreases phosphorylation multiple interactions |
ISO |
fraxetin results in decreased phosphorylation of AKT1 protein fraxetin inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein] |
CTD |
PMID:34553399 PMID:37867445 |
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NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression decreases expression |
ISO |
Fraxetin increases expression of BAX protein in colorectum fraxetin results in decreased expression of BAX protein fraxetin results in increased expression of BAX mRNA; fraxetin results in increased expression of BAX protein |
CTD RGD |
PMID:15996779 PMID:37867445 PMID:32504672 |
RGD:125097526 |
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression |
ISO |
Fraxetin decreases expression of BCL2 protein in colorectum fraxetin results in decreased expression of BCL2 mRNA; fraxetin results in decreased expression of BCL2 protein |
CTD RGD |
PMID:37867445 PMID:32504672 |
RGD:125097526 |
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Casp3 |
caspase 3 |
decreases activity increases cleavage |
ISO |
fraxetin results in decreased activity of CASP3 protein fraxetin results in increased cleavage of CASP3 protein |
CTD |
PMID:15996779 PMID:37867445 |
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NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
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G |
Casp9 |
caspase 9 |
decreases activity |
ISO |
fraxetin results in decreased activity of CASP9 protein |
CTD |
PMID:15996779 |
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Ensembl chr 5:154,109,046...154,126,626
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G |
Cat |
catalase |
multiple interactions |
ISO |
fraxetin inhibits the reaction [Rotenone results in increased expression of and results in increased activity of CAT protein] |
CTD |
PMID:15904944 |
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NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
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G |
Ccna2 |
cyclin A2 |
decreases expression |
ISO |
Fraxetin decreases expression of CCNA2 protein in colorectum |
RGD |
PMID:32504672 |
RGD:125097526 |
NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:119,426,089...119,433,577
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G |
Ccne1 |
cyclin E1 |
decreases expression |
ISO |
Fraxetin decreases expression of CCNE1 protein in colorectum |
RGD |
PMID:32504672 |
RGD:125097526 |
NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:90,781,949...90,791,101
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G |
Cdk2 |
cyclin dependent kinase 2 |
decreases expression |
ISO |
Fraxetin decreases expression of CDK2 protein in colorectum |
RGD |
PMID:32504672 |
RGD:125097526 |
NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,129,811...1,137,403
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G |
Cycs |
cytochrome c, somatic |
affects localization |
ISO |
fraxetin affects the localization of CYCS protein |
CTD |
PMID:15996779 |
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NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
fraxetin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL6 mRNA] |
CTD |
PMID:30496664 |
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NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
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G |
Jak2 |
Janus kinase 2 |
decreases phosphorylation |
ISO |
Fraxetin decreases phosphorylation of JAK2 protein in colorectum |
RGD |
PMID:32504672 |
RGD:125097526 |
NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:226,995,334...227,054,189
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
decreases phosphorylation |
ISO |
fraxetin results in decreased phosphorylation of MAPK8 protein |
CTD |
PMID:37867445 |
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NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981
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G |
Mki67 |
marker of proliferation Ki-67 |
decreases expression |
ISO |
fraxetin results in decreased expression of MKI67 protein |
CTD |
PMID:37867445 |
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NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:190,496,319...190,522,762
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
increases cleavage |
ISO |
fraxetin results in increased cleavage of PARP1 protein |
CTD |
PMID:37867445 |
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NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404
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G |
Skp2 |
S-phase kinase associated protein 2 |
decreases expression |
ISO |
Fraxetin decreases expression of SKP2 mRNA and protein in colorectum |
RGD |
PMID:32504672 |
RGD:125097526 |
NCBI chr 2:59,888,406...59,916,471
Ensembl chr 2:58,161,229...58,189,338
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G |
Sod2 |
superoxide dismutase 2 |
multiple interactions |
ISO |
fraxetin inhibits the reaction [Rotenone results in increased expression of and results in increased activity of SOD2 protein] |
CTD |
PMID:15904944 |
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NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189
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G |
Stat3 |
signal transducer and activator of transcription 3 |
decreases phosphorylation |
ISO |
Fraxetin decreases phosphorylation of STAT3 protein in colorectum |
RGD |
PMID:32504672 |
RGD:125097526 |
NCBI chr10:86,311,528...86,363,513
Ensembl chr10:85,811,218...85,863,057
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
fraxetin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of TNF mRNA] |
CTD |
PMID:30496664 |
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NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
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