Samhd1 (SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1) - Rat Genome Database

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Gene: Samhd1 (SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1) Rattus norvegicus
Analyze
Symbol: Samhd1
Name: SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1
RGD ID: 1308369
Description: Predicted to enable several functions, including dGTP binding activity; dGTPase activity; and nucleic acid binding activity. Predicted to be involved in several processes, including DNA metabolic process; modulation by host of viral RNA genome replication; and purine deoxyribonucleoside triphosphate catabolic process. Predicted to be located in nucleoplasm; site of double-strand break; and tetraspanin-enriched microdomain. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome; Chilblain lupus; acute myeloid leukemia; hepatitis B; and hepatitis C. Orthologous to human SAMHD1 (SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: deoxynucleoside triphosphate triphosphohydrolase SAMHD1; LOC311580; SAM domain and HD domain, 1; SAM domain and HD domain-containing protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83166,179,742 - 166,214,448 (-)NCBIGRCr8
mRatBN7.23145,761,549 - 145,794,420 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3145,761,558 - 145,794,386 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3149,586,957 - 149,619,774 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03158,084,906 - 158,117,628 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03155,825,467 - 155,858,563 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03153,210,829 - 153,250,705 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3153,210,829 - 153,250,641 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03158,468,644 - 158,504,183 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43147,689,421 - 147,727,429 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13147,595,329 - 147,627,065 (-)NCBI
Celera3144,468,270 - 144,500,913 (-)NCBICelera
Cytogenetic Map3q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-alpha-phellandrene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (ISO)
alpha-pinene  (ISO)
alpha-Zearalanol  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
coumarin  (ISO)
cyclosporin A  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dGTP  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
enzyme inhibitor  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
Genipin  (ISO)
gentamycin  (EXP)
indometacin  (ISO)
irinotecan  (ISO)
ivermectin  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
mercury dibromide  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
nickel atom  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylmercury acetate  (ISO)
picoxystrobin  (ISO)
quercetin  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP,ISO)
succimer  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP)
triptonide  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. A viral kinase counteracts in vivo restriction of murine cytomegalovirus by SAMHD1. Deutschmann J, etal., Nat Microbiol. 2019 Dec;4(12):2273-2284. doi: 10.1038/s41564-019-0529-z. Epub 2019 Sep 23.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. SAMHD1 inhibits epithelial cell transformation in vitro and affects leukemia development in xenograft mice. Kodigepalli KM, etal., Cell Cycle. 2018;17(23):2564-2576. doi: 10.1080/15384101.2018.1550955. Epub 2018 Dec 4.
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Identification of natural splice variants of SAMHD1 in virus-infected HCC. Shi Y, etal., Oncol Rep. 2014 Feb;31(2):687-92. doi: 10.3892/or.2013.2895. Epub 2013 Dec 5.
Additional References at PubMed
PMID:19525956   PMID:22056990   PMID:22069334   PMID:22461318   PMID:23601106   PMID:23972988   PMID:24141705   PMID:24217394   PMID:25038827   PMID:26294762   PMID:27920203   PMID:28834754  
PMID:28871089   PMID:29379009   PMID:29669924   PMID:29670289  


Genomics

Comparative Map Data
Samhd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83166,179,742 - 166,214,448 (-)NCBIGRCr8
mRatBN7.23145,761,549 - 145,794,420 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3145,761,558 - 145,794,386 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3149,586,957 - 149,619,774 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03158,084,906 - 158,117,628 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03155,825,467 - 155,858,563 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03153,210,829 - 153,250,705 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3153,210,829 - 153,250,641 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03158,468,644 - 158,504,183 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43147,689,421 - 147,727,429 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13147,595,329 - 147,627,065 (-)NCBI
Celera3144,468,270 - 144,500,913 (-)NCBICelera
Cytogenetic Map3q42NCBI
SAMHD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382036,889,773 - 36,951,708 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2036,890,229 - 36,951,893 (-)EnsemblGRCh38hg38GRCh38
GRCh372035,518,176 - 35,580,111 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362034,954,059 - 35,013,590 (-)NCBINCBI36Build 36hg18NCBI36
Build 342034,954,058 - 35,013,590NCBI
Celera2032,227,775 - 32,287,786 (-)NCBICelera
Cytogenetic Map20q11.23NCBI
HuRef2032,255,951 - 32,316,085 (-)NCBIHuRef
CHM1_12035,421,787 - 35,482,498 (-)NCBICHM1_1
T2T-CHM13v2.02038,614,121 - 38,676,051 (-)NCBIT2T-CHM13v2.0
Samhd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392156,939,454 - 156,977,016 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2156,939,453 - 156,977,185 (-)EnsemblGRCm39 Ensembl
GRCm382157,097,534 - 157,135,096 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2157,097,533 - 157,135,265 (-)EnsemblGRCm38mm10GRCm38
MGSCv372156,923,265 - 156,960,958 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362156,788,970 - 156,826,663 (-)NCBIMGSCv36mm8
Celera2163,030,928 - 163,069,082 (-)NCBICelera
Cytogenetic Map2H1NCBI
cM Map278.0NCBI
Samhd1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542224,735,161 - 24,778,830 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542224,714,103 - 24,780,672 (+)NCBIChiLan1.0ChiLan1.0
SAMHD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22142,629,145 - 42,687,452 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12042,622,243 - 42,680,550 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02033,224,200 - 33,282,018 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12034,341,367 - 34,398,514 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2034,341,367 - 34,398,314 (-)Ensemblpanpan1.1panPan2
SAMHD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12425,623,997 - 25,676,336 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2425,626,134 - 25,680,902 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2425,269,008 - 25,324,975 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02426,321,372 - 26,377,665 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2426,322,848 - 26,373,771 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12425,599,032 - 25,655,273 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02425,699,545 - 25,755,789 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02426,189,021 - 26,245,159 (-)NCBIUU_Cfam_GSD_1.0
Samhd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640174,510,839 - 174,568,927 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365614,180,546 - 4,229,036 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365614,180,607 - 4,238,623 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SAMHD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1740,107,462 - 40,171,878 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11740,117,348 - 40,171,935 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21745,558,314 - 45,611,643 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SAMHD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1257,641,634 - 57,699,685 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl257,639,046 - 57,699,525 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666054357,564 - 415,279 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Samhd1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248422,591,148 - 2,647,742 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248422,591,016 - 2,649,746 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Samhd1
243 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:55
Count of miRNA genes:47
Interacting mature miRNAs:53
Transcripts:ENSRNOT00000008961, ENSRNOT00000067748
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
61335Bp20Blood pressure QTL 203arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141339236155617360Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
2317883Alcrsp26Alcohol response QTL 261.80.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)3145526770169034231Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141339013162184794Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3121056165145956249Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3121056165157309487Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3140069424146976080Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3130193298161695983Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat

Markers in Region
RH139202  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map31341.1UniSTS
Cytogenetic Map3q42UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 6 19 12 18 12 12 10 25 10
Low 1 37 38 29 1 29 8 11 62 25 16 1 8
Below cutoff

Sequence


Ensembl Acc Id: ENSRNOT00000008961   ⟹   ENSRNOP00000008961
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3145,761,558 - 145,794,386 (-)Ensembl
Rnor_6.0 Ensembl3153,210,829 - 153,250,641 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000067748   ⟹   ENSRNOP00000059210
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3145,761,558 - 145,789,602 (-)Ensembl
Rnor_6.0 Ensembl3153,211,004 - 153,246,433 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103535   ⟹   ENSRNOP00000087823
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3145,761,973 - 145,794,386 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116624   ⟹   ENSRNOP00000090074
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3145,761,558 - 145,794,386 (-)Ensembl
RefSeq Acc Id: NM_001191743   ⟹   NP_001178672
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83166,181,588 - 166,214,410 (-)NCBI
mRatBN7.23145,761,558 - 145,794,386 (-)NCBI
Rnor_6.03153,210,829 - 153,250,641 (-)NCBI
Rnor_5.03158,468,644 - 158,504,183 (+)NCBI
Celera3144,468,270 - 144,500,913 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039105087   ⟹   XP_038961015
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83166,179,742 - 166,214,448 (-)NCBI
mRatBN7.23145,761,549 - 145,794,420 (-)NCBI
RefSeq Acc Id: XM_039105088   ⟹   XP_038961016
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83166,179,742 - 166,202,555 (-)NCBI
mRatBN7.23145,761,549 - 145,782,530 (-)NCBI
RefSeq Acc Id: NP_001178672   ⟸   NM_001191743
- UniProtKB: D3Z898 (UniProtKB/TrEMBL),   A0A8I6ACW3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000008961   ⟸   ENSRNOT00000008961
Ensembl Acc Id: ENSRNOP00000059210   ⟸   ENSRNOT00000067748
RefSeq Acc Id: XP_038961015   ⟸   XM_039105087
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A3V5 (UniProtKB/TrEMBL),   A0A8I6ACW3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961016   ⟸   XM_039105088
- Peptide Label: isoform X2
- UniProtKB: A6JWR1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000087823   ⟸   ENSRNOT00000103535
Ensembl Acc Id: ENSRNOP00000090074   ⟸   ENSRNOT00000116624
Protein Domains
HD   SAM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3Z898-F1-model_v2 AlphaFold D3Z898 1-620 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692608
Promoter ID:EPDNEW_R3133
Type:multiple initiation site
Name:Samhd1_1
Description:SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03153,250,624 - 153,250,684EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308369 AgrOrtholog
BioCyc Gene G2FUF-47065 BioCyc
Ensembl Genes ENSRNOG00000006418 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000008961.8 UniProtKB/TrEMBL
  ENSRNOT00000067748.4 UniProtKB/TrEMBL
  ENSRNOT00000103535.1 UniProtKB/TrEMBL
  ENSRNOT00000116624.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.150.50 UniProtKB/TrEMBL
  3.30.70.2760 UniProtKB/TrEMBL
  Hypothetical protein af1432 UniProtKB/TrEMBL
InterPro HD/PDEase_dom UniProtKB/TrEMBL
  Metal-dep_PHydrolase_HD_sub UniProtKB/TrEMBL
  SAM UniProtKB/TrEMBL
  SAM/pointed UniProtKB/TrEMBL
KEGG Report rno:311580 UniProtKB/TrEMBL
NCBI Gene 311580 ENTREZGENE
PANTHER DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE UniProtKB/TrEMBL
  DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1 UniProtKB/TrEMBL
Pfam PF01966 UniProtKB/TrEMBL
  SAM_2 UniProtKB/TrEMBL
PhenoGen Samhd1 PhenoGen
PROSITE PS51831 UniProtKB/TrEMBL
  SAM_DOMAIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006418 RatGTEx
SMART HDc UniProtKB/TrEMBL
  SAM UniProtKB/TrEMBL
Superfamily-SCOP HD-domain/PDEase-like UniProtKB/TrEMBL
  SSF47769 UniProtKB/TrEMBL
UniProt A0A8I6A3V5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ACW3 ENTREZGENE, UniProtKB/TrEMBL
  A6JWR1 ENTREZGENE, UniProtKB/TrEMBL
  D3Z898 ENTREZGENE, UniProtKB/TrEMBL
  D4A2W9_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-11 Samhd1  SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1  Samhd1  SAM domain and HD domain, 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Samhd1  SAM domain and HD domain, 1   Samhd1_predicted  SAM domain and HD domain, 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Samhd1_predicted  SAM domain and HD domain, 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED