SAMHD1 (SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1) - Rat Genome Database

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Gene: SAMHD1 (SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1) Pan paniscus
Analyze
Symbol: SAMHD1
Name: SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1
RGD ID: 11756775
Description: ENCODES a protein that exhibits RNA nuclease activity (ortholog); INVOLVED IN modulation by host of viral RNA genome replication (ortholog); negative regulation of viral life cycle (ortholog); positive regulation of DNA-templated transcription (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); Aicardi-Goutieres syndrome (ortholog); Aicardi-Goutieres Syndrome 5 (ortholog); FOUND IN chromosome (inferred); nucleoplasm (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: deoxynucleoside triphosphate triphosphohydrolase SAMHD1; SAM domain and HD domain-containing protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22142,629,145 - 42,687,452 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12042,622,243 - 42,680,550 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02033,224,200 - 33,282,018 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12034,341,367 - 34,398,514 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2034,341,367 - 34,398,314 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22284954   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SAMHD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22142,629,145 - 42,687,452 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12042,622,243 - 42,680,550 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02033,224,200 - 33,282,018 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12034,341,367 - 34,398,514 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2034,341,367 - 34,398,314 (-)Ensemblpanpan1.1panPan2
SAMHD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382036,889,773 - 36,951,708 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2036,890,229 - 36,951,893 (-)EnsemblGRCh38hg38GRCh38
GRCh372035,518,176 - 35,580,111 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362034,954,059 - 35,013,590 (-)NCBINCBI36Build 36hg18NCBI36
Build 342034,954,058 - 35,013,590NCBI
Celera2032,227,775 - 32,287,786 (-)NCBICelera
Cytogenetic Map20q11.23NCBI
HuRef2032,255,951 - 32,316,085 (-)NCBIHuRef
CHM1_12035,421,787 - 35,482,498 (-)NCBICHM1_1
T2T-CHM13v2.02038,614,121 - 38,676,051 (-)NCBIT2T-CHM13v2.0
Samhd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392156,939,454 - 156,977,016 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2156,939,453 - 156,977,185 (-)EnsemblGRCm39 Ensembl
GRCm382157,097,534 - 157,135,096 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2157,097,533 - 157,135,265 (-)EnsemblGRCm38mm10GRCm38
MGSCv372156,923,265 - 156,960,958 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362156,788,970 - 156,826,663 (-)NCBIMGSCv36mm8
Celera2163,030,928 - 163,069,082 (-)NCBICelera
Cytogenetic Map2H1NCBI
cM Map278.0NCBI
Samhd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83166,179,742 - 166,214,448 (-)NCBIGRCr8
mRatBN7.23145,761,549 - 145,794,420 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3145,761,558 - 145,794,386 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3149,586,957 - 149,619,774 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03158,084,906 - 158,117,628 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03155,825,467 - 155,858,563 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03153,210,829 - 153,250,705 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3153,210,829 - 153,250,641 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03158,468,644 - 158,504,183 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43147,689,421 - 147,727,429 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13147,595,329 - 147,627,065 (-)NCBI
Celera3144,468,270 - 144,500,913 (-)NCBICelera
Cytogenetic Map3q42NCBI
Samhd1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542224,735,161 - 24,778,830 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542224,714,103 - 24,780,672 (+)NCBIChiLan1.0ChiLan1.0
SAMHD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12425,623,997 - 25,676,336 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2425,626,134 - 25,680,902 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2425,269,008 - 25,324,975 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02426,321,372 - 26,377,665 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2426,322,848 - 26,373,771 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12425,599,032 - 25,655,273 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02425,699,545 - 25,755,789 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02426,189,021 - 26,245,159 (-)NCBIUU_Cfam_GSD_1.0
Samhd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640174,510,839 - 174,568,927 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365614,180,546 - 4,229,036 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365614,180,607 - 4,238,623 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SAMHD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1740,107,462 - 40,171,878 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11740,117,348 - 40,171,935 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21745,558,314 - 45,611,643 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SAMHD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1257,641,634 - 57,699,685 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl257,639,046 - 57,699,525 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666054357,564 - 415,279 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Samhd1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248422,591,148 - 2,647,742 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248422,591,016 - 2,649,746 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000053527   ⟹   ENSPPAP00000030664
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2034,341,367 - 34,398,314 (-)Ensembl
RefSeq Acc Id: NM_001279186   ⟹   NP_001266115
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22142,629,145 - 42,687,452 (-)NCBI
NHGRI_mPanPan12042,622,243 - 42,680,550 (-)NCBI
Mhudiblu_PPA_v02033,224,200 - 33,282,018 (-)NCBI
PanPan1.12034,341,367 - 34,398,314 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001266115 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AFB71158 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000030664
  ENSPPAP00000030664.1
RefSeq Acc Id: NP_001266115   ⟸   NM_001279186
- UniProtKB: H6WE98 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSPPAP00000030664   ⟸   ENSPPAT00000053527
Protein Domains
HD   SAM


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000038261 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000053527 ENTREZGENE
  ENSPPAT00000053527.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.150.50 UniProtKB/TrEMBL
  3.30.70.2760 UniProtKB/TrEMBL
  Hypothetical protein af1432 UniProtKB/TrEMBL
InterPro dGTPase UniProtKB/TrEMBL
  HD/PDEase_dom UniProtKB/TrEMBL
  HD_domain UniProtKB/TrEMBL
  SAM UniProtKB/TrEMBL
  SAM/pointed_sf UniProtKB/TrEMBL
KEGG Report pps:100972586 UniProtKB/TrEMBL
NCBI Gene SAMHD1 ENTREZGENE
PANTHER DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE UniProtKB/TrEMBL
  DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1 UniProtKB/TrEMBL
Pfam PF01966 UniProtKB/TrEMBL
  SAM_2 UniProtKB/TrEMBL
PROSITE PS51831 UniProtKB/TrEMBL
  SAM_DOMAIN UniProtKB/TrEMBL
SMART HDc UniProtKB/TrEMBL
  SAM UniProtKB/TrEMBL
Superfamily-SCOP HD-domain/PDEase-like UniProtKB/TrEMBL
  SSF47769 UniProtKB/TrEMBL
UniProt H6WE98 ENTREZGENE, UniProtKB/TrEMBL