SAMHD1 (SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1) - Rat Genome Database

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Gene: SAMHD1 (SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1) Sus scrofa
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Symbol: SAMHD1
Name: SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1
RGD ID: 14080891
Description: ENCODES a protein that exhibits dGTP binding (ortholog); dGTPase activity (ortholog); nucleic acid binding (ortholog); INVOLVED IN modulation by host of viral RNA genome replication; negative regulation of viral life cycle; positive regulation of DNA-templated transcription; ASSOCIATED WITH acute myeloid leukemia (ortholog); Aicardi-Goutieres syndrome (ortholog); Aicardi-Goutieres Syndrome 5 (ortholog); FOUND IN nucleus; nucleoplasm (ortholog); plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: deoxynucleoside triphosphate triphosphohydrolase SAMHD1; SAM domain and HD domain 1; SAM domain and HD domain-containing protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1740,107,462 - 40,171,878 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11740,117,348 - 40,171,935 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21745,558,314 - 45,611,643 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SAMHD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1740,107,462 - 40,171,878 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11740,117,348 - 40,171,935 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21745,558,314 - 45,611,643 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SAMHD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382036,889,773 - 36,951,708 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2036,890,229 - 36,951,893 (-)EnsemblGRCh38hg38GRCh38
GRCh372035,518,176 - 35,580,111 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362034,954,059 - 35,013,590 (-)NCBINCBI36Build 36hg18NCBI36
Build 342034,954,058 - 35,013,590NCBI
Celera2032,227,775 - 32,287,786 (-)NCBICelera
Cytogenetic Map20q11.23NCBI
HuRef2032,255,951 - 32,316,085 (-)NCBIHuRef
CHM1_12035,421,787 - 35,482,498 (-)NCBICHM1_1
T2T-CHM13v2.02038,614,121 - 38,676,051 (-)NCBIT2T-CHM13v2.0
Samhd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392156,939,454 - 156,977,016 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2156,939,453 - 156,977,185 (-)EnsemblGRCm39 Ensembl
GRCm382157,097,534 - 157,135,096 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2157,097,533 - 157,135,265 (-)EnsemblGRCm38mm10GRCm38
MGSCv372156,923,265 - 156,960,958 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362156,788,970 - 156,826,663 (-)NCBIMGSCv36mm8
Celera2163,030,928 - 163,069,082 (-)NCBICelera
Cytogenetic Map2H1NCBI
cM Map278.0NCBI
Samhd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83166,179,742 - 166,214,448 (-)NCBIGRCr8
mRatBN7.23145,761,549 - 145,794,420 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3145,761,558 - 145,794,386 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3149,586,957 - 149,619,774 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03158,084,906 - 158,117,628 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03155,825,467 - 155,858,563 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03153,210,829 - 153,250,705 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3153,210,829 - 153,250,641 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03158,468,644 - 158,504,183 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43147,689,421 - 147,727,429 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13147,595,329 - 147,627,065 (-)NCBI
Celera3144,468,270 - 144,500,913 (-)NCBICelera
Cytogenetic Map3q42NCBI
Samhd1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542224,735,161 - 24,778,830 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542224,714,103 - 24,780,672 (+)NCBIChiLan1.0ChiLan1.0
SAMHD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22142,629,145 - 42,687,452 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12042,622,243 - 42,680,550 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02033,224,200 - 33,282,018 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12034,341,367 - 34,398,514 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2034,341,367 - 34,398,314 (-)Ensemblpanpan1.1panPan2
SAMHD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12425,623,997 - 25,676,336 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2425,626,134 - 25,680,902 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2425,269,008 - 25,324,975 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02426,321,372 - 26,377,665 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2426,322,848 - 26,373,771 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12425,599,032 - 25,655,273 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02425,699,545 - 25,755,789 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02426,189,021 - 26,245,159 (-)NCBIUU_Cfam_GSD_1.0
Samhd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640174,510,839 - 174,568,927 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365614,180,546 - 4,229,036 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365614,180,607 - 4,238,623 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SAMHD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1257,641,634 - 57,699,685 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl257,639,046 - 57,699,525 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666054357,564 - 415,279 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Samhd1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248422,591,148 - 2,647,742 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248422,591,016 - 2,649,746 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SAMHD1
1304 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 2 5 14 12 23 3 6 3

Sequence


Ensembl Acc Id: ENSSSCT00000028674   ⟹   ENSSSCP00000023070
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1740,118,492 - 40,171,878 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000028943   ⟹   ENSSSCP00000027150
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1740,107,462 - 40,171,858 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000078425   ⟹   ENSSSCP00000061926
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1740,118,492 - 40,171,878 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000080962   ⟹   ENSSSCP00000074351
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1740,118,490 - 40,171,877 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000086514   ⟹   ENSSSCP00000070173
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1740,121,396 - 40,171,878 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000086809   ⟹   ENSSSCP00000060044
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1740,118,492 - 40,171,878 (-)Ensembl
RefSeq Acc Id: NM_001292105   ⟹   NP_001279034
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11740,118,490 - 40,171,877 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021077221   ⟹   XP_020932880
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11740,122,190 - 40,171,935 (-)NCBI
Sequence:
RefSeq Acc Id: XR_002339825
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11740,117,348 - 40,171,935 (-)NCBI
Sequence:
RefSeq Acc Id: XR_002339826
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11740,118,489 - 40,171,935 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001279034   ⟸   NM_001292105
- UniProtKB: A0A023VTS2 (UniProtKB/TrEMBL),   A0A8D0MRV6 (UniProtKB/TrEMBL),   A0A8D1KSI6 (UniProtKB/TrEMBL),   I3LG77 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020932880   ⟸   XM_021077221
- Peptide Label: isoform X1
- UniProtKB: A0A8D1ZX92 (UniProtKB/TrEMBL),   A0A4X1TII1 (UniProtKB/TrEMBL),   A0A8D0RAT9 (UniProtKB/TrEMBL),   A0A8D1EV32 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000061926   ⟸   ENSSSCT00000078425
Ensembl Acc Id: ENSSSCP00000074351   ⟸   ENSSSCT00000080962
Ensembl Acc Id: ENSSSCP00000070173   ⟸   ENSSSCT00000086514
Ensembl Acc Id: ENSSSCP00000023070   ⟸   ENSSSCT00000028674
Ensembl Acc Id: ENSSSCP00000027150   ⟸   ENSSSCT00000028943
Ensembl Acc Id: ENSSSCP00000060044   ⟸   ENSSSCT00000086809
Protein Domains
HD   SAM


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000027806 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015012697 UniProtKB/TrEMBL
  ENSSSCG00025023301 UniProtKB/TrEMBL
  ENSSSCG00030020733 UniProtKB/TrEMBL
  ENSSSCG00035031607 UniProtKB/TrEMBL
  ENSSSCG00040046530 UniProtKB/TrEMBL
  ENSSSCG00045007218 UniProtKB/TrEMBL
  ENSSSCG00055019867 UniProtKB/TrEMBL
  ENSSSCG00060074956 UniProtKB/TrEMBL
  ENSSSCG00065071595 UniProtKB/TrEMBL
  ENSSSCG00070009704 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000028674 ENTREZGENE
  ENSSSCT00000028674.3 UniProtKB/TrEMBL
  ENSSSCT00000028943.4 UniProtKB/TrEMBL
  ENSSSCT00000078425.1 UniProtKB/TrEMBL
  ENSSSCT00000080962.2 UniProtKB/TrEMBL
  ENSSSCT00000086514 ENTREZGENE
  ENSSSCT00000086514.2 UniProtKB/TrEMBL
  ENSSSCT00000086809.1 UniProtKB/TrEMBL
  ENSSSCT00015017330.1 UniProtKB/TrEMBL
  ENSSSCT00025031615.1 UniProtKB/TrEMBL
  ENSSSCT00025031771.1 UniProtKB/TrEMBL
  ENSSSCT00030028650.1 UniProtKB/TrEMBL
  ENSSSCT00035041857.1 UniProtKB/TrEMBL
  ENSSSCT00035041870.1 UniProtKB/TrEMBL
  ENSSSCT00035041896.1 UniProtKB/TrEMBL
  ENSSSCT00040063797.1 UniProtKB/TrEMBL
  ENSSSCT00040064310.1 UniProtKB/TrEMBL
  ENSSSCT00045012226.1 UniProtKB/TrEMBL
  ENSSSCT00045012294.1 UniProtKB/TrEMBL
  ENSSSCT00055038958.1 UniProtKB/TrEMBL
  ENSSSCT00055039401.1 UniProtKB/TrEMBL
  ENSSSCT00060103471.1 UniProtKB/TrEMBL
  ENSSSCT00065098903.1 UniProtKB/TrEMBL
  ENSSSCT00065098944.1 UniProtKB/TrEMBL
  ENSSSCT00065098963.1 UniProtKB/TrEMBL
  ENSSSCT00070018979.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.150.50 UniProtKB/TrEMBL
  3.30.70.2760 UniProtKB/TrEMBL
  Hypothetical protein af1432 UniProtKB/TrEMBL
InterPro dGTPase UniProtKB/TrEMBL
  HD/PDEase_dom UniProtKB/TrEMBL
  HD_domain UniProtKB/TrEMBL
  SAM UniProtKB/TrEMBL
  SAM/pointed_sf UniProtKB/TrEMBL
KEGG Report ssc:100154500 UniProtKB/TrEMBL
NCBI Gene SAMHD1 ENTREZGENE
PANTHER DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE UniProtKB/TrEMBL
  DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1 UniProtKB/TrEMBL
Pfam PF01966 UniProtKB/TrEMBL
  SAM_2 UniProtKB/TrEMBL
PROSITE PS51831 UniProtKB/TrEMBL
  SAM_DOMAIN UniProtKB/TrEMBL
SMART HDc UniProtKB/TrEMBL
  SAM UniProtKB/TrEMBL
Superfamily-SCOP HD-domain/PDEase-like UniProtKB/TrEMBL
  SSF47769 UniProtKB/TrEMBL
UniProt A0A023VTS2 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1TII1 ENTREZGENE, UniProtKB/TrEMBL
  A0A5G2Q7I5_PIG UniProtKB/TrEMBL
  A0A5G2QUS9_PIG UniProtKB/TrEMBL
  A0A5G2QZ64_PIG UniProtKB/TrEMBL
  A0A5G2RD15_PIG UniProtKB/TrEMBL
  A0A8D0MRV6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0RAT9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1EV32 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1KSI6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1ZX92 ENTREZGENE, UniProtKB/TrEMBL
  I3LG77 ENTREZGENE, UniProtKB/TrEMBL
  I3LSQ7_PIG UniProtKB/TrEMBL
VGNC ID VGNC:95712 ENTREZGENE