Bdnf (brain-derived neurotrophic factor) - Rat Genome Database

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Gene: Bdnf (brain-derived neurotrophic factor) Rattus norvegicus
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Symbol: Bdnf
Name: brain-derived neurotrophic factor
RGD ID: 2202
Description: Enables neurotrophin TRKB receptor binding activity. Involved in several processes, including behavioral response to cocaine; neuron projection development; and regulation of neuronal synaptic plasticity. Acts upstream of or within positive regulation of DNA-binding transcription factor activity; positive regulation of nuclear receptor-mediated glucocorticoid signaling pathway; and positive regulation of peptidyl-serine phosphorylation. Located in several cellular components, including mitochondrial crista; perikaryon; and secretory vesicle. Used to study several diseases, including alcohol dependence; cocaine dependence; neuropathy (multiple); status epilepticus; and transient cerebral ischemia. Biomarker of several diseases, including alcohol dependence; alcohol use disorder; brain disease (multiple); cognitive disorder (multiple); and neuropathy (multiple). Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; cocaine dependence; cognitive disorder (multiple); congenital central hypoventilation syndrome; and neurodegenerative disease (multiple). Orthologous to human BDNF (brain derived neurotrophic factor); PARTICIPATES IN brain-derived neurotrophic factor signaling pathway; Huntington's disease pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH (+)-catechin; (+)-pilocarpine; (-)-epigallocatechin 3-gallate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Brain derived neurothrophic factor; brain derived neurotrophic factor; MGC105254; neurotrophic factor BDNF precursor form; proBDNF
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Bdnfem1Sage
Genetic Models: SD-Bdnfem1Sage+/-
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83116,619,633 - 116,670,212 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3116,619,633 - 116,670,657 (+)EnsemblGRCr8
mRatBN7.2396,165,042 - 96,215,621 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl396,165,042 - 96,215,615 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx399,726,226 - 99,776,801 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03108,325,184 - 108,375,759 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03106,087,694 - 106,138,272 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03100,768,637 - 100,819,216 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3100,768,637 - 100,819,210 (+)Ensemblrn6Rnor6.0
Rnor_5.03107,371,329 - 107,421,908 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera395,191,318 - 95,241,949 (+)NCBICelera
Cytogenetic Map3q34NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
acoustic neuroma  (ISO)
acute stress disorder  (IEP)
alcohol dependence  (IDA,IEP,ISO)
alcohol use disorder  (IEP,ISO)
alcohol withdrawal syndrome  (IEP,ISO)
Alcohol-Related Disorders  (IEP)
Alcoholic Intoxication  (ISO)
alopecia  (ISO)
Alzheimer's disease  (IEP,IMP,ISO)
amnestic disorder  (IEP,ISO)
amphetamine abuse  (IEP,ISO)
Amyloid Plaques  (ISO)
Anhedonia  (IEP)
anxiety disorder  (IEP)
Arthralgia  (IMP)
asthma  (ISO)
Ataxia  (ISO)
atopic dermatitis  (ISO)
attention deficit hyperactivity disorder  (IEP)
autism spectrum disorder  (ISO)
autistic disorder  (ISO)
bacterial meningitis  (IEP,ISO)
Binge Drinking  (IEP)
bipolar disorder  (ISO)
Body Weight  (ISO)
borna disease  (IEP)
Brain Injuries  (IEP,ISO)
brain ischemia  (ISO)
cannabis abuse  (IEP)
Cerebral Hemorrhage  (ISO)
Chronic Pain  (IEP)
cocaine abuse  (ISO)
cocaine dependence  (IMP,ISO)
Cocaine-Related Disorders  (IMP,ISO)
cognitive disorder  (IEP,ISO)
colitis  (ISO)
color blindness  (ISO)
congenital central hypoventilation syndrome  (ISO)
cystitis  (IEP,IMP)
Deafness  (ISO)
depressive disorder  (IDA,IEP,ISO)
Diabetic Nephropathies  (IMP)
diabetic neuropathy  (IEP,IMP)
diabetic retinopathy  (IEP)
Drug Eruptions  (ISO)
Dysbiosis  (ISO)
epilepsy  (ISO)
epilepsy with generalized tonic-clonic seizures  (ISO)
Experimental Autoimmune Encephalomyelitis  (IEP)
Experimental Diabetes Mellitus  (IEP)
Experimental Seizures  (IDA,IEP)
focal epilepsy  (ISO)
Frontotemporal Lobar Degeneration  (ISO)
glaucoma  (IDA,IEP,ISO)
Gliosis  (ISO)
Hearing Loss  (IEP)
Hearing Loss, Noise-Induced  (IEP,ISO)
heroin dependence  (ISO)
Huntington's disease  (ISO)
Hyperalgesia  (IDA,IEP,IMP,ISO)
Hyperoxia  (IEP)
hypertensive encephalopathy  (IEP)
hypothyroidism  (IEP)
Hypoxia  (ISO)
Inflammation  (IEP,ISO)
inner ear disease  (ISO)
intellectual disability  (ISO)
intermediate coronary syndrome  (ISO)
interstitial lung disease  (ISO)
Intervertebral Disc Disease  (ISO)
Intervertebral Disc Displacement  (IEP)
intestinal disease  (IDA)
irritable bowel syndrome  (ISO)
keratoconus  (ISO)
Leukoencephalopathies  (IEP)
low tension glaucoma  (ISO)
major depressive disorder  (ISO)
Memory Disorders  (IEP,ISO)
Metabolic Syndrome  (ISO)
middle cerebral artery infarction  (IEP)
mood disorder  (ISO)
morbid obesity  (ISO)
morphine dependence  (IEP,ISO)
morphine withdrawal syndrome  (IEP)
multiple sclerosis  (ISO)
Nasal Polyps  (ISO)
neovascular inflammatory vitreoretinopathy  (ISO)
Nerve Degeneration  (IEP,ISO)
Nerve Injuries  (IEP)
nervous system disease  (ISO)
nicotine dependence  (IEP,ISO)
obesity  (ISO)
obsessive-compulsive disorder  (IEP,ISO)
obstructive sleep apnea  (ISO)
opiate dependence  (ISO)
Optic Nerve Injuries  (IEP,ISO)
Pain  (IEP)
Parkinson's disease  (ISO)
Parkinsonism  (ISO)
Peripheral Nerve Injuries  (IEP,IMP,ISO)
post-traumatic stress disorder  (IEP,ISO)
Postoperative Cognitive Dysfunction  (IEP,ISO)
premature ejaculation  (IEP)
Prenatal Exposure Delayed Effects  (IEP,ISO)
Presbycusis  (IEP)
primary open angle glaucoma  (ISO)
psychotic disorder  (ISO)
pulmonary fibrosis  (ISO)
pulmonary sarcoidosis  (ISO)
Radiation Injuries  (IEP)
Referred Pain  (IMP)
Reperfusion Injury  (IEP)
Respiration Disorders  (ISO)
Respiratory Tract Infections  (ISO)
Retina Reperfusion Injury  (ISO)
retinal degeneration  (IDA,ISO)
rhinitis  (IEP,ISO)
schizophrenia  (ISO)
sciatic neuropathy  (IDA,IEP)
Seasonal Allergic Rhinitis  (ISO)
sensorineural hearing loss  (ISO)
Sjogren's syndrome  (ISO)
Sleep Deprivation  (IEP)
Spinal Cord Injuries  (IDA,IEP,ISO)
Spinal Cord Reperfusion Injury  (IEP)
Starvation  (IEP)
status epilepticus  (IMP,ISO)
Stomach Neoplasms  (ISO)
stroke  (IEP)
systemic scleroderma  (ISO)
Tinnitus  (IEP,ISO)
transient cerebral ischemia  (IDA)
traumatic brain injury  (IEP)
trigeminal neuralgia  (IEP)
type 2 diabetes mellitus  (ISO)
urticaria  (ISO)
vascular dementia  (IEP)
Visceral Pain  (ISO)
withdrawal disorder  (IEP,ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP)
(+)-epicatechin-3-O-gallate  (ISO)
(+)-pilocarpine  (EXP,ISO)
(+)-syringaresinol beta-D-glucoside  (ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(20S)-ginsenoside Rg3  (ISO)
(R)-salsolinol  (EXP)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-3,5-dihydroxyphenylglycine  (ISO)
(S)-AMPA  (EXP)
(S)-amphetamine  (EXP,ISO)
(S)-colchicine  (EXP)
(S)-naringenin  (EXP)
(S)-nicotine  (EXP,ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (EXP)
1-bromopropane  (EXP,ISO)
1-chloro-2,4-dinitrobenzene  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthol  (ISO)
13,14-dihydro-Delta(12)-prostaglandin J2  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,3-Dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2,5-hexanedione  (EXP)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (ISO)
2-methyl-6-(phenylethynyl)pyridine  (EXP)
2-palmitoylglycerol  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-dihydroxybenzoic acid  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-Methoxynobiletin  (EXP)
3-nitropropanoic acid  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4,5,6,7-TETRABROMOBENZOTRIAZOLE  (ISO)
4-[1-hydroxy-2-[4-(phenylmethyl)-1-piperidinyl]propyl]phenol  (EXP)
4-hydroxynon-2-enal  (EXP)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-azacytidine  (ISO)
5-fluorouracil  (EXP)
5-methoxypsoralen  (ISO)
6-anilino-5,8-quinolinedione  (ISO)
6-Cyano-7-nitroquinoxaline-2,3-dione  (EXP)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
[6]-Shogaol  (ISO)
AB-Fubinaca  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (EXP)
acrylamide  (EXP)
actinomycin D  (EXP)
aflatoxin B1  (EXP,ISO)
agathisflavone  (EXP)
agmatine  (ISO)
agomelatine  (EXP,ISO)
alcohol  (ISO)
aldehydo-D-glucosamine  (ISO)
all-trans-retinoic acid  (ISO)
alpha-D-galactose  (ISO)
alpha-pinene  (EXP)
alpha-Solamarine  (ISO)
aluminium hydroxide  (ISO)
AM-251  (ISO)
amantadine  (EXP)
amiodarone  (EXP)
ammonium chloride  (EXP)
amphetamine  (ISO)
aniracetam  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
apigenin  (EXP)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (EXP,ISO)
arsanilic acid  (EXP)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
asiaticoside  (EXP)
Atractylone  (ISO)
atrazine  (EXP,ISO)
Bardoxolone methyl  (ISO)
Bay-K-8644  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-D-glucosamine  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
brequinar  (ISO)
bromocriptine  (ISO)
bucladesine  (ISO)
bupivacaine  (ISO)
buprenorphine  (EXP)
Butylbenzyl phthalate  (ISO)
Butylparaben  (EXP)
C60 fullerene  (EXP)
cabergoline  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
cannabidiol  (EXP,ISO)
capsaicin  (EXP)
carbamazepine  (EXP)
carbon dioxide  (EXP)
carbon monoxide  (EXP)
carbon nanotube  (ISO)
celastrol  (ISO)
CGP 52608  (ISO)
CGS-21680  (EXP)
chaetocin  (EXP)
chlorohydrocarbon  (ISO)
chloroprene  (ISO)
chlorpromazine  (EXP,ISO)
chlorpyrifos  (EXP,ISO)
cholesterol  (EXP)
choline  (ISO)
chondroitin sulfate  (ISO)
chrysin  (ISO)
cisplatin  (EXP,ISO)
Citreoviridin  (ISO)
clofibrate  (ISO)
clopidogrel  (ISO)
clozapine  (EXP)
cocaine  (EXP,ISO)
coenzyme Q10  (EXP)
colforsin daropate hydrochloride  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (EXP)
corticosterone  (EXP,ISO)
creatine  (ISO)
crocidolite asbestos  (ISO)
crocin-1  (EXP)
Cuprizon  (EXP)
curcumin  (EXP,ISO)
cyanocob(III)alamin  (EXP)
cyclophosphamide  (EXP)
cyclosporin A  (EXP,ISO)
cyfluthrin  (EXP)
cypermethrin  (EXP,ISO)
daidzein 7-O-beta-D-glucoside  (ISO)
dantrolene  (ISO)
DDE  (EXP,ISO)
DDT  (ISO)
decabromodiphenyl ether  (EXP,ISO)
deguelin  (ISO)
dermatan sulfate  (ISO)
desferrioxamine B  (EXP)
desipramine  (ISO)
dexamethasone  (EXP,ISO)
diallyl disulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
diazepam  (EXP,ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (EXP,ISO)
dihydroactinidiolide  (ISO)
dihydrolipoic acid  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
diisopropyl fluorophosphate  (EXP)
dimethyl fumarate  (EXP)
dioxygen  (EXP,ISO)
diphenyl diselenide  (ISO)
disulfiram  (ISO)
dizocilpine maleate  (EXP)
donepezil hydrochloride  (ISO)
dopamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
echinacoside  (EXP)
elemental selenium  (EXP)
endosulfan  (EXP)
enzacamene  (EXP)
epoxiconazole  (EXP)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
Ethylenethiourea  (ISO)
etoposide  (ISO)
eugenol  (ISO)
Evodiamine  (ISO)
excitatory amino acid agonist  (EXP)
Fast green FCF  (ISO)
fentanyl  (EXP)
fenvalerate  (EXP,ISO)
ferrostatin-1  (EXP)
fingolimod hydrochloride  (ISO)
fisetin  (EXP)
fluoranthene  (ISO)
fluoxetine  (EXP,ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
Fusaric acid  (EXP)
galactose  (ISO)
galangin  (EXP)
gallic acid  (ISO)
gallocatechin  (ISO)
gamma-aminobutyric acid  (EXP)
gamma-hexachlorocyclohexane  (EXP)
Gastrodin  (EXP)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
gingerol  (ISO)
glycidol  (EXP)
glycyrrhizinic acid  (EXP)
glyphosate  (ISO)
haloperidol  (EXP,ISO)
herbicide  (EXP)
heroin  (EXP,ISO)
hydrogen peroxide  (ISO)
ifosfamide  (EXP)
imipramine  (EXP,ISO)
inulin  (ISO)
kainic acid  (EXP)
ketamine  (EXP,ISO)
ketanserin  (EXP)
KT 5823  (EXP,ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lamotrigine  (EXP)
lead diacetate  (EXP,ISO)
lead(0)  (EXP,ISO)
linuron  (EXP)
lipopolysaccharide  (EXP,ISO)
lithium atom  (EXP,ISO)
lithium chloride  (ISO)
lithium hydride  (EXP,ISO)
lovastatin  (EXP)
LY294002  (EXP,ISO)
lycopene  (EXP,ISO)
malathion  (ISO)
maneb  (EXP,ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
melatonin  (EXP,ISO)
melittin  (ISO)
mercury atom  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (ISO)
mercury(0)  (ISO)
metformin  (EXP)
methamphetamine  (EXP,ISO)
methyl beta-cyclodextrin  (ISO)
methyl methanesulfonate  (ISO)
methylglyoxal  (ISO)
methyllycaconitine  (ISO)
methylmercury chloride  (EXP,ISO)
methylphenidate  (EXP,ISO)
mevastatin  (ISO)
mifepristone  (EXP,ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (EXP)
morin  (EXP)
morphine  (EXP,ISO)
muscimol  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-methyl-N-nitrosourea  (EXP)
naproxen  (EXP)
nicardipine  (EXP)
nickel atom  (ISO)
nicotine  (EXP,ISO)
nicotinic acid  (EXP)
nifedipine  (EXP)
nimodipine  (ISO)
nitric oxide  (ISO)
Nonylphenol  (EXP,ISO)
ochratoxin A  (EXP)
olanzapine  (EXP,ISO)
oleuropein  (ISO)
ouabain  (EXP)
Oxadiazon  (ISO)
oxaliplatin  (EXP)
oxidopamine  (ISO)
ozone  (EXP,ISO)
paclitaxel  (EXP)
paliperidone palmitate  (EXP)
panaxydol  (EXP)
papaverine  (EXP)
paracetamol  (EXP,ISO)
paraldehyde  (EXP)
paraquat  (EXP,ISO)
parathion-methyl  (EXP)
paroxetine  (ISO)
pentetrazol  (EXP,ISO)
pentobarbital  (EXP)
perchlorate  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
permethrin  (EXP,ISO)
peroxynitrous acid  (EXP)
PF-3758309  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
phosphorothioic O,O,S-acid  (ISO)
picrotoxin  (EXP,ISO)
pioglitazone  (ISO)
poly(I:C)  (EXP,ISO)
potassium atom  (EXP,ISO)
potassium chloride  (ISO)
potassium chromate  (ISO)
prasugrel hydrochloride  (EXP)
prochloraz  (EXP)
procymidone  (EXP)
prodigiosin  (EXP)
progesterone  (EXP,ISO)
propanal  (ISO)
pyrethrins  (ISO)
Pyridostigmine bromide  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quartz  (ISO)
quercetin  (EXP,ISO)
quetiapine fumarate  (EXP)
quinolinic acid  (EXP)
reserpine  (EXP,ISO)
resveratrol  (EXP,ISO)
rimonabant  (ISO)
risperidone  (EXP,ISO)
ritanserin  (EXP)
rivastigmine  (EXP)
roflumilast  (EXP)
rolipram  (EXP)
romidepsin  (EXP)
rotenone  (EXP,ISO)
royal jelly  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
salvianolic acid B  (ISO)
saroglitazar  (EXP)
saxagliptin  (EXP)
SB 431542  (ISO)
scopolamine  (EXP,ISO)
selenium atom  (EXP)
serotonin  (EXP,ISO)
sertraline  (ISO)
sevoflurane  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP)
sirolimus  (ISO)
SKF-96365 hydrochloride  (ISO)
SL-327  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (EXP,ISO)
Soman  (EXP)
sterigmatocystin  (EXP)
streptozocin  (EXP,ISO)
sulforaphane  (ISO)
sumatriptan  (EXP)
tacrine  (ISO)
tacrolimus hydrate  (EXP)
tadalafil  (ISO)
tamibarotene  (EXP,ISO)
tamoxifen  (EXP,ISO)
taurine  (EXP,ISO)
telmisartan  (ISO)
tert-butyl hydroperoxide  (ISO)
Testosterone propionate  (EXP)
tetrodotoxin  (EXP,ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP,ISO)
toluene  (ISO)
topiramate  (EXP)
torcetrapib  (ISO)
tranylcypromine  (EXP)
triacsin C  (ISO)
triazolam  (ISO)
triazophos  (EXP)
trichloroethene  (ISO)
trichostatin A  (EXP,ISO)
undecane  (EXP)
valproic acid  (EXP,ISO)
venlafaxine hydrochloride  (EXP)
veratridine  (EXP,ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
vortioxetine  (EXP)
VX nerve agent  (ISO)
wortmannin  (EXP,ISO)
xenon atom  (EXP)
xenon(0)  (EXP)
zearalenone  (ISO)
zinc atom  (ISO)
zinc dichloride  (EXP)
zinc sulfate  (EXP,ISO)
zinc(0)  (ISO)
zolpidem  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
axon extension  (ISO)
axon guidance  (ISO)
axon target recognition  (ISO)
behavioral fear response  (ISO)
behavioral response to cocaine  (IMP)
cell surface receptor protein tyrosine kinase signaling pathway  (IBA)
cellular response to nerve growth factor stimulus  (IEP)
cellular response to norepinephrine stimulus  (IEP)
cellular response to potassium ion  (IEP)
cellular response to tumor necrosis factor  (IEP)
chronic inflammatory response  (IEP)
circadian rhythm  (ISO)
cognition  (IEP)
collateral sprouting  (IEA,ISO)
conditioned place preference  (IMP)
dendrite development  (ISO)
dendrite extension  (ISO)
excitatory postsynaptic potential  (IMP)
fear response  (ISO)
feeding behavior  (ISO)
gamma-aminobutyric acid signaling pathway  (ISO)
glutamate secretion  (ISO)
inhibitory postsynaptic potential  (ISO)
inner ear development  (ISO)
learning  (IMP)
learning or memory  (ISO)
mechanoreceptor differentiation  (ISO)
mitochondrial electron transport, NADH to ubiquinone  (IMP)
modulation of chemical synaptic transmission  (IBA)
negative regulation of apoptotic process  (ISO)
negative regulation of apoptotic signaling pathway  (ISO)
negative regulation of myotube differentiation  (IMP)
negative regulation of neuroblast proliferation  (ISO)
negative regulation of neuron apoptotic process  (IBA,ISO)
negative regulation of programmed cell death  (ISO)
negative regulation of striated muscle tissue development  (IMP)
negative regulation of synaptic transmission, GABAergic  (ISO)
nerve development  (IBA,ISO)
nerve growth factor signaling pathway  (IBA)
nervous system development  (IDA)
neuron differentiation  (TAS)
neuron projection extension  (IDA)
neuron projection morphogenesis  (IBA)
neuron projection regeneration  (IMP)
neuron recognition  (ISO)
positive regulation of axon regeneration  (IMP)
positive regulation of collateral sprouting  (IEA,ISO)
positive regulation of long-term neuronal synaptic plasticity  (IMP)
positive regulation of neuron apoptotic process  (IMP)
positive regulation of neuron differentiation  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of nuclear receptor-mediated glucocorticoid signaling pathway  (IDA)
positive regulation of peptidyl-serine phosphorylation  (IGI,ISO)
positive regulation of synapse assembly  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IDA)
regeneration  (IDA)
regulation of axon extension  (IMP)
regulation of collateral sprouting  (ISO)
regulation of long-term neuronal synaptic plasticity  (IDA)
regulation of neuron apoptotic process  (ISO)
regulation of retinal cell programmed cell death  (ISO)
regulation of short-term neuronal synaptic plasticity  (IDA)
regulation of synaptic plasticity  (ISO)
response to activity  (IEP)
response to anesthetic  (IEP)
response to auditory stimulus  (IEP)
response to electrical stimulus  (IEP)
response to ethanol  (IEP)
response to food  (IEP)
response to hormone  (IEP)
response to hyperoxia  (IEP)
response to hypoxia  (IEP)
response to L-glutamate  (IEP)
response to light intensity  (IEP)
response to light stimulus  (IEP)
response to morphine  (IEP)
response to nerve growth factor  (IEP)
response to nutrient levels  (IEP)
response to potassium ion  (IEP)
response to tumor necrosis factor  (IEP)
response to vitamin A  (IEP)
response to xenobiotic stimulus  (IEP,ISO)
signal transduction  (IEA)
synapse assembly  (IEA,ISO)
taste bud development  (ISO)
trans-synaptic signaling by BDNF, modulating synaptic transmission  (ISO)
ureteric bud development  (ISO)

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
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83. Alterations in BDNF and synapsin I within the occipital cortex and hippocampus after mild traumatic brain injury in the developing rat: reflections of injury-induced neuroplasticity. Griesbach GS, etal., J Neurotrauma 2002 Jul;19(7):803-14.
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89. Physical Exercise Promotes Beneficial Changes on Neurotrophic Factors in Mesolimbic Brain Areas After AMPH Relapse: Involvement of the Endogenous Opioid System. H Z R, etal., Neurotox Res. 2023 Dec;41(6):741-751. doi: 10.1007/s12640-023-00675-y. Epub 2023 Oct 31.
90. Sequence variants of the brain-derived neurotrophic factor (BDNF) gene are strongly associated with obsessive-compulsive disorder. Hall D, etal., Am J Hum Genet 2003 Aug;73(2):370-6. Epub 2003 Jun 27.
91. Association of brain-derived neurotrophic factor (BDNF) haploinsufficiency with lower adaptive behaviour and reduced cognitive functioning in WAGR/11p13 deletion syndrome. Han JC, etal., Cortex. 2013 Nov-Dec;49(10):2700-10. doi: 10.1016/j.cortex.2013.02.009. Epub 2013 Feb 19.
92. Transplantation of BDNF-secreting mesenchymal stem cells provides neuroprotection in chronically hypertensive rat eyes. Harper MM, etal., Invest Ophthalmol Vis Sci. 2011 Jun 23;52(7):4506-15. doi: 10.1167/iovs.11-7346.
93. Ethanol-induced alterations in the expression of neurotrophic factors in the developing rat central nervous system. Heaton MB, etal., Brain Res Dev Brain Res. 2000 May 11;121(1):97-107. doi: 10.1016/s0165-3806(00)00032-8.
94. Ethanol effects on neonatal rat cortex: comparative analyses of neurotrophic factors, apoptosis-related proteins, and oxidative processes during vulnerable and resistant periods. Heaton MB, etal., Brain Res Dev Brain Res. 2003 Nov 12;145(2):249-62. doi: 10.1016/j.devbrainres.2003.08.005.
95. Serum levels of BDNF are associated with craving in opiate-dependent patients. Heberlein A, etal., J Psychopharmacol. 2011 Nov;25(11):1480-4. doi: 10.1177/0269881111411332. Epub 2011 Sep 2.
96. BDNF and GDNF serum levels in alcohol-dependent patients during withdrawal. Heberlein A, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2010 Aug 16;34(6):1060-4. doi: 10.1016/j.pnpbp.2010.05.025. Epub 2010 May 27.
97. Treadmill exercise ameliorates disturbance of spatial learning ability in scopolamine-induced amnesia rats. Heo YM, etal., J Exerc Rehabil. 2014 Jun 30;10(3):155-61. doi: 10.12965/jer.140110. eCollection 2014 Jun.
98. Variation in the BDNF and NGFB genes in German atopic dermatitis patients. Hoffjan S, etal., Mol Cell Probes. 2009 Feb;23(1):35-8. doi: 10.1016/j.mcp.2008.10.005. Epub 2008 Nov 11.
99. A study of the cough reflex in idiopathic pulmonary fibrosis. Hope-Gill BD, etal., Am J Respir Crit Care Med. 2003 Oct 15;168(8):995-1002. Epub 2003 Aug 13.
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PMID:21756773   PMID:21756980   PMID:21767606   PMID:21792677   PMID:21801814   PMID:21803120   PMID:21835234   PMID:21839142   PMID:21839807   PMID:21856381   PMID:21861389   PMID:21865474  
PMID:21890320   PMID:21907460   PMID:21945647   PMID:21946312   PMID:22024546   PMID:22027236   PMID:22044922   PMID:22050733   PMID:22069327   PMID:22128191   PMID:22134693   PMID:22174809  
PMID:22178325   PMID:22178659   PMID:22193444   PMID:22195050   PMID:22209827   PMID:22223265   PMID:22227452   PMID:22234237   PMID:22244747   PMID:22253429   PMID:22265241   PMID:22272355  
PMID:22280975   PMID:22306205   PMID:22345308   PMID:22374757   PMID:22410736   PMID:22426107   PMID:22428625   PMID:22442695   PMID:22469747   PMID:22499464   PMID:22500633   PMID:22510533  
PMID:22515203   PMID:22521816   PMID:22527999   PMID:22553040   PMID:22561407   PMID:22573254   PMID:22573708   PMID:22649026   PMID:22650038   PMID:22650039   PMID:22650040   PMID:22650041  
PMID:22650043   PMID:22672085   PMID:22678720   PMID:22730318   PMID:22778217   PMID:22796076   PMID:22841916   PMID:22847550   PMID:22848609   PMID:22886995   PMID:22917619   PMID:22930524  
PMID:22936723   PMID:22959240   PMID:23017014   PMID:23035088   PMID:23056528   PMID:23058367   PMID:23080167   PMID:23086941   PMID:23134146   PMID:23157205   PMID:23160045   PMID:23168995  
PMID:23179587   PMID:23185000   PMID:23189980   PMID:23219910   PMID:23237316   PMID:23255148   PMID:23261589   PMID:23271640   PMID:23274899   PMID:23326507   PMID:23337714   PMID:23337936  
PMID:23349925   PMID:23367482   PMID:23376487   PMID:23392678   PMID:23432085   PMID:23436435   PMID:23439217   PMID:23512738   PMID:23531843   PMID:23534605   PMID:23550026   PMID:23564488  
PMID:23599427   PMID:23643896   PMID:23700463   PMID:23715956   PMID:23749289   PMID:23762244   PMID:23770418   PMID:23785138   PMID:23811393   PMID:23825410   PMID:23842743   PMID:23870838  
PMID:23918351   PMID:23942837   PMID:23949197   PMID:23963709   PMID:23993653   PMID:23999152   PMID:24006456   PMID:24021607   PMID:24035762   PMID:24076087   PMID:24092446   PMID:24114393  
PMID:24127005   PMID:24157309   PMID:24201284   PMID:24244357   PMID:24280707   PMID:24302729   PMID:24303055   PMID:24316448   PMID:24321407   PMID:24345682   PMID:24361450   PMID:24365909  
PMID:24372023   PMID:24378336   PMID:24401942   PMID:24431454   PMID:24440750   PMID:24465591   PMID:24503120   PMID:24573299   PMID:24625911   PMID:24709620   PMID:24714156   PMID:24747049  
PMID:24747659   PMID:24753016   PMID:24802968   PMID:24811179   PMID:24839168   PMID:24917666   PMID:24921856   PMID:24934279   PMID:24965890   PMID:24966334   PMID:24968020   PMID:24978397  
PMID:24978930   PMID:24993297   PMID:25010399   PMID:25011012   PMID:25052557   PMID:25055143   PMID:25059794   PMID:25082546   PMID:25087780   PMID:25110093   PMID:25143381   PMID:25182413  
PMID:25203492   PMID:25209292   PMID:25226925   PMID:25231482   PMID:25241777   PMID:25282819   PMID:25424467   PMID:25444867   PMID:25445195   PMID:25449846   PMID:25451258   PMID:25453757  
PMID:25481360   PMID:25519736   PMID:25527489   PMID:25542970   PMID:25555929   PMID:25559382   PMID:25623071   PMID:25665281   PMID:25681548   PMID:25692578   PMID:25755749   PMID:25783782  
PMID:25860428   PMID:25868795   PMID:25869354   PMID:25886766   PMID:25894678   PMID:25904806   PMID:25934485   PMID:25963324   PMID:26000806   PMID:26019338   PMID:26027495   PMID:26047381  
PMID:26088421   PMID:26090759   PMID:26111610   PMID:26111928   PMID:26146031   PMID:26148339   PMID:26163515   PMID:26166726   PMID:26189832   PMID:26198255   PMID:26200505   PMID:26211445  
PMID:26239042   PMID:26239616   PMID:26291061   PMID:26339375   PMID:26368940   PMID:26388293   PMID:26391661   PMID:26396035   PMID:26398857   PMID:26449489   PMID:26459016   PMID:26469350  
PMID:26471218   PMID:26554621   PMID:26571801   PMID:26586578   PMID:26630405   PMID:26676568   PMID:26682524   PMID:26691781   PMID:26700412   PMID:26708520   PMID:26712630   PMID:26794594  
PMID:26802511   PMID:26820887   PMID:26844865   PMID:26861177   PMID:26877199   PMID:26881097   PMID:26888068   PMID:26926964   PMID:26941165   PMID:26960058   PMID:27006395   PMID:27010597  
PMID:27013094   PMID:27028464   PMID:27085775   PMID:27094192   PMID:27132084   PMID:27137405   PMID:27151332   PMID:27154426   PMID:27181637   PMID:27252349   PMID:27267245   PMID:27270670  
PMID:27306412   PMID:27310873   PMID:27329329   PMID:27381812   PMID:27435421   PMID:27474832   PMID:27503312   PMID:27521083   PMID:27550421   PMID:27569259   PMID:27597545   PMID:27611779  
PMID:27624937   PMID:27639585   PMID:27683907   PMID:27693383   PMID:27727393   PMID:27744091   PMID:27771283   PMID:27830679   PMID:27832087   PMID:27857218   PMID:27874237   PMID:27913431  
PMID:27914953   PMID:27926876   PMID:28072837   PMID:28078614   PMID:28119091   PMID:28145853   PMID:28238708   PMID:28254195   PMID:28258626   PMID:28261618   PMID:28281382   PMID:28306606  
PMID:28330827   PMID:28420943   PMID:28440877   PMID:28445707   PMID:28492549   PMID:28524001   PMID:28598964   PMID:28600519   PMID:28622174   PMID:28634074   PMID:28640008   PMID:28663119  
PMID:28698933   PMID:28711394   PMID:28767193   PMID:28770018   PMID:28821448   PMID:28829495   PMID:28854337   PMID:28855298   PMID:28857460   PMID:28865749   PMID:28890399   PMID:28965325  
PMID:29075579   PMID:29098710   PMID:29126980   PMID:29263199   PMID:29288061   PMID:29305263   PMID:29353374   PMID:29380665   PMID:29401579   PMID:29420916   PMID:29425916   PMID:29499310  
PMID:29540150   PMID:29545098   PMID:29611441   PMID:29621970   PMID:29648487   PMID:29704115   PMID:29773102   PMID:29777700   PMID:29781158   PMID:29800645   PMID:29802680   PMID:29911174  
PMID:30001178   PMID:30024334   PMID:30076998   PMID:30100066   PMID:30102916   PMID:30119135   PMID:30127343   PMID:30129982   PMID:30132570   PMID:30151608   PMID:30185459   PMID:30200858  
PMID:30226568   PMID:30308090   PMID:30308117   PMID:30373907   PMID:30477252   PMID:30483749   PMID:30503681   PMID:30548775   PMID:30569121   PMID:30639279   PMID:30680641   PMID:30695408  
PMID:30710509   PMID:30741614   PMID:30761261   PMID:30851317   PMID:30940563   PMID:30956976   PMID:31014242   PMID:31017891   PMID:31114979   PMID:31134851   PMID:31213568   PMID:31219215  
PMID:31281833   PMID:31327126   PMID:31329835   PMID:31412259   PMID:31415765   PMID:31449911   PMID:31492038   PMID:31524100   PMID:31539886   PMID:31557760   PMID:31577916   PMID:31694441  
PMID:31770584   PMID:31773433   PMID:31828524   PMID:31883222   PMID:31883511   PMID:31915257   PMID:31922368   PMID:31960229   PMID:31973999   PMID:31982414   PMID:32027953   PMID:32043504  
PMID:32179157   PMID:32189593   PMID:32214273   PMID:32219700   PMID:32222405   PMID:32323597   PMID:32417176   PMID:32445041   PMID:32488870   PMID:32505509   PMID:32507324   PMID:32585251  
PMID:32588398   PMID:32671697   PMID:32681810   PMID:32738378   PMID:32770453   PMID:32787648   PMID:32820184   PMID:33075004   PMID:33103739   PMID:33147870   PMID:33148515   PMID:33204065  
PMID:33206632   PMID:33245480   PMID:33290797   PMID:33359781   PMID:33436052   PMID:33560226   PMID:33577886   PMID:33649977   PMID:33745752   PMID:33763156   PMID:33874962   PMID:33961393  
PMID:33982757   PMID:34008409   PMID:34061025   PMID:34068707   PMID:34086671   PMID:34101873   PMID:34102241   PMID:34192516   PMID:34225593   PMID:34274327   PMID:34295224   PMID:34299002  
PMID:34328517   PMID:34348149   PMID:34374467   PMID:34374900   PMID:34454019   PMID:34497360   PMID:34529365   PMID:34536437   PMID:34543287   PMID:34619155   PMID:34695541   PMID:34700232  
PMID:34743976   PMID:34907761   PMID:34929632   PMID:34937120   PMID:34948299   PMID:34960080   PMID:35013359   PMID:35059698   PMID:35216241   PMID:35256586   PMID:35293071   PMID:35439934  
PMID:35481944   PMID:35557046   PMID:35596908   PMID:35644274   PMID:35769142   PMID:35806000   PMID:35820831   PMID:35921478   PMID:36041572   PMID:36233065   PMID:36316156   PMID:36375307  
PMID:36499323   PMID:36567651   PMID:36622548   PMID:36649932   PMID:36674499   PMID:36725696   PMID:36736275   PMID:36884028   PMID:36902428   PMID:36988364   PMID:37094390   PMID:37252844  
PMID:37269900   PMID:37298449   PMID:37464198   PMID:37523044   PMID:37572160   PMID:37632136   PMID:37635135   PMID:37700085   PMID:37859350   PMID:37936493   PMID:37972713   PMID:38244886  
PMID:38323385   PMID:38342427   PMID:38347284   PMID:38423239   PMID:38430395   PMID:38612728   PMID:38622072   PMID:38648864   PMID:38796067   PMID:38838971   PMID:38892438   PMID:39125587  


Genomics

Comparative Map Data
Bdnf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83116,619,633 - 116,670,212 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3116,619,633 - 116,670,657 (+)EnsemblGRCr8
mRatBN7.2396,165,042 - 96,215,621 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl396,165,042 - 96,215,615 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx399,726,226 - 99,776,801 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03108,325,184 - 108,375,759 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03106,087,694 - 106,138,272 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03100,768,637 - 100,819,216 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3100,768,637 - 100,819,210 (+)Ensemblrn6Rnor6.0
Rnor_5.03107,371,329 - 107,421,908 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera395,191,318 - 95,241,949 (+)NCBICelera
Cytogenetic Map3q34NCBI
BDNF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381127,654,893 - 27,722,030 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1127,654,893 - 27,722,058 (-)Ensemblhg38GRCh38
GRCh371127,676,440 - 27,743,577 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361127,633,016 - 27,699,872 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341127,633,019 - 27,637,249NCBI
Celera1127,822,548 - 27,889,725 (-)NCBICelera
Cytogenetic Map11p14.1NCBI
HuRef1127,374,586 - 27,441,772 (-)NCBIHuRef
CHM1_11127,675,184 - 27,742,527 (-)NCBICHM1_1
T2T-CHM13v2.01127,795,301 - 27,862,460 (-)NCBIT2T-CHM13v2.0
Bdnf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392109,505,045 - 109,557,388 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2109,505,045 - 109,557,352 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm382109,674,700 - 109,727,043 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2109,674,700 - 109,727,007 (+)Ensemblmm10GRCm38
MGSCv372109,514,857 - 109,567,200 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362109,475,539 - 109,527,845 (+)NCBIMGSCv36mm8
Celera2110,835,441 - 110,887,723 (+)NCBICelera
Cytogenetic Map2E3NCBI
cM Map256.63NCBI
Bdnf
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554766,772,088 - 6,822,588 (-)Ensembl
ChiLan1.0NW_0049554766,773,244 - 6,822,201 (-)NCBIChiLan1.0ChiLan1.0
BDNF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2929,867,082 - 29,934,015 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11129,867,593 - 29,934,527 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01127,618,322 - 27,687,661 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11127,520,306 - 27,589,239 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1127,520,312 - 27,589,239 (-)EnsemblpanPan2panpan1.1
BDNF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12148,191,580 - 48,243,699 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2148,192,670 - 48,204,480 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2147,689,871 - 47,691,000 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02149,335,793 - 49,386,964 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.12148,338,131 - 48,339,260 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02148,489,388 - 48,490,517 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02149,083,467 - 49,084,596 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Bdnf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494736,374,992 - 36,427,979 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365405,529,942 - 5,585,014 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365405,530,081 - 5,582,765 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BDNF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl232,624,048 - 32,679,765 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1232,623,668 - 32,679,293 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2235,206,996 - 35,265,002 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BDNF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1137,386,825 - 37,451,380 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl137,449,593 - 37,450,336 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666038134,690,869 - 134,762,531 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bdnf
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476617,279,630 - 17,330,490 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476617,281,882 - 17,330,601 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Bdnf
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1587,969,541 - 88,020,106 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Bdnf
306 total Variants
miRNA Target Status (No longer updated)

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mirlet7drno-let-7d-5pMirtarbaseexternal_infoWestern blot;qRT-PCRNon-Functional MTI19703567
Mir376brno-miR-376b-5pMirtarbaseexternal_infoWestern blot//Luciferase reporter assayFunctional MTI22396777
Mir134rno-miR-134-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18258830

Predicted Target Of
Summary Value
Count of predictions:424
Count of miRNA genes:216
Interacting mature miRNAs:297
Transcripts:ENSRNOT00000073636
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358293Bw38Body weight QTL 3860.0000031body mass (VT:0001259)body weight (CMO:0000012)374364268119364268Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)396509147141509147Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)373592512136118980Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)3116582412136118980Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)385062224136118980Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)385062224136118980Rat
7387306Bw124Body weight QTL 1243.20.0003body mass (VT:0001259)body weight (CMO:0000012)3104545086149545086Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)381425008141509147Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)370845569136091483Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)393829559138829559Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)3112250810157250810Rat
2302273Gluco35Glucose level QTL 355.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)3101255536134750886Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)396509147141509147Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3110225882155225882Rat
631200Cm25Cardiac mass QTL 254.80.0001heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)381541464126563126Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)390755164141509147Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)342158111124558371Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
1582252Sual1Serum uric acid level QTL 13.40.0123blood uric acid amount (VT:0010302)blood uric acid level (CMO:0000501)3116582412122654872Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)342158111124558371Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3110634702155634702Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)3116188400161188400Rat

Markers in Region
D3Arb11  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2396,210,913 - 96,211,109 (+)MAPPERmRatBN7.2
Rnor_6.03100,814,509 - 100,814,704NCBIRnor6.0
Rnor_5.03107,417,201 - 107,417,396UniSTSRnor5.0
Celera395,237,242 - 95,237,437UniSTS
Cytogenetic Map3q33UniSTS
D3Mgh28  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2396,210,959 - 96,211,098 (+)MAPPERmRatBN7.2
Rnor_6.03100,814,555 - 100,814,693NCBIRnor6.0
Rnor_5.03107,417,247 - 107,417,385UniSTSRnor5.0
Celera395,237,288 - 95,237,426UniSTS
Cytogenetic Map3q33UniSTS
Bdnf  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2396,212,191 - 96,212,608 (+)MAPPERmRatBN7.2
Rnor_6.03100,815,787 - 100,816,203NCBIRnor6.0
Rnor_5.03107,418,479 - 107,418,895UniSTSRnor5.0
Celera395,238,520 - 95,238,936UniSTS
Cytogenetic Map3q33UniSTS
BE101548  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr83116,668,423 - 116,668,578 (+)Marker Load Pipeline
mRatBN7.2396,213,832 - 96,213,987 (+)MAPPERmRatBN7.2
Rnor_6.03100,817,428 - 100,817,582NCBIRnor6.0
Rnor_5.03107,420,120 - 107,420,274UniSTSRnor5.0
Celera395,240,161 - 95,240,315UniSTS
RH 3.4 Map3750.8UniSTS
Cytogenetic Map3q33UniSTS
UniSTS:463961  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2396,212,223 - 96,212,305 (+)MAPPERmRatBN7.2
Rnor_6.03100,815,819 - 100,815,900NCBIRnor6.0
Rnor_5.03107,418,511 - 107,418,592UniSTSRnor5.0
Celera395,238,552 - 95,238,633UniSTS
Cytogenetic Map3q33UniSTS
BDNF  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2396,211,989 - 96,212,604 (+)MAPPERmRatBN7.2
Rnor_6.03100,815,585 - 100,816,199NCBIRnor6.0
Rnor_5.03107,418,277 - 107,418,891UniSTSRnor5.0
Celera395,238,318 - 95,238,932UniSTS
Cytogenetic Map3q33UniSTS
Bdnf  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2396,212,236 - 96,212,458 (+)MAPPERmRatBN7.2
Rnor_6.03100,815,832 - 100,816,053NCBIRnor6.0
Rnor_5.03107,418,524 - 107,418,745UniSTSRnor5.0
Celera395,238,565 - 95,238,786UniSTS
Cytogenetic Map3q33UniSTS


Genetic Models
This gene Bdnf is modified in the following models/strains:
SD-Bdnfem1Sage+/-    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
15 11 65 144 65 64 34 43 34 6 255 139 10 124 59 80 30 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001270630 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270631 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270633 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270634 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_012513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006234684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AY011462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY176065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY559248 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY559249 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY559250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC087634 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN544668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D10938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF125675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF125676 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF125677 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF125678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF125679 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF125680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF125686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF125687 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF125688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF125689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF125690 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ395803 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC855561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M61175 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M61178 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S76757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S76758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S76759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S76760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S76799 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X67108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000073636   ⟹   ENSRNOP00000064356
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3116,638,952 - 116,670,206 (+)Ensembl
mRatBN7.2 Ensembl396,184,359 - 96,215,615 (+)Ensembl
Rnor_6.0 Ensembl3100,787,956 - 100,819,210 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000077703   ⟹   ENSRNOP00000072849
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3116,620,730 - 116,670,657 (+)Ensembl
mRatBN7.2 Ensembl396,166,244 - 96,215,615 (+)Ensembl
Rnor_6.0 Ensembl3100,769,839 - 100,819,210 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000078543   ⟹   ENSRNOP00000072315
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3116,622,245 - 116,670,511 (+)Ensembl
mRatBN7.2 Ensembl396,183,852 - 96,215,615 (+)Ensembl
Rnor_6.0 Ensembl3100,787,449 - 100,819,210 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000080190   ⟹   ENSRNOP00000073265
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3116,637,559 - 116,670,657 (+)Ensembl
mRatBN7.2 Ensembl396,183,265 - 96,215,615 (+)Ensembl
Rnor_6.0 Ensembl3100,786,862 - 100,819,210 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000083289   ⟹   ENSRNOP00000074338
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3116,666,223 - 116,670,511 (+)Ensembl
mRatBN7.2 Ensembl396,185,209 - 96,215,615 (+)Ensembl
Rnor_6.0 Ensembl3100,788,806 - 100,819,210 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000083542   ⟹   ENSRNOP00000073647
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3116,619,633 - 116,670,206 (+)Ensembl
mRatBN7.2 Ensembl396,165,042 - 96,215,615 (+)Ensembl
Rnor_6.0 Ensembl3100,768,637 - 100,819,210 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000089233   ⟹   ENSRNOP00000075479
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3116,621,794 - 116,670,657 (+)Ensembl
mRatBN7.2 Ensembl396,167,380 - 96,215,615 (+)Ensembl
Rnor_6.0 Ensembl3100,770,975 - 100,819,210 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000090445   ⟹   ENSRNOP00000073685
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3116,637,984 - 116,670,511 (+)Ensembl
mRatBN7.2 Ensembl396,185,265 - 96,215,615 (+)Ensembl
Rnor_6.0 Ensembl3100,788,862 - 100,819,210 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000122945   ⟹   ENSRNOP00000104100
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3116,639,348 - 116,668,326 (+)Ensembl
RefSeq Acc Id: NM_001270630   ⟹   NP_001257559
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83116,638,952 - 116,670,212 (+)NCBI
mRatBN7.2396,184,359 - 96,215,621 (+)NCBI
Rnor_6.03100,787,956 - 100,819,216 (+)NCBI
Rnor_5.03107,371,329 - 107,421,908 (+)NCBI
Celera395,210,686 - 95,241,949 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001270631   ⟹   NP_001257560
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83116,620,835 - 116,670,212 (+)NCBI
mRatBN7.2396,166,244 - 96,215,621 (+)NCBI
Rnor_6.03100,769,839 - 100,819,216 (+)NCBI
Rnor_5.03107,371,329 - 107,421,908 (+)NCBI
Celera395,192,520 - 95,241,949 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001270632   ⟹   NP_001257561
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83116,620,835 - 116,670,212 (+)NCBI
mRatBN7.2396,166,244 - 96,215,621 (+)NCBI
Rnor_6.03100,769,839 - 100,819,216 (+)NCBI
Rnor_5.03107,371,329 - 107,421,908 (+)NCBI
Celera395,192,520 - 95,241,949 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001270633   ⟹   NP_001257562
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83116,637,858 - 116,670,212 (+)NCBI
mRatBN7.2396,183,265 - 96,215,621 (+)NCBI
Rnor_6.03100,786,862 - 100,819,216 (+)NCBI
Rnor_5.03107,371,329 - 107,421,908 (+)NCBI
Celera395,209,592 - 95,241,949 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001270634   ⟹   NP_001257563
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83116,639,858 - 116,670,212 (+)NCBI
mRatBN7.2396,185,265 - 96,215,621 (+)NCBI
Rnor_6.03100,788,862 - 100,819,216 (+)NCBI
Rnor_5.03107,371,329 - 107,421,908 (+)NCBI
Celera395,211,592 - 95,241,949 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001270635   ⟹   NP_001257564
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83116,621,971 - 116,670,212 (+)NCBI
mRatBN7.2396,167,380 - 96,215,621 (+)NCBI
Rnor_6.03100,770,975 - 100,819,216 (+)NCBI
Rnor_5.03107,371,329 - 107,421,908 (+)NCBI
Celera395,193,706 - 95,241,949 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001270636   ⟹   NP_001257565
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83116,639,802 - 116,670,212 (+)NCBI
mRatBN7.2396,185,209 - 96,215,621 (+)NCBI
Rnor_6.03100,788,806 - 100,819,216 (+)NCBI
Rnor_5.03107,371,329 - 107,421,908 (+)NCBI
Celera395,211,536 - 95,241,949 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001270637   ⟹   NP_001257566
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83116,620,835 - 116,670,212 (+)NCBI
mRatBN7.2396,166,244 - 96,215,621 (+)NCBI
Rnor_6.03100,769,839 - 100,819,216 (+)NCBI
Rnor_5.03107,371,329 - 107,421,908 (+)NCBI
Celera395,192,520 - 95,241,949 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001270638   ⟹   NP_001257567
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83116,638,445 - 116,670,212 (+)NCBI
mRatBN7.2396,183,852 - 96,215,621 (+)NCBI
Rnor_6.03100,787,449 - 100,819,216 (+)NCBI
Rnor_5.03107,371,329 - 107,421,908 (+)NCBI
Celera395,210,179 - 95,241,949 (+)NCBI
Sequence:
RefSeq Acc Id: NM_012513   ⟹   NP_036645
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83116,619,633 - 116,670,212 (+)NCBI
mRatBN7.2396,165,042 - 96,215,621 (+)NCBI
Rnor_6.03100,768,637 - 100,819,216 (+)NCBI
Rnor_5.03107,371,329 - 107,421,908 (+)NCBI
Celera395,191,318 - 95,241,949 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006234684   ⟹   XP_006234746
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83116,639,322 - 116,667,822 (+)NCBI
mRatBN7.2396,184,408 - 96,215,621 (+)NCBI
Rnor_6.03100,788,310 - 100,819,216 (+)NCBI
Rnor_5.03107,371,329 - 107,421,908 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001257559 (Get FASTA)   NCBI Sequence Viewer  
  NP_001257560 (Get FASTA)   NCBI Sequence Viewer  
  NP_001257561 (Get FASTA)   NCBI Sequence Viewer  
  NP_001257562 (Get FASTA)   NCBI Sequence Viewer  
  NP_001257563 (Get FASTA)   NCBI Sequence Viewer  
  NP_001257564 (Get FASTA)   NCBI Sequence Viewer  
  NP_001257565 (Get FASTA)   NCBI Sequence Viewer  
  NP_001257566 (Get FASTA)   NCBI Sequence Viewer  
  NP_001257567 (Get FASTA)   NCBI Sequence Viewer  
  NP_036645 (Get FASTA)   NCBI Sequence Viewer  
  XP_006234746 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA16841 (Get FASTA)   NCBI Sequence Viewer  
  AAA63483 (Get FASTA)   NCBI Sequence Viewer  
  AAG47495 (Get FASTA)   NCBI Sequence Viewer  
  AAH87634 (Get FASTA)   NCBI Sequence Viewer  
  AAO17828 (Get FASTA)   NCBI Sequence Viewer  
  AAP31983 (Get FASTA)   NCBI Sequence Viewer  
  AAP31984 (Get FASTA)   NCBI Sequence Viewer  
  AAP31985 (Get FASTA)   NCBI Sequence Viewer  
  AAP31986 (Get FASTA)   NCBI Sequence Viewer  
  AAP31987 (Get FASTA)   NCBI Sequence Viewer  
  AAS67380 (Get FASTA)   NCBI Sequence Viewer  
  AAS67381 (Get FASTA)   NCBI Sequence Viewer  
  AAS67382 (Get FASTA)   NCBI Sequence Viewer  
  ABM30161 (Get FASTA)   NCBI Sequence Viewer  
  ABM30162 (Get FASTA)   NCBI Sequence Viewer  
  ABM30163 (Get FASTA)   NCBI Sequence Viewer  
  ABM30164 (Get FASTA)   NCBI Sequence Viewer  
  ABM30165 (Get FASTA)   NCBI Sequence Viewer  
  ABM30166 (Get FASTA)   NCBI Sequence Viewer  
  ABM30172 (Get FASTA)   NCBI Sequence Viewer  
  ABM30173 (Get FASTA)   NCBI Sequence Viewer  
  ABM30174 (Get FASTA)   NCBI Sequence Viewer  
  ABM30175 (Get FASTA)   NCBI Sequence Viewer  
  ABM30176 (Get FASTA)   NCBI Sequence Viewer  
  ACU43589 (Get FASTA)   NCBI Sequence Viewer  
  AGR50952 (Get FASTA)   NCBI Sequence Viewer  
  BAA01732 (Get FASTA)   NCBI Sequence Viewer  
  CAA47481 (Get FASTA)   NCBI Sequence Viewer  
  EDL79752 (Get FASTA)   NCBI Sequence Viewer  
  EDL79753 (Get FASTA)   NCBI Sequence Viewer  
  EDL79754 (Get FASTA)   NCBI Sequence Viewer  
  EDL79755 (Get FASTA)   NCBI Sequence Viewer  
  EDL79756 (Get FASTA)   NCBI Sequence Viewer  
  EDL79757 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000064356
  ENSRNOP00000072315
  ENSRNOP00000072315.1
  ENSRNOP00000072849
  ENSRNOP00000072849.1
  ENSRNOP00000073265
  ENSRNOP00000073265.1
  ENSRNOP00000073647
  ENSRNOP00000073685.1
  ENSRNOP00000074338.1
  ENSRNOP00000075479
  ENSRNOP00000075479.1
  ENSRNOP00000104100
GenBank Protein P23363 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036645   ⟸   NM_012513
- Peptide Label: isoform 2 preproprotein
- UniProtKB: A0A0G2K624 (UniProtKB/TrEMBL),   A6HP01 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257560   ⟸   NM_001270631
- Peptide Label: isoform 3 preproprotein
- UniProtKB: Q53YL8 (UniProtKB/Swiss-Prot),   P23363 (UniProtKB/Swiss-Prot),   A6HP04 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257561   ⟸   NM_001270632
- Peptide Label: isoform 3 preproprotein
- UniProtKB: Q53YL8 (UniProtKB/Swiss-Prot),   P23363 (UniProtKB/Swiss-Prot),   A6HP04 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257566   ⟸   NM_001270637
- Peptide Label: isoform 3 preproprotein
- UniProtKB: Q53YL8 (UniProtKB/Swiss-Prot),   P23363 (UniProtKB/Swiss-Prot),   A6HP04 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257564   ⟸   NM_001270635
- Peptide Label: isoform 3 preproprotein
- UniProtKB: Q53YL8 (UniProtKB/Swiss-Prot),   P23363 (UniProtKB/Swiss-Prot),   A6HP04 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257562   ⟸   NM_001270633
- Peptide Label: isoform 3 preproprotein
- UniProtKB: Q53YL8 (UniProtKB/Swiss-Prot),   P23363 (UniProtKB/Swiss-Prot),   A6HP04 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257567   ⟸   NM_001270638
- Peptide Label: isoform 3 preproprotein
- UniProtKB: Q53YL8 (UniProtKB/Swiss-Prot),   P23363 (UniProtKB/Swiss-Prot),   A6HP04 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257559   ⟸   NM_001270630
- Peptide Label: isoform 1
- UniProtKB: A0A0H2UI28 (UniProtKB/TrEMBL),   A6HP02 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257565   ⟸   NM_001270636
- Peptide Label: isoform 3 preproprotein
- UniProtKB: Q53YL8 (UniProtKB/Swiss-Prot),   P23363 (UniProtKB/Swiss-Prot),   A6HP04 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257563   ⟸   NM_001270634
- Peptide Label: isoform 3 preproprotein
- UniProtKB: Q53YL8 (UniProtKB/Swiss-Prot),   P23363 (UniProtKB/Swiss-Prot),   A6HP04 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234746   ⟸   XM_006234684
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000073265   ⟸   ENSRNOT00000080190
Ensembl Acc Id: ENSRNOP00000075479   ⟸   ENSRNOT00000089233
Ensembl Acc Id: ENSRNOP00000064356   ⟸   ENSRNOT00000073636
Ensembl Acc Id: ENSRNOP00000073685   ⟸   ENSRNOT00000090445
Ensembl Acc Id: ENSRNOP00000072849   ⟸   ENSRNOT00000077703
Ensembl Acc Id: ENSRNOP00000072315   ⟸   ENSRNOT00000078543
Ensembl Acc Id: ENSRNOP00000074338   ⟸   ENSRNOT00000083289
Ensembl Acc Id: ENSRNOP00000073647   ⟸   ENSRNOT00000083542
Ensembl Acc Id: ENSRNOP00000104100   ⟸   ENSRNOT00000122945
Protein Domains
Nerve growth factor-related

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P23363-F1-model_v2 AlphaFold P23363 1-249 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692279
Promoter ID:EPDNEW_R2803
Type:single initiation site
Name:Bdnf_2
Description:brain-derived neurotrophic factor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R2804  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03100,786,889 - 100,786,949EPDNEW
RGD ID:13692281
Promoter ID:EPDNEW_R2804
Type:multiple initiation site
Name:Bdnf_1
Description:brain-derived neurotrophic factor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R2803  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03100,788,008 - 100,788,068EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2202 AgrOrtholog
BioCyc Gene G2FUF-48479 BioCyc
Ensembl Genes ENSRNOG00000047466 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000073636 ENTREZGENE
  ENSRNOT00000077703 ENTREZGENE
  ENSRNOT00000077703.2 UniProtKB/Swiss-Prot
  ENSRNOT00000078543 ENTREZGENE
  ENSRNOT00000078543.2 UniProtKB/Swiss-Prot
  ENSRNOT00000080190 ENTREZGENE
  ENSRNOT00000080190.2 UniProtKB/Swiss-Prot
  ENSRNOT00000083289.2 UniProtKB/Swiss-Prot
  ENSRNOT00000083542 ENTREZGENE
  ENSRNOT00000089233 ENTREZGENE
  ENSRNOT00000089233.2 UniProtKB/Swiss-Prot
  ENSRNOT00000090445.2 UniProtKB/Swiss-Prot
  ENSRNOT00000122945 ENTREZGENE
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7319966 IMAGE-MGC_LOAD
InterPro Brain-der_neurotrophic_factor UniProtKB/Swiss-Prot
  Cystine-knot_cytokine UniProtKB/Swiss-Prot
  Nerve_growth_factor-like UniProtKB/Swiss-Prot
  Nerve_growth_factor-rel UniProtKB/Swiss-Prot
  Nerve_growth_factor_CS UniProtKB/Swiss-Prot
KEGG Report rno:24225 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105254 IMAGE-MGC_LOAD
NCBI Gene 24225 ENTREZGENE
PANTHER PTHR11589 UniProtKB/Swiss-Prot
  PTHR11589:SF3 UniProtKB/Swiss-Prot
Pfam NGF UniProtKB/Swiss-Prot
PharmGKB BDNF RGD
PhenoGen Bdnf PhenoGen
PIRSF NGF UniProtKB/Swiss-Prot
PRINTS BDNFACTOR UniProtKB/Swiss-Prot
  NGF UniProtKB/Swiss-Prot
PROSITE NGF_1 UniProtKB/Swiss-Prot
  NGF_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000047466 RatGTEx
SMART NGF UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot
UniProt A0A0G2K624 ENTREZGENE, UniProtKB/TrEMBL
  A0A0H2UI28 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LQJ4_RAT UniProtKB/TrEMBL
  A6HP01 ENTREZGENE, UniProtKB/TrEMBL
  A6HP02 ENTREZGENE, UniProtKB/TrEMBL
  A6HP04 ENTREZGENE, UniProtKB/TrEMBL
  BDNF_RAT UniProtKB/Swiss-Prot
  C8CEB1_RAT UniProtKB/TrEMBL
  P23363 ENTREZGENE
  Q53YL8 ENTREZGENE
  Q99NV7_RAT UniProtKB/TrEMBL
UniProt Secondary Q53YL8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Bdnf  brain derived neurotrophic factor    Brain derived neurothrophic factor  Name updated 629478 APPROVED
2002-06-10 Bdnf  Brain derived neurothrophic factor      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expression is regulated by both glutamate and GABA 631754
gene_expression expressed in cortical neurons 625735
gene_function functions as a neurotrophic factor 631710
gene_function binds to TrkB receptor 631754
gene_process involved in regulating the survival, differentiation of neurons 631754
gene_process involved in activity-dependent modifications of neuronal connectivity and synaptic length at cortical as well as hippocampal synapses, establishment of hippocampal long-term potentiation (LPT) 628410
gene_process mediates limbic epileptogenesis 628430
gene_process plays a role in differentiation of serotoninergic neurons 628412
gene_process increased expression in hippocampal explant cultures induces axonal branching and basal dendrites in the dentate granule cells (DGCs) 625735
gene_process may encode temporal features of hippocampal neuronal activity 625735
gene_regulation may induces serortonin transporter,5HT1a and 1b serotonin receptors and BDNF receptor tyroisine kinase B (TrkB) 625735
gene_regulation effects on morphological plasticity are inhibited by tyrosine kinase inhibitor K252a 625735
gene_regulation activity dependent secretion requires N-type calcium channel mediated calcium influx and calcium mobilization from intracellular stores 625735
gene_regulation promoters are rapidly hyperacetylated by histones (e.g. H4) in hippocampal CA3 neurons after seizures 625735
gene_transcript contains a NRSE element, which is located between exons I and II 625735