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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2202
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bdnf
Name: brain-derived neurotrophic factor
Acc ID: CHEBI:39421
Term: perfluorooctane-1-sulfonic acid
Definition: A perfluoroalkanesulfonic acid that is octane-1-sulfonic acid in which all seventeen of the hydrogens that are attached to carbons hvae been replaced by fluorines.
Chemical ID: MESH:C076994
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bdnfdecreases expressionEXP 6480464CTDperfluorooctane sulfonic acid results in decreased expression of BDNF proteinPMID:25524167
Bdnfincreases expressionEXP 6480464CTDperfluorooctane sulfonic acid results in increased expression of BDNF mRNA; perfluorooctane sulfonic acid results in increased expression of BDNF proteinPMID:21436126 PMID:25524167
Bdnfmultiple interactionsEXP 6480464CTD2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of BDNF mRNA]; 2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of BDNF protein]; 2,2',4,4'-tetrabromodiphenyl ether promotes the reaction [perfluorooctane sulfonic acid results in increased expression of BDNF mRNA]; 2,2',4,4'-tetrabromodiphenyl ether promotes the reaction [perfluorooctane sulfonic acid results in increased expression of BDNF protein]; [2,2',4,4'-tetrabromodiphenyl ether co-treated with perfluorooctane sulfonic acid] results in increased expression of BDNF proteinPMID:21436126
Bdnfmultiple interactionsISOBdnf (Mus musculus)6480464CTD[perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of BDNF mRNAPMID:36331819
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