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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2202
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bdnf
Name: brain-derived neurotrophic factor
Acc ID: CHEBI:81584
Term: 2,2',4,4'-Tetrabromodiphenyl ether
Definition: An organobromine compound that has formula C12H6Br4O.
Chemical ID: MESH:C511295
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bdnfdecreases methylationEXP 6480464CTD2,2',4,4'-tetrabromodiphenyl ether results in decreased methylation of BDNF genePMID:25533936
Bdnfincreases expressionEXP 6480464CTD2,2',4,4'-tetrabromodiphenyl ether results in increased expression of BDNF mRNA; 2,2',4,4'-tetrabromodiphenyl ether results in increased expression of BDNF proteinPMID:21436126
Bdnfmultiple interactionsEXP 6480464CTD2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of BDNF mRNA]; 2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of BDNF protein]; 2,2',4,4'-tetrabromodiphenyl ether promotes the reaction [perfluorooctane sulfonic acid results in increased expression of BDNF mRNA]; 2,2',4,4'-tetrabromodiphenyl ether promotes the reaction [perfluorooctane sulfonic acid results in increased expression of BDNF protein]; [2,2',4,4'-tetrabromodiphenyl ether co-treated with perfluorooctane sulfonic acid] results in increased expression of BDNF proteinPMID:21436126
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