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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2202
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bdnf
Name: brain-derived neurotrophic factor
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bdnfaffects expressionEXP 6480464CTDCadmium Chloride affects the expression of BDNF mRNAPMID:29548726
Bdnfdecreases expressionEXP 6480464CTDCadmium Chloride results in decreased expression of BDNF proteinPMID:32392679
Bdnfincreases methylationEXP 6480464CTDCadmium Chloride results in increased methylation of BDNF promoterPMID:22457795
Bdnfmultiple interactionsEXP 6480464CTD[sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] results in decreased expression of BDNF protein; protocatechuic acid inhibits the reaction [Cadmium Chloride results in decreased expression of BDNF protein]; zinc chloride affects the reaction [Cadmium Chloride affects the expression of BDNF mRNA]PMID:23680456 PMID:29548726 PMID:32392679
Bdnfincreases expressionISOBDNF (Homo sapiens)6480464CTDCadmium Chloride results in increased expression of BDNF proteinPMID:26138014
Bdnfmultiple interactionsISOBdnf (Mus musculus)6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of BDNF protein; Curcumin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of BDNF protein]; Pioglitazone inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of BDNF protein]PMID:32735850
Bdnfmultiple interactionsISOBDNF (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of BDNF protein]PMID:26138014
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